Lipid profile changes in patients with rheumatic diseases receiving a treatment with TNF-α blockers: a meta-analysis of prospective studies.

Some studies showed an anti-atherogenic effect of TNF-α blockers on lipid profile, but these data have been challenged.To perform a meta-analysis on lipid profile changes induced by TNF-α blocker treatment.Prospective studies on rheumatic patients receiving TNF-α blockers and providing before-and-after treatment values of triglycerides (TGs), total cholesterol (TC), HDL-cholesterol (HDLc), LDL-cholesterol (LDLc), and atherogenic index (AI) were included. Standardized mean differences (SMD) in lipid profile were analyzed at short-term (2-12 weeks), middle-term (13-24 weeks), and long-term (25-52 weeks) assessments.Thirty articles (1707 patients) were included. TNF-α blockers determined an increase in TC at short-term, middle-term, and long-term assessments (SMD: 0.20 mmol/L [95% CI: 0.04, 0.35]; SMD: 0.27 mmol/L [95% CI: 0.08, 0.46]; SMD: 0.22 mmol/L [95% CI: 0.01, 0.43]). HDLc increased only at the short-term assessment (SMD: 0.19 mmol/L [95% CI: 0.10, 0.28]), and TGs achieved a significant increase at the long-term assessment (SMD: 0.19 mmol/L [95% CI: 0.04, 0.34]). LDLc and AI were not affected by TNF-α blocker treatment.Slight but significant increases in TC occurred without any significant change in LDLc and AI. Changes in HDLc and TGs were not consistent among the different time point assessments. These quantitative changes in lipid profile do not seem to be able to explain cardiovascular risk improvement reported in patients receiving TNF-α blockers. Further studies on other mechanisms are needed to address this issue

Reply to “Comment on ‘The 21 August 2017 Md 4.0 Casamicciola Earthquake: First Evidence of Coseismic Normal Surface Faulting at the Ischia Volcanic Island’ by Nappi et al. (2018)” by V. De Novellis, S. Carlino, R. Castaldo, A. Tramelli, C. De Luca, N. A. Pino, S. Pepe, V. Convertito, I. Zinno, P. De Martino, M. Bonano, F. Giudicepietro, F. Casu, G. Macedonio, M. Manunta, M. Manzo, G. Solaro, P. Tizzani, G. Zeni, and R. Lanari

In this article, we show why the geological model of the 21 August 2017 earthquake proposed by Nappi et al. (2018) has less uncertainty than the sourcemodel proposed by De Novellis et al. (2018). As a matter of fact, the Nappi et al. (2018) model takes into account all geophysical and geological information collected soon after the earthquake. On the contrary, the model proposed by DeNovellis et al. (2018) is based on a limited database, which does not include (1) the available geological and macroseismic information and (2) the extensive scientific literature concerning the correlation between seismic source and surface faulting, also in volcanic areas similar to Ischia. Nevertheless, we are grateful for the comments from De Novellis et al. (2018) because they give us the opportunity to consider the epistemological landscape in which we should frame the research for the best source model of the 21 August 2017 Casamicciola earthquake.Published316-3211T. Deformazione crostale attivaJCR Journa

The 21 August 2017 Md 4.0 Casamicciola Earthquake: First Evidence of Coseismic Normal Surface Faulting at the Ischia Volcanic Island

On 21 August 2017, a shallow earthquake of Md 4.0 struck the CasamicciolaTerme village in the north of Ischia volcanic island (Italy). It caused two fatalities and heavy damage in a restricted area of a few square kilometers. Casamicciola Terme has been recurrently destroyed in the last centuries by similar volcano-tectonic earthquakes (1762, 1767, 1796, 1828, 1881, and 1883). After the catastrophic 1883 Casamicciola event (2343 casualties), this is the first heavy damaging earthquake at Ischia that provides, for the first time, the opportunity of integrating historical seismicity, macroseismic observations, instrumental information, and detailed mapping of coseismic geological effects. Soon after the 2017 mainshock we surveyed the epicentral area to collect data on the coseismic ground effects, recording more than 100 geological field observations. Mapped effects define a belt which closely follows the trace of the Casamicciola E–W-trending normal fault system, bounding the northern slope of Mt. Epomeo, previously known as a Latest Pleistocene to Holocene normal fault with a slip rate of ∼3:0 cm=yr. We found significant evidence for coseismic surface faulting, testified by a main alignment of ruptures for a 2 km end-to-end length and normal dip-slip displacement of 1–3 cm. The geometry and regularity of the structural pattern, together with constant kinematics of the coseismic ruptures with the north side down, strongly suggest a primary tectonic origin for the mapped ruptures and strongly supports an E–W normal-faulting focal mechanism for the 2017 Casamicciola earthquake.Macroseismic information supports the notion that previous historical events also had a similar style of faulting.Published1323-13343T. Sorgente sismicaJCR Journa

