18,302 research outputs found
PatologÃas óseas en un esqueleto de Oso pardo macho adulto de la Cordillera Cantábrica (Reserva Nacional de Caza de Riaño, León.)
[Abstract] In this paper we describe with detail the pathological conditions found on the skeleton of an adult male brown bear from the Cantabrian Mountains. This specimen shows a great number of pathologies, some of infectious origin and others of traumatic origin, as well as pathologies such as caries. We discuss the possible aetiology of the lesions, development and consequences, as well as how they did affect the living animal and its survival opportunities
KRAS early testing. Consensus initiative and cost-effectiveness evaluation for metastatic colorectal patients in an italian setting
KRAS testing is relevant for the choice of the most appropriate first-line therapy of metastatic colorectal cancer (CRC). Strategies for preventing unequal access to the test should be implemented, but their relevance in the practice is related to economic sustainability. The study adopted the Delphi technique to reach a consensus on several topics. Issues related to execution of KRAS testing were identified by an expert's board and proposed to 108 Italian oncologists and pathologists through two subsequent questionnaires. The emerging proposal was evaluated by decision analyses models employed by technology assessment agencies in order to assess cost-effectiveness. Alternative therapeutic strategies included most commonly used chemotherapy regimens alone or in combination with cetuximab or bevacizumab. The survey indicated that time interval for obtaining KRAS test should not exceed 15 days, 10 days being an optimal interval. To assure the access to proper treatment, a useful strategy should be to anticipate the test after radical resection in patients at high risk of relapse. Early KRAS testing in high risk CRC patients generates incremental cost-effectiveness ratios between 6,000 and 13,000 Euro per quality adjusted life year (QALY) gained. In extensive sensitivity analyses ICER's were always below 15,000 Euro per QALY gained, far within the threshold of 60,000 Euro/QALY gained accepted by regulatory institutions in Italy. In metastatic CRC a time interval higher than 15 days for result of KRAS testing limits access to therapeutic choices. Anticipating KRAS testing before the onset of metastatic disease in patients at high risk does not affect the sustainability and cost-effectiveness profile of cetuximab in first-line mCRC. Early KRAS testing may prevent this inequality in high-risk patients, whether they develop metastases, and is a cost-effective strategy. Based on these results, present joined recommendations of Italian societies of Oncology and Pathology should be updated including early KRAS testing
Fertility preservation in ovarian tumours
A considerable number of patients with a cancer diagnosis are of childbearing age and have not satisfied their desire for a family. Despite ovarian cancer (OC) usually occurring in older patients, 3%–14% are diagnosed at a fertile age with the overall 5-year survival rate being 91.2% in women ≤44 years of age when it is found at 1A–B stage. In this scenario, testing the safety and the efficacy of fertility sparing strategies in OC patients is very important overall in terms of quality of life. Unfortunately, the lack of randomised trials to validate conservative approaches does not guarantee the safety of fertility preservation strategies. However, evidence-based data from descriptive series suggest that in selected cases, the preservation of the uterus and at least one part of the ovary does not lead to a high risk of relapse. This conservative surgery helps to maintain organ function, giving patients of childbearing age the possibility to preserve their fertility. We hereby analysed the main evidence from the international literature on this topic in order to highlight the selected criteria for conservative management of OC patients, including healthy BRCA mutations carriers
Relação entre a radiação fotossinteticamente ativa e a radiação global para diferentes classificações de céu.
