96 research outputs found
Saffold Virus, a Human Theiler's-Like Cardiovirus, Is Ubiquitous and Causes Infection Early in Life
- Author
- A Kapoor
- AL Palmer
- AW Sylwester
- ChY Chiu
- DG Higgins
- EM van Leeuwen
- ES Barton
- Esther Schoondermark-van de Ven
- Fazekas de St Groth
- FJ van Kuppeveld
- Frank J. M. van Kuppeveld
- Frans Verduyn Lunel
- G Stanway
- H Hyoty
- HL Lipton
- HL Lipton
- HS Jun
- J Felsenstein
- J Lederberg
- Jan Zoll
- JF Drexler
- JL Melnick
- JM Galama
- JM Galama
- Jochem M. D. Galama
- K Benschop
- K Jnaoui
- Karla Kirkegaard
- Kjerstin Lanke
- KM Bedard
- KS Lole
- M Brahic
- M Honeyman
- M Zuker
- MA Verboon-Maciolek
- Merja Roivainen
- MS Jones
- O Blinkova
- O Vaarala
- O van Eyll
- P Froussard
- P Simmonds
- PE Lobert
- PJ Sansonetti
- S Hato
- S Mueller
- Sandra Erkens Hulshof
- SM Oberste
- SM Oberste
- T Allander
- UF Greber
- V van Pesch
- VR Racaniello
- Willem J. G. Melchers
- WP Kong
- Y Abed
- Z Liang
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2009
- Field of study
The family Picornaviridae contains well-known human pathogens (e.g., poliovirus, coxsackievirus, rhinovirus, and parechovirus). In addition, this family contains a number of viruses that infect animals, including members of the genus Cardiovirus such as Encephalomyocarditis virus (EMCV) and Theiler's murine encephalomyelits virus (TMEV). The latter are important murine pathogens that cause myocarditis, type 1 diabetes and chronic inflammation in the brains, mimicking multiple sclerosis. Recently, a new picornavirus was isolated from humans, named Saffold virus (SAFV). The virus is genetically related to Theiler's virus and classified as a new species in the genus Cardiovirus, which until the discovery of SAFV did not contain human viruses. By analogy with the rodent cardioviruses, SAFV may be a relevant new human pathogen. Thus far, SAFVs have sporadically been detected by molecular techniques in respiratory and fecal specimens, but the epidemiology and clinical significance remained unclear. Here we describe the first cultivated SAFV type 3 (SAFV-3) isolate, its growth characteristics, full-length sequence, and epidemiology. Unlike the previously isolated SAFV-1 and -2 viruses, SAFV-3 showed efficient growth in several cell lines with a clear cytopathic effect. The latter allowed us to conduct a large-scale serological survey by a virus-neutralization assay. This survey showed that infection by SAFV-3 occurs early in life (>75% positive at 24 months) and that the seroprevalence reaches >90% in older children and adults. Neutralizing antibodies were found in serum samples collected in several countries in Europe, Africa, and Asia. In conclusion, this study describes the first cultivated SAFV-3 isolate, its full-length sequence, and epidemiology. SAFV-3 is a highly common and widespread human virus causing infection in early childhood. This finding has important implications for understanding the impact of these ubiquitous viruses and their possible role in acute and/or chronic disease
A simulation model of colorectal cancer surveillance and recurrence
- Author
- A Figueredo
- A Jemal
- AB Knudsen
- AG Renehan
- AL Frazier
- AR Neilson
- B Bohm
- BJ Kjeldsen
- BJ Kjeldsen
- C Glover
- C Lejeune
- C Lejeune
- C Valls
- C Valls
- CE Desch
- Chung Yin Kong
- CY Kong
- D Cunningham
- D Gyrd-Hansen
- DJ Sargent
- DK Rex
- E Tan
- EM Grossmann
- F Borie
- F Loeve
- FS Erenay
- Gregory S Cooper
- GS Gazelle
- H Sorbye
- I Lansdorp-Vogelaar
- J McIntosh
- J Olak
- J Pfannschmidt
- JH Scholefield
- JJ Telford
- JJ Tjandra
- Johnie Rose
- K Song
- KM Kuntz
- Knut Magne Augestad
- KS Hughes
- KS Virgo
- L Staib
- M Jeffery
- M Pignone
- Michael W Kattan
- MJ OâConnell
- N Pietra
- National Comprehensive Cancer Network
- Neal J Meropol
- NJ Petrelli
- P Wille-Jorgensen
- PC Simmonds
- PE Valk
- PF Engstrom
- PF Engstrom
- PM McCormack
- Qingqing Hong
- R Konopke
- RA Audisio
- RA Graham
- RE Davila
- RT Clemen
- S Roberts
- S Vijan
- S Winawer
- SJ Winawer
- T Anthony
- U Haug
- University hospitals Southampton NHS Foundation Trust
- WA Bleeker
- World Health Organization
- Xuebei An
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years
- Author
- A'hern R
- A\u2019hern R
- Abe O
- Abe R
- Abu\u2010zahra Ht
- Af Trampe E
- Aft R
- Ahlgren J
- Ahn Jh
- Aihara T
- Albain K
- Albano J
- Alberro Ja
- Amadori D
- Anderson H
- Anderson S
- Andr\ue9 F
- Arnesson Lg
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Barlow W
- Barrett\u2010lee Pj
- Bartelink H
- Bartlett J
- Bartsch R
- Bass G
- Bastert G
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Bengtsson No
- Benraadt J
- Bergh J
- Bergsten\u2010nordstr\uf6m E
- Berry D
- Bighin C
- Bijker N
- Bishop H
- Blamey Rw
- Bliss J
- Bliss Jm
- Blohmer Ju
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesson T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell Vh
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brockschmidt J
- Brookes C
- Brown A
- Browne L
- Brufsky Am
- Bruzzi P
- Bryant Ajs
- Bryant J
- Bundred Nj
- Burrett Ja
- Buyse M
- Buzdar Au
- Caffier H.
