The use of aerial- and close-range photogrammetry for the mapping of the Lavini di Marco tracksite (Hettangian, Southern Alps, NE Italy)

(EXCERPT FROM ABSTRACT) Close-range photogrammetry was executed following the procedure proposed by Mallison & Wings (2014). More than seventy 3D models were obtained and interpreted by means of color-coded and contour line images, which allow to improve the ichno- logical knowledge of the tracksite. The 3D models of the best-preserved tracks were used for the osteological reconstruction of the trackmakers’ autopodia, supposing the arthral position of the phalangeal pads. Three indirect methods were used to correlate tracks and their trackmakers: (i) synapomorphy-based approach; (ii) phenetic correlation; (iii) coincidence correlation (see Carrano & Wilson, 2001) The final map was produced with different level of knowledge due to the distribution of tracks and current state of site preservation. Furthermore, it represents a complete documentation that will be used for future work of enhancement, preservation and valorization of the tracksite. The ichnotaxonomical review of the quadrupedal trackways led us to emend the diagnosis of Lavinipes cheminii Avanzini et al. (2003) and to assign several other sparse tracks and trackways to L. chemini. The skeletal reconstruction of fore and hind limbs points towards Gongxianosaurus sp. as the most suitable trackmaker of L. cheminii. The herein supposed Laurasian affinity of the Lavini di Marco dinosaur assemblage clashes with the previous hypotheses that always link the Southern Alps sector with the Gondwana mainland

Prevalence of low antithrombin levels in preeclamptic women and perinatal outcome

Objective. The aim of this study is to evaluate the prevalence of low antithrombin levels in our population in order to assess an intervention trial feasibility. Methods. This is a retrospective study. A database was created by using queries to find out medical records of patients requiring hospitalization for preeclampsia or gestational hypertension or superimposed preeclampsia to chronic hypertension at Modena University Hospital between June 2015 and July 2019. Results. We screened 11845 deliveries. Overall, 221 (1.9%) cases of preeclampsia were identified. Antithrombin level was available for 201 women, thus included in the analysis. Median antithrombin value was 87% (IQ range: 77-98). The prevalence of low antithrombin levels was 9%. Antithrombin < 80% was found in 21% of the subjects. The remnant showed normal values. Median antithrombin was significantly lower in severe respect with mild preeclampsia (83% ± 14 vs 89% ± 14, p = 0.003). The rate of small for gestational age was significantly higher in low antithrombin levels group (44.4% vs 22.4%, p = 0.042). Considering mean values, antithrombin levels were also significantly lower in case of small for gestational age (84% ± 14 vs 89% ± 14; p = 0.040). Conclusions. In our population, low antithrombin levels (1 in 10 patients) were associated with severity of preeclampsia, namely with small for gestational age babies. Data suggest this subpopulation as a better target for trials assessing the efficacy of antithrombin supplementation

Vaginal alpha-lipoic acid shows an anti-inflammatory effect on the cervix, preventing its shortening after primary tocolysis. A pilot, randomized, placebo-controlled study

Introduction: Inflammation might be an important underlying cause of preterm birth. Our aim is to explore whether vaginal administration α-lipoic acid reduces cervical inflammation and shortening after primary tocolysis. Materials and methods: Singleton pregnancies between 24–30 weeks remaining undelivered after hospitalization for preterm labor were randomly allocated to placebo (20 women, 15 analyzed) or vaginal ALA 400 mg (active ingredient 10 mg) daily (20 women, 17 analyzed) for 30 days. A cervical swab to quantify pro-inflammatory (IL1, IL2, IL6, IL8, TNFα) and anti-inflammatory (IL4, IL10) cytokines as well as transvaginal ultrasound cervical length measurement (CL) were performed before and after treatment. Results: The % changes of pro-inflammatory cytokines do not differ between treatment groups, while IL4 significantly increases by vaginal ALA in comparison to placebo (118.0 ± 364.3% versus 29.9 ± 103.5%, p = 0.012). Combined anti-inflammatory cytokines show same trend (292.5 ± 208.5% versus 64.5 ± 107.4, p = 0.03). CL remains similar in vaginal ALA group (from 23.1 ± 6.6 to 20.80 ± 7.9 mm), while it significantly decreased in placebo group (from 20.4 ± 6.5 to 13.8 ± 7.5 mm, p < 0.001 versus Baseline; p = 0.003 versus vaginal ALA). Conclusion: Vaginal ALA significantly stimulates anti-inflammatory ILs in the cervix of undelivered women after a preterm labor episode. This effect is associated with a stabilization of the CL

