SCREENING ELDERLY PATIENTS FOR COGNITIVE FUNCTION AT A REFERENCE CENTER IN NORTHEAST BRAZIL

Introduction: Both demographic and epidemiologic transitions experienced by the country in the past decades bring a number of crucial issues for the health care system, especially in the context of severe social inequality, poverty and fragility of institutions. Objectives: To identify the cognitive profile of non-institutionalized elderly outpatients seen at a reference center in São Luís, Brazil. Methods: Cross-sectional study conducted in a reference center in São Luís, MA, Brazil. Final sample consisted of 102 individuals. Inclusion criteria were: age equal to or over 60 years at first consultation, and ability to understand and to answer the tests for cognitive assessment. This study utilized 3 validated tests that have been widely used in Brazil, including the Mini-Mental State Examination (MMSE), the Verbal Fluency Test (VFT) and the Clock Drawing Test (CDT). Results: A total of 102 individuals were included. The majority of patients were women (72%), aged 60-64 years (33.3%), married or living in consensual union (43.1%), and had non-white skin color (52.9%). The prevalence of cognitive impairment was 60.7% for the Minimental state examination, 23.5% for the Verbal Fluency Test and 59.8 % for the Clock Drawing Test. Regarding the presence of cognitive impairment in at least one test, a total of 83.3% was observed. There was an association between the occurrence of cognitive impairment with both marital status and self-perception of health status (p < 0.05). Conclusions: Hence, in the present study, the occurrence of cognitive impairment was considered high and might be associated with marital and health status.Keywords: Health of the Elderly. Aging. Cognition

Wobbly syndrome in an african pygmy hedgehog (Atelerix albiventris) : Neuropathological and immunohistochemical studies Síndrome de wobbly em um ouriço pigmeu africano (Atelerix albiventris): estudo neuropatológico e imuno-histoquímico

Scholarships were provided by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) - Finance Code 001. Additional support was provided by Pró-Reitoria de Pesquisa da Universidade Federal de Minas Gerais (UFMG).A three-year-old female African pygmy hedgehog (Atelerix albiventris), born and domiciled in Brazil, presented apathy, prostration, and difficulty to stay standing. Its parents were siblings but did not present clinical signs related to this condition. As its clinical condition worsened, the animal was euthanized and referred for necropsy. No gross lesions were found in the central nervous system (CNS). Histologically, there was vacuolation with axonal degeneration in the white matter of the CNS and in peripheral nervous tissue. The Kluver-Barrera (KB) stain confirmed demyelination in vacuolated areas. Immunohistochemistry using several neural markers confirmed astrocytosis and microgliosis associated with vacuolated areas. In addition, there was a mild decrease in the immuno intensity of myelin proteolipid protein (PLP) in these areas. These results suggest a genetic origin of the present demyelination, which resulted in the wobbly syndrome described in this report

CUIDADOS PALIATIVOS NA ATENÇÃO PRIMÁRIA: CONHECIMENTO DOS MÉDICOS E ENFERMEIROS DA ESTRATÉGIA SAÚDE DA FAMÍLIA

Introdução: A transiçaõ demograf́ ica e epidemioloǵ ica aumenta a prevalência de doenças crônico-degenerativas colocando em evidência os cuidados no final da vida. Assim, deve-se difundir o conhecimento dos Cuidados Paliativos (CP) entre profissionais de saúde. Objetivo: Identificar o conhecimento e as principais fragilidades em CP dos profissionais de saud́ e de niv́ el superior que atuam na Estrateǵ ia Saúde da Família (ESF). Métodos: Estudo transversal, analítico, realizado na ESF de Saõ Jose ́de Ribamar - MA com med́ icos e enfermeiros, utilizou-se um questionaŕ io alemaõ (Bonn Palliative Care Knowledge Test), versaõ em português, para avaliar conhecimento e perfil de autoconfiança em CP. Foram entrevistados 66 pessoas, sendo 30 (45,4%) med́ icos e 36 (54,6%) enfermeiros. Para o caĺ culo estatiś tico, foi utilizado o software SPSS v. 19 (niv́ el de significância de 0,05). Para se avaliar os questionaŕ ios de conhecimento foi empregado o teste do Qui-quadrado. Resultados: Não houve diferenças significativas na frequência de acertos entre médicos e enfermeiros, o maior nuḿ ero de acertos foi em questoẽ s que abordam a dimensaõ fiś ica. A aferiçaõ de pressaõ arterial e da glicemia capilar foram as prat́ icas mais comuns na assistência ao paciente em CP, 46 profissionais (69,7%). Os profissionais de saúde que tiveram melhor desempenho tinham tempo de graduação ≤ 5 anos (dentre os med́ icos) e ≥ 10 anos (dentre os enfermeiros) Conclusão: As prat́ icas assistenciais e entendimento dos profissionais para pacientes em CP saõ predominantemente voltadas para os aspectos fiś icos. Os profissionais expressam um elevado perfil de autoconfiança, porém de modo equivocado no que se refere aos CP.Palavras-chave: Cuidados paliativos. Atenção Primária à Saúde. Saúde da Família