Three-axial Fiber Bragg Grating Strain Sensor for Volcano Monitoring

Fiber optic and FBGs sensors have attained a large diffusion in the last years as cost-effective monitoring and diagnostic devices in civil engineering. However, in spite of their potential impact, these instruments have found very limited application in geophysics. In order to study earthquakes and volcanoes, the measurement of crustal deformation is of crucial importance. Stress and strain behaviour is among the best indicators of changes in the activity of volcanoes .. Deep bore-hole dilatometers and strainmeters have been employed for volcano monitoring. These instruments are very sensitive and reliable, but are not cost-effective and their installation requires a large effort. Fiber optic based devices offer low cost, small size, wide frequency band, easier deployment and even the possibility of creating a local network with several sensors linked in an array. We present the realization, installation and first results of a shallow-borehole (8,5 meters depth) three-axial Fiber Bragg Grating (FBG) strain sensor prototype. This sensor has been developed in the framework of the MED-SUV project and installed on Etna volcano, in the facilities of the Serra La Nave astrophysical observatory. The installation siteis about 7 Km South-West of the summit craters, at an elevation of about 1740 m. The main goal of our work is the realization of a three-axial device having a high resolution and accuracy in static and dynamic strain measurements, with special attention to the trade-off among resolution, cost and power consumption. The sensor structure and its read-out system are innovative and offer practical advantages in comparison with traditional strain meters. Here we present data collected during the first five months of operation. In particular, the very clear signals recorded in the occurrence of the Central Italy seismic event of October 30th demonstrate the performances of our device.PublishedWien7TM. Sviluppo e Trasferimento Tecnologic

Analysis of tourism in Campania as a tool for the development of high-quality cultural services for sightseers: The “Reale Osservatorio Vesuviano” case history

The purpose of this work is to identify the guidelines for the development and diversification of the cultural touristic offer achievable at the Reale Osservatorio Vesuviano (ROV). Founded in 1841, it is the oldest volcano observatory in the world and it has always had the vocation for scientific-naturalistic and formative tourism. The present study investigates the connections between the sociology of tourism and the ROV’s sustainability and competitiveness as a tourist destination. Here it is performed a study of the tourist flow, based on the sociology of tourism and on the correct processing of data sets, distinguishing the ''statistical information on tourism" from "tourism statistics", as such a study is the basis of a proper market strategy in different sectors. Tourism remains, in fact, an important phenomenon in world economy: despite the economic crisis of recent years, international tourist arrivals show a positive development of the trend in all the major sub-areas into which the large international areas are traditionally divided. The principles for a future marketing plan were outlined after collecting all the relevant information. The plan was designed to enhance the overall touristic offer of the ROV, never ceasing to consider the integration of natural- scientific aspects and cultural events to be offered within the observatory itself.Published64-872TM. Divulgazione Scientifica6TM. Poli Museali1VV. AltroN/A or not JC

