5,011 research outputs found
Integrated control of hypertension by olmesartan medoxomil and hydrochlorothiazide and rationale for combination
Hypertension affects nearly one-third of all individuals in the US, yet one-half of all treated patients achieve blood pressure (BP) controlled to recommended goals. The percentage of patients with uncontrolled BP is likely to be much higher when considering the number of patients who are not even aware of their hypertensive state. Elevated BP is associated with increased risks of cardiovascular events and end-organ damage. Antihypertensive monotherapy is not always sufficient to achieve BP goals, and thus more aggressive treatment regimens need to be considered. Antihypertensive combination therapy, which may improve tolerability, offers the benefit of targeting different mechanisms of action. Numerous outcomes studies support the use of a renin–angiotensin system inhibitor as a first-line choice in antihypertensive therapy. This review discusses the benefits of combination therapy with the angiotensin type II receptor blocker olmesartan medoxomil (OM) paired with the thiazide diuretic hydrochlorothiazide (HCTZ). The pharmacokinetic properties of OM will be reviewed in addition to efficacy studies that support OM + HCTZ combination therapy over other possible antihypertensive combinations. Finally, a rationale for choosing HCTZ over another diuretic, chlorthalidone, will also be discussed based on pharmacokinetic differences, clinical concerns, and trends in use
Rigorous luminosity function determination in presence of a background: theory and application to two intermediate redshift clusters
In this paper we present a rigorous derivation of the luminosity function
(LF) in presence of a background. Our approach is free from the logical
contradictions of assigning negative values to positively defined quantities
and avoid the use of incorrect estimates for the 68 % confidence interval
(error bar). It accounts for Poisson fluctuations ignored in previous
approaches and does not requires binning of the data. The method is extensible
to more complex situations, does not require the existence of an
environment--independent LF, and clarifies issues common to field LF
derivations. We apply the method to two clusters of galaxies at intermediate
redshift (z~0.3) with among the deepest and widest K_s observations ever taken.
Finally, we point out short-comings of flip--flopping magnitudes.Comment: MNRAS, in pres
Enumeration of s-d separators in DAGs with application to reliability analysis in temporal graphs
Temporal graphs are graphs in which arcs have temporal labels, specifying at which time they can be traversed. Motivated by recent results concerning the reliability analysis of a temporal graph through the enumeration of minimal cutsets in the corresponding line graph, in this paper we attack the problem of enumerating minimal s-d separators in s-d directed acyclic graphs (in short, s-d DAGs), also known as 2-terminal DAGs or s-t digraphs. Our main result is an algorithm for enumerating all the minimal s-d separators in a DAG with O(nm) delay, where n and m are respectively the number of nodes and arcs, and the delay is the time between the output of two consecutive solutions. To this aim, we give a characterization of the minimal s-d separators in a DAG through vertex cuts of an expanded version of the DAG itself. As a consequence of our main result, we provide an algorithm for enumerating all the minimal s-d cutsets in a temporal graph with delay O(m3), where m is the number of temporal arcs
Protection of vaccine preventable diseases in a population of hiv-infected children: A 3 years prospective study
Human Immunodeficiency Virus (HIV) infected children have a 30–70% chance of being incompletely immunized and may not respond serologically with the same magnitude or durability as uninfected children. The aim of the study was to describe the rate of protective antibodies titre and the persistence of the response against four recommended vaccinations in HIV infected children and adolescents. A two-phase observational study was performed in which protective IgG antibodies to measles, mumps, rubella and hepatitis B were determined and monitored for 12 and 24 months, in 26 perinatally HIV-infected children. The rate of protection for rubella and hepatitis B was significantly lower in the HIV group compared to the control group (92% vs. 65% for rubella and 78.4% vs. 45.4% for hepatitis B; p < 0.05). Children who received primary vaccination after initiating combination antiretroviral therapy (cART) had a higher rate of response. Seronegative patients who received a booster dose of vaccine had a good immunological response. HIV infection is associated with a lower response to vaccines against rubella and hepatitis. The beginning of cART before vaccination may be associated with a better response. The evaluation of the serological response is crucial in children with HIV infection in order to evaluate the protection of vaccine preventable diseases
