Desenvolvimento de ferramenta vocacionada para o dimensionamento de estruturas metálicas de acordo com a NP EN 1993-1-1

Trabalho desenvolvido em parceria com a empresa Casais.A presente comunicação descreve o desenvolvimento de uma ferramenta informática vocacionada para o dimensionamento de estruturas metálicas de acordo com a NP EN 1993 1 1 [1]. A ferramenta AciariUM é direcionada para a verificação e dimensionamento (ELU) de vigas-coluna em aço sujeitas a flexão composta desviada. Foi desenvolvida como meio de análise de elementos em aço e de verificação expedita dos resultados recolhidos a partir de programas comerciais de análise estrutural. Permite ao utilizador um controlo total sobre os resultados, na medida em que todo o algoritmo e procedimento de cálculo relativo a cada parâmetro está disponível para consulta e edição.É dirigido um especial agradecimento: à CASAIS – Engenharia e Construção, S.A. e à Universidade do Minho por acolherem este projeto; aos suportes dos programas CYPE 3D e Robot Structural Analysis pela disponibilidade com que interagiram com os autores deste projeto sempre que a sua intervenção foi solicitada

Digestibilidade da matéria seca do feno de alfafa e farelo de mamona desintoxicada pela técnica do "saco de nylon".

Comparação da digestibilidade de matéria seca do feno de alfafa e do farelo de mamona desintoxicada, pela técnica do saco de nylon, utilizando-se como repetições 2 bovinos fistulados adultos da raça holandesa

dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction

Abstract: Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of dendrimers, a commonly explored drug vector, based on physicochemical properties. We have manually curated the largest relational database of dendrimer pharmacokinetic parameters and their structural/physicochemical properties. This was used to develop a machine learning-based model capable of accurately predicting pharmacokinetic parameters, including half-life, clearance, volume of distribution and dose recovered in the liver and urine. dendPoint successfully predicts dendrimer pharmacokinetic properties, achieving correlations of up to r = 0.83 and Q2 up to 0.68. dendPoint is freely available as a user-friendly web-service and database at http://biosig.unimelb.edu.au/dendpoint. This platform is ultimately expected to be used to guide dendrimer construct design and refinement prior to embarking on more time consuming and expensive in vivo testing

Fatigue behaviour of laser repairing welded joints

This paper presents a fatigue study in Nd-YAG laser surface repairing welded joints in specimens of two base materials used in mould production. The tests were carried out in a servo-hydraulic machine in tension, under constant amplitude loading, with two stress ratios R = 0 and R = 0.4. Welded specimens were prepared with U notches and filled with laser welding deposits. The fatigue results are presented in the form of S-N curves obtained in welded and non-welded conditions. Complementary measurements of hardness and residual stresses profiles were carried out along the surface of laser welded specimens to understand the observed fatigue behaviour. The melted material was the weaker region, with lower values of hardness and higher tensile residual stresses, presenting also a high number of defects that are potential failure sites. The presence of such defects can explain the relatively poor fatigue strength of the laser repairing joints in comparison to base materials.http://www.sciencedirect.com/science/article/B6V2X-4N2M6PH-1/1/945a7f442fb922704c73d665abcb0b0

Mould steels repaired by laser welding

Laser-deposit welding, by using Nd-YAG, is a mould repairing process, which has the advantages relatively to the traditional methods of achieving a less change of the metal composition around the repaired zone and permitting a very accurate deposition of a small volume of the filler material in the area chosen at the work-piece surface. This paper presents a fatigue study in specimens of two base materials used in mould production (AISI H13 and P20). Filler material as well as welding parameters were analysed in order to obtain better fatigue strength. The tests were carried out under constant amplitude loading, with two stress ratios R = 0 and R = 0.4. Welded specimens were prepared with V notches and filled with laser welding deposits. The fatigue results are presented in the form of S-N curves obtained in welded and non-welded conditions. Complementary measurements of hardness profiles and SEM analysis were carried out to understanding the fatigue behaviour and failure sites. The laser-deposit material was the weaker region in both steels, due to a high level of tensile residual stresses and also to some planar defects that are potential failure sites. Fatigue crack initiation is therefore reduced and the fatigue propagation life is enhanced. A significant mean stress effect in the base material was also observed in both mould steels.http://www.sciencedirect.com/science/article/B6V2X-4S03RKY-3/1/b8b7da232b765381e7d08d9f3d7f897

Determinação da fração de mineralização de compostos nitrogenados de lodos de esgoto aplicados em solo agrícola.

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