- Calais G
- Camerini T
- Cameron D
- Camisa R
- Camphausen K
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter Jt
- Carrasco E
- Carstensen J
- Castiglione M
- Celebioglu F
- Chen Be
- Chen Zm
- Chetty U
- Chilvers Ced
- Chlebowski Rt
- Christiaens R
- Christiansen P
- Cirrincione C
- Clack G
- Clarke M
- Coates A
- Cocconi G
- Coleman R
- Coleman Re
- Colleoni M
- Collett V
- Collins J
- Comis Rl
- Coombes Rc
- Cooper Mr
- Corcoran N
- Correa C
- Costa A
- Costa Sd
- Costantino J
- Crossley E
- Crowley J
- Cufer T
- Cunningham Mp
- Cutter D
- Cuzick J
- D\u2019amico C
- Dafni U
- Dahlberg K
- Dalesio O
- Danforth D
- Davidson N
- Davidson Ne
- Davies C
- Davis Hl
- De La Huerta R
- De La Lande B
- De Lafontan B
- De Laurentiis M
- De Oliveira Cf
- De Pablo Jl
- De Placido S
- De Schryver A
- De Vries Ege
- Del Mastro L
- Delaloge S
- Delmestri A
- Delozier T
- Dent Dm
- Deshpande N
- Deulofeu P
- Deutsch Gp
- Di Blasio B
- Di Leo A
- Di Martino L
- Di Mauro Mg
- Di Palma M
- Dignam J
- Dixon Jm
- Dodwell D
- Dolci S
- Douglas P
- Dowsett M
- Dozin B
- Duane F
- Dubois Jb
- Dufmats M
- Dunn J
- Durand M
- Eidtmann H
- Eiermann W
- Ejlertsen B
- Ellis Io
- Ellis P
- Emdin S
- Enomoto K
- Erazo A
- Erikstein B
- Evans V
- Ewertz M
- Ewing Gh
- F\ue1bregas R
- Falkson Ci
- Fargeot P
- Fehm T
- Fentiman Is
- Fernando I
- Fesl C
- Firth La
- Fisher B
- Fitzal F
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes Jf
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- G\uf6ransson E
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet Jc
- Gelber R
- Gelber Rd
- Gelman Rs
- Gelmon K
- George Wd
- Gerber B
- Gerv\ue1sio H
- Gettins L
- Geyer C
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldstein Lj
- Goodwin P
- Gordilho J
- Gordon Nh
- Goss Pe
- Graham P
- Gralow J
- Gray R
- Greil R
- Griffon B
- Gubern Jm
- Gudgeon Ca
- Gundersen S
- H\uf8st H
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Hannisdal E
- Harbeck N
- Harris A
- Harris Jr
- Harvey Vj
- Hauer\u2010jensen M
- Hayat H
- Haybittle Jl
- Hayes Df
- Hayward Jl
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway Im
- Holli K
- Holmberg L
- Horiguchi J
- Horsman Jm
- Hortobagyi G
- Houghton J
- Howell A
- Hozumi Y
- Hsu L
- Hudis Ca
- Huovinen R
- Hupperets Psgj
- Iiristo M
- Ikeda T
- Inbar Mj
- Ingle J
- Ingle Jn
- Inokuchi K
- Ivanov V
- Iwata H
- J\ue4nicke F
- Jack W
- Jackisch C
- Jackson Im
- Jacobsen Ab
- Jagsi R
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen Mb
- Joensuu H
- Johansen H
- Johansson U
- Jonat W
- Jones Se
- Jonsson H
- Julien Jp
- Jung Kh
- Karlsson P
- Kaufmann M
- Kay Rg
- Kerbrat P
- Kerr A
- Kikuchi K
- Kilburn L
- Killander F
- Kissin M
- Klefstrom P
- Klijn Jgm
- Kohno N
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscielny S
- Koyama H
- Kreienberg R
- Krushen\u2010kosloski Jl
- Kunkler I
- Kwong Dlw
- L\uf6fgren L
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
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- Leone B
- Lester J
- Levine M
- Levine Mn
- Lichter A
- Liedtke C
- Liefers Gj
- Liljegren G
- Linderholm Bk
- Lindman H
- Lindsay Ma
- Lindtner A
- Lindtner J
- Lioce M
- Lippman M
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart Ha
- Lohrisch C
- Loibl S
- Lopez M
- Love Rr
- Luporsi E
- Lythgoe Jp
- Mace Lesec\u2019h J
- Mackey J
- Mackinnon E
- Maibach R
- Makris A
- Mallon E
- Malmstr\uf6m P
- Mamounas Ep
- Mannu G
- Mansel Re
- Margreiter R
- Markopoulos C
- Marshall Hc
- Martelli G
- Marth C
- Martin Al
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason Bh
- Masood Mb
- Masuda H
- Math\ue9 G
- Mauriac L
- Mavroudis D
- Mcardle Cs
- Mcgale P
- Mchugh T
- Meakin Jw
- Medina Jy
