479 research outputs found

    The behavior of statically-indeterminate structural members and frames with cracks present

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    Arts et Métiers ParisTech, invitation en tant que professeur invité de Paul C. Paris au LAMEFIPCrack stability is discussed as affected by their presence in statically-indeterminate beams, frames, rings, etc. loaded into the plastic range. The stability of a crack in a section, which has become plastic, is analyzed with the remainder of the structure elastic and with subsequent additional plastic hinges occurring. The reduction of energy absorption characteristics for large deformations is also discussed. The methods of elastic–plastic tearing instability are incorporated to show that in many cases the fully plastic collapse mechanism must occur for complete failure.The authors acknowledge Arts et Metiers Paris Tech and Foundation Arts et Metiers for the financial support of the Prof. P.C. Paris’ stay at LAMEFIP in 2008 and 2009. The encouragement of Prof. Ivan Iordanoff, Director of LAMEFIP, is also acknowledged with thanks

    Dydrogesterone and norethisterone regulate expression of lipoprotein lipase and hormones-sensitive lipase in human subcutaneous abdominal adipocytes

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    Aim: In premenopausal women, hyper-androgenicity is associated with central obesity and an increased cardiovascular risk. We investigated the effects of dydrogesterone (DYD)(a non-androgenic progestogen) and norethisterone (NET)(an androgenic progestogen) on lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and glycerol release in adipocytes isolated from subcutaneous abdominal adipose tissue. Methods: Adipose tissue was obtained from 12 non-diabetic women, mean age 51 years (range 37-78) and mean BMI 25.4kg/m2 (range 20.3-26.4). Adipocytes were treated with increasing doses of DYD and NET for 48 hours prior to protein extraction. Effects on lipogenesis and lipolysis were assessed using western blotting to determine the expression of key enzymes, LPL (56kDa) and HSL (84kDa) respectively. Measurement of glycerol release into the medium provided an assessment of lipolytic activity. Results: Expression of LPL was increased by DYD and NET (mean protein expression relative to control ± SEM); with greatest effect at 10-8M for DYD: 2.32±0.51(p0.05). Conclusions: DYD and NET significantly increased LPL expression relative to control whilst significantly reducing HSL expression. At the concentrations studied, similar effects were observed with the androgenic NET and the non-androgenic DYD despite differing effects on the lipid profile when taken in combination with estrogen. Further work in this area may improve knowledge about the effects of different progestogens on body fat distribution and enable progestogen use to be tailored to the individual to achieve maximal benefits

    Low dimensional ordering and fluctuations in methanol-β\beta-hydroquinone-clathrate studied by X-ray and neutron diffraction

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    Methanol-β\beta-hydroquinone-clathrate has been established as a model system for dielectric ordering and fluctuations and is conceptually close to magnetic spin systems. In X-ray and neutron diffraction experiments, we investigated the ordered structure, the one-dimensional (1D) and the three-dimensional (3D) critical scattering in the paraelectric phase, and the temperature dependence of the lattice constants. Our results can be explained by microscopic models of the methanol pseudospin in the hydroquinone cage network, in consistency with previous dielectric investigations

    The power of light – From dental materials processing to diagnostics and therapeutics

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    Harnessing the power of light and its photonic energy is a powerful tool in biomedical applications. Its use ranges from biomaterials processing and fabrication of polymers to diagnostics and therapeutics. Dental light curable materials have evolved over several decades and now offer very fast (≤ 10 s) and reliable polymerization through depth (4–6 mm thick). This has been achieved by developments on two fronts: (1) chemistries with more efficient light absorption characteristics (camphorquinone [CQ], ~30 L mol-1 cm1[ʎmax 470 nm]; monoacylphosphine oxides [MAPO], ~800 L mol-1 cm-1 [ʎmax 385 nm]; bisacylphosphine oxide [BAPO], ~1,000 L mol-1 cm-1 [ʎmax 385 nm]) as well mechanistically efficient and prolonged radical generation processes during and after light irradiation, and; (2) introducing light curing technologies (light emitting diodes [LEDs] and less common lasers) with higher powers (≤ 2 W), better spectral range using multiple diodes (short: 390–405 nm; intermediate: 410–450 nm; and long: 450–480 nm), and better spatial power distribution (i.e. homogenous irradiance). However, adequate cure of materials falls short for several reasons, including improper selection of materials and lights, limitations in the chemistry of the materials, and limitations in delivering light through depth. Photonic energy has further applications in dentistry which include transillumination for diagnostics, and therapeutic applications that include photodynamic therapy, photobiomodulation, and photodisinfection. Light interactions with materials and biological tis-sues are complex and it is important to understand the advantages and limitations of these interactions for successful treatment outcomes. This article highlights the advent of photonic technologies in dentistry, its applications, the advantages and limitations, and possible future developments

    Formation of the Chah-Gaz iron oxide-apatite ore (IOA) deposit, Bafq District, Iran: constraints from halogens, trace element concentrations, and Sr-Nd isotopes of fluorapatite

