Peritoneal dissemination: comparison of 18F-FDG PET/CT and DWI with conventional MRI

Scientific Formal (Paper) Presentation - SSK13: Nuclear Medicine (Oncology)PURPOSE: The purpose of this study was to evaluate the diagnostic performance of 18F-FDG PET/CT in peritoneal dissemination detection, in comparison to MRI with and without diffusion-weighted imaging (DWI). METHOD AND MATERIALS: Prospective subjects with peritoneal metastases were recruited for 18F-FDG PET/CT and MRI, performed within 4-week of each other, without intervening therapeutic interventions. Images were evaluated in separate sessions as following: DWI alone, conventional MRI alone, DWI with conventional MRI, and 18F-FDG PET/CT for peritoneal dissemination in 16 anatomical ...postprin

Metabolic Phenotype of Stage IV Lung Adenocarcinoma: relationship with epidermal growth factor receptor mutation

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Factors affecting ventilation effectiveness in SARS wards

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The Effect of Air Density on Atmospheric Electric Fields Required for Lightning Initiation from a Long Airborne Object

The purpose of the work was to determine minimum atmospheric electric fields required for lightning initiation from an airborne vehicle at various altitudes up to 10 km. The problem was reduced to the determination of a condition for initiation of a viable positive leader from a conductive object in an ambient electric field. It was shown that, depending on air density and shape and dimensions of the object, critical atmospheric fields are governed by the condition for leader viability or that for corona onset. To establish quantitative criteria for reduced air densities, available observations of spark discharges in long laboratory gaps were analyzed, the effect of air density on leader velocity was discussed and evolution in time of the properties of plasma in the leader channel was numerically simulated. The results obtained were used to evaluate the effect of pressure on the quantitative relationships between the potential difference near the leader tip, leader current and its velocity; based on these relationships, criteria for steady development of a leader were determined for various air pressures. Atmospheric electric fields required for lightning initiation from rods and ellipsoidal objects of various dimensions were calculated at different air densities. It was shown that there is no simple way to extend critical ambient fields obtained for some given objects and pressures to other objects and pressures

Human preferences for sexually dimorphic faces may be evolutionarily novel

This article has been made available through the Brunel Open Access Publishing Fund.A large literature proposes that preferences for exaggerated sex typicality in human faces (masculinity/femininity) reflect a long evolutionary history of sexual and social selection. This proposal implies that dimorphism was important to judgments of attractiveness and personality in ancestral environments. It is difficult to evaluate, however, because most available data come from largescale, industrialized, urban populations. Here, we report the results for 12 populations with very diverse levels of economic development. Surprisingly, preferences for exaggerated sex-specific traits are only found in the novel, highly developed environments. Similarly, perceptions that masculine males look aggressive increase strongly with development, specifically, urbanization. These data challenge the hypothesis that facial dimorphism was an important ancestral signal of heritable mate value. One possibility is that highly developed environments provide novel opportunities to discern relationships between facial traits and behavior by exposing individuals to large numbers of unfamiliar faces, revealing patterns too subtle to detect with smaller samples

Evaluation of cervical cancer and normal cervix based on intravoxel incoherent motion imaging model-preliminary experience

This journal suppl. entitled: Book of Abstracts ESMRMB 2013 (e-only)Session - Female MRI: Let‘s take it to the next phase!PURPOSE/INTRODUCTION: We aim to investigate the differences between cervical cancer (CC) and normal cervix (NC) using intravoxel incoherent motion imaging (IVIM). SUBJECTS AND METHODS: Six patients with CC were prospectively recruited to undergo pre-treatment IVIM and routine MRI on a 3.0-T MRI. IVIM was performed ...postprin

