263 research outputs found
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Psilocybin with psychological support is showing promise as a treatment model in psychiatry but its therapeutic mechanisms are poorly understood. Here, cerebral blood flow (CBF) and blood oxygen-level dependent (BOLD) resting-state functional connectivity (RSFC) were measured with functional magnetic resonance imaging (fMRI) before and after treatment with psilocybin (serotonin agonist) for treatment-resistant depression (TRD). Quality pre and post treatment fMRI data were collected from 16 of 19 patients. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. Whole-brain analyses revealed post-treatment decreases in CBF in the temporal cortex, including the amygdala. Decreased amygdala CBF correlated with reduced depressive symptoms. Focusing on a priori selected circuitry for RSFC analyses, increased RSFC was observed within the default-mode network (DMN) post-treatment. Increased ventromedial prefrontal cortex-bilateral inferior lateral parietal cortex RSFC was predictive of treatment response at 5-weeks, as was decreased parahippocampal-prefrontal cortex RSFC. These data fill an important knowledge gap regarding the post-treatment brain effects of psilocybin, and are the first in depressed patients. The post-treatment brain changes are different to previously observed acute effects of psilocybin and other ‘psychedelics’ yet were related to clinical outcomes. A ‘reset’ therapeutic mechanism is proposed
A transonic collisionless model of the solar wind
Because of the semi-collisional nature of the solar wind, the collisionless
or exospheric approach as well as the hydrodynamic one are both inaccurate.
However, the advantage of simplicity makes them useful for enlightening some
basic mechanisms of solar wind acceleration. Previous exospheric models have
been able to reproduce winds that were already nearly supersonic at the
exobase, the altitude above which there are no collisions. In order to allow
transonic solutions, a lower exobase has to be considered, in which case the
protons are experiencing a non-monotonic potential energy profile. This is done
in the present work. In this model, the electron velocity distribution in the
corona is assumed non-thermal. Parametric results are presented and show that
the high acceleration obtained does not depend on the details of the
non-thermal distributions. This acceleration seems, therefore, to be a robust
result produced by the presence of a sufficient number of suprathermal
electrons. A method for improving the exospheric description is also given,
which consists in mapping particle orbits in terms of their invariants of
motion.Comment: 18 pages, 18 figures, accepted for publication in The Astrophysical
Journal (1 May 2004
Deep Sequencing Whole Transcriptome Exploration of the σE Regulon in Neisseria meningitidis
Bacteria live in an ever-changing environment and must alter protein expression promptly to adapt to these changes and survive. Specific response genes that are regulated by a subset of alternative σ70-like transcription factors have evolved in order to respond to this changing environment. Recently, we have described the existence of a σE regulon including the anti-σ-factor MseR in the obligate human bacterial pathogen Neisseria meningitidis. To unravel the complete σE regulon in N. meningitidis, we sequenced total RNA transcriptional content of wild type meningococci and compared it with that of mseR mutant cells (ΔmseR) in which σE is highly expressed. Eleven coding genes and one non-coding gene were found to be differentially expressed between H44/76 wildtype and H44/76ΔmseR cells. Five of the 6 genes of the σE operon, msrA/msrB, and the gene encoding a pepSY-associated TM helix family protein showed enhanced transcription, whilst aniA encoding a nitrite reductase and nspA encoding the vaccine candidate Neisserial surface protein A showed decreased transcription. Analysis of differential expression in IGRs showed enhanced transcription of a non-coding RNA molecule, identifying a σE dependent small non-coding RNA. Together this constitutes the first complete exploration of an alternative σ-factor regulon in N. meningitidis. The results direct to a relatively small regulon indicative for a strictly defined response consistent with a relatively stable niche, the human throat, where N. meningitidis resides
Interstellar Grains -- The 75th Anniversary
The year of 2005 marks the 75th anniversary since Trumpler (1930) provided
the first definitive proof of interstellar grains by demonstrating the
existence of general absorption and reddening of starlight in the galactic
plane. This article reviews our progressive understanding of the nature of
interstellar dust.Comment: invited review article for the "Light, Dust and Chemical Evolution"
conference (Gerace, Italy, 26--30 September 2004), edited by F. Borghese and
R. Saija, 2005, in pres
A counterfactual approach to measure the impact of wet grassland conservation on UK breeding bird populations
Wet grassland wader populations in the United Kingdom have experienced severe declines over the last three decades. To help mitigate these declines, the Royal Society for the Protection of Birds (RSPB) has restored and managed lowland wet grassland nature reserves to benefit these and other species. However, the impact that these reserves have on bird population trends has not been experimentally evaluated, as appropriate control populations do not readily exist. In this study, we compare population trends from 1994 ‐ 2018 for five bird species of conservation concern that breed on these nature reserves with counterfactual trends using matched breeding bird survey observations. Our results showed positive effects of conservation interventions for all four wader species that these reserves aim to benefit: Lapwing (Vanellus vanellus), Redshank (Tringa totanus), Curlew (Numenius arquata) and Snipe (Gallinago gallinago). There was no positive effect of conservation interventions on reserves for the passerine, Yellow Wagtail (Motacilla flava). We compared reserve trends with three different counterfactuals, based on different scenarios of how reserve populations could have developed in the absence of conservation, and found that reserve trends performed better regardless of the counterfactual used. Our approach using monitoring data to produce valid counterfactual controls is a broadly applicable method allowing large‐scale evaluation of conservation impact
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