- Meier P
- Meisner C
- Michiels S
- Mihura J
- Misset Jl
- Mitchell Ak
- Miyashita M
- Mlineritsch B
- Monson K
- Monypenny Ij
- Moral A
- Morgan Dal
- Morimoto K
- Morris P
- Mouret\u2010fourme E
- Mouridsen H
- Mouridsen Ht
- Mukai H
- Murray E
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- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen\u2010meyer R
- Nitz U
- Nogaret Jm
- Nomura Y
- Nordenskj\uf6ld B
- Norton L
- Notter G
- Oates Gd
- Ogawa M
- Ohashi Y
- Ohno S
- Osborne Ck
- Owen Jr
- Pai Vr
- Paik S
- Palmer Mk
- Palshof T
- Paltuev R
- Pan H
- Panieri E
- Pannuti F
- Panzarella T
- Paradiso A
- Paridaens R
- Parker D
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- Parulekar W
- Passalacqua R
- Pastorino S
- Pater Jl
- Paterson Ahg
- Patnick J
- Pe\uf1alva G
- Peek U
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- Pennert K
- Perbeck L
- Peretz T
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- Perrone F
- Peto R
- Petruzelka L
- Pfeiler G
- Philippson C
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- Ravdin P
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- Redmond C
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- Ro J
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- Romain S
- Romestaing P
- Rossbach J
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- Rotstein S
- Rouhento K
- Royle Gt
- Rubagotti A
- Rubens Rd
- Rubino C
- Rudenstam Cm
- Rutgers E
- Ryd\ue9n L
- S\uf6derberg M
- Saarto T
- Sacco M
- Sadoon M
- Safra T
- Sainz Mg
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- Schmid P
- Schmitt M
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- Seifert M
- Semiglazov V
- Senanayake F
- Senn Hj
- Serra C
- Sertoli Mr
- Sestak I
- Sevelda P
- Shan Y
- Shao Yf
- Shapiro Cl
- Shepherd Le
- Shien T
- Simmonds Pd
- Singer Cf
- Skilton D
- Skolyszewski J
- Skoog L
- Slamon D
- Sledge G
- Smart D
- Smith Dc
- Smith Ie
- Sohn Hc
- Sol\ue0 M
- Solarnau L
- Solin Lj
- Solomayer E
- Solsona J
- Sonoo H
- Sparano J
- Sparano Ja
- Spittle M
- Spooner D
- St\uf6ger H
- Stallard S
- Steger Gg
- Steinberg S
- Stewart Hj
- Stroner P
- Sugimachi K
- Suman Vj
- Svane G
- Swain S
- Swindell R
- Takao S
- Takatsuka Y
- Takei H
- Talbot D
- Taylor C
- Taylor M
- Th\ufcrlimann B
- Thomssen C
- Thuerlimann B
- Tinterri C
- Tobias Js
- Toi M
- Tominaga T
- Tormey Dc
- Trampisch Hj
- Treurniet\u2010donker Ad
- Tu D
- Tulusan Ah
- Tutt A
- Uchino J
- Ueo H
- Untch M
- Vakaet L
- Valagussa P
- Valentini M
- Vallejo Ct
- Van De Velde Ao
- Van De Velde Cjh
- Van Den Bogaert W
- Van Dongen Ja
- Van Poznak C
- Van Putten Wlj
- Van Tinteren H
- Varhaug Je
- Veloso E
- Venturini M
- Vermorken Jb
- Veronesi U
- Viale G
- Vidal S
- Vilcoq Jr
- Von Minckwitz G
- W\ue4rnberg F
- Wadstr\uf6m C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Weiss Rb
- Werner Id
- Whelan T
- Wickerham L
- Wilcken N
- Williams L
- Winer E
- Winter Mc
- Wittes R
- Wolmark N
- Wood W
- Yamashita J
- Yarnold Jr
- Yosef Hma
- Yoshida M
- Yoshimoto M
- Zambetti M
- Zhao Db
- Zielinski Cc
- Zwenger A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years could help determine whether to extend treatment
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A DĂĄvalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
- A Pradhan
- A Protti
- A Rattner
- A Ravati
- A Rehman
- A Reynolds
- A Richmond
- A Roetto
- A Roetto
- A Rostom
- A Rumbold
- A Russo
- A Rötig
- A Saltelli
- A Saltelli
- A Sandek
- A Sassano
- A Scalbert
- A Scalbert
- A Scalbert
- A Sica
- A Smahi
- A Sola
- A Stintzi
- A Szewczyk
- A Taguchi
- A Tedgui
- A Terman
- A Terman
- A Terman
- A Undas
- A Virdis
- A Wagner
- A Wagner
- A Wagner
- A Wagner