Nutrients and pathways that regulate health span and life span

Both life span and health span are influenced by genetic, environmental and lifestyle factors. With the genetic influence on human life span estimated to be about 20\u201325%, epigenetic changes play an important role in modulating individual health status and aging. Thus, a main part of life expectance and healthy aging is determined by dietary habits and nutritional factors. Excessive or restricted food consumption have direct effects on health status. Moreover, some dietary interventions including a reduced intake of dietary calories without malnutrition, or a restriction of specific dietary component may promote health benefits and decrease the incidence of aging-related comorbidities, thus representing intriguing potential approaches to improve healthy aging. However, the relationship between nutrition, health and aging is still not fully understood as well as the mechanisms by which nutrients and nutritional status may affect health span and longevity in model organisms. The broad effect of different nutritional conditions on health span and longevity occurs through multiple mechanisms that involve evolutionary conserved nutrient-sensing pathways in tissues and organs. These pathways interacting each other include the evolutionary conserved key regulators mammalian target of rapamycin, AMP-activated protein kinase, insulin/insulin-like growth factor 1 pathway and sirtuins. In this review we provide a summary of the main molecular mechanisms by which different nutritional conditions, i.e., specific nutrient abundance or restriction, may affect health span and life span

Multiscale integration of satellite, airborne and field data for Mediterranean vegetation studies in the natural area of the Castelporziano Estate (Rome)

new experimental approach to land analysis has recently been developed, based on the integration of information acquired on different scales; it enables the structure and the functionality of the vegetation in natural ecosystems to be analysed. This research aims at assessing the potentiality of the experimental approach by the integration of airborne and satellite remotely sensed data with ground measurements of structural parameters. In July 1999 a joint campaign for the acquisition of airborne (MIVIS, spatial resolution 3 m) and satellite remotely sensed data (Landsat 5TM, spatial resolution 30 m) and measures taken at ground (PAI), was deployed in the Presidential Estate at Castelporziano (Rome, Italy). The spectral signatures of the main vegetational types of the Estate were examined and the PAI were related to NDVI values, calculated by means of satellite and airborne images. The adopted approach enabled PAI maps to be produced. The linear relation between measured PAI and estimated PAI showed a higher coefficient of determination when the MIVIS data were used. The sensor high spectral resolution has moreover allowed to better describe the structural characteristics of the main plant typologies at Castelporziano Estate

Induced pluripotent stem cell-based models: Are we ready for that heart in a dish?

Non present

Multiscale integration of satellite, airborne and field data for Mediterranean vegetation studies in the natural area of the Castelporziano Estate (Rome)

new experimental approach to land analysis has recently been developed, based on the integration of information acquired on different scales; it enables the structure and the functionality of the vegetation in natural ecosystems to be analysed. This research aims at assessing the potentiality of the experimental approach by the integration of airborne and satellite remotely sensed data with ground measurements of structural parameters. In July 1999 a joint campaign for the acquisition of airborne (MIVIS, spatial resolution 3 m) and satellite remotely sensed data (Landsat 5TM, spatial resolution 30 m) and measures taken at ground (PAI), was deployed in the Presidential Estate at Castelporziano (Rome, Italy). The spectral signatures of the main vegetational types of the Estate were examined and the PAI were related to NDVI values, calculated by means of satellite and airborne images. The adopted approach enabled PAI maps to be produced. The linear relation between measured PAI and estimated PAI showed a higher coefficient of determination when the MIVIS data were used. The sensor high spectral resolution has moreover allowed to better describe the structural characteristics of the main plant typologies at Castelporziano Estate