428 research outputs found
Embracing Civility, Community, and Citizenship: A Qualitative Study of Multimodal College Composition Classrooms
This thesis will examine ways of teaching college composition through a lens where civility, citizenship, and community are the focus of the composition classroom. By drawing from critical composition pedagogy scholars and rich examples of civil/civic dialogue from the media, I will construct a series of actionable strategies to foster civil dialogue in the multimodal college composition classroom. Using scholarship in the field of rhetoric and composition, this classroom-based research project will seek to answer questions such as: How can a first-year college composition class teach civil dialogue and promote understanding in a society where the loudest, shrillest voices win? and How can a university implement and assess civility awareness? This study adds to the conversation regarding the need to work toward a more civil society and explores ways to work toward this by way of the first-year college composition classroom
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Fluorescent and colorimetric molecular recognition probe for hydrogen bond acceptors
YesThe association constants for formation of 1â:â1 complexes between a H-bond donor, 1-naphthol, and a diverse range of charged and neutral H-bond acceptors have been measured using UV/vis absorption and fluorescence emission titrations. The performance of 1-naphthol as a dual colorimetric and fluorescent molecular recognition probe for determining the H-bond acceptor (HBA) parameters of charged and neutral solutes has been investigated in three solvents. The data were employed to establish self-consistent H-bond acceptor parameters (β) for benzoate, azide, chloride, thiocyanate anions, a series of phosphine oxides, phosphate ester, sulfoxide and a tertiary amide. The results demonstrate both the transferability of H-bond parameters between different solvents and the utility of the naphthol-based dual molecular recognition probe to exploit orthogonal spectroscopic techniques to determine the HBA properties of neutral and charged solutes. The benzoate anion is the strongest HBA studied with a β parameter of 15.4, and the neutral tertiary amide is the weakest H-bond acceptor investigated with a β parameter of 8.5. The H-bond acceptor strength of the azide anion is higher than that of chloride (12.8 and 12.2 respectively), and the thiocyanate anion has a β value of 10.8 and thus is a significantly weaker H-bond acceptor than both the azide and chloride anions.Supported by the ESPRC
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Solvatomorphism of Reichardt's dye
YesA systematic study of the influence of solvent on the crystal packing behaviour of Reichardt's dye demonstrates that the structure of the assembly formed in the solid state depends on the nature of the solventâsolute interactions present in the solution phase. Apolar aprotic solvents lead to solvates with a hexagonal channel topology, but this supramolecular assembly is perturbed by the presence of aromatic or polar protic solvents
Delayed Feedback in Generalised Linear Bandits Revisited
The stochastic generalised linear bandit is a well-understood model for
sequential decision-making problems, with many algorithms achieving
near-optimal regret guarantees under immediate feedback. However, in many real
world settings, the requirement that the reward is observed immediately is not
applicable. In this setting, standard algorithms are no longer theoretically
understood. We study the phenomenon of delayed rewards in a theoretical manner
by introducing a delay between selecting an action and receiving the reward.
Subsequently, we show that an algorithm based on the optimistic principle
improves on existing approaches for this setting by eliminating the need for
prior knowledge of the delay distribution and relaxing assumptions on the
decision set and the delays. This also leads to improving the regret guarantees
from to , where denotes the
expected delay, is the dimension and the time horizon and we have
suppressed logarithmic terms. We verify our theoretical results through
experiments on simulated data
Influence of ligand and nuclearity on the cytotoxicity of cyclometallated C^N^C platinum(II) complexes
A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine 1 (HC^N^CH), have been synthesized and characterized. This library of compounds includes [(C^N^C)Pt(II)(L)] (L = dimethylsulfoxide (DMSO) 2 and triphenylphosphine (PPh3) 3) and [((C^N^C)Pt(II))2(L`)] (where L` = N-heterocycles (pyrazine (pyr) 4, 4,4,`-bipyridine (4,4`-bipy) 5 or diphosphine (1,4-bis(diphenylphosphino)butane (dppb) 6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2 and 3). Complex 6 is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values > 29.5 (A2780) and > 11.2 (A2780cisR), and outperforming cisplatin by > 4-fold and > 18-fold respectively
Dynamic platinum(II)- based metallosupramolecular architectures
Over the past two decades, transitions metals have been extensively employed
towards the construction (using coordination driven assembly) and operation (using
reversible metal-ligand switching motifs) of supramolecular architectures. This
Thesis details the investigation of an array of dynamic platinum(II)-based
metallosupramolecular architectures and includes a series of model studies on
switchable platinum(II) coordination modes.
Chapter Two describes the synthesis and study of a series of prototype noninterlocked
molecular machines. The inherent dynamics of intramolecular metalligand
substitution reactions (metallotrophic shifts) are exploited to drive a d8
platinum(II-)-phenanthroline component along different ligating architectures to
achieve translational (and in one case rotary) motion of the sub-molecular
components. Variable temperature NMR studies of these complexes have established
the kinetic parameters for the observed shuttling processes.
In Chapter Three, the switchable behaviour of a metal-ligand coordination motif is
reported in which a proton input is employed to modify the overall thermodynamic
bias and light is orthogonally utilized to selectively lower the energetic barrier for
the binding event to re-equilibration. A discussion of the light-promoted ligand
exchange reaction is presented, supported by a combination of TD-DFT calculations
and kinetic studies.
Chapter Four describes the exploitation of this discovered pH-switchable metalligand
motif for the stimuli-responsive reversible assembly of two dimensional and
three dimensional metallosupramolecular architectures. Whilst Chapter Five details
how this reversible motif can be exploited to induce controlled exchange between
â3+1â and â2+2â square planar platinum donor sets in response to the application
of acid-base stimuli
Examining the reliability of using fNIRS in realistic HCI settings for spatial and verbal tasks
Recent efforts have shown that functional near-infrared spectroscopy (fNIRS) has potential value for brain sensing in HCI user studies. Research has shown that, although large head movement significantly affects fNIRS data, typical keyboard use, mouse movement, and non-task-related verbalisations do not affect measurements during Verbal tasks. This work aims to examine the Reliability of fNIRS, by 1) confirming these prior findings, and 2) significantly extending our understanding of how artefacts affect recordings during Spatial tasks, since much of user interfaces and interaction is inherently spatial. Our results show that artefacts have a significantly different impact during Verbal and Spatial tasks. We contribute clearer insights into using fNIRS as a tool within HCI user studies
Examining the reliability of using fNIRS in realistic HCI settings for spatial and verbal tasks
Recent efforts have shown that functional near-infrared spectroscopy (fNIRS) has potential value for brain sensing in HCI user studies. Research has shown that, although large head movement significantly affects fNIRS data, typical keyboard use, mouse movement, and non-task-related verbalisations do not affect measurements during Verbal tasks. This work aims to examine the Reliability of fNIRS, by 1) confirming these prior findings, and 2) significantly extending our understanding of how artefacts affect recordings during Spatial tasks, since much of user interfaces and interaction is inherently spatial. Our results show that artefacts have a significantly different impact during Verbal and Spatial tasks. We contribute clearer insights into using fNIRS as a tool within HCI user studies
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