No presente trabalho, dados de vários anos da estação do projeto Sonda, localizada em Planaltina, DF, foram utilizados com o objetivo de se obter a relação entre a Rg e a RFA para diferentes tipos de céu, caracterizados por Ãndices de claridade e brilho
The motion of two masses coupled to a massive spring
We discuss the classical motion of a spring of arbitrary mass coupled to two
arbitrary massive blocks attached at its ends. A general approach to the
problem is presented and some general results are obtained. Examples for which
a simple elastic function can be inferred are discussed and the normal modes
and normal frequencies obtained. An approximation procedure to the evaluation
of the normel frequencies in the case of uniform elastic function and mass
density is also discussed.Comment: Standard Latex file plus three eps figure
Evidence for a Variable Ultrafast Outflow in the Newly Discovered Ultraluminous Pulsar NGC 300 ULX-1
Ultraluminous pulsars are a definite proof that persistent super-Eddington
accretion occurs in nature. They support the scenario according to which most
Ultraluminous X-ray Sources (ULXs) are super-Eddington accretors of stellar
mass rather than sub-Eddington intermediate mass black holes. An important
prediction of theories of supercritical accretion is the existence of powerful
outflows of moderately ionized gas at mildly relativistic speeds. In practice,
the spectral resolution of X-ray gratings such as RGS onboard XMM-Newton is
required to resolve their observational signatures in ULXs. Using RGS, outflows
have been discovered in the spectra of 3 ULXs (none of which are currently
known to be pulsars). Most recently, the fourth ultraluminous pulsar was
discovered in NGC 300. Here we report detection of an ultrafast outflow (UFO)
in the X-ray spectrum of the object, with a significance of more than
3{\sigma}, during one of the two simultaneous observations of the source by
XMM-Newton and NuSTAR in December 2016. The outflow has a projected velocity of
65000 km/s (0.22c) and a high ionisation factor with a log value of 3.9. This
is the first direct evidence for a UFO in a neutron star ULX and also the first
time that this its evidence in a ULX spectrum is seen in both soft and hard
X-ray data simultaneously. We find no evidence of the UFO during the other
observation of the object, which could be explained by either clumpy nature of
the absorber or a slight change in our viewing angle of the accretion flow.Comment: 10 pages, 4 figures. Accepted to MNRA
Quantum Cosmology in Scalar-Tensor Theories With Non Minimal Coupling
Quantization in the minisuperspace of non minimal scalar-tensor theories
leads to a partial differential equation which is non separable. Through a
conformal transformation we can recast the Wheeler-DeWitt equation in an
integrable form, which corresponds to the minimal coupling case, whose general
solution is known. Performing the inverse conformal transformation in the
solution so found, we can construct the corresponding one in the original
frame. This procedure can also be employed with the bohmian trajectories. In
this way, we can study the classical limit of some solutions of this quantum
model. While the classical limit of these solutions occurs for small scale
factors in the Einstein's frame, it happens for small values of the scalar
field non minimally coupled to gravity in the Jordan's frame, which includes
large scale factors.Comment: latex, 18 page
Was the GLE on May 17, 2012 linked with the M5.1-class flare the first in the 24th solar cycle?
On May 17, 2012 an M5.1-class flare exploded from the sun. An O-type coronal
mass ejection (CME) was also associated with this flare. There was an instant
increase in proton flux with peak at MeV, leading to S2 solar
radiation storm level. In about 20 minutes after the X-ray emission, the solar
particles reached the Earth.It was the source of the first (since December
2006) ground level enhancement (GLE) of the current solar cycle 24. The GLE was
detected by neutron monitors (NM) and other ground based detectors. Here we
present an observation by the Tupi muon telescopes (Niteroi, Brazil, , , 3 m above sea level) of the enhancement of muons at ground
level associated with this M5.1-class solar flare. The Tupi telescopes
registered a muon excess over background in the 5-min binning time
profile. The Tupi signal is studied in correlation with data obtained by
space-borne detectors (GOES, ACE), ground based neutron monitors (Oulu) and air
shower detectors (the IceTop surface component of the IceCube neutrino
observatory). We also report the observation of the muon signal possibly
associated with the CME/sheath striking the Earth magnetosphere on May 20,
2012. We show that the observed temporal correlation of the muon excess
observed by the Tupi muon telescopes with solar transient events suggests a
real physical connection between them. Our observation indicates that
combination of two factors, the low energy threshold of the Tupi muon
telescopes and the location of the Tupi experiment in the South Atlantic
Anomaly region, can be favorable in the study and detection of the solar
transient events. Our experiment provides new data complementary to other
techniques (space and ground based) in the study of solar physics.Comment: 9 pages, 10 figure
Eficiência de fungicidas no controle do mÃldio (Peronosclerospora sorghi) associado as sementes de sorgo.
bitstream/CNPMS/16150/1/Com_70.pd
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