51 research outputs found
Late-onset benefit in progressive advanced hepatocellular carcinoma with continued sorafenib therapy: a case report
<p>Abstract</p> <p>Introduction</p> <p>In the past, no effective systemic therapy has existed for patients with advanced hepatocellular carcinoma. Sorafenib, an oral multikinase inhibitor, has recently been shown to improve overall survival in patients with advanced hepatocellular carcinoma in two randomized, double-blinded, placebo-controlled trials. This drug has been approved as the first-line therapy for advanced hepatocellular carcinoma patients. We report an intriguing case of advanced hepatocellular carcinoma in which the patient achieved late- onset partial response by prolonged administration of sorafenib in spite of progressive disease.</p> <p>Case presentation</p> <p>A 54-year-old Japanese man was treated with sorafenib for multiple lung metastases after surgical resection for advanced hepatocellular carcinoma accompanied by vascular invasion of the left branch of the portal vein. Although the effective diagnosis was progressive disease, almost all sites began to reduce or disappear eight months after the diagnosis of progressive disease. A dramatic reduction in alpha-fetoprotein and des-gamma-carboxy prothrombin levels was observed. The patient finally achieved partial response and his status remains unchanged.</p> <p>Conclusions</p> <p>If tolerated, prolonged sorafenib treatment may be beneficial.</p
Meta-analysis of percutaneous radiofrequency ablation versus ethanol injection in hepatocellular carcinoma
Values - reviewing the construct and drawing implications for values work in organisation and leadership. Kap. 2
I: H.Askeland, G. Espedal, B. Jelstad Løvaas & S. Sirris (Eds.), Understanding values work : Institutional perspectives in organizations and leadershipThis chapter outlines the trajectory of values, particularly within streams of organisational institutionalism, in order to analyse its application to values work in organisation and leadership. Conveying a frame for discussing values work, it aims at clarifying how to conceptualise the term values. Discussing classic and recent contributions, the chapter proposes seeing values as individual and collective conceptions of desirable trans-situational behaviours, objectives and ideals, serving to guide or valuate practice. Despite being an essential part of defining organisational institutionalism, and its sub-streams, values are seldom explicated. Utilising values in organisational and leadership research requires attention to their situatedness in contexts, and this chapter argues they are salient to organisations operating in pluralistic institutional environment. Studying values work, attention should be given to who and how such work is performed.publishedVersio
Antiangiogenic effects of pazopanib in xenograft hepatocellular carcinoma models: evaluation by quantitative contrast-enhanced ultrasonography
Cardiff cardiac ablation patient-reported outcome measure (C-CAP): validation of a new questionnaire set for patients undergoing catheter ablation for cardiac arrhythmias in the UK
C-arm computed tomography parenchymal blood volume measurement in evaluation of hepatocellular carcinoma before transarterial chemoembolization with drug eluting beads
The Core Value Compass: visually evaluating the goodness of brands that do good
yesBrands that do good for the society as well as for
themselves are motivated by the core values they espouse,
which necessitates a better understanding of what qualities a
true core value must possess. The inherent tension within
brands that do good, between commercial interests to
increase competitiveness, and societal interests that are
closely linked to the brand’s authenticity, has largely been
overlooked. Hence, we develop and demonstrate a relatively
easy-to-apply visual tool for evaluating core values based on
a set of ‘goodness’ criteria derived from extant theory. The
Core Value Compass adopts a paradox-based, evolutionary
perspective by incorporating the inherent tensions within
true core values, and classifying them according to their
temporal orientation. Thus, we contribute towards a better
understanding of underlying tensions of core values and
provide a practical tool that paves the way for improved, and
indeed ethical, corporate branding strategies. Furthermore,
we demonstrate the Compass’ application using the case of a
public sector brand, which is a quintessential brand that does
good. Therefore, we also contribute to the nascent theoretical
discourse on public sector branding. This paper therefore
adds to the notable attempts to bridge the gap between theory
and practice in core values-based corporate branding
Long-term intracavernous self-injection with prostaglandin E1 for the treatment of erectile dysfunction
Long-term intracavernous self-injection with prostaglandin E1 for the treatment of erectile dysfunction.
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