The two-way relationship between entrepreneurship and economic performance

This paper examines the two-way relationship between entrepreneurship and economic performance, using a harmonized data set covering 21 OECD countries in the period 1981-2006. While the relation between entrepreneurship and economic performance has been investigated extensively, most papers in this research field suffer from one or more methodological flaws, so that the important question: "does entrepreneurship cause economic performance?" can still not be answered up till the present day. In this paper we investigate the relationship in a Vector Error Correction Model (VECM) framework. We find evidence for the existence of a long-run equilibrium relation between the level of business ownership and per capita income. We also find evidence that increases in business ownership actually cause economic growth. However, our impulse response analysis reveals that the effect depends on the number of business owners already present in the economy, i.e. we find decreasing marginal returns to entrepreneurship. We also find that the effect depends on the size of the shock (i.e. the increase in entrepreneurship), where too big shocks may lead to negative effects on GDP due to 'overshooting'. �

Modifications on Translation Initiation

Two studies by Meyer et al. and Wang et al. demonstrate a role for m6A modification of mRNA in stimulating translation initiation. These findings add to the growing number of diverse mechanisms for translation initiation in eukaryotes

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression

The control of messenger RNA (mRNA) function by micro RNAs (miRNAs) in animal cells requires the GW182 protein. GW182 is recruited to the miRNA repression complex via interaction with Argonaute protein, and functions downstream to repress protein synthesis. Interaction with Argonaute is mediated by GW/WG repeats, which are conserved in many Argonaute-binding proteins involved in RNA interference and miRNA silencing, from fission yeast to mammals. GW182 contains at least three effector domains that function to repress target mRNA. Here, we analyze the functions of the N-terminal GW182 domain in repression and Argonaute1 binding, using tethering and immunoprecipitation assays in Drosophila cultured cells. We demonstrate that its function in repression requires intact GW/WG repeats, but does not involve interaction with the Argonaute1 protein, and is independent of the mRNA polyadenylation status. These results demonstrate a novel role for the GW/WG repeats as effector motifs in miRNA-mediated repressio

RNA turnover: The helicase story unwinds

AbstractRecent results show that RNA helicases play important roles in RNA decay, both as exoribonuclease accessory factors and in communicating signals to RNA decay machinery

Some early economic threads in the history of children's homes

The way in which children's homes have been funded has had a considerable bearing on their development. This is the principal 'thread' that will be traced in what follows, although a few diversions will be made to related economic issues. Our 'principal thread' is well illustrated in the early history of the reformatories and industrial schools; so, we begin with that

P bodies promote stress granule assembly in Saccharomyces cerevisiae

Recent results indicate that nontranslating mRNAs in eukaryotic cells exist in distinct biochemical states that accumulate in P bodies and stress granules, although the nature of interactions between these particles is unknown. We demonstrate in Saccharomyces cerevisiae that RNA granules with similar protein composition and assembly mechanisms as mammalian stress granules form during glucose deprivation. Stress granule assembly is dependent on P-body formation, whereas P-body assembly is independent of stress granule formation. This suggests that stress granules primarily form from mRNPs in preexisting P bodies, which is also supported by the kinetics of P-body and stress granule formation both in yeast and mammalian cells. These observations argue that P bodies are important sites for decisions of mRNA fate and that stress granules, at least in yeast, primarily represent pools of mRNAs stalled in the process of reentry into translation from P bodies

Interactions between Upf1 and the Decapping Factors Edc3 and Pat1 in Saccharomyces cerevisiae

In Saccharomyces cerevisiae, mRNA transcripts with premature termination codons are targeted for deadenylation independent decapping and 5′ to 3′ decay in a quality control pathway termed nonsense-mediated decay (NMD). Critical factors in NMD include Upf1, Upf2, and Upf3, as well as the decapping enzyme, Dcp2/Dcp1. Loss of Upf2 or Upf3 leads to the accumulation of not only Upf1 and Dcp2 in P-bodies, but also of the decapping-activators Pat1, Dhh1, and Lsm1. An interaction between Upf1 and Dcp2 has been identified, which might recruit Dcp2 to the NMD decapping complex. To determine the nature and significance of the Dcp2-Upf1 interaction, we utilized the yeast two-hybrid assay to assess Upf1 interactions with various mRNA decapping factors. We find that although Dcp2 can interact with Upf1, this interaction is indirect and is largely dependent on the Edc3 protein, which interacts with the N-terminal domain of Upf1 at an overlapping, but not identical, site as Upf2. We also found that Pat1 has an independent two-hybrid interaction with the N-terminus of Upf1. Assessment of both reporter and endogenous NMD transcripts suggest that the decapping stimulators, including Edc3 and Pat1, as well as Edc1 and Edc2, are not essential for NMD under normal conditions. This work defines a larger decapping complex involved in NMD, but indicates that components of that complex are not required for general NMD and might either regulate a subset of NMD transcripts or be essential for proper NMD under different environmental conditions

Symbolic Magnifying Lens Abstraction in Markov Decision Processes

In this paper, we combine abstraction-refinement and symbolic techniques to fight the state-space explosion problem when model checking Markov decision processes (MDPs). The abstract-refinement technique, called "magnifying-lens abstraction" (MLA), partitions the state-space into regions and computes upper and lower bounds for reachability and safety properties on the regions, rather than the states. To compute such bounds, MLA iterates over the regions, analyzing the concrete states of each region in turn - as if one was sliding a magnifying lens across the system to view the states. The algorithm adaptively refines the regions, using smaller regions where more detail is required, until the difference between the bounds is below a specified accuracy. The symbolic technique is based on multi-terminal binary decision diagrams (MTBDDs) which have been used extensively to provide compact encodings of probabilistic models. We introduce a symbolic version of the MLA algorithm, called "symbolic MLA", which combines the power of both practical techniques when verifying MDPs. An implementation of symbolic MLA in the probabilistic model checker PRISM and experimental results to illustrate the advantages of our approach are presented

ECONOMIC, ENVIRONMENTAL AND ENERGY USE IMPLICATIONS OF SHORT-SEASON COTTON PRODUCTION: TEXAS LOWER RIO GRANDE VALLEY

Crop Production/Industries,