911 research outputs found
Evidence that stimulation of gluconeogenesis by fatty acid is mediated through thermodynamic mechanisms
AbstractWe have studied the stimulatory effects of palmitate on the rate of glucose synthesis from lactate in isolated hepatocytes. Control of the metabolic flow was achieved by modulating the activity of enolase using graded concentrations of fluoride. Unexpectedly, palmitate stimulated gluconeogenesis even when enolase was rate-limiting. This stimulation was also observed when the activities of phosphoenolpyruvate carboxykinase and aspartate aminotransferase were modulated using graded concentrations of quinolinate and aminooxyacetate, respectively. Linear force-flow relationships were found between the rate of gluconeogenesis and indicators of cellular energy status (i.e. mitochondrial membrane and redox potentials and cellular phosphorylation potential). These findings suggest that the fatty acid stimulation of glucose synthesis is in part mediated through thermodynamic mechanisms
The effect of a barnacle-shaped excrescence on the hydrodynamic performance of a tidal turbine blade section
Efficient tidal turbine designs rely upon the hydrodynamic performance of the turbine blade sections. A significant consideration for the likely power generation capacity of a tidal turbine is the effect of biofouling on the blade performance. A turbine blade surface is susceptible to large scale macrofouling, mainly from encrusters, such as barnacles and molluscs, colonising the developing surface. This paper considers the case of when a barnacle attaches to the upper (suction) surface of the blade section. Results of experiments to investigate the unsteady flow characteristics of the blade section are presented, and the modification of the hydrodynamic performance coefficients due to the presence of a barnacle is evaluated. The barnacle has no significant effect upon the lift in steady flow and unsteady flow, but there is a very large increase in the drag. Dependent upon the degree of barnacle encrustation, the effect on a turbine blade drag may be significant and lead to a degradation of a turbine predicted performance
The extended empirical process test for non-Gaussianity in the CMB, with an application to non-Gaussian inflationary models
In (Hansen et al. 2002) we presented a new approach for measuring
non-Gaussianity of the Cosmic Microwave Background (CMB) anisotropy pattern,
based on the multivariate empirical distribution function of the spherical
harmonics a_lm of a CMB map. The present paper builds upon the same ideas and
proposes several improvements and extensions. More precisely, we exploit the
additional information on the random phases of the a_lm to provide further
tests based on the empirical distribution function. Also we take advantage of
the effect of rotations in improving the power of our procedures. The suggested
tests are implemented on physically motivated models of non-Gaussian fields;
Monte-Carlo simulations suggest that this approach may be very promising in the
analysis of non-Gaussianity generated by non-standard models of inflation. We
address also some experimentally meaningful situations, such as the presence of
instrumental noise and a galactic cut in the map.Comment: 15 pages, 6 figures, submitted to Phys. Rev.
An overview of the impacts of fishing on seabirds, including identifying future research directions
Knowledge of fisheries impacts, past and present, is essential for understanding the ecology and conservation of seabirds, but in a rapidly changing world, knowledge and research directions require updating. In this Introduction and in the articles in this Themed Set “Impacts of fishing on seabirds”, we update our understanding of how fishing impacts seabird communities and identify areas for future research. Despite awareness of the problems and mitigation efforts for >20 years, fisheries still negatively impact seabirds via the effects of bycatch, competition, and discards. Bycatch continues to kill hundreds of thousands of seabirds annually, with negative population-level consequences. Fisheries for forage fish (e.g. anchovy, sandeel, and krill) negatively impact seabirds by competing for the same stocks. Historically, discards supplemented seabird diets, benefitting some species but also increasing bycatch rates and altering seabird community composition. However, declining discard production has led to potentially deleterious diet switches, but reduced bycatch rates. To improve research into these problems, we make the following recommendations: (1) improve data collection on seabird–vessel interaction and bycatch rates, on fishing effort and vessel movements (especially small-scale fleets), and on mitigation compliance, (2) counter the current bias towards temperate and high-latitude ecosystems, larger-bodied species and particular life stages or times of year (e.g. adults during breeding), and (3) advance our currently poor understanding of combined effects of fisheries and other threats (e.g. climate change, offshore renewables). In addition, research is required on under-studied aspects of fishing impacts: consequences for depleted sub-surface predators, impacts of illegal, unreported and unregulated fishing, artisanal and emerging fisheries, such as those targeting mesopelagic fish, have received insufficient research attention. Some of these shortfalls can be overcome with new tools (e.g. electronic monitoring, remote sensing, artificial intelligence, and big data) but quantifying and addressing fishing impacts on seabirds requires greater research investment at appropriate spatio-temporal scales, and more inclusive dialogue from grassroots to national and international levels to improve governance as fishing industries continue to evolve
Analysis of three-nucleon forces effects in the system
Using modern nucleon-nucleon interactions in the description of the
nuclear systems the per datum results to be much bigger than one. In
particular it is not possible to reproduce the three- and four-nucleon binding
