Investigating the near-criticality of the Higgs boson

We extract from data the parameters of the Higgs potential, the top Yukawa coupling and the electroweak gauge couplings with full 2-loop NNLO precision, and we extrapolate the SM parameters up to large energies with full 3-loop NNLO RGE precision. Then we study the phase diagram of the Standard Model in terms of high-energy parameters, finding that the measured Higgs mass roughly corresponds to the minimum values of the Higgs quartic and top Yukawa and the maximum value of the gauge couplings allowed by vacuum metastability. We discuss various theoretical interpretations of the near-criticality of the Higgs mass.We extract from data the parameters of the Higgs potential, the top Yukawa coupling and the electroweak gauge couplings with full 2-loop NNLO precision, and we extrapolate the SM parameters up to large energies with full 3-loop NNLO RGE precision. Then we study the phase diagram of the Standard Model in terms of high-energy parameters, finding that the measured Higgs mass roughly corresponds to the minimum values of the Higgs quartic and top Yukawa and the maximum value of the gauge couplings allowed by vacuum metastability. We discuss various theoretical interpretations of the near-criticality of the Higgs mass

Retinoblastoma-related p107 and pRb2/p130 proteins in malignant lymphomas: distinct mechanisms of cell growth control.

pRb/p105, p107, and pRb2/p130 compose the retinoblastoma (RB) family of proteins and regulate cellular growth and differentiation. Because recent functional studies have indicated that the expression of the RB-related proteins p107 and pRb2/p130 are tightly cell cycle regulated, we were interested in investigating their expression along with cellular kinetic characteristics and proliferative features of non-Hodgkin's lymphomas (NHLs). p107 and pRb2/ p130 expression was determined immunohistochemically in biopsy specimens from 83 untreated patients with NHLs of various histiotypes. The expression of these two RB-related proteins was correlated with the mitotic index, apoptotic index, and percentages of Ki-67(+), cyclin A(+), p34(+), and cyclin B(+) cells. The overall survival rate was evaluated according to the Kaplan-Meier method and the log-rank test. We found a positive correlation between the percentages of cells positive for p107 and proliferative features such as mitotic index and percentage of Ki-67(+) and cyclin A(+) cells, whereas such correlation could not be demonstrated for the percentages of pRb2/p130 positive cells. Low immunohistochemical levels of pRb2/p130 detected in untreated patients with NHLs of various histiotypes inversely correlated with a large fraction of cells expressing high levels of p107 and proliferation-associated proteins. Such a pattern of protein expression is normally observed in continuously cycling cells. Interestingly, such cases showed the highest survival percentage (82.5%) after the observation period of 10 years. Thus, down-regulation of the RB-related pRb2/p130 protein could be one of the reasons why these cases display such a high rate of proliferation and why they respond so well to therapy

Axions as hot and cold dark matter

The presence of a hot dark matter component has been hintedat 3σ by a combination of the results from differentcosmological observations. We examine a possibility that pseudoNambu-Goldstone bosons account for both hot and cold dark mattercomponents. We show that the QCD axions can do the job for theaxion decay constant fa(1010) GeV, if theyare produced by the saxion decay and the domain wall annihilation.We also investigate the cases of thermal QCD axions, pseudoNambu-Goldstone bosons coupled to the standard model sector throughthe Higgs portal, and axions produced by modulus decay