- A Wojas-Pelc
- A Wong
- A Xu
- A Yoritaka
- A Yoshimura
- A-L BarabĂĄsi
- AA Andreadis
- AA Borisy
- AA Farooqui
- AA Qutub
- AA Qutub
- AA Vlessis
- AB Nathens
- AB Parsons
- AB Parsons
- AB Thompson
- AB Thomson
- AC Bayne
- AC Bharti
- AC Cave
- AC Mello Filho
- AD d'Hardemare
- AD de Silva
- Ad hoc committee on systemic lupus erythematosus response criteria for fatigue
- ADL van der
- AE Aust
- AE Baue
- AE Finefrock
- AE Heazell
- AE Heazell
- AE Kartikasari
- AEC Ihekwaba
- AEC Ihekwaba
- AF Tramontano
- AH Berg
- AH Koeppen
- AH Koeppen
- AH Tong
- AI Bush
- AI Bush
- AI Bush
- AI Bush
- AI Faden
- AJ Ghio
- AJ Ghio
- AJ Ghio
- AJ Hulbert
- AJ Kowaltowski
- AJ Lusis
- AJ Matthews
- AJ Reyes
- AJ van Oostrom
- AJ Watson
- AJ White
- AJ Williams
- AK Junk
- AL Beal
- AL Hemdahl
- AL Hopkins
- AL Hopkins
- AL Lagan
- AL Mark
- AL Sirén
- AL Sirén
- AL Sirén
- AL Takeda
- AM Abeles
- AM Borzychowski
- AM Choi
- AM Dolga
- AM Elneihoum
- AM Elneihoum
- AM Feist
- AM Harvey
- AM Jenkinson
- AM Lin
- AM Samuni
- AM Snyder
- AN Crowson
- AN Tabah
- AP Bolger
- AP Breen
- AP Liappis
- AR Kallianpur
- AR Kallianpur
- AR Martin
- AR Ness
- AR Rechner
- AR Rumbold
- AS Baldwin Jr
- AS Binbrek
- AS Kaprelyants
- AS Wierzbicki
- AT McKie
- AV Lebedev
- AV Perkins
- AV Rao
- AW Maresso
- AY Andreyev
- AY Sun
- B Chakravarti
- B Chance
- B Cronin
- B de Valk
- B De Vries
- B Desoize
- B Drayer
- B Faller
- B Goodell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Halliwell
- B Huppertz
- B Jayawardhana
- B Kwak
- B Lachili
- B Lipinski
- B Mackenzie
- B Marshall
- B Mignotte
- B Oldenburg
- B Poeggeler
- B Pradines
- B Pradines
- B Regland
- B Russell
- B Schiessl
- B Shipley
- B Skibska
- B Sturm
- B Thorand
- B Wang
- B Wolff
- B Wolozin
- B Wolozin
- B Xu
- B Zhang
- B Zhou
- BA Maddux
- BA Molitoris
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Aggarwal
- BB Sizoo
- BB Song
- BB Song
- BC Daniels
- BC Jones
- BD LaMarca
- BH Havsteen
- BI Giasson
- BI Hoffman
- BJ Marshall
- BK Kennedy
- BK Rinehart
- BK Wagner
- BL Halvorsen
- BL Zhao
- BM Babior
- BN Ames
- BP Leung
- BP Oberg
- BP Yu
- BR Kwak
- BR Otto
- BS Chen
- BS van Asbeck
- BT Mossman
- BV Naidu
- BY Tung
- BĂ Palsson
- C Arnaud
- C Beaumont
- C Behl
- C Biondi
- C Bolin
- C Bozzini
- C Breymann
- C Brooksbank
- C Bubici
- C Bubici
- C Burdon
- C Camaschella
- C Camaschella
- C Caris
- C Cavdar
- C Chen
- C Delaby
- C Demougeot
- C Finch
- C Fleury
- C GarcĂa-Ruiz
- C Gasche
- C Gasche
- C GerhÀuser
- C Goble
- C Henry
- C Herce-Pagliai
- C Herder
- C Hershko
- C Hershko
- C Hershko
- C Hershko
- C Jacob
- C Kenyon
- C Knox
- C Kretz-Remy
- C Kunsch
- C Köhle
- C Leadbeater
- C Li
- C Lu
- C Manach
- C Manach
- C Manach
- C Mancuso
- C Moon
- C Moon
- C Mouralian
- C Muscoli
- C Peyssonnaux
- C Peyssonnaux
- C Peyssonnaux
- C Pigeon
- C Popa
- C Quintana
- C Ramassamy
- C Ramassamy
- C Ratledge
- C Rigamonti
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- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
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- Williams B
- Williams RL
- Williams RSB
- Williamson PR
- Wilson RA
- Winner B
- Winsor NJ
- Witkin SS
- Wodrich H
- Woehlbier U
- Wollert T
- Wong E
- Wong JH
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- Wong VKW
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- Wu A-G
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- Wu WKK
- Wu X
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- Xavier RJ
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- Xiang G
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- Xiao B
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- Xiao H-T
