Proof of concept of an innovative detector for nuclear imaging applications

The 4DM-PET experiment aims to develop an innovative detector module for PET applications. The detector is based on a 20 × 20 × 10mm3 LYSO monolithic scintillator crystal coupled on the large opposite surfaces to 4 × 4 Silicon Photomultiplier pixel matrices of 5mm pitch. The Detector is connected to a custom designed Front-End ASICs managed by an FPGA-based read-out system. This configuration allows measuring the Depth of Interaction of gamma photons interacting in the crystal volume. To test the spatial resolution capabilities of this module the detector has been scanned with a pencil beam produced by collimated radioactive sources along the three dimensions of the crystal block. The results of the prototype characterization in terms of spatial resolution in the x-y plane and the Depth Of Interaction resolution are presented here

Comparing the emerging psychological meaning of tattoos in drug-addicted and not drug-addicted adults: A look inside health risks

Although tattoos have been historically characteristic of criminals and drug addicts therefore carrying negative associations, it is now an accepted and appreciated form of body modification. Tattoos could be considered as a projective psychological test, most people use their body as blackboard to represent the most varied meanings related to the way they perceive themselves. It is also true that tattoos can assume the role of diagnostic indicators for a possible abuse of psychoactive substances, as well as their aggregating and communicative functions within the group of drug addicts. The aim of this cross-sectional study was to explore the relation among personality traits, self-efficacy, locus of control and motivations for tattooing. The sample consisted of 150 subjects, 50 tattooed adults, 50 tattooed drug addicted adults, and 50 non-tattooed adults. Data were collected by using the Big Five Questionnaire (BFQ), the Perceived Self- efficacy Test, the Mini Locus of Control scale and a Tattoos Inventory. Results of the present study contribute to a deeper understanding of the new meaning of tattoos, they no longer represent personality traits, they rather have the function of reinforcing beliefs about how to perceive oneself, this happens especially in drug addicts in which the presence of tattoos reinforces the illusory belief of self-esteem and internal locus of control. Given the rising presence of tattoos today, this could be useful to get a better understanding of the existential unease of certain populations

Alpha-particle clustering in excited expanding self-conjugate nuclei

The fragmentation of quasi-projectiles from the nuclear reaction 40Ca + 12C at 25 MeV/nucleon was used to produce alpha-emission sources. From a careful selection of these sources provided by a complete detection and from comparisons with models of sequential and simultaneous decays, strong indications in favour of $\alpha$-particle clustering in excited 16O, 20Ne and 24}Mg are reported.Comment: 8 pages, 4 figures, 12th International Conference on Nucleus-Nucleus collisions (NN2015), 21-26 June 2015, Catania, Ital

A Teledentistry System for the Second Opinion

In this paper we present a teledentistry system aimed to the Second Opinion task. It make use of a particular camera called intra-oral camera, also called dental camera, in order to perform the photo shooting and real-time video of the inner part of the mouth. The pictures acquired by the Operator with such a device are sent to the Oral Medicine Expert (OME) by means of a current File Transfer Protocol (FTP) service and the real-time video is channeled into a video streaming thanks to the VideoLan client/server (VLC) application. It is composed by a HTML5 web-pages generated by PHP and allows to perform the Second Opinion both when Operator and OME are logged and when one of them is offline

Burnout syndrome in reception systems for illegal immigrants in the Mediterranean. A quantitative and qualitative study of Italian practitioners

Illegal immigration throughout the Mediterranean Sea is an intense and epoch-making phenomenon. This quantitative and qualitative study, based on the framework of the JD-R Model of burnout, described and assessed the risk of burnout among practitioners working in the reception system for illegal immigrants. A sample of Italian practitioners completed the Link Burnout Questionnaire (N = 193) and a semistructured interview (N = 108). The analysis of the questionnaires was carried out via ANOVA and χ2 test. The content of the interviews was examined using T-LAB. Quantitative results showed that the sample was generally at risk of burnout, and about a quarter were at severe risk. Qualitative results highlighted aspects of burnout that are specific to this working context: large workload, mental fatigue, and lack of social support; inability to understand the language and cultural differences of the immigrants; having to deal with organisational problems that come up repeatedly. This study offers coping strategies that can improve organisational health and performance of practitioners working in illegal immigration. Italy's shape, geographical location, and geo-political role make it a case in point for the whole European continent regarding the sustainability of illegal immigration across the Mediterranean Sea

