A⁴⁰/K⁴⁰ Ages of Micas and Feldspars from the Glenarm Series near Baltimore, Maryland

The inner zone of the central Appalachian Mountains is a belt of metamorphic and plutonic rocks which crop out in the Blue Ridge province and underlie most of the Piedmont province. In southeastern Pennsylvania and adjacent parts of Maryland, the oldest rock is the Baltimore gneiss, which forms domical uplifts surrounded and overlain by the Glenarm series. This series consists of a basal quartzite (Setters) overlain by a marble (Cockeysville) and a thick series of mica schists (Wissahickon and Peters Creek) of sedimentary origin but including in some places altered volcanics (1). The Glenarm group is locally cut by pegmatite, granite, and other plutonic rocks

An investigation of the relationship between narcissism and forgiveness of imagined relationship identity in college students

In this study, participants = 74) read a scenario about an imaginary romantic partner cheating on him/her by having sex with someone else and responded to a short survey concerned with infidelity forgiveness and a measure of narcissism. The method of how the infidelity was revealed to the victim was manipulated between participants. A high narcissism score was predicted to be indicative of a low forgiveness score regardless of the method of infidelity discovery. A significant main effect was predicted in the infidelity discovery method; specifically that unsolicited partner discovery will be more likely to be forgiven than redhanded discovery. A significant main effect was predicted for participant sex, with males showing lower scores overall on the forgiveness scale. A significant interaction effect for sex and forgiveness was predicted, with males in the red-handed discovery condition being the least likely to forgive their partners. Results indicated that forgiveness was most likely when the imaginary partner openly confessed to the infidelity as opposed to the participant catching the partner in the act of cheating. Male participants were more likely to forgive partners who were caught red-handed in the act of cheating, as opposed to having their partners admit to the infidelity. The findings suggest that more research should be conducted with an adequate range of narcissism scores to determine the relationship that specific personality traits, such as narcissism, play in the role of predicting the likelihood of forgiveness

Effect of Exercise and Sham Exercise Trackers on Perceived Workout Intensity and Mood in College Students

Exercise is an essential contributor to both physical and mental health and is a significant part of a person’s overall lifestyle. With the increasing popularity of exercise trackers, researchers were interested in the effects of sham exercise trackers on perceptions of workouts and affect. Researchers predicted participants wearing a sham Fitbit band would report greater perceptions of workout intensity, challenge, and satisfaction compared to those without sham Fitbit bands. In addition, those wearing sham Fitbit bands were predicted to report greater positive affect and lower negative affect than those without bands. One hundred twenty student participants (60 in each group; one group with a sham Fitbit and one group with no Fitbit) were recruited from campus workout classes of Zumba, spinning, and body sculpting. Participants worked out and completed a PANAS survey, plus other workout perception questions. When using a sham Fitbit, participants believed the workout was more intense, physically challenging, and they were more satisfied with their workout. However, presence of a sham Fitbit band did not significantly affect mood. Results suggest that knowledge of wearing an exercise tracker, even without any workout data feedback, has an effect on workout perceptions, but has little effect on mood

Resource security impacts men’s female breast size preferences

It has been suggested human female breast size may act as signal of fat reserves, which in turn indicates access to resources. Based on this perspective, two studies were conducted to test the hypothesis that men experiencing relative resource insecurity should perceive larger breast size as more physically attractive than men experiencing resource security. In Study 1, 266 men from three sites in Malaysia varying in relative socioeconomic status (high to low) rated a series of animated figures varying in breast size for physical attractiveness. Results showed that men from the low socioeconomic context rated larger breasts as more attractive than did men from the medium socioeconomic context, who in turn perceived larger breasts as attractive than men from a high socioeconomic context. Study 2 compared the breast size judgements of 66 hungry versus 58 satiated men within the same environmental context in Britain. Results showed that hungry men rated larger breasts as significantly more attractive than satiated men. Taken together, these studies provide evidence that resource security impacts upon men’s attractiveness ratings based on women’s breast size

Behavior and Impact of Zirconium in the Soil–Plant System: Plant Uptake and Phytotoxicity

Because of the large number of sites they pollute, toxic metals that contaminate terrestrial ecosystems are increasingly of environmental and sanitary concern (Uzu et al. 2010, 2011; Shahid et al. 2011a, b, 2012a). Among such metals is zirconium (Zr), which has the atomic number 40 and is a transition metal that resembles titanium in physical and chemical properties (Zaccone et al. 2008). Zr is widely used in many chemical industry processes and in nuclear reactors (Sandoval et al. 2011; Kamal et al. 2011), owing to its useful properties like hardness, corrosion-resistance and permeable to neutrons (Mushtaq 2012). Hence, the recent increased use of Zr by industry, and the occurrence of the Chernobyl and Fukashima catastrophe have enhanced environmental levels in soil and waters (Yirchenko and Agapkina 1993; Mosulishvili et al. 1994 ; Kruglov et al. 1996)

DNA Clasping by Mycobacterial HU: The C-Terminal Region of HupB Mediates Increased Specificity of DNA Binding

BACKGROUND: HU a small, basic, histone like protein is a major component of the bacterial nucleoid. E. coli has two subunits of HU coded by hupA and hupB genes whereas Mycobacterium tuberculosis (Mtb) has only one subunit of HU coded by ORF Rv2986c (hupB gene). One noticeable feature regarding Mtb HupB, based on sequence alignment of HU orthologs from different bacteria, was that HupB(Mtb) bears at its C-terminal end, a highly basic extension and this prompted an examination of its role in Mtb HupB function. METHODOLOGY/PRINCIPAL FINDINGS: With this objective two clones of Mtb HupB were generated; one expressing full length HupB protein (HupB(Mtb)) and another which expresses only the N terminal region (first 95 amino acid) of hupB (HupB(MtbN)). Gel retardation assays revealed that HupB(MtbN) is almost like E. coli HU (heat stable nucleoid protein) in terms of its DNA binding, with a binding constant (K(d)) for linear dsDNA greater than 1000 nM, a value comparable to that obtained for the HUalphaalpha and HUalphabeta forms. However CTR (C-terminal Region) of HupB(Mtb) imparts greater specificity in DNA binding. HupB(Mtb) protein binds more strongly to supercoiled plasmid DNA than to linear DNA, also this binding is very stable as it provides DNase I protection even up to 5 minutes. Similar results were obtained when the abilities of both proteins to mediate protection against DNA strand cleavage by hydroxyl radicals generated by the Fenton's reaction, were compared. It was also observed that both the proteins have DNA binding preference for A:T rich DNA which may occur at the regulatory regions of ORFs and the oriC region of Mtb. CONCLUSIONS/SIGNIFICANCE: These data thus point that HupB(Mtb) may participate in chromosome organization in-vivo, it may also play a passive, possibly an architectural role

DNA repair, genome stability and cancer: a historical perspective

The multistep process of cancer progresses over many years. The prevention of mutations by DNA repair pathways led to an early appreciation of a role for repair in cancer avoidance. However, the broader role of the DNA damage response (DDR) emerged more slowly. In this Timeline article, we reflect on how our understanding of the steps leading to cancer developed, focusing on the role of the DDR. We also consider how our current knowledge can be exploited for cancer therapy