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- Xilouri M
- Xu C
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- Xue Y
- Yakhine-Diop SMS
- Yamaguchi M
- Yamaguchi O
- Yamamoto A
- Yamashina S
- Yan S
- Yan S-J
- Yan Z
- Yanagi Y
- Yang C
- Yang D-S
- Yang H
- Yang H
- Yang H-T
- Yang J
- Yang J
- Yang J-M
- Yang L
- Yang L
- Yang M
- Yang P-M
- Yang Q
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- Yang S
- Yang S-F
- Yang W
- Yang WY
- Yang X
- Yang X
- Yang Y
- Yang Y
- Yao H
- Yao S
- Yao X
- Yao Y-G
- Yao Y-M
- Yasui T
- Yazdankhah M
- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
- Yin Y
- Yin Z
- Yin Z
- Ying M
- Ying Z
- Yip CK
- Yiu SPT
- Yoo YH
- Yoshida K
- Yoshii SR
- Yoshimori T
- Yousefi B
- Yu B
- Yu H
- Yu J
- Yu J
- Yu L
- Yu M-L
- Yu S-W
- Yu VC
- Yu WH
- Yu Z
- Yu Z
- Yuan J
- Yuan L-Q
- Yuan S
- Yuan S-SF
- Yuan Y
- Yuan Z
- Yue J
- Yue Z
- Yun J
- Yung RL
- Zacks DN
- Zaffagnini G
- Zambelli VO
- Zanella I
- Zang QS
- Zanivan S
- Zappavigna S
- Zaragoza P
- Zarbalis KS
- Zarebkohan A
- Zarrouk A
- Zeitlin SO
- Zeng J
- Zeng J-D
- Zhan L
- Zhang B
- Zhang DD
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H
- Zhang H-L
- Zhang J
- Zhang J
- Zhang J-P
- Zhang KYB
- Zhang L
- Zhang L
- Zhang L
- Zhang L
- Zhang LW
- Zhang M
- Zhang P
- Zhang S
- Zhang W
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X
- Zhang X-W
- Zhang XD
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y-D
- Zhang Y-Y
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhang Z
- Zhao H
- Zhao L
- Zhao S
- Zhao T
- Zhao X-F
- Zhao Y
- Zhao Y
- Zhao Y
- Zhao Y
- Zheng G
- Zheng K
- Zheng L
- Zheng S
- Zheng X-L
- Zheng Y
- Zheng Z-G
- Zhivotovsky B
- Zhong Q
- Zhou A
- Zhou B
- Zhou C
- Zhou G
- Zhou H
- Zhou H
- Zhou H
- Zhou J
- Zhou J
- Zhou J
- Zhou J
- Zhou K
- Zhou R
- Zhou X-J
- Zhou Y
- Zhou Y
- Zhou Y
- Zhou Z
- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
- Zhu H
- Zhu H
- Zhu H
- Zhu W-G
- Zhu Y
- Zhu Y
- Zhuang H
- Zhuang X
- Zientara-Rytter K
- Zimmermann CM
- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
- Zou Z
- Zou Z
- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Major genes determining yield-related traits in wheat and barley
- Author
- A Börner
- A Börner
- A Börner
- A Börner
- A Distelfeld
- A Distelfeld
- A Druka
- A Kapazoglou
- A Nadolska-Orczyk
- A Turner
- AN Olsen
- Anna Nadolska-Orczyk
- B Qu
- BC Sharman
- BP Forster
- BR Nallamilli
- C Chang
- C Dockter
- C Dockter
- C Uauy
- C Uauy
- CA Helliwell
- CY Wu
- D Fu
- D Gasperini
- D Schulte
- D Yadav
- DE Nelson
- DW Lawlor
- DW Mok
- E Bortiri
- E Millet
- EA Kellogg
- F Jiang
- F Shahinnia
- Gosman N Srinivasachary
- GT Vu
- GTH Vu
- H Li
- H Liu
- H Sakakibara
- I Saalbach
- Izabela K. Rajchel
- J Beales
- J Bednarek
- J Cockram
- J DoleĆŸel
- J Dubcovsky
- J Hou
- J Lu
- J Peng
- J Simmonds
- J Song
- J Wang
- J Zheng
- JA Higgins
- JD Franckowiak
- JE Flintham
- JE Flintham
- JI Cho
- JP Ral
- JP Ral
- K Houston
- K Ishimaru
- K Mochida
- K Watanabe
- KF Mayer
- KJ Simons
- KK Bhati
- KS Gill
- KS Gill
- L Barboza
- L Ma
- L Ramsay
- L Zhang
- LM Shaw
- LM Shaw
- LS Dahleen
- LT Evans
- M Ashikari
- M Chono
- M Echeverry-Solarte
- M Hanif
- M Jost
- M Kesavan
- M Ma
- M Pfeifer
- M Shahbaz
- M Tester
- M-J Hu
- MA Mulki
- MC Lima Neto
- MD Bennett
- MD Gale
- MD Gale
- MV Remizowa
- MW Christiansen
- MW Christiansen
- MW Jones-Rhoades
- N Poursarebani
- N Sreenivasulu
- N Weichert
- NE Appleford
- NE Borlaug
- O Dobrovolskaya
- P Hedden
- P Paul
- P Skov Kristensen
- PA Brocklehurst
- PE Jameson
- PK Endress
- PM Chandler
- PM Chandler
- Q Jia
- Q Jiang
- Q Shan
- R Che
- R Koppolu
- R Valluru
- R Zhang
- RD Vierstra
- RJ Lawrence