Myelomonocytic Cell Lines in Modeling HIV-1 Infection of the Bone Marrow

Human immunodeficiency virus type 1 (HIV-1), the etiologic agent of acquired immunodeficiency syndrome (AIDS), primarily infects T cells and cells of the monocyte-macrophage lineage. This is due to the presence of the cell surface receptor CD4 and the coreceptors, CXCR4, and CCR5. While the T-cell has classically been the cell type associated with HIV-1 disease progression, cells of the monocyte-macrophage lineage have also been shown to play a major role in this viral pathologic process. Classically, this has involved monocytic cells in the peripheral blood and tissue macrophages, however, over the course of HIV disease, the promyelomonocytic cells of the bone marrow (BM) have also been shown to play a role in pathogenesis retroviral disease in that they play an integral role in the reseeding of the periphery and end-organ tissues. This has involved an initial infection of the bone marrow hematopoietic progenitor cells. Given this observation, over the years there have been a number of cell lines that have been developed and provided valuable insights into research questions surrounding HIV-1 infection of the monocyte-macrophage cell lineage. In this regard, we will examine the biological and immunological properties of these BM-derived cell lines with respect to their utility in exploring the pathogenesis of HIV-1 in humans

Anti-Transglutaminase Antibody Assay of the Culture Medium of Intestinal Biopsy Specimen Can Improve the Accuracy of Celiac Disease Diagnosis.

BACKGROUND: We measured anti-transglutaminase (anti-tTG) antibody in the culture medium of intestinal biopsy specimens from patients with suspected celiac disease (CD) and evaluated the relationship between antibody production and severity of intestinal mucosal damage. METHODS: We performed diagnostic testing for CD on 273 consecutive patients. In addition to routine histologic evaluation of duodenal biopsy specimens, we assayed anti-tTG antibodies in serum and in the culture medium of duodenal biopsy specimens. RESULTS: CD was diagnosed in 191 of the 273 patients. Sensitivity and specificity of the serum anti-endomysium (EmA) and anti-tTG assays were 83% and 85% and 99% and 95%, respectively, and both had 88% diagnostic accuracy. EmA and anti-tTG assayed in the culture medium had 98% sensitivity, 100% specificity, and 98% diagnostic accuracy (vs serum assays; P <0.0001). Twenty-nine CD patient specimens (16%) were negative for serum anti-tTG and EmA; for 24 of these patients, anti-tTG assay of the culture medium was positive. The CD patients whose biopsy specimens were positive for serum antibodies showed the following intestinal histologies: total villous atrophy, 35%; severe villous atrophy, 25%; mild atrophy, 25%; villi with no atrophy but with increased intraepithelial lymphocytes, 15%. None of the CD patients whose specimens were negative for serum antibodies showed total or severe villous atrophy; 77% had mild villous atrophy, and 23% had no villous atrophy but had increased intraepithelial lymphocyte counts. Mild villous atrophy was also seen in specimens from approximately 15% of patients without CD. CONCLUSION: Anti-tTG assay of the culture medium of biopsy specimens can improve the accuracy of CD diagnosis in patients negative for serum antibodies

Importance of Co-operative Hydrogen Bonding in the Apramycin-Ribosomal Decoding A-Site Interaction

An intramolecular hydrogen bond between the protonated equatorial 7'-methylamino group of apramycin and the vicinal axial 6'-hydroxy group acidifies the 6'-hydroxy group leading to a strong hydrogen bond to A1408 in the ribosomal drug binding pocket in the decoding A site of the small ribosomal subunit. In 6'-epiapramycin, the trans-nature of the 6'-hydroxy group and the 7'-methylamino group results in a much weaker intramolecular hydrogen bond, and a consequently weaker cooperative hydrogen bonding network with A1408, resulting overall in reduced inhibition of protein synthesis and antibacterial activity

Production of α\alpha-particle condensate states in heavy-ion collisions

The fragmentation of quasi-projectiles from the nuclear reaction $^{40}Ca$ + $^{12}C$ at 25 MeV/nucleon was used to produce excited states candidates to $\alpha$-particle condensation. The experiment was performed at LNS-Catania using the CHIMERA multidetector. Accepting the emission simultaneity and equality among the $\alpha$-particle kinetic energies as experimental criteria for deciding in favor of the condensate nature of an excited state, we analyze the $0_2^+$ and $2_2^+$ states of $^{12}$C and the $0_6^+$ state of $^{16}$O. A sub-class of events corresponding to the direct 3-$\alpha$ decay of the Hoyle state is isolated.Comment: contribution to the 2nd Workshop on "State of the Art in Nuclear Cluster Physics" (SOTANCP2), Universite Libre de Bruxelles (Belgium), May 25-28, 2010, to be published in the International Journal of Modern Physics