11 research outputs found
Statistical approaches to evaluate the aquatic ecosystem qualities of a significant mining area: Emet stream basin (Turkey)
Optimization of Process Parameters using Response Surface Methodology for PCL based Biodegradable Composite Membrane for Water Purification
Green Reduction of Graphene Oxide using Kaffir Lime Peel Extract (Citrus hystrix) and Its Application as Adsorbent for Methylene Blue
Ultrastructure and subcellular distribution of Cr in Iris pseudacorus L. using TEM and X-ray microanalysis
Prevalence of human papillomavirus in young Italian women with normal cytology: how should we adapt the national vaccination policy?
Toxic metals in oil sands: review of human health implications, environmental impact, and potential remediation using membrane-based approach
Glutathione and its dependent enzymes' modulatory responses to toxic metals and metalloids in fish: a review
Toxic metals and metalloid are being rapidly
added from multiple pathways to aquatic ecosystem and
causing severe threats to inhabiting fauna including fish.
Being common in all the type of aquatic ecosystems such
as freshwater, marine and brackish water fish are the first to
get prone to toxic metals and metalloids. In addition to a
number of physiological/biochemical alterations, toxic
metals and metalloids cause enhanced generation of varied
reactive oxygen species (ROS) ultimately leading to a situ-
ation called oxidative stress. However, as an important com-
ponent of antioxidant defence system in fish, the tripeptide
glutathione (GSH) directly or indirectly regulates the scav-
enging of ROS and their reaction products. Additionally,
several other GSH-associated enzymes such as GSH reduc-
tase (GR, EC 1.6.4.2), GSH peroxidase (EC 1.11.1.9), and
GSH sulfotransferase (glutathione-S-transferase (GST), EC
2.5.1.18) cumulatively protect fish against ROS and their
reaction products accrued anomalies under toxic metals and
metalloids stress conditions. The current review highlights
recent research findings on the modulation of GSH, its redox
couple (reduced glutathione/oxidised glutathione), and other
GSH-related enzymes (GR, glutathione peroxidase, GST)
involved in the detoxification of harmful ROS and their
reaction products in toxic metals and metalloids-exposed
fish