Hmong Adults Self-Rated Oral Health: A Pilot Study

Since 1975, the Hmong refugee population in the U.S. has increased over 200%. However, little is known about their dental needs or self-rated oral health (SROH). The study aims were to: (1) describe the SROH, self-rated general health (SRGH), and use of dental/physician services; and (2) identify the factors associated with SROH among Hmong adults. A cross-sectional study design with locating sampling methodology was used. Oral health questionnaire was administered to assess SROH and SRGH, past dental and physician visits, and language preference. One hundred twenty adults aged 18–50+ were recruited and 118 had useable information. Of these, 49% rated their oral health as poor/fair and 30% rated their general health as poor/fair. Thirty-nine percent reported that they did not have a regular source of dental care, 46% rated their access to dental care as poor/fair, 43% visited a dentist and 66% visited a physician within the past 12 months. Bivariate analyses demonstrated that access to dental care, past dental visits, age and SRGH were significantly associated with SROH (P \u3c 0.05). Multivariate analyses demonstrated a strong association between access to dental care and good/excellent SROH. About half of Hmong adults rated their oral health and access to dental care as poor. Dental insurance, access to dental care, past preventive dental/physician visits and SRGH were associated with SROH

Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration

Cisplatin is a highly emetogenic cancer chemotherapy agent, which is often used to induce nausea and emesis in animal models. The cytotoxic properties of cisplatin also cause adverse events that negatively impact on animal welfare preventing repeated administration of cisplatin. In this study, we assessed whether a low (subclinical) dose of cisplatin could be utilized as a model of nausea and emesis in the dog while decreasing the severity of adverse events to allow repeated administration. The emetic, nausea-like behavior and potential biomarker response to both the clinical dose (70 mg/m2) and low dose (15 mg/m2) of cisplatin was assessed. Plasma creatinine concentrations and granulocyte counts were used to assess adverse effects on the kidneys and bone marrow, respectively. Nausea-like behavior and emesis was induced by both doses of cisplatin, but the latency to onset was greater in the low-dose group. No significant change in plasma creatinine was detected for either dose groups. Granulocytes were significantly reduced compared with baseline (P = 0.000) following the clinical, but not the low-dose cisplatin group. Tolerability of repeated administration was assessed with 4 administrations of an 18 mg/m2 dose cisplatin. Plasma creatinine did not change significantly. Cumulative effects on the granulocytes occurred, they were significantly decreased (P = 0.03) from baseline at 3 weeks following cisplatin for the 4th administration only. Our results suggest that subclinical doses (15 and 18 mg/m2) of cisplatin induce nausea-like behavior and emesis but have reduced adverse effects compared with the clinical dose allowing for repeated administration in crossover studies

Optimal Management of Adverse Events From Copanlisib in the Treatment of Patients With Non-Hodgkin Lymphomas

INTRODUCTION: Copanlisib is a phosphoinositol 3-kinase (PI3K) inhibitor approved for the third-line treatment of follicular non-Hodgkin lymphoma. Although the drug is generally well-tolerated, it can be associated with several unique and potentially serious adverse effects (AEs). Two of the most common toxicities not seen with other PI3K inhibitors include hyperglycemia and hypertension, which primarily occur during infusion and resolve shortly thereafter, and likely relate to targeting the PI3K alpha isoform. Other toxicities less commonly observed with copanlisib than with other approved drugs in this class include non-infectious pneumonitis, infections, diarrhea and colitis, and hepatobiliary toxicity. MATERIALS AND METHODS: A panel composed of experts in lymphoma, diabetes, and hypertension convened to develop guidance pertaining to the administration of copanlisib and the management of the AEs associated with copanlisib treatment. RESULTS: Recommendations were formulated pertaining to the management of AEs associated with copanlisib treatment, particularly infusion-related hyperglycemia and hypertension, noninfectious pneumonitis, infections, diarrhea, and colitis. The recommendations herein reflect the consensus of the members of this panel, all of whom contributed to these suggested approaches to patient supportive care. CONCLUSION: There are a number of challenges associated with the use of copanlisib. Infusion-related hypertension and hyperglycemia occur frequently, although they are transient, reversible, and rarely of clinical significance; this report provides guidance as to their management