Technological innovations at the onset of the Mid-Pleistocene Climate Transition in high-latitude East Asia

The interplay between Pleistocene climatic variability and hominin adaptations to diverse terrestrial ecosystems is a key topic in human evolutionary studies. Early and Middle Pleistocene environmental change and its relation to hominin behavioural responses has been a subject of great interest in Africa and Europe, though little information is available for other key regions of the Old World, particularly from Eastern Asia. Here we examine key Early Pleistocene sites of the Nihewan Basin, in high-latitude northern China, dating between ∼1.4 to 1.0 million years ago (Ma). We compare stone tool assemblages from three Early Pleistocene sites in the Nihewan Basin, including detailed assessment of stone tool refitting sequences at the ∼1.1 Ma-old site of Cenjiawan. Increased toolmaking skills and technological innovations are evident in the Nihewan Basin at the onset of the Mid-Pleistocene Climate Transition (MPT). Examination of the lithic technology of the Nihewan sites, together with an assessment of other key Palaeolithic sites of China, indicates that toolkits show increasing diversity at the outset of the MPT and in its aftermath. The overall evidence indicates the adaptive flexibility of early hominins to ecosystem changes since the MPT, though regional abandonments are also apparent in high-latitudes, likely owing to cold and oscillating environmental conditions. The view presented here sharply contrasts with traditional arguments that stone tool technologies of China are homogeneous and continuous over the course of the Early Pleistocene.Introduction Results - Stone-tool-knapping skills recorded in the Cenjiawan assemblage - Technological comparisons of the Nihewan Basin assemblages Discussio

Bryophytes: how to conquer an alien planet and live happily (ever after)

There are many push and pull factors that commonly drive individuals to leave their homeland. For example, escaping competition and occupying a novel habitat undoubtedly offer the advantage of new opportunities to pilgrims, but the absence of unfavorable biotic interactions can be counterbalanced by other antagonistic abiotic forces. After all, conquering an alien planet is not now nor ever was an easy task. We cannot know how many attempts and failures have punctuated the journey that led ancestral, photosynthetic organisms to leave the aquatic world and successfully establish on dry land. However, some traits developed by the ancestors of modern bryophytes that allowed them to adapt their life cycle to such a different habitat and persist there, have been undoubtedly identified

Assessment of the radiological impact of a decommissioning nuclear power plant in Italy

The assessment of the radiological impact of a decommissioning Nuclear Power Plant is presented here through the results of an environmental monitoring survey carried out in the area surrounding the Garigliano Power Plant. The levels of radioactivity in soil, water, air and other environmental matrices are shown, in which {\alpha}, {\beta} and {\gamma} activity and {\gamma} equivalent dose rate are measured. Radioactivity levels of the samples from the Garigliano area are analyzed and then compared to those from a control zone situated more than 100 km away. Moreover, a comparison is made with a previous survey held in 2001. The analyses and comparisons show no significant alteration in the radiological characteristics of the area surroundings the plant, with an overall radioactivity depending mainly from the global fallout and natural sources

Assessment of the radiological impact of a decommissioning nuclear power plant in Italy

The assessment of the radiological impact of a decommissioning Nuclear Power Plant is presented here through the results of an environmental monitoring survey carried out in the area surrounding the Garigliano Power Plant. The levels of radioactivity in soil, water, air and other environmental matrices are shown, in which {\alpha}, {\beta} and {\gamma} activity and {\gamma} equivalent dose rate are measured. Radioactivity levels of the samples from the Garigliano area are analyzed and then compared to those from a control zone situated more than 100 km away. Moreover, a comparison is made with a previous survey held in 2001. The analyses and comparisons show no significant alteration in the radiological characteristics of the area surroundings the plant, with an overall radioactivity depending mainly from the global fallout and natural sources.Comment: 13 pages, 6 figures, 2 table

Increased expression of antimüllerian hormone and its receptor in endometriosis

To evaluate antimüllerian hormone (AMH) and AMH receptor II (AMHRII) mRNA and protein expression in endometrium and in ovarian or deep lesions of women with endometriosis

Increased adrenal steroid secretion in response to CRF in women with hypothalamic amenorrhea

Objectie: To evaluate adrenal steroid hormone secretion in response to corticotropin-releasing factor (CRF) or to adrenocorticotropin hormone in women with hypothalamic amenorrhea. Design: Controlled clinical study. Setting: Department of Reproductive Medicine and Child Development, Section of Gynecology and Obstetrics, University of Pisa, Italy. Patient(s): Fifteen women with hypothalamic amenorrhea were enrolled in the study. Eight normal cycling women were used as control group. Interention(s): Blood samples were collected before and after an injection of ovine CRF (0.1 g/kg iv bolus) or after synthetic ACTH (0.25 mg iv). Main outcome measure(s): Plasma levels of ACTH, 17-hydroxypregnenolone (17OHPe), progesterone (P), dehydroepiandrosterone (DHEA), 17-hydroxyprogesterone (17OHP), cortisol (F), 11-deoxycortisol (S) and androstenedione (A). Result(s): Basal plasma concentrations of ACTH, cortisol, 11-deoxycortisol, DHEA and 17OHPe were significantly higher in patients than in controls, whereas plasma levels of progesterone and 17-OHP were significantly lower in patients than in controls. In amenorrheic women the ratio of 17-OHPe/DHEA, of 17-OHPe/17-OHP and of 11-deoxycortisol/cortisol were significantly higher than in controls, while a significant reduction in the ratio of 17-OHP/androstenedione, of 17-OHP/11-deoxycortisol was obtained. In response to corticotropin-releasing factor test, plasma levels of ACTH, cortisol, 17-OHP, 11-deoxycortisol, DHEA and androstenedione were significantly lower in patients than in controls. In response to adrenocorticotropin hormone, plasma levels of 17-OHP, androstenedione and androstenedione/cortisol were significantly higher in patients than in controls. Conclusions: Patients suffering for hypothalamic amenorrhea showed an increased activation of hypothalamus-pituitaryadrenal (HPA) axis, as shown by the higher basal levels and by augmented adrenal hormone response to corticotropin-releasing factor administration. These data suggest a possible derangement of adrenal androgen enzymatic pathway

Deep endometriosis infiltrating the recto-sigmoid: critical factors to consider before management

Mauricio Simoes Abrao1,, Felice Petraglia2, Tommaso Falcone3, Joerg Keckstein4, Yutaka Osuga5, and Charles Chapron6,7,8 Endometriosis Division, Obstetrics and Gynecological Department – Sao Paulo University, Sao Paulo, Brazil Obstetrics and Gynecology, Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy Obstetrics, Gynecology andWomen's Health Institute, Cleveland Clinic, Cleveland, OH, USA Department of Obstetrics and Gynecology, Center for Endometriosis, Villach Hospital, Villach, Austria Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo, Tokyo, Japan Universite Paris Descartes, Sorbonne Paris Cite, Faculte de Medecine, Assistance Publique – Hopitaux de Paris (APHP), Groupe Hospitalier Universitaire (GHU) Ouest, Centre Hospitalier Universitaire (CHU) Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, 75679 Paris, France Institut Cochin, Universite Paris Descartes, Sorbonne Paris Cite CNRS (UMR 8104), Paris, France Inserm, Universite Paris Descartes, Sorbonne Paris Cite, Unite de recherche U1016, Paris, Franc