muography with nuclear emulsions stromboli and other projects

The muon radiography is a novel imaging technique to probe the volcanoes interior, using the capability of high energy cosmic ray muons to penetrate large thicknesses of rock. In this way it is possible to derive a 2D density map along the muon trajectory of volcanic edifices and deduce information on the variations in the rock density distribution, like those expected from dense lava conduits, or low density magma supply paths. This method is applicable also to study geological objects as glaciers, faults, oil underground reservoirs, engineering constructions, where a density contrast is present. Nuclear emulsions are well suited to be employed in this context for their excellent angular resolution; they are compact and robust detectors, able to work in harsh environments without need of power supply. On the other side, a long exposure time is required for a reasonable detector surface (~10 m 2 ) in order to collect a sufficient statistics of muons, and a quasi-real time analysis of the emulsion data is rather difficult due to the scanning time needed by the optical microscopes. Such drawback is on the way to be overcome thanks to a recent R&D program on ultra-fast scanning systems. Muon radiography technique, even if limited to the summit part of the volcano edifice, represents an important tool of investigation, at higher spatial resolution, complementary to the conventional geophysics techniques. The first successful result in this field was obtained by a Japanese group that observed in 2007 the conduit structure of Mt. Asama. Since 2010, other interesting volcanoes have been probed with the same method: Stromboli in 2011, Mt. Teide in 2012 and La Palma in 2014. Here we discuss the muon imaging technique reporting the nuclear emulsion detector design exposed at Stromboli and results of the data analysis

Management of psoriatic arthritis: a consensus opinion by expert rheumatologists

Background: Psoriatic arthritis (PsA) is a chronic inflammatory musculoskeletal disease involving several articular and extra-articular structures. Despite the important progresses recently made in all of the aspects of this disease, its management is still burdened by unresolved issues. The aim of this exercise was to provide a set of statements that may be helpful for the management of PsA. Methods: A group of 38 Italian rheumatologists with recognized expertise in PsA selected and addressed the following four topics: "early PsA," "axial-PsA," "extra-articular manifestations and comorbidities," "therapeutic goals." Relevant articles from the literature (2016-2022) were selected by the experts based on a PubMed search. A number of statements for each topic were elaborated. Results: Ninety-four articles were selected and evaluated, 68 out of the 1,114 yielded by the literature search and 26 added by the Authors. Each of the four topic was subdivided in themes as follows: transition from psoriasis to PsA, imaging vs. CASPAR criteria in early diagnosis, early treatment for "early PsA"; axial-PsA vs. axialspondyloarthritis, diagnosis, clinical evaluation, treatment, standard radiography vs. magnetic resonance imaging for "axial PsA"; influence of inflammatory bowel disease on the therapeutic choice, cardiovascular comorbidity, bone damage, risk of infection for "comorbidities and extra-articular manifestations"; target and tools, treat-to-target strategy, role of imaging for "therapeutic goals." The final document consisted of 49 statements. Discussion: The final product of this exercise is a set of statements concerning the main issues of PsA management offering an expert opinion for some unmet needs of this complex disease

Bulky DNA adducts, 4-aminobiphenyl-haemoglobin adducts and diet in the European Prospective Investigation into Cancer and Nutrition (EPIC) prospective study

In contrast to some extensively examined food mutagens, for example, aflatoxins, N-nitrosamines and heterocyclic amines, some other food contaminants, in particular polycyclic aromatic hydrocarbons (PAH) and other aromatic compounds, have received less attention. Therefore, exploring the relationships between dietary habits and the levels of biomarkers related to exposure to aromatic compounds is highly relevant. We have investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort the association between dietary items (food groups and nutrients) and aromatic DNA adducts and 4-aminobiphenyl-Hb adducts. Both types of adducts are biomarkers of carcinogen exposure and possibly of cancer risk, and were measured, respectively, in leucocytes and erythrocytes of 1086 (DNA adducts) and 190 (Hb adducts) non-smokers. An inverse. statistically significant, association has been found between DNA adduct levels and dietary fibre intake (P=0.02), vitamin E (P =0.04) and alcohol (P=0.03) but not with other nutrients or food groups. Also, an inverse association between fibre and fruit intake, and BMI and 4-aminobiphenyl-Hb adducts (P=0.03, 0.04, and 0.03 respectively) was observed. After multivariate regression analysis these inverse correlations remained statistically significant, except for the correlation adducts v. fruit intake. The present study suggests that fibre intake in the usual range can modify the level of DNA or Hb aromatic adducts, but Such role seems to be quantitatively modest. Fibres could reduce the formation of DNA adducts in different manners, by diluting potential food mutagens and carcinogens in the gastrointestinal tract, by speeding their transit through the colon and by binding carcinogenic substances