Bibliothèque virtuele et ressources sur la prévention quaternaire

Since Quaternary Prevention is very extensive and complex, during the design process for database input, an indexing structure with the use of coding tools and categories was considered. This design will allow the addition of materials and will provide easy access to them. To add documents, 13 data fields must be populated. To access the input data form, for the purpose of adding documents, use this link: http://j.tinyurl.com/P4-Library To avoid duplication of data entries, it is necessary to review and perform an audit. In the beginning, we will provide this tutorial to a few data entry collaborators. To become a data entry collaborator, please send an e-mail to the following address: [email protected] Charts are available in eight languages to code with Q-Codes: http://3cgp.docpatient.net/tabular/Since the beginning of the work on Latin American networks on Quaternary Prevention, it has been necessary to provide a bibliographic database and resources with the objective of disseminating the concept and its application. The current platform has been designed to be augmented from various sources and shared with whomever necessary. The documents and materials that are uploaded to the platform can be shared through an Excel document. The entries have been coded with the multilingual terminology of general practice and family medicine, Q-Codes (http://3cgp.docpatient.net/2017160

Central Retina Functional Damage in Usher Syndrome Type 2: 22 Years of Focal Macular ERG Analysis in a Patient Population From Central and Southern Italy.

PURPOSE: Recent studies show that patients with Usher syndrome type 2 (USH2) have abnormal cone structure and density in the central retina. This occurs in the presence of normal acuity, opening the quest for additional sensitive functional measures of central cone function in USH. We tested here whether focal macular cone electroretinogram (fERG) could be such a tool. METHODS: This retrospective study of central cone function loss was based on data from 47 patients with USH2 from the Ophthalmology Department of the Policlinico Gemelli/Catholic University in Rome. The analysis focused on the decrease of the fERG, obtained in response to a 41-Hz sinusoidal modulation of a uniform field presented to the central 18\ub0, generated by red light-emitting diodes (LEDs) and superimposed on an equiluminant steady adapting background. fERG decrease was compared with the decrease of best-corrected visual acuity and Goldmann kinetic perimetry V4E field. RESULTS: fERG follow-up data document a severe and precocious loss of central cone function in USH2 patients, preceding losses in other measures of cone function. fERG is already reduced to 40% of control at the beginning of the second decade of life, and by 25 years of age, all USH2 patients have fERGs less than 30% of control values. CONCLUSIONS: fERG represents a sensitive tool to evaluate central cone function in USH2, anticipating the decline of other central cone function measures, such as visual acuity and Goldmann perimetry

PREPARASI ZEOLIT ALAM LAMPUNG DENGAN LARUTAN HF, HCl DAN KALSINASI UNTUK ADSORPSI GAS CO

Penelitian ini bertujuan untuk mengurangi kadar gas CO pada asap pembaaran dengan proses adsorpsi menggunakan zeolit alam lampung. Penelitian ini meliputi preparasi zeolit alam dengan larutan HF, HCl, dan kalsinasi dan uji terhadap CO. Proses preparasi zeolit alam meliputi: dealuminasi dengan larutan HF 2%, perendaman dengan larutan HCl 6 M dan kalsinasi pada temperatur 500 oC. Kemudian uji adsorpsi gas CO dilakukan secara kontinyu. Karakterisasi kandungan air yang terikat secara fisika pada zeolit dilakukan dengan memanaskan zeolit pada suhu 105 oC, diperoleh kandungan air pada zoelit alam sebanyak 5,3% berat. Senyawa organik yang terikat secara kimia pada zeolit diperoleh dari penurunan berat zeolit setelah proses kalsinasi, yaitu sebesar 7,5% berat. Hasil karaterisasi luas permukaan sebelum dan setelah treatment adalah 46,13 m2/gr dan 42,25 m2/gr. Perbandingan Si/Al sebelum dan sesudah treatment adalah 7,56 dan 12,15. Aktivasi zeolit mampu meningkatkan efesiensi adsorpsi dalam mengadsorp gas CO dari 1,14% menjadi 6,25% pada konsentrasi awal CO 10% dan ukuran partikel 50μ. Ukuran partikel 50μm mempunyai daya serap lebih banyak dibandingkan partikel zeolit untuk ukuran 100μm dan 150μm . Jumlah gas CO yang paling banyak terserap diperoleh pada laju alir 17% dengan ukuran partikel 50 μm

bahan referensi penetaran

268 hlm., 20 c

Bahan referensi penataran

268 hlm., 20 c

Les maximums profonds de CHL A en mer des Sargasses. Données physiques, chimiques et biologiques. Campagne CHLOMAX. 14 septembre -13 octobre 1987

