14,257 research outputs found
Functional adaptivity for digital library services in e-infrastructures: the gCube approach
We consider the problem of e-Infrastructures that wish to reconcile the generality of their services with the bespoke requirements of diverse user communities. We motivate the requirement of functional adaptivity in the context of gCube, a service-based system that integrates Grid and Digital Library technologies to deploy, operate, and monitor Virtual Research Environments deïŹned over infrastructural resources. We argue that adaptivity requires mapping service interfaces onto multiple implementations, truly alternative interpretations of the same functionality. We then analyse two design solutions in which the alternative implementations are, respectively, full-ïŹedged services and local components of a single service. We associate the latter with lower development costs and increased binding ïŹexibility, and outline a strategy to deploy them dynamically as the payload of service plugins. The result is an infrastructure in which services exhibit multiple behaviours, know how to select the most appropriate behaviour, and can seamlessly learn new behaviours
Public-Private Partnerships (PPP) in Transportation: An Analysis of Alternatives
Public-Private Partnerships (PPP) are in the forefront of approaches to funding transportation infrastructure improvements. Highlighted in the highway area by long-term leases of the Chicago Skyway and Indiana Toll Road, a variety of states are investigating the use of public private partnerships either as âBrownfieldâ leases like the Chicago and Indiana cases, or âGreenfieldâ Design, Build, Operate, Transfer arrangements. These and other PPP projects raise a variety of issues, including the length of the lease, toll escalation permitted, and use of funds. This paper develops a rationale for PPPs in transportation, evaluates several approaches to PPPs using this rationale, and analyzes some of the difficult issues that can surface
The blue sky of GJ3470b: the atmosphere of a low-mass planet unveiled by ground-based photometry
GJ3470b is a rare example of a "hot Uranus" transiting exoplanet orbiting a
nearby M1.5 dwarf. It is of crucial interest for atmospheric studies because it
is one of the most inflated low-mass planets known, bridging the boundary
between "super-Earths" and Neptunian planets. We present two new ground-based
light curves of GJ3470b gathered by the LBC camera at the Large Binocular
Telescope. Simultaneous photometry in the ultraviolet (lambda_c = 357.5 nm) and
optical infrared (lambda_c = 963.5 nm) allowed us to detect a significant
change of the effective radius of GJ3470b as a function of wavelength. This can
be interpreted as a signature of scattering processes occurring in the
planetary atmosphere, which should be cloud-free and with a low mean molecular
weight. The unprecedented accuracy of our measurements demonstrates that the
photometric detection of Earth-sized planets around M dwarfs is achievable
using 8-10m size ground-based telescopes. We provide updated planetary
parameters, and a greatly improved orbital ephemeris for any forthcoming study
of this planet.Comment: 8 pages, 6 figures, 1 table; accepted for publication in A&
Recommended from our members
Securitization, transparency, and liquidity
We present a model in which issuers of asset-backed securities choose to release coarse information to enhance the liquidity of their primary market, at the cost of reducing secondary market liquidity. The degree of transparency is inefficiently low if the social value of secondary market liquidity exceeds its private value. We show that various types of public intervention (mandatory transparency standards, provision of liquidity to distressed banks, or secondary market price support) have quite different welfare implications. Finally, we extend the model by endogenizing the private and social value of liquidity and the proportion of sophisticated investors
A strongly interacting gas of two-electron fermions at an orbital Feshbach resonance
We report on the experimental observation of a strongly interacting gas of
ultracold two-electron fermions with orbital degree of freedom and magnetically
tunable interactions. This realization has been enabled by the demonstration of
a novel kind of Feshbach resonance occurring in the scattering of two 173Yb
atoms in different nuclear and electronic states. The strongly interacting
regime at resonance is evidenced by the observation of anisotropic hydrodynamic
expansion of the two-orbital Fermi gas. These results pave the way towards the
realization of new quantum states of matter with strongly correlated fermions
with orbital degree of freedom.Comment: 5 pages, 4 figure
Markov Chain Beam Randomization: a study of the impact of PLANCK beam measurement errors on cosmological parameter estimation
We introduce a new method to propagate uncertainties in the beam shapes used
to measure the cosmic microwave background to cosmological parameters
determined from those measurements. The method, which we call Markov Chain Beam
Randomization, MCBR, randomly samples from a set of templates or functions that
describe the beam uncertainties. The method is much faster than direct
numerical integration over systematic `nuisance' parameters, and is not
restricted to simple, idealized cases as is analytic marginalization. It does
not assume the data are normally distributed, and does not require Gaussian
priors on the specific systematic uncertainties. We show that MCBR properly
accounts for and provides the marginalized errors of the parameters. The method
can be generalized and used to propagate any systematic uncertainties for which