Grandezza e limiti della modernit\ue0: I rapporti tra diritto e politica in Villey, Cotta, Hervada
Questo lavoro cerca di presentare il pensiero di Villey, Cotta e Hervada sui rapporti tra il diritto e la filosofia politica. Dopo aver collocato il pensiero di questi autori nel quadro storico del fine della modernit\ue0, l\u2019autore cerca di sistemare i loro argomenti secondo i seguenti elementi: i diritti al di sopra dello stato, l\u2019universalit\ue0 del diritto, il ritorno dell\u2019aspetto relazionale e il binomio diritto-politica, la giurisprudenza come scienza pratica.The present work seeks to present the thought of Villey, Cotta and Hervada with regard to the relationship between the right and political philosophy. Having contextu20 alized the thought of these authors in the historical framework of the end of modernity, the author seeks to categorize the elements of their thought on the subjcet according to the following elements: right above the political state, universality of right, the return of the relational aspect and the \u201cright-politics\u201d relationship, jurisprudence as practical science
The artificial retina for track reconstruction at the LHC crossing rate
We present the results of an R&D study for a specialized processor capable of
precisely reconstructing events with hundreds of charged-particle tracks in
pixel and silicon strip detectors at , thus suitable for
processing LHC events at the full crossing frequency. For this purpose we
design and test a massively parallel pattern-recognition algorithm, inspired to
the current understanding of the mechanisms adopted by the primary visual
cortex of mammals in the early stages of visual-information processing. The
detailed geometry and charged-particle's activity of a large tracking detector
are simulated and used to assess the performance of the artificial retina
algorithm. We find that high-quality tracking in large detectors is possible
with sub-microsecond latencies when the algorithm is implemented in modern,
high-speed, high-bandwidth FPGA devices.Comment: 3 pages, 3 figures, ICHEP14. arXiv admin note: text overlap with
arXiv:1409.089
Simulation and performance of an artificial retina for 40 MHz track reconstruction
We present the results of a detailed simulation of the artificial retina
pattern-recognition algorithm, designed to reconstruct events with hundreds of
charged-particle tracks in pixel and silicon detectors at LHCb with LHC
crossing frequency of . Performances of the artificial retina
algorithm are assessed using the official Monte Carlo samples of the LHCb
experiment. We found performances for the retina pattern-recognition algorithm
comparable with the full LHCb reconstruction algorithm.Comment: Final draft of WIT proceedings modified according to JINST referee's
comment
Eprosartan mesylate, an angiotensin II receptor antagonist
The title compound, eprosartan mesylate {systematic name: 2-butyl-1-(4-carboxybenzyl)-5-[(E)-2-carboxy-3-(thiophen-2-yl)prop-1-enyl]-1H-imidazol-3-ium methanesulfonate}, C23H25N2O4S+·CH3O3S−, one of the angiotensin II-receptor antagonists, is effective in regulating hypertension, induced or exacerbated by angiotensin II, and in the treatment of congestive heart failure, renal failure and glaucoma. In the eprosartan residue, which appears in this crystal in the cationic imidazolium form, the benzene ring plane is almost orthogonal to that of the imidazole ring, making a dihedral angle of 87.89 (2)°. The thiophene ring forms dihedral angles of 66.54 (2) and 67.12 (2)° with the benzene and imidazole rings, respectively. The imidazolium NH group and the H atom of the aromatic carboxyl group participate in hydrogen bonds with the the O atoms of the anion, thus forming centrosymmetric aggregates made up of two cations and two anions each. The second carboxyl group further links the above-mentioned aggregates through a conventional centrosymmetric hydrogen-bonding motif into infinite chains along [011]
A Specialized Processor for Track Reconstruction at the LHC Crossing Rate
We present the results of an R&D study of a specialized processor capable of
precisely reconstructing events with hundreds of charged-particle tracks in
pixel detectors at 40 MHz, thus suitable for processing LHC events at the full
crossing frequency. For this purpose we design and test a massively parallel
pattern-recognition algorithm, inspired by studies of the processing of visual
images by the brain as it happens in nature. We find that high-quality tracking
in large detectors is possible with sub-s latencies when this algorithm is
implemented in modern, high-speed, high-bandwidth FPGA devices. This opens a
possibility of making track reconstruction happen transparently as part of the
detector readout.Comment: Presented by G.Punzi at the conference on "Instrumentation for
Colliding Beam Physics" (INSTR14), 24 Feb to 1 Mar 2014, Novosibirsk, Russia.
Submitted to JINST proceeding
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