438 research outputs found
Non-adiabatic radiative collapse of a relativistic star under different initial conditions
We examine the role of space-time geometry in the non-adiabatic collapse of a
star dissipating energy in the form of radial heat flow, studying its evolution
under different initial conditions. The collapse of a star with interior
comprising of a homogeneous perfect fluid is compared with that of a star
filled with inhomogeneous imperfect fluid with anisotropic pressure. Both the
configurations are spherically symmetric, however, in the latter case, the
physical space of the configurations is assumed to be
inhomogeneous endowed with spheroidal or pseudo-spheroidal geometry. It is
observed that as long as the collapse is shear-free, its evolution depends only
on the mass and size of the star at the onset of collapse.Comment: To appear in Pramana- j. of physic
Holographic Evolution of Entanglement Entropy
We study the evolution of entanglement entropy in a 2-dimensional
equilibration process that has a holographic description in terms of a Vaidya
geometry. It models a unitary evolution in which the field theory starts in a
pure state, its vacuum, and undergoes a perturbation that brings it far from
equilibrium. The entanglement entropy in this set up provides a measurement of
the quantum entanglement in the system. Using holographic techniques we recover
the same result obtained before from the study of processes triggered by a
sudden change in a parameter of the hamiltonian, known as quantum quenches.
Namely, entanglement in 2-dimensional conformal field theories propagates with
velocity v^2=1. Both in quantum quenches and in the Vaidya model equilibration
is only achieved at the local level. Remarkably, the holographic derivation of
this last fact requires information from behind the apparent horizon generated
in the process of gravitational collapse described by the Vaidya geometry. In
the early stages of the evolution the apparent horizon seems however to play no
relevant role with regard to the entanglement entropy. We speculate on the
possibility of deriving a thermalization time for occupation numbers from our
analysis.Comment: 26 pages, 10 figure
Kypho-IORT - a novel approach of intraoperative radiotherapy during kyphoplasty for vertebral metastases
<p>Abstract</p> <p>Background</p> <p>Instable and painful vertebral metastases in patients with progressive visceral metastases present a common therapeutic dilemma. We developed a novel approach to deliver intraoperative radiotherapy (IORT) during kyphoplasty and report the first treated case.</p> <p>Methods/Results</p> <p>60 year old patient with metastasizing breast cancer under chemotherapy presented with a newly diagnosed painful metastasis in the 12<sup>th </sup>thoracic vertebra. Under general anaesthesia, a bipedicular approach into the vertebra was chosen with insertion of specially designed metallic sleeves to guide the electron drift tube of the miniature X-ray generator (INTRABEAM, Carl Zeiss Surgical, Oberkochen, Germany). This was inserted with a novel sheet designed for this approach protecting the drift tube. A radiation dose of 8 Gy in 5 mm distance (50 kV X-rays) was delivered. The kyphoplasty balloons (KyphX, Kyphon Inc, Sunnyvale) were inflated after IORT and polymethylmethacrylate cement was injected. The whole procedure lasted less than 90 minutes.</p> <p>Conclusion</p> <p>In conclusion, this novel, minimally invasive procedure can be performed in standard operating rooms and may become a valuable option for patients with vertebral metastases providing immediate stability and local control. A phase I/II study is under way to establish the optimal dose prescription.</p
Radiating Shear-Free Gravitational Collapse with Charge
We present a new shear free model for the gravitational collapse of a
spherically symmetric charged body. We propose a dissipative contraction with
radiation emitted outwards. The Einstein field equations, using the junction
conditions and an ansatz, are integrated numerically. A check of the energy
conditions is also performed. We obtain that the charge delays the black hole
formation and it can even halt the collapse.Comment: 22 pages, 9 figures. It has been corrected several typos and included
several references. Accepted for publication in GR
Thermalization with a chemical potential from AdS spaces
The time-scale of thermalization in holographic dual models with a chemical
potential in diverse number of dimensions is systematically investigated using
the gauge/gravity duality. We consider a model with a thin-shell of charged
dust collapsing from the boundary toward the bulk interior of asymptotically
anti-de Sitter (AdS) spaces. In the outer region there is a
Reissner-Nordstr\"om-AdS black hole (RNAdS-BH), while in the inner region there
is an anti-de Sitter space. We consider renormalized geodesic lengths and
minimal area surfaces as probes of thermalization, which in the dual quantum
field theory (QFT) correspond to two-point functions and expectation values of
Wilson loops, respectively. We show how the behavior of these extensive probes
changes for charged black holes in comparison with Schwarzschild-AdS black
holes (AdS-BH), for different values of the black hole mass and charge. The
full range of values of the chemical potential over temperature ratio in the
dual QFT is investigated. In all cases, the structure of the thermalization
curves shares similar features with those obtained from the AdS-BH. On the
other hand, there is an important difference in comparison with the AdS-BH: the
thermalization times obtained from the renormalized geodesic lengths and the
minimal area surfaces are larger for the RNAdS-BH, and they increase as the
black hole charge increases.Comment: 32 pages, 4 figures, references added, appendix added, typos
correcte
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.