Portuguese Ministers, 1851-1999: Social Background and Paths to Power

Disponível em: http://193.136.113.6/Opac/Pages/Search/Results.aspx?SearchText=UID=bb8aa8d5-c6b6-466a-81bb-fe8a67693cee&DataBase=10449_UNLFCSHThis paper provides an empirical analysis of the impact of regime changes in the composition and patterns of recruitment of the Portuguese ministerial elite throughout the last 150 years. The ‘out-of-type’, violent nature of most regime transformations accounts for the purges in and the extensive replacements of the political personnel, namely of the uppermost officeholders. In the case of Cabinet members, such discontinuities did not imply, however, radical changes in their social profile. Although there were some significant variations, a series of salient characteristics have persisted over time. The typical Portuguese minister is a male in his midforties, of middle-class origin and predominantly urban-born, highly educated and with a state servant background. The two main occupational contingents have been university professors - except for the First Republic (1910-26) - and the military, the latter having only recently been eclipsed with the consolidation of contemporary democracy. As regards career pathways, the most striking feature is the secular trend for the declining role of parliamentary experience, which the democratic regime did not clearly reverse. In this period, a technocratic background rather than political experience has been indeed the privileged credential for a significant proportion of minister

Extended Haplotypes in the Growth Hormone Releasing Hormone Receptor Gene (GHRHR) Are Associated with Normal Variation in Height

Mutations in the gene for growth hormone releasing hormone receptor (GHRHR) cause isolated growth hormone deficiency (IGHD) but this gene has not been found to affect normal variation in height. We performed a whole genome linkage analysis for height in a population from northern Sweden and identified a region on chromosome 7 with a lod-score of 4.7. The GHRHR gene is located in this region and typing of tagSNPs identified a haplotype that is associated with height (p = 0.00077) in the original study population. Analysis of a sample from an independent population from the most northern part of Sweden also showed an association with height (p = 0.0039) but with another haplotype in the GHRHR gene. Both haplotypes span the 3′ part of the GHRHR gene, including the region in which most of the mutations in IGHD have been located. The effect size of these haplotypes are larger than that of any gene previously associated with height, which indicates that GHRHR might be one of the most important genes so far identified affecting normal variation in human height

Search For Heavy Pointlike Dirac Monopoles

We have searched for central production of a pair of photons with high transverse energies in $p\bar p$ collisions at $\sqrt{s} = 1.8$ TeV using $70 pb^{-1}$ of data collected with the D\O detector at the Fermilab Tevatron in 1994--1996. If they exist, virtual heavy pointlike Dirac monopoles could rescatter pairs of nearly real photons into this final state via a box diagram. We observe no excess of events above background, and set lower 95% C.L. limits of $610, 870, or 1580 GeV/c^2$ on the mass of a spin 0, 1/2, or 1 Dirac monopole.Comment: 12 pages, 4 figure

The Dijet Mass Spectrum and a Search for Quark Compositeness in bar{p}p Collisions at sqrt{s} = 1.8 TeV

Using the DZero detector at the 1.8 TeV pbarp Fermilab Tevatron collider, we have measured the inclusive dijet mass spectrum in the central pseudorapidity region |eta_jet| < 1.0 for dijet masses greater than 200 Gev/c^2. We have also measured the ratio of spectra sigma(|eta_jet| < 0.5)/sigma(0.5 < |eta_jet| < 1.0). The order alpha_s^3 QCD predictions are in good agreement with the data and we rule out models of quark compositeness with a contact interaction scale < 2.4 TeV at the 95% confidence level.Comment: 11 pages, 4 figures, 2 tables, submitted to Phys. Rev. Let