- RJ Saville
- S Cao
- S Gasparis
- S Gasparis
- S Pearce
- S Sakuma
- S Travella
- S Youssefian
- Sebastian Gasparis
- SIM Houimli
- T Komatsuda
- T Lawrenson
- T Sakamoto
- T Werner
- TH Kebrom
- The International Wheat Genome Sequencing C
- TJ Stephenson
- TJ Stephenson
- TP Sun
- U Lundqvist
- U Lundqvist
- UK Divi
- V Khripach
- W Qi
- W Wen
- W Zalewski
- W Zalewski
- W Zalewski
- WacĆaw Orczyk
- X He
- X Wei
- XJ Song
- XP Li
- Y Hong
- Y Jiang
- Y Li
- Y Wang
- Y Zhang
- Z Su
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials
- Author
- A'Hern R
- Abe O
- Abe O
- Abe R
- Abu-Zahra HT
- af Trampe E
- Aft R
- Ahlgren J
- Ahn J-H
- Albain K
- Albano J
- Alberro JA
- Amadori D
- Anderson H
- Andre F
- Arnesson L-G
- Arriagada R
- Asmar L
- Asselain B
- Bahi J
- Balic M
- Ballester B
- Bamia C
- Barlow W
- Barrett-Lee PJ
- Bartelink H
- Bartlett JMS
- Bartlett JMS
- Bartsch R
- Basso SMM
- Bastert G
- Bastiaannet E
- Bastiaannet E
- Bates T
- Baum M
- Belfiglio M
- Bell R
- Benraadt J
- Bergh J
- Berry D
- Bijker N
- Bishop H
- Blamey RW
- Bliss J
- Bliss JM
- Blohmer JU
- Blomqvist C
- Boccardo F
- Boddington C
- Bogaerts J
- Bonadonna G
- Bondesso T
- Bonneterre J
- Borovik R
- Bowden S
- Bradley R
- Brain E
- Bramwell VH
- Braun S
- Braybrooke J
- Brenner H
- Broadwater G
- Brookes C
- Brufsky AM
- Bryant AJS
- Bundred NJ
- Burrett JA
- Buyse M
- Buzdar AU
- Caffier H
- Calais G
- Camerini T
- Cameron D
- Cameron D
- Camisa R
- Canavese G
- Canney P
- Cardoso F
- Carlomagno C
- Carpenter TJ
- Carrasco E
- Carstense J
- Castiglione M
- Castiglione M
- Celebiogl F
- Chen BE
- Chetty U
- Chetty U
- Chia SKL
- Chilvers CED
- Chlebowski RT
- Christiaens R
- Christiansen P
- Cirrincione C
- Clarke M
- Coates A
- Coleman RE
- Coleman RE
- Coleman RE
- Coles CE
- Colleoni M
- Collett V
- Collins J
- Comis RL
- Coombes RC
- Corcoran N
- Costa A
- Costa SD
- Crowley J
- Cufer T
- Cunningham MP
- Cutter D
- Cuzick J
- Cuzick J
- Dafni U
- Dahlberg K
- Dalesio O
- Davidson NE
- Davies C
- Davies C
- Davis HL
- de la Huerta R
- de La Lande B
- de Lafontan B
- De Laurentiis M
- de Oliveira CF
- de Pablo JL
- De Placido S
- De Salvo GL
- de Schryver A
- de Vries EGE
- Del Bianco P
- Delaloge S
- Delaloge S
- Delmestri A
- Delozier T
- Dent DM
- Deshpande N
- Deulofeu P
- Deutsch GP
- Di Leo A
- di Martino L
- Di Mauro MG
- Dixon JM
- Dodwell D
- Dodwell D
- Dolci S
- Douglas P
- Duane F
- Dubois JB
- Dufmats M
- Dunn J
- Durand M
- Early Breast Cancer Trialists' Collaborative Group (EBCTCG)
- EBCTCG
- EBCTCG
- Eidtmann H
- Eierman W
- Ejlertsen B
- Ejlertsen B
- Ellis IO
- Ellis IO
- Ellis P
- Enomoto K
- Erazo A
- Evans V
- Ewertz M
- Ewing GH
- Fabregas R
- Fargeot P
- Fehm T
- Fentiman IS
- Fentiman IS
- Fernando I
- Fesl C
- Firth LA
- Fitzal F
- Focan C
- Fohler H
- Fohlin H
- Forbes J
- Forbes JF
- Forbes JF
- Formelli F
- Fornander T
- Forrest P
- Forsyth S
- Forsyth S
- Foster L
- Fountzilas G
- Fraile M
- Francis PA
- Fredriksson I
- Frisell J
- Fumoleau P
- Fyles A
- Gallen M
- Galligioni E
- Garaud P
- Garmo H
- Gazet JC
- Gelbe RD
- Gelman RS
- Gelmon K
- George WD
- George WS
- Gerber B
- Gervasio H
- Gettins L
- Gianni L
- Giokas G
- Gluz O
- Gnant M
- Godwin J
- Goldhirsch A
- Goldhirsch A
- Goldstein LJ
- Goransson E
- Gordilho J
- Gordon NH
- Goss PE
- Gralow J
- Gray R
- Gray R
- Gray R
- Greil R
- Griffon B
- Gubern JM
- Gudgeon CA
- Hacking A
- Hacking A
- Hackshaw A
- Hadji P
- Hakes T
- Hall E
- Harbeck N
- Harbeck N
- Harris JR
- Harvey VJ
- Hayat H
- Haybittle JL
- Hayes D
- Hayes D
- Hayes D
- Hayward JL
- Henderson C
- Hercbergs A
- Hilfrich J
- Hill C
- Hinsley S
- Holdaway IM
- Holli K
- Holmberg L
- Horiguchi J
- Horsman JM