energies and the scattering length simultaneously. This is one
manifestation of the necessity of including a three-nucleon force in the
nuclear Hamiltonian. In this paper we perform an analysis of some, widely used,
three-nucleon force models. We analyze their capability to describe the
aforementioned quantities and, to improve their description, we propose
modifications in the parametrization of the models. The effects of these new
parametrization are studied in some polarization observables at low energies.Comment: 10 pages, to be published in Few-Body Systems. Presented at the
workshop on "Relativistic Description of Two- and Three-body Systems in
Nuclear Physics" ECT* Trento, 19 - 23 October 200
Modern nuclear force predictions for the neutron-deuteron scattering lengths
The nd doublet and quartet scattering lengths have been calculated based on
the modern NN and 3N interactions. We also studied the effect of the
electromagnetic interactions in the form introduced in AV18. Switching them off
for the various nuclear force models leads to shifts of up to +0.04 fm for
doublet scattering length, which is significant for present day standards. The
electromagnetic effects have also a noticeable effect on quartet scattering
length, which otherwise is extremely stable under the exchange of the nuclear
forces. For the current nuclear force models there is a strong scatter of the
3H binding energy and the doublet scattering length values around an averaged
straight line (Phillips line). This allows to use doublet scattering length and
the 3H binding energy as independent low energy observables.Comment: 16 pages, 1 table, 4 ps figure
Elastic p-3He and n-3H scattering with two- and three-body forces
We report on a microscopic calculation of n-3H and p-3He scattering employing
the Argonne v_{18} and v_8' nucleon-nucleon potentials with and without
additional three-nucleon force. An R-matrix analysis of the p-3He and n-3H
scattering data is presented. Comparisons are made for the phase shifts and a
selection of measurements in both scattering systems. Differences between our
calculation and the R-matrix results or the experimental data can be attributed
to only two partial waves (3P0 and 3P2). We find the effect of the Urbana IX
and the Texas-Los Alamos three-nucleon forces on the phase shifts to be
negligible.Comment: submitted to Phys. Rev.
Universal Correlations in Pion-less EFT with the Resonating Group Model: Three and Four Nucleons
The Effective Field Theory "without pions" at next-to-leading order is used
to analyze universal bound state and scattering properties of the 3- and
4-nucleon system. Results of a variety of phase shift equivalent nuclear
potentials are presented for bound state properties of 3H and 4He, and for the
singlet S-wave 3He-neutron scattering length a_0(3He-n). The calculations are
performed with the Refined Resonating Group Method and include a full treatment
of the Coulomb interaction and the leading-order 3-nucleon interaction. The
results compare favorably with data and values from AV18(+UIX) model
calculations. A new correlation between a_0(3He-n) and the 3H binding energy is
found. Furthermore, we confirm at next-to-leading order the correlations,
already found at leading-order, between the 3H binding energy and the 3H charge
radius, and the Tjon line. With the 3H binding energy as input, we get
predictions of the Effective Field Theory "without pions" at next-to-leading
order for the root mean square charge radius of 3H of (1.6\pm 0.2) fm, for the
4He binding energy of (28\pm 2.5) MeV, and for Re(a_0(3He-n)) of (7.5\pm
0.6)fm. Including the Coulomb interaction, the splitting in binding energy
between 3H and 3He is found to be (0.66\pm 0.03) MeV. The discrepancy to data
of (0.10\mp 0.03) MeV is model independently attributed to higher order charge
independence breaking interactions. We also demonstrate that different results
for the same observable stem from higher order effects, and carefully assess
that numerical uncertainties are negligible. Our results demonstrate the
convergence and usefulness of the pion-less theory at next-to-leading order in
the 4He channel. We conclude that no 4-nucleon interaction is needed to
renormalize the theory at next-to-leading order in the 4-nucleon sector.Comment: 24 pages revtex4, including 8 figures as .eps files embedded with
includegraphicx, leading-order results added, calculations include the LO
three-nucleon interaction explicitly, comment on Wigner bound added, minor
modification
Nucleon Polarizabilities from Deuteron Compton Scattering within a Green's-Function Hybrid Approach
We examine elastic Compton scattering from the deuteron for photon energies
ranging from zero to 100 MeV, using state-of-the-art deuteron wave functions
and NN-potentials. Nucleon-nucleon rescattering between emission and absorption
of the two photons is treated by Green's functions in order to ensure gauge
invariance and the correct Thomson limit. With this Green's-function hybrid
approach, we fulfill the low-energy theorem of deuteron Compton scattering and
there is no significant dependence on the deuteron wave function used.
Concerning the nucleon structure, we use Chiral Effective Field Theory with
explicit \Delta(1232) degrees of freedom within the Small Scale Expansion up to
leading-one-loop order. Agreement with available data is good at all energies.
Our 2-parameter fit to all elastic data leads to values for the
static isoscalar dipole polarizabilities which are in excellent agreement with
the isoscalar Baldin sum rule. Taking this value as additional input, we find
\alpha_E^s= (11.3+-0.7(stat)+-0.6(Baldin)) x 10^{-4} fm^3 and \beta_M^s =
(3.2-+0.7(stat)+-0.6(Baldin)) x 10^{-4} fm^3 and conclude by comparison to the
proton numbers that neutron and proton polarizabilities are essentially the
same.Comment: 47 pages LaTeX2e with 20 figures in 59 .eps files, using graphicx.
Minor modifications; extended discussion of theoretical uncertainties of
polarisabilities extraction. Version accepted for publication in EPJ
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