a set of templates is available. We apply the method to the Planck satellite,
and consider future experiments. Beam measurement errors should have a small
effect on cosmological parameters as long as the beam fitting is performed
after removal of 1/f noise.Comment: 17 pages, 23 figures, revised version with improved explanation of
the MCBR and overall wording. Accepted for publication in Astronomy and
Astrophysics (to appear in the Planck pre-launch special issue
A novel CMB polarization likelihood package for large angular scales built from combined WMAP and Planck LFI legacy maps
We present a CMB large-scale polarization dataset obtained by combining WMAP
Ka, Q and V with Planck 70 GHz maps. We employ the legacy frequency maps
released by the WMAP and Planck collaborations and perform our own Galactic
foreground mitigation technique, which relies on Planck 353 GHz for polarized
dust and on Planck 30 GHz and WMAP K for polarized synchrotron. We derive a
single, optimally-noise-weighted, low-residual-foreground map and the
accompanying noise covariance matrix. These are shown, through
analysis, to be robust over an ample collection of Galactic masks. We use this
dataset, along with the Planck legacy Commander temperature solution, to build
a pixel-based low-resolution CMB likelihood package, whose robustness we test
extensively with the aid of simulations, finding excellent consistency. Using
this likelihood package alone, we constrain the optical depth to reionazation
at C.L., on 54\% of the sky. Adding the
Planck high- temperature and polarization legacy likelihood, the Planck
lensing likelihood and BAO observations we find
in a full CDM exploration. The
latter bounds are slightly less constraining than those obtained employing
\Planck\ HFI CMB data for large angle polarization, that only include EE
correlations. Our bounds are based on a largely independent dataset that does
include also TE correlations. They are generally well compatible with Planck
HFI preferring slightly higher values of . We make the low-resolution
Planck and WMAP joint dataset publicly available along with the accompanying
likelihood code.Comment: The WMAP+LFI likelihood module is available on
\http://www.fe.infn.it/u/pagano/low_ell_datasets/wmap_lfi_legacy
RNA Recognition by the Caenorhabditis elegans Embryonic Determinants MEX-5 and MEX-3: A Dissertation
Post-transcriptional regulation of gene expression is a mechanism that governs developmental and cellular events in metazoans. In early embryogenesis, transcriptionally quiescent cells depend upon maternally supplied factors such as RNA binding proteins and RNA that control key decisions. Morphogen gradients form and in turn pattern the early embryo generating different cell types and spatial order. In the nematode Caenorhabditis elegans, the early embryo relies upon several RNA binding proteins that control mRNA stability, translation efficiency, and/or mRNA localization of cell fate determinants essential for proper development.
MEX-5 and MEX-3 are two conserved RNA-binding proteins required to pattern the anterior/posterior axis and early embryo. Mutation of either gene results in a maternal effect lethal phenotype with proliferating posterior muscle into the anterior blastomeres (Muscle EXcess). Several cell-fate determinants are aberrantly expressed in mex-5 and mex-3 embryos. Both proteins are thought to interact with cis-regulatory elements present in 3â-UTRs of target RNAs controlling their metabolism. However, previous studies failed to demonstrate that these proteins regulate maternal transcripts directly.
This dissertation presents a thorough assessment of the RNA binding properties of MEX-5 and MEX-3. Quantitative biochemical approaches were used to determine the RNA binding specificity of both proteins. MEX-5 has a relaxed specificity, binding with high affinity to linear RNA containing a tract of six or more uridines within an eight-nucleotide window. This is very different from its mammalian homologs Tristetraprolin (TTP) and ERF-2. I was able to identify two amino acids present within the MEX-5 RNA binding domain that are required for the differential RNA recognition observed between MEX-5 and TTP. MEX-3 on the other hand is a specific RNA binding protein, recognizing a bipartite element with flexible spacing between two four-nucleotide half-sites. I demonstrate that this element is required for MEX-3 dependent regulation in vivo. Previous studies only identify a small number of candidate regulatory targets of MEX-5 and MEX-3. The defined sequence specificity of both proteins is used to predict new putative targets that may be regulated by either protein. Collectively, this study examines the RNA binding properties of MEX-5 and MEX-3 to clarify their role as post-transcriptional regulators in nematode development
Stolon Mass and Classes in White Clover (\u3ci\u3eTrifolium repens\u3c/i\u3e L.) with Two Soil Water Availability Levels
Two trials were carried out to study the stolon mass and classes in white clover (Trifolium repens L.) under two soil water availability levels in summer. In each trial, treatments were two white clover cultivars. From December 15th to February 15th in 1993/94 and again during the same period the following year, white clover was grown under 30 to 70 % (Forced water uptake) or 85-to100 % (Maximum water uptake) of field capacity. Every two months, throughout two years, total stolon mass, and buried, superficial, and aerial stolons were measured. Differences between cultivars were detected in stolon mass and percentage of each stolon class in both trials
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