BACKGROUND: Gametogenesis and fertilization play crucial roles in malaria transmission. While male gametes are thought to be amongst the simplest eukaryotic cells and are proven targets of transmission blocking immunity, little is known about their molecular organization. For example, the pathway of energy metabolism that power motility, a feature that facilitates gamete encounter and fertilization, is unknown.
METHODS: Plasmodium berghei microgametes were purified and analysed by whole-cell proteomic analysis for the first time. Data are available via ProteomeXchange with identifier PXD001163.
RESULTS: 615 proteins were recovered, they included all male gamete proteins described thus far. Amongst them were the 11 enzymes of the glycolytic pathway. The hexose transporter was localized to the gamete plasma membrane and it was shown that microgamete motility can be suppressed effectively by inhibitors of this transporter and of the glycolytic pathway.
CONCLUSIONS: This study describes the first whole-cell proteomic analysis of the malaria male gamete. It identifies glycolysis as the likely exclusive source of energy for flagellar beat, and provides new insights in original features of Plasmodium flagellar organization
Isolated and dynamical horizons and their applications
Over the past three decades, black holes have played an important role in
quantum gravity, mathematical physics, numerical relativity and gravitational
wave phenomenology. However, conceptual settings and mathematical models used
to discuss them have varied considerably from one area to another. Over the
last five years a new, quasi-local framework was introduced to analyze diverse
facets of black holes in a unified manner. In this framework, evolving black
holes are modeled by dynamical horizons and black holes in equilibrium by
isolated horizons. We review basic properties of these horizons and summarize
applications to mathematical physics, numerical relativity and quantum gravity.
This paradigm has led to significant generalizations of several results in
black hole physics. Specifically, it has introduced a more physical setting for
black hole thermodynamics and for black hole entropy calculations in quantum
gravity; suggested a phenomenological model for hairy black holes; provided
novel techniques to extract physics from numerical simulations; and led to new
laws governing the dynamics of black holes in exact general relativity.Comment: 77 pages, 12 figures. Typos and references correcte
Connection between Telomerase Activity in PBMC and Markers of Inflammation and Endothelial Dysfunction in Patients with Metabolic Syndrome
Metabolic syndrome (MS) is a constellation of metabolic derangements associated with vascular endothelial dysfunction and oxidative stress and is widely regarded as an inflammatory condition, accompanied by an increased risk for cardiovascular disease. The present study tried to investigate the implications of telomerase activity with inflammation and impaired endothelial function in patients with metabolic syndrome. Telomerase activity in circulating peripheral blood mononuclear cells (PBMC), TNF-α, IL-6 and ADMA were monitored in 39 patients with MS and 20 age and sex-matched healthy volunteers. Telomerase activity in PBMC, TNF-α, IL-6 and ADMA were all significantly elevated in patients with MS compared to healthy volunteers. PBMC telomerase was negatively correlated with HDL and positively correlated with ADMA, while no association between TNF-α and IL-6 was observed. IL-6 was increasing with increasing systolic pressure both in the patients with MS and in the healthy volunteers, while smoking and diabetes were positively correlated with IL-6 only in the patients' group. In conclusion, in patients with MS characterised by a strong dyslipidemic profile and low diabetes prevalence, significant telomerase activity was detected in circulating PBMC, along with elevated markers of inflammation and endothelial dysfunction. These findings suggest a prolonged activity of inflammatory cells in the studied state of this metabolic disorder that could represent a contributory pathway in the pathogenesis of atherosclerosis
Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector
Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente
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