82 research outputs found
A Novel Role for Lymphocyte Expression of the Cyclin-Dependent Kinase 5 (CDK5) in the Generation of Allogeneic T Cell Responses After BMT
Modulational instability of two pairs of counter-propagating waves and energy exchange in two-component media
The dynamics of two pairs of counter-propagating waves in two-component media
is considered within the framework of two generally nonintegrable coupled
Sine-Gordon equations. We consider the dynamics of weakly nonlinear wave
packets, and using an asymptotic multiple-scales expansion we obtain a suite of
evolution equations to describe energy exchange between the two components of
the system. Depending on the wave packet length-scale vis-a-vis the wave
amplitude scale, these evolution equations are either four non-dispersive and
nonlinearly coupled envelope equations, or four non-locally coupled nonlinear
Schroedinger equations. We also consider a set of fully coupled nonlinear
Schroedinger equations, even though this system contains small dispersive terms
which are strictly beyond the leading order of the asymptotic multiple-scales
expansion method. Using both the theoretical predictions following from these
asymptotic models and numerical simulations of the original unapproximated
equations, we investigate the stability of plane-wave solutions, and show that
they may be modulationally unstable. These instabilities can then lead to the
formation of localized structures, and to a modification of the energy exchange
between the components. When the system is close to being integrable, the
time-evolution is distinguished by a remarkable almost periodic sequence of
energy exchange scenarios, with spatial patterns alternating between
approximately uniform wavetrains and localized structures.Comment: 35 pages, 13 figure
Strongly Coupled Grand Unification in Higher Dimensions
We consider the scenario where all the couplings in the theory are strong at
the cut-off scale, in the context of higher dimensional grand unified field
theories where the unified gauge symmetry is broken by an orbifold
compactification. In this scenario, the non-calculable correction to gauge
unification from unknown ultraviolet physics is naturally suppressed by the
large volume of the extra dimension, and the threshold correction is dominated
by a calculable contribution from Kaluza-Klein towers that gives the values for
\sin^2\theta_w and \alpha_s in good agreement with low-energy data. The
threshold correction is reliably estimated despite the fact that the theory is
strongly coupled at the cut-off scale. A realistic 5d supersymmetric SU(5)
model is presented as an example, where rapid d=6 proton decay is avoided by
putting the first generation matter in the 5d bulk.Comment: 17 pages, latex, to appear in Phys. Rev.
CP Violation in Supersymmetric U(1)' Models
The supersymmetric CP problem is studied within superstring-motivated
extensions of the MSSM with an additional U(1)' gauge symmetry broken at the
TeV scale. This class of models offers an attractive solution to the mu problem
of the MSSM, in which U(1)' gauge invariance forbids the bare mu term, but an
effective mu parameter is generated by the vacuum expectation value of a
Standard Model singlet S which has superpotential coupling of the form SH_uH_d
to the electroweak Higgs doublets. The effective mu parameter is thus
dynamically determined as a function of the soft supersymmetry breaking
parameters, and can be complex if the soft parameters have nontrivial
CP-violating phases. We examine the phenomenological constraints on the
reparameterization invariant phase combinations within this framework, and find
that the supersymmetric CP problem can be greatly alleviated in models in which
the phase of the SU(2) gaugino mass parameter is aligned with the soft
trilinear scalar mass parameter associated with the SH_uH_d coupling. We also
study how the phases filter into the Higgs sector, and find that while the
Higgs sector conserves CP at the renormalizable level to all orders of
perturbation theory, CP violation can enter at the nonrenormalizable level at
one-loop order. In the majority of the parameter space, the lightest Higgs
boson remains essentially CP even but the heavier Higgs bosons can exhibit
large CP-violating mixings, similar to the CP-violating MSSM with large mu
parameter.Comment: 29 pp, 3 figs, 2 table
Phenomenology of flavor-mediated supersymmetry breaking
The phenomenology of a new economical SUSY model that utilizes dynamical SUSY
breaking and gauge-mediation (GM) for the generation of the sparticle spectrum
and the hierarchy of fermion masses is discussed. Similarities between the
communication of SUSY breaking through a messenger sector, and the generation
of flavor using the Froggatt-Nielsen (FN) mechanism are exploited, leading to
the identification of vector-like messenger fields with FN fields, and the
messenger U(1) as a flavor symmetry. An immediate consequence is that the first
and second generation scalars acquire flavor-dependent masses, but do not
violate FCNC bounds since their mass scale, consistent with effective SUSY, is
of order 10 TeV. We define and advocate a minimal flavor-mediated model (MFMM),
recently introduced in the literature, that successfully accommodates the small