- Hortobagyi G
- Host H
- Houghton J
- Howell A
- Hozumi J
- Hsu L
- Hudis CA
- Huovinen R
- Hupperets PSGJ
- Iiristo M
- Ikeda T
- Inbar MJ
- Inokuchi K
- Iwata H
- Jack W
- Jackisch C
- Jakesz R
- James S
- Janauer M
- Janer J
- Janni W
- Jensen M-B
- Jensen MB
- Joensuu H
- Johansson U
- Jonat W
- Jones SE
- Julien JP
- Jung KH
- JĂ€nicke F
- Karlsson P
- Karpov A
- Kaufmann M
- Kaufmann M
- Kay RG
- Kerbrat P
- Kerr A
- Kikuchi K
- Kikuchi K
- Kilburn L
- Killander F
- Klefstrom P
- Klijn JGM
- Kohno N
- Koliou G-A
- Kondylis D
- Kooi M
- Korzeniowski S
- Koscienly S
- Koyama H
- Kreienberg R
- Krushen-Kosloski JL
- Kunkler I
- Kwong DLW
- Larsimont D
- Ledermann J
- Lee M
- Lehingue Y
- Lemonnier J
- Lenner E
- Leonard CF
- Leone B
- Lesec'h JM
- Lester J
- Levine MN
- Liedtke C
- Liefers GJ
- Linderholm BK
- Lindman H
- Lindsay MA
- Lindtner A
- Lindtner J
- Lissaios B
- Litton A
- Liu H
- Livingston R
- Llombart HA
- Lofgren L
- Lohrisch C
- Loib S
- Lopez M
- Love RR
- Lumachi F
- Luporsi E
- Mackey J
- MacKinnon E
- Maibach R
- Mallon E
- Malmstrom P
- Mannu G
- Manousou K
- Mansel RE
- Margreiter R
- Markopoulos C
- Marshall HC
- Martelli G
- Marth C
- Martin AL
- Martin M
- Martin M
- Martin M
- Martin P
- Martino S
- Martoni A
- Marty M
- Mason BH
- Masood MB
- Masuda H
- Mauriac L
- Mavroudis D
- McArdle CS
- McGale P
- McHugh T
- Meakin JW
- Medina JY
- Meier P
- Meisner C
- Michiels S
- Mihura J
- Miyashita M
- Mlineritsch B
- Moebus V
- Monson K
- Monypenny IJ
- Moral A
- Morgan DAL
- Morris P
- Mouret-Fourme E
- Mouridsen H
- Mouridsen HT
- Murray E
- Murray N
- Musolino A
- Muss H
- Mustacchi G
- Namer M
- Neven P
- Nichol A
- Nicolucci A
- Nikolaidis P
- Nissen-Meyer R
- Nitz U
- Nogaret JM
- Nomura Y
- Nordenskjold B
- Norton L
- Norton L
- Notter G
- Oates GD
- Ogawa M
- Ohashi Y
- Osborne CK
- Owen JR
- Pai VR
- Pan HC
- Panieri E
- Pannuti F
- Panzarella T
- Paridaens R
- Parker D
- Parulekar W
- Passalacqua R
- Pater JL
- Paterson AHG
- Patnick J
- Peek U
- Pellegrini F
- Penalva G
- Perbeck L
- Peretz T
- Perrone F
- Peto R
- Peto R
- Petruzelka L
- Pfeiler G
- Philippson C
- Piccart MJ
- Pierce LJ
- Pinder S
- Pinder SE
- Pirozzoli MC
- Poole C
- Poortmans PM
- Portnoj SL
- Possinger K
- Powell J
- Pribylova O
- Price JJ
- Price KN
- Pritchard KI
- Pritchard KI
- Pritchard KI
- Puig P
- Ramos M
- Rauschecker H
- Ravdin PM
- Rea D
- Rea D
- Read S
- Regan MM
- Reid M
- Robert N
- Robinson E
- Roche H
- Rodenhuis S
- Rojo R
- Romain S
- Romestaing P
- Rossbach J
- Rotmensz N
- Rotstein S
- Rouhento K
- Royle GT
- Rubagotti A
- Rubens RD
- Rubino C
- Rudenstam CM
- Rutgers E
- Ryden L
- Saarto T
- Sacco M
- Sadoon M
- Safra T
- Sainz MG
- Sakai K
- Salmon RJ
- Sandelin K
- Santesteban P
- Sauer R
- Sauerbrei W
- Sawa K
- Sayer J
- Schauer A
- Schem C
- Scheurlen H
- Schmid P
- Schmitt M
- Schumacher M
- Schumacher M
- Segui MA
- Seifert M
- Senanayake F
- Senn HJ
- Senn HJ
- Serra C
- Sestak I
- Sestak I
- Sevelda P
- Shan Y
- Shao YF
- Shapiro CL
- Shepherd LE
- Shien T
- Simmonds PD
- Singer CF
- Skilton D
- Skolyszewski J
- Skoog L
- Sledge G
- Smith DC
- Soderberg M
- Sohn HC
- Sola M
- Solarnau L
- Solin LJ
- Solomayer E
- Solsona J
- Sonoo H
- Sparano JA
- Spittle M
- Spooner D
- Stallard S
- Steger GG
- Stewart HJ
- Stoeger H
- Stroner P
- Sugimachi K
- Sundqvist M
- Svane G
- Swindell R
- Takao S
- Takei H
- Taylor C
- Thomssen C
- Thuerlimann B
- Thurlimann B
- Tinterri C
- Tobias JS
- Toi M
- Tominaga T
- Tormey DC
- Trampisch HJ
- Treurniet-Donker AD
- Trialists GROCTA
- Tu D
- Tulusan AH
- Uchino J
- Untch M
- Untch M
- Vakaet L
- Valagussa P
- Valagussa P
- Valentini M
- Vallejo CT
- van de Velde AO
- van de Velde CJH
