Muscle pathology in upper motor neuron paraplegia

During the last 30 years acceptance of the muscle biopsy by paraplegic patients have accumulated a large body of knowledge on effects of spinal cord injury (SCI) on the skeletal muscle microstructure. Light and electron microscopy analyses combined with computerized methods provided a large body of knowledge on the progression of muscle atrophy and on the effects of rehabilitation strategies. Beside a summary of normal human muscle results, we will here discuss the time-course of muscle events related to SCI affecting the upper motor neuron. Furthermore the concomitant events on the microcirculation of skeletal muscle will be described in relation to the frequent complications of deep venous thrombosis, decubitus ulcers and paraosteoarthrosis

Removal of acetaldehyde from saliva by mucoadhesive formulations containing cysteine and chlorhexidine diacetate: a possible approach to the prevention of oral cavity alcohol-related cancer

The aim of our work has been to develop buccoadhesive formulations (tablets) containing both L-cysteine and chlorhexidine diacetate and to verify their ability to reduce oral acetaldehyde produced after alcoholic drinks consumption

Muscle pathology in upper motor neuron paraplegia

During the last 30 years acceptance of the muscle biopsy by paraplegic patients have accumulated a large body of knowledge on effects of spinal cord injury (SCI) on the skeletal muscle microstructure. Light and electron microscopy analyses combined with computerized methods provided a large body of knowledge on the progression of muscle atrophy and on the effects of rehabilitation strategies. Beside a summary of normal human muscle results, we will here discuss the time-course of muscle events related to SCI affecting the upper motor neuron. Furthermore the concomitant events on the microcirculation of skeletal muscle will be described in relation to the frequent complications of deep venous thrombosis, decubitus ulcers and paraosteoarthrosis

Pro-collagen I COOH-terminal trimer induces directional migration and metalloproteinases in breast cancer cells.

Breast and prostatic carcinomas, melanoma, and endothelial cell lines are chemoattracted by medium conditioned by mature osteoblasts. The chemoattractant for endothelial cells was identified with C3, carboxyl-terminal trimer of pro-collagen type I. We report that C3 induces directional migration and proliferation, the expression of tissue inhibitor of metalloproteinases-2, pro-metalloproteinase-2 and -9, and their activation in MDA MB231 cells, without changing the expression of tissue inhibitor of metalloproteinases-1 and of metalloproteinase-14. Antiserum against metalloproteinase-2 or -9 or -14, tissue inhibitor of metalloproteinases-1, or GM6001 inhibits the C3-induced migration. Urokinase and its receptor are detected and unchanged upon exposure to C3. The antibody against urokinase or addition of plasminogen activator inhibitor inhibits migration. Blocking antibodies to integrins alpha(2), alpha(6), beta(1), and beta(3) inhibit chemotaxis and do not change urokinase and urokinase receptor expression. Blockage of alpha(2), beta(1), and beta(3) integrins affect differently the induction by C3 of pro-metalloproteinase-2 and -9 and of tissue inhibitor of metalloproteinases-2. Chemotaxis to C3 is also inhibited by genistein, by pertussis toxin, which also inhibits C3-induced pro-metalloproteinase -2 and -9, but not urokinase expression. Wortmannin partially inhibits C3-induced cell migration. Other, but not all, breast carcinoma lines tested responded to C3 with migration and pro-metalloproteinase-2 induction. Presently C3 is the only agent known to induce migration specifically of both endothelial and breast carcinoma cells. The mitogenic and motogenic role of C3 in vitro might prefigure a role in in vivo carcinogenesis and in the establishment of metastasis

Über die Technik der Fiktion im Hochbarock und aus der Sicht der Aufklärung : zu Andrea Pozzos "Perspectiva pictorum et architectorum", Rom 1693-1700

Wissenschaftliches Kolloquium vom 27. bis 30. Juni 1996 in Weimar an der Bauhaus-Universität zum Thema: ‚Techno-Fiction. Zur Kritik der technologischen Utopien

Multi-Agents Corporate Memory Management System

International audienceThis paper presents an approach to design a multi-agent system managing a corporate memory in the form of a distributed semantic web and describes the resulting architecture. The system was designed during the CoMMA European project (Corporate MemoryManagement through Agents) and aims at helping users in the management of a corporate memory, facilitating the creation, dissemination, transmission and reuse of knowledge in an organisation. The implementation integrated several emerging technologies: multi-agents system technology (using the JADE FIPA-compliant platform), knowledge modelling and XML technology for information retrieval (using the CORESE semantic search engine) and machine learning techniques. Here, we describe the agent roles and interactions, we explain the design rationale for the agent societies and we discuss the configuration and implementation issues

Characterisation of innate lymphoid cell subsets infiltrating colorectal carcinoma

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