flavor-breaking parameters of the standard model using order one couplings and
ratios of flavon field vevs. The mediation of SUSY breaking occurs via two-loop
log-enhanced GM contributions, as well as several one-loop and two-loop
Yukawa-mediated contributions for which we provide analytical expressions. The
MFMM is parameterized by a small set of masses and couplings, with values
restricted by several model constraints and experimental data. The
next-to-lightest sparticle (NLSP) always has a decay length that is larger than
the scale of a detector, and is either the lightest stau or the lightest
neutralino. Similar to ordinary GM models, the best collider search strategies
are, respectively, inclusive production of at least one highly ionizing track,
or events with many taus plus missing energy. In addition, D^0 - \bar{D}^0
mixing is also a generic low energy signal. Finally, the dynamical generation
of the neutrino masses is briefly discussed.Comment: 54 pages, LaTeX, 8 figure
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Energetic particle influence on the Earth's atmosphere
This manuscript gives an up-to-date and comprehensive overview of the effects of energetic particle precipitation (EPP) onto the whole atmosphere, from the lower thermosphere/mesosphere through the stratosphere and troposphere, to the surface. The paper summarizes the different sources and energies of particles, principally
galactic cosmic rays (GCRs), solar energetic particles (SEPs) and energetic electron precipitation (EEP). All the proposed mechanisms by which EPP can affect the atmosphere
are discussed, including chemical changes in the upper atmosphere and lower thermosphere, chemistry-dynamics feedbacks, the global electric circuit and cloud formation. The role of energetic particles in Earth’s atmosphere is a multi-disciplinary problem that requires expertise from a range of scientific backgrounds. To assist with this synergy, summary tables are provided, which are intended to evaluate the level of current knowledge of the effects of energetic particles on processes in the entire atmosphere
Avaliação da coagulação plasmática e plaquetometria em cães não infectados e infectados experimentalmente com Ehrlichia spp.
Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019
Background: Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods: 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were generated using a Bayesian hierarchical cohort component model that analysed estimated age-specific fertility and mortality rates along with 1250 censuses and 747 population registry years. We classified location-years into seven categories on the basis of the natural rate of increase in population (calculated by subtracting the crude death rate from the crude birth rate) and the net migration rate. We computed healthy life expectancy (HALE) using years lived with disability (YLDs) per capita, life tables, and standard demographic methods. Uncertainty was propagated throughout the demographic estimation process, including fertility, mortality, and population, with 1000 draw-level estimates produced for each metric. Findings: The global TFR decreased from 2•72 (95% uncertainty interval [UI] 2•66–2•79) in 2000 to 2•31 (2•17–2•46) in 2019. Global annual livebirths increased from 134•5 million (131•5–137•8) in 2000 to a peak of 139•6 million (133•0–146•9) in 2016. Global livebirths then declined to 135•3 million (127•2–144•1) in 2019. Of the 204 countries and territories included in this study, in 2019, 102 had a TFR lower than 2•1, which is considered a good approximation of replacement-level fertility. All countries in sub-Saharan Africa had TFRs above replacement level in 2019 and accounted for 27•1% (95% UI 26•4–27•8) of global livebirths. Global life expectancy at birth increased from 67•2 years (95% UI 66•8–67•6) in 2000 to 73•5 years (72•8–74•3) in 2019. The total number of deaths increased from 50•7 million (49•5–51•9) in 2000 to 56•5 million (53•7–59•2) in 2019. Under-5 deaths declined from 9•6 million (9•1–10•3) in 2000 to 5•0 million (4•3–6•0) in 2019. Global population increased by 25•7%, from 6•2 billion (6•0–6•3) in 2000 to 7•7 billion (7•5–8•0) in 2019. In 2019, 34 countries had negative natural rates of increase; in 17 of these, the population declined because immigration was not sufficient to counteract the negative rate of decline. Globally, HALE increased from 58•6 years (56•1–60•8) in 2000 to 63•5 years (60•8–66•1) in 2019. HALE increased in 202 of 204 countries and territories between 2000 and 2019. Interpretation: Over the past 20 years, fertility rates have been dropping steadily and life expectancy has been increasing, with few exceptions. Much of this change follows historical patterns linking social and economic determinants, such as those captured by the GBD Socio-demographic Index, with demographic outcomes. More recently, several countries have experienced a combination of low fertility and stagnating improvement in mortality rates, pushing more populations into the late stages of the demographic transition. Tracking demographic change and the emergence of new patterns will be essential for global health monitoring. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 licens
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