The Chlomax cruise was carried out aboard R.V. “Suroît” and was focused on planktonic community structure and photosynthetic activities in the deep chlorophyll maximum which are regularly observed in oligotrophic marine ecosystems. It was conducted in the SW Sargasso Sea, between 20 and 30°N and all along 61°W approximately. Communities structure was determined using several quantitative and qualitative technics (spectrofluorometric analysis of chlorophylls; cell counts of pico and nanoplankton using flow cytometry, epifluorescence and inverted microscopy; species identification by scanning electron microscopy, particularly coccolithophorids; total biomass and counts of the various components of the mesozooplankton). Physiological state and photosynthetic activities of phytoplankton were assessed from in situ primary production measurements, photosynthesis-light curves and from induction kinetics of in vivo chlorophyll a fluorescence in presence ofDCMU. The results showed large quantities of a new type of prokaryotes (green photosynthetic bacteria or prochlorophytes) in the deep chlorophyll a maximum. It contains chlorophylls which exhibit a 7-8 nm shift in their fluorescence excitation maximum as compared to chlorophylls a and b from eukaryotes. Photosynthesis-light curves revealed that algae from the deep chlorophyll a maximum are really photoadapted to the use of low light levels. Fluorescence induction kinetics indicated that they are in good physiological state. Hydrological and chemical structure of the sampling area were also investigated. This work has been organized and funded by the CNRS-GDR P4 (pelagic production and physical phenomena) and was accomplished by a multidisciplinary research team composed of scientists from different French and one Spanish laboratories.La campagne Chlomax du n.o. “Suroît” avait pour but essentiel de préciser la structure et l’activité des communautés planctoniques dans les maximums profonds de chlorophylle a d’une zone océanique oligotrophe. Elle s’est déroulée dans le sud-ouest de la mer des Sargasses, du 14 septembre au 13 octobre 1987, entre 20 et 30°N et aux environs de 61°W. La structure des communautés a été principalement déterminée grâce à l’utilisation de diverses techniques quantitatives et qualitatives (analyse spectrofluorimétrique des chlorophylles ; comptages des cellules du pico et du nanoplancton en combinant la cytométrie en flux, la microscopie à épifluorescence et la microscopie inversée ; identification des espèces (en particulier coccolithophoridés, par microscopie électronique à balayage ; comptages et biomasse du mesozooplancton). L’activité et l’état physiologique du phytoplancton ont été déterminés à partir des mesures de production primaire in situ, de courbes lumièrephotosynthèse et de la mesure des cinétiques d’induction de fluorescence de la chlorophylle a in vivo. Les résultats mettent en évidence, en particulier dans les maximums profonds de chl a, un grand nombre de cellules procaryotes d’un type nouveau (bactéries vertes photosynthétiques ou prochlorophytes). Ces cellules contiennent des chlorophylles dont les maximums d’excitation de fluorescence sont décalés d’environ 7-8 nm vers les grandes longueurs d’onde, par rapport à ceux des chlorophylles a et b des eucaryotes. Les communautés des maximums profonds de chl a apparaissent en bon état physiologique et bien adaptées à l’utilisation des basses lumières. L’étude des structures hydrologique et chimique de la région concernée a également été effectuée. Ces travaux pluridisciplinaires ont été organisés dans le cadre de la formation CNRS-GDR P4 (production pélagique et phénomènes physiques) et réalisés par une équipe scientifique regroupant des chercheurs de divers laboratoires français (Station biologique de Roscoff, LPCM et Station zoologique de Villefranche-sur-Mer, Laboratoire Arago de Banyuls-sur-Mer, Laboratoire de biologie végétale de Perpignan) et d’un laboratoire espagnol (CEAB Blanès)

Effects of different sampling strategies on predictions of blood cyclosporine concentrations in haematological patients with multidrug resistance by Bayesian and non-linear least squares methods

The Bayesian method (BM) can use previous information for the optimization of dosage regimen. However, Bayes' law remains true when the parameters are obtained from the infinite population. Therefore a bias might exist in the previous information and affect BM predictive performance. To overcome this shortcoming, the blood drug concentration of a patient can be used to individualize his pharmacokinetic parameters. Until now, at least two sampling strategies, i.e. steady-state and non-steady-state sampling strategies, have been developed to individualize and predict blood drug concentration. In the present study we used five sampling strategies: (1) all samples; (2) post-infusion samples; (3) during-infusion samples; (4) samples within 95% confidence interval/interquartile range of a steady-state concentration; (5) the sample of the mean/median at the mid-time-point of a steady-state to individualize and predict blood cyclosporine concentrations in haematological patients with multidrug resistance. We investigated the effects of different sampling strategies on BM and the nonlinear least squared method (NLLSM) predictive performances. The results showed that BM predictive performance was better than NLLSM. But the results did not prove that the steady-state sampling strategies were superior to the non-steady-state ones