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    The textures, chemistry and Sr-Nd isotopic compositions of apatite from the Chah-Gaz iron-oxide apatite (IOA) deposit in the Bafq metallogenic belt, central Iran, were studied to investigate the formation of this ore deposit. Two generations of apatite were recognized based on Cl/F and Cl/OH ratios. Primary fluorapatite, which is coeval with magnetite in the massive ore bodies, is chemically homogeneous and characterized by Cl/F < 0.05 and Cl/OH in the range of 0.01–0.07. By contrast, F-depleted apatite rims are present in apatite hosted in veinlets that crosscut the massive ore bodies and are disseminated in the igneous host rocks, and have Cl/F and Cl/OH-apatite ratios of 0.08–0.12 and 0.15–0.79, respectively. The F-depleted rims are also depleted in LREEs, Th and U, consistent with the presence of secondary monazite, xenotime and thorite that formed by coupled dissolution-reprecipitation. The whole-rock Nd–Sr isotopic data ((87Sr/86Sr)(I) = 0.7052 to 0.7064 and ɛNd(t) = +1.3 to + 2.7) of gabbro-diorite indicate an mantle source, while the high -K, calc-alkaline-shoshonitic volcanic host rocks have εNd(t) = − 5.5 to − 7.6, clearly reflecting mixing between mantle-derived mafic magmas and assimilated Proterozoic basement. The initial 87Sr/86Sr ratios and ɛNd values of both F-rich and -depleted apatites (0.7038 to 0.7050 and −0.3 to + 6.5, respectively) are similar to gabbroic rocks and support a magmatic source for primary fluorapatite, with minimal or no crustal contribution, and indicate that the magmatic event with negative ɛNd values did not affect the whole-rock Sm-Nd signature of the ore. Petrography plus geochemical and Nd-Sr isotopic data of both studied fluorapatite, which come from iron oxide stage, are consistent with a combined igneous/magmatic-hydrothermal genesis for the Chah-Gaz IOA deposit, with low degrees of hydrothermal overprint, as evidenced by the formation of F-depleted (Cl-rich) apatite rims. The relatively constant Sr-Nd data in apatite are consistent with superimposed, episodic hydrothermal fluids from the same, evolving, magmatic-hydrothermal system

    The relationship between mantle potential temperature and oceanic lithosphere buoyancy

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    The Earth's mantle potential temperature () is thought to have cooled by ∼250 ∘C since the Archean, causing a progressive change in both the structure and composition of oceanic lithosphere. These variables affect the negative buoyancy of subducting slabs, which is known to be an important force in driving plate motions. However, the relationship between and slab buoyancy remains unclear. Here, we model the formation and subduction of oceanic lithosphere as a function of , to investigate how influences the buoyancy of subducting slabs, and by extension how buoyancy forces may have changed through time. First, we simulate isentropic melting of peridotite at mid-ocean ridges over a range of (1300–1550 ∘C) to calculate oceanic lithosphere structure and composition. Second, we model the thermal evolution of oceanic plates undergoing subduction for a variety of scenarios (by varying lithospheric thickness, slab length and subduction velocity). Finally, we integrate the structural, compositional and thermal constraints to forward model subduction metamorphism of oceanic plates to determine down-going slab density structures. When compared with ambient mantle, these models allow us to calculate buoyancy forces acting on subducting slabs. Our results indicate that oceanic lithosphere derived from hotter mantle has a greater negative buoyancy, and therefore subduction potential, than lithosphere derived from cooler mantle for a wide range of subduction scenarios. With respect to the early Earth, this conclusion supports the viability of subduction, and models of subduction zone initiation that invoke the concept of oceanic lithosphere being primed to subduct. However, we also show that decreases to lithosphere thickness and slab length, and reduced crustal hydration, progressively reduce slab negative buoyancy. These results highlight the need for robust estimates of early Earth lithospheric properties when considering whether subduction was operative at this time. Nevertheless, our findings suggest that subduction processes on the early Earth may have been uniformitarian

    On the enigmatic mid-Proterozoic : Single-lid versus plate tectonics

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    The mid-Proterozoic (ca. 1850-850 Ma) is a peculiar period of Earth history in many respects: ophiolites and passive margins of this age are rare, whereas anorthosite and A-type granite suites are abundant; metamorphic rocks typically record high thermobaric (temperature/pressure) ratios, whereas ultrahigh pressure (UHP) rocks are rare; and the abundance of economic mineral deposits features rare porphyry Cu-Au and abundant Ni-Cu and Fe-oxide Cu-Ag (IOCG) deposit types. These collective observations have been used to propose that a stagnant-lid, or single-lid, tectonic regime operated at this time, between periods of plate tectonics in the Paleoproterozoic and Neoproterozoic. In our reappraisal of the mid -Proterozoic geological record, we not only assess the viability of the single-lid hypothesis for each line of evidence, but also that of the plate tectonic alternative. We find that evidence for the single-lid hypothesis is equivocal in all cases, whereas for plate tectonics the evidence is equivocal or supporting. We therefore find no reason to abandon a plate tectonic model for the mid-Proterozoic time period. Instead, we propose that the peculiarities of this enigmatic interval can be reconciled through the combination of two processes working in tandem: secular mantle cooling and the exceptionally long tenure and incomplete breakup of Earth's first supercontinent, where both of these phenomena had a dramatic effect on lithospheric behaviour and its resulting imprint in the geological record. (c) 2022 British Geological Survey (c) UKRI 2022. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe
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