13 research outputs found
Potencial antimicrobiano de extratos de plantas na inibição de leveduras do gĂȘnero Candida
The increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. The Candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. The purpose of this study was to evaluate dichloromethane and methanol extracts from Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum and Syzygium cumini against Candida species through the analysis of Minimum Inhibitory Concentration (MIC). Results presented activity of these extracts against Candida species, especially the methanol extract.Devido ao aumento da resistĂȘncia aos antimicrobianos em uso, as plantas medicinais tĂȘm sido intensamente estudadas como agentes alternativos para a prevenção de doenças e infecçÔes. A levedura do gĂȘnero Candida, por ser um patĂłgeno oportunista, tem sua virulĂȘncia aumentada ao adquirir resistĂȘncia aos antifĂșngicos, desencadeando doenças, principalmente em hospedeiros imunossuprimidos. O propĂłsito deste trabalho foi avaliar os extratos diclorometano e metanol das plantas Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum e Syzygium cumini contra linhagens do gĂȘnero Candida atravĂ©s dos testes de Concentração InibitĂłria MĂnima (CIM). Os resultados demonstraram atividade dos extratos sobre as espĂ©cies de Candida, particularmente o extrato metanol.10651068Fundação de Amparo Ă Pesquisa do Estado de SĂŁo Paulo (FAPESP
Novel strategies to fight Candida species infection
In recent years, there has been a significant increase in the incidence of human fungal infections. The increase in cases of infection caused by Candida species, and the consequent excessive use of antimicrobials, has favored the emergence of resistance to conventional antifungal agents over the past decades. Consequently, Candida infections morbidity and mortality are also increasing. Therefore, new approaches are needed to improve the outcome of patients suffering from Candida infections, because it seems unlikely that the established standard treatments will drastically lower the morbidity of mucocutaneous Candida infections and the high mortality associated with invasive candidiasis. This review aims to present the last advances in the traditional antifungal therapy, and present an overview of novel strategies that are being explored for the treatment of Candida infections, with a special focus on combined antifungal agents, antifungal therapies with alternative compounds (plant extracts and essential oils), adjuvant immunotherapy, photodynamic therapy and laser therapy.Consolidating Research Expertise and Resources on
Cellular and Molecular Biotechnology at CEB/IBBââ, Ref.
FCOMP-01-0124-FEDER-027462BioHealth â Biotechnology
and Bioengineering approaches to improve health qualityââ,
Ref. NORTE-07-0124-FEDER-000027 co-funded by the
Programa Operacional Regional do Norte (ON.2 â O Novo
Norte), QREN, FEDER
Antimicrobial potential of some plant extracts against Candida species
The increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. The Candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. The purpose of this study was to evaluate dichloromethane and methanol extracts from Mentha piperita, Rosmarinus officinalis, Arrabidaea chica, Tabebuia avellanedae, Punica granatum and Syzygium cumini against Candida species through the analysis of Minimum Inhibitory Concentration (MIC). Results presented activity of these extracts against Candida species, especially the methanol extract
Controle dos vasos renais usando clips vasculares e fio cirĂșrgico em nefrectomias vĂdeo-assistidas de doadores vivos
OBJETIVO: A nefrectomia laparoscĂłpica em doadores vivos para transplante renal vem assumindo um papel importante na era das cirurgias minimamente invasivas, acarretando menor morbidade aos doadores, e resultados semelhantes Ă tĂ©cnica aberta no que se refere ao enxerto renal. O objetivo do presente artigo Ă© relatar a experiĂȘncia do nosso serviço utilizando a tĂ©cnica de controle dos vasos renais usando fio cirĂșrgico e clips vasculares. MĂTODO: Foram realizadas 45 nefrectomias utilizando a tĂ©cnica vĂdeo-assistida, com ligadura dos vasos renais com clips de titĂąnio (LT-300) e fio cirĂșrgico. As variĂĄveis analisadas foram tempo cirĂșrgico, perda sangĂŒĂnea, tempo de isquemia quente, permanĂȘncia hospitalar, necessidade de conversĂŁo e complicaçÔes. RESULTADOS: O procedimento foi realizado com sucesso em todos os casos. O tempo cirĂșrgico mĂ©dio foi de 118 minutos, com perda sangĂŒĂnea estimada em 84ml e tempo de isquemia quente de 4,3 minutos. Dois casos de Ăleo prolongado, uma lesĂŁo de veia gonadal, um escape de artĂ©ria renal e uma necrose de ureter foram observados. A permanĂȘncia hospitalar mĂ©dia foi de 3,7 dias. O uso de clips vasculares e fio cirĂșrgico reduziu a perda de tecido venoso comparado Ă tĂ©cnica com staplers e gerou redução de custos. CONCLUSĂES: A nefrectomia vĂdeo-assistida com a tĂ©cnica descrita Ă© factĂvel e mostrou ser efetiva na contenção de gastos e na redução de tecido venoso perdido