- van de Velde CJH
- van de Velde CJH
- Van den Bogaert W
- van Dongen JA
- van Putten WLJ
- van Tinteren H
- Veloso E
- Vermorken JB
- Veronesi U
- Viale G
- Vidal S
- Vilcoq JR
- von Minckwitz G
- Wadstrom C
- Wallgren A
- Wallwiener D
- Wang X
- Wang Y
- Wang Z
- Warnberg F
- Weiss RB
- Werner ID
- Whelan T
- Wilcken N
- Williams L
- Winer E
- Winter MC
- Wittes R
- Wood W
- Yamashita J
- Yarnold JR
- Yosef HMA
- Yoshida M
- Yoshimoto M
- Zavagno G
- Zhao DB
- Zielinski CC
- Zwenger A
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Background
Neoadjuvant chemotherapy (NACT) for early breast cancer can make breast-conserving surgery more feasible and might be more likely to eradicate micrometastatic disease than might the same chemotherapy given after surgery. We investigated the long-term benefits and risks of NACT and the influence of tumour characteristics on outcome with a collaborative meta-analysis of individual patient data from relevant randomised trials.
Methods
We obtained information about prerandomisation tumour characteristics, clinical tumour response, surgery, recurrence, and mortality for 4756 women in ten randomised trials in early breast cancer that began before 2005 and compared NACT with the same chemotherapy given postoperatively. Primary outcomes were tumour response, extent of local therapy, local and distant recurrence, breast cancer death, and overall mortality. Analyses by intention-to-treat used standard regression (for response and frequency of breast-conserving therapy) and log-rank methods (for recurrence and mortality).
Findings
Patients entered the trials from 1983 to 2002 and median follow-up was 9 years (IQR 5â14), with the last follow-up in 2013. Most chemotherapy was anthracycline based (3838 [81%] of 4756 women). More than two thirds (1349 [69%] of 1947) of women allocated NACT had a complete or partial clinical response. Patients allocated NACT had an increased frequency of breast-conserving therapy (1504 [65%] of 2320 treated with NACT vs 1135 [49%] of 2318 treated with adjuvant chemotherapy). NACT was associated with more frequent local recurrence than was adjuvant chemotherapy: the 15 year local recurrence was 21·4% for NACT versus 15·9% for adjuvant chemotherapy (5·5% increase [95% CI 2·4â8·6]; rate ratio 1·37 [95% CI 1·17â1·61]; p=0·0001). No significant difference between NACT and adjuvant chemotherapy was noted for distant recurrence (15 year risk 38·2% for NACT vs 38·0% for adjuvant chemotherapy; rate ratio 1·02 [95% CI 0·92â1·14]; p=0·66), breast cancer mortality (34·4% vs 33·7%; 1·06 [0·95â1·18]; p=0·31), or death from any cause (40·9% vs 41·2%; 1·04 [0·94â1·15]; p=0·45).
Interpretation
Tumours downsized by NACT might have higher local recurrence after breast-conserving therapy than might tumours of the same dimensions in women who have not received NACT. Strategies to mitigate the increased local recurrence after breast-conserving therapy in tumours downsized by NACT should be consideredâeg, careful tumour localisation, detailed pathological assessment, and appropriate radiotherapy
MAGNETOCAPACITANCE AND PHOTOLUMINESCENCE SPECTROSCOPY STUDIES OF CHARGE STORAGE, BISTABILITY AND ENERGY RELAXATION EFFECTS IN RESONANT TUNNELING DEVICES
- Publication venue
- Publication date
- 01/01/1991
- Field of study
A NEW TECHNIQUE FOR DIRECTLY PROBING THE INTRINSIC TRISTABILITY AN DITS TEMPERATURE-DEPENDENCE IN A RESONANT-TUNNELING DIODE
- Publication venue
- Publication date
- 01/04/1994
- Field of study
MAGNETIC-FIELD STUDIES OF NEGATIVE DIFFERENTIAL CONDUCTIVITY IN DOUBLE BARRIER RESONANT TUNNELLING STRUCTURES BASED ON N-INP/(INGA)AS
- Publication venue
- Publication date
- 01/03/1988
- Field of study
- âŠ