1,322 research outputs found
Increasing the spatial resolution of agricultural land cover maps using a Hopfield neural network
Land cover class composition of remotely sensed image pixels can be estimated using soft classification techniques increasingly available in many GIS packages. However, their output provides no indication of how such classes are distributed spatially within the instantaneous field of view represented by the pixel. Techniques that attempt to provide an improved spatial representation of land cover have been developed, but not tested on the difficult task of mapping from real satellite imagery. The authors investigated the use of a Hopfield neural network technique to map the spatial distributions of classes reliably using information of pixel composition determined from soft classification previously. The approach involved designing the energy function to produce a ‘best guess’ prediction of the spatial distribution of class components in each pixel. In previous studies, the authors described the application of the technique to target identification, pattern prediction and land cover mapping at the sub-pixel scale, but only for simulated imagery.We now show how the approach can be applied to Landsat Thematic Mapper (TM) agriculture imagery to derive accurate estimates of land cover and reduce the uncertainty inherent in such imagery. The technique was applied to Landsat TM imagery of small-scale agriculture in Greece and largescale agriculture near Leicester, UK. The resultant maps provided an accurate and improved representation of the land covers studied, with RMS errors for the Landsat imagery of the order of 0.1 in the new fine resolution map recorded. The results showed that the neural network represents a simple efficient tool formapping land cover from operational satellite sensor imagery and can deliver requisite results and improvements over traditional techniques for the GIS analysis of practical remotely sensed imagery at the sub pixel scale
Some observations on the state of nutrition of infants and toddlers in Sekhukhuniland
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If it’s not one thing, HIF’s another : immunoregulation by hypoxia inducible factors in disease
Hypoxia‐inducible factors (HIFs) have emerged in recent years as critical regulators of immunity. Localised, low oxygen tension is a hallmark of inflamed and infected tissues. Subsequent myeloid cell HIF stabilisation plays key roles in the innate immune response, alongside emerging oxygen‐independent roles. Manipulation of regulatory proteins of the HIF transcription factor family can profoundly influence inflammatory profiles, innate immune cell function and pathogen clearance and, as such, has been proposed as a therapeutic strategy against inflammatory diseases. The direction and mode of HIF manipulation as a therapy are dictated by the inflammatory properties of the disease in question, with innate immune cell HIF reduction being, in general, advantageous during chronic inflammatory conditions, while upregulation of HIF is beneficial during infections. The therapeutic potential of targeting myeloid HIFs, both genetically and pharmacologically, has been recently illuminated in vitro and in vivo , with an emerging range of inhibitory and activating strategies becoming available. This review focuses on cutting edge findings that uncover the roles of myeloid cell HIF signalling on immunoregulation in the contexts of inflammation and infection and explores future directions of potential therapeutic strategies
Two decades of pulsar timing of Vela
Pulsar timing at the Mt Pleasant observatory has focused on Vela, which can
be tracked for 18 hours of the day. These nearly continuous timing records
extend over 24 years allowing a greater insight into details of timing noise,
micro glitches and other more exotic effects. In particular we report the
glitch parameters of the 2004 event, along with the reconfirmation that the
spin up for the Vela pulsar occurs instantaneously to the accuracy of the data.
This places a lower limit of about 30 seconds for the acceleration of the
pulsar to the new rotational frequency. We also confirm of the low braking
index for Vela, and the continued fall in the DM for this pulsar.Comment: Isolated Neutron Stars conference, London, April 24-28 200
Beyond the Brotherhood: Skoal Bandits' role in the evolution of marketing moist smokeless tobacco pouches.
Background: Since 2006, “snus” smokeless tobacco has been sold in the U.S.. However, U.S. Smokeless Tobacco
(USST) and Swedish Match developed and marketed pouched moist snuff tobacco (MST) since 1973.
Methods: Analysis of previously secret tobacco documents, advertisements and trade press.
Results: USST partnered with Swedish Match, forming United Scandia International to develop pouch products as
part of the “Lotus Project.” Pouched MST was not commonly used, either in Sweden or the U.S. prior to the Lotus Project’s
innovation in 1973. The project aimed to transform smokeless tobacco from being perceived as an “unsightly habit of old
men” into a relevant, socially acceptable urban activity, targeting 15–35 year-old men. While USST’s initial pouched product
“Good Luck,” never gained mainstream traction, Skoal Bandits captured significant market share after its 1983 introduction.
Internal market research found that smokers generally used Skoal Bandits in smokefree environments, yet continued to
smoke cigarettes in other contexts. Over time, pouch products increasingly featured increased flavor, size, nicotine strength
and user imagery variation.
Conclusions: Marlboro and Camel Snus advertising mirrors historical advertising for Skoal Bandits, designed to recruit new
users and smokers subjected to smokefree places. Despite serious efforts, pouched MST marketing has been unable to
dispel its association with traditional smokeless tobacco stereotypes as macho and rural. Public education efforts to
discourage new users and dual use of MST and cigarettes should emphasize that “new” pouch products are simply
repackaging “old” smokeless tobacco
Hif‐1alpha stabilisation is protective against infection in zebrafish comorbid models
Multi‐drug‐resistant tuberculosis is a worldwide problem, and there is an urgent need for host‐derived therapeutic targets, circumventing emerging drug resistance. We have previously shown that hypoxia‐inducible factor‐1α (Hif‐1α) stabilisation helps the host to clear mycobacterial infection via neutrophil activation. However, Hif‐1α stabilisation has also been implicated in chronic inflammatory diseases caused by prolonged neutrophilic inflammation. Comorbid infection and inflammation can be found together in disease settings, and it remains unclear whether Hif‐1α stabilisation would be beneficial in a holistic disease setting. Here, we set out to understand the effects of Hif‐1α on neutrophil behaviour in a comorbid setting by combining two well‐characterised in vivo zebrafish models – TB infection (Mycobacterium marinum infection) and sterile injury (tailfin transection). Using a local Mm infection near to the tailfin wound site caused neutrophil migration between the two sites that was reduced during Hif‐1α stabilisation. During systemic Mm infection, wounding leads to increased infection burden, but the protective effect of Hif‐1α stabilisation remains. Our data indicate that Hif‐1α stabilisation alters neutrophil migration dynamics between comorbid sites and that the protective effect of Hif‐1α against Mm is maintained in the presence of inflammation, highlighting its potential as a host‐derived target against TB infection
Hypoxia induces macrophage tnfa expression via cyclooxygenase and prostaglandin E2 in vivo
Macrophage phenotypes are poorly characterized in disease systems in vivo. Appropriate macrophage activation requires complex coordination of local microenvironmental cues and cytokine signaling. If the molecular mechanisms underpinning macrophage activation were better understood, macrophages could be pharmacologically tuned during disease situations. Here, using zebrafish tnfa:GFP transgenic lines as in vivo readouts, we show that physiological hypoxia and stabilization of Hif-1α promotes macrophage tnfa expression. We demonstrate a new mechanism of Hif-1α-induced macrophage tnfa expression via a cyclooxygenase/prostaglandin E2 axis. These findings uncover a macrophage HIF/COX/TNF axis that links microenvironmental cues to macrophage phenotype, with important implications during inflammation, infection, and cancer, where hypoxia is a common microenvironmental feature and where cyclooxygenase and TNF are major mechanistic players
A Multiwavelength Investigation of Unidentified EGRET Sources
Statistical studies indicate that the 271 point sources of high-energy gamma
rays belong to two groups: a Galactic population and an isotropic extragalactic
population. Many unidentified extragalactic sources are certainly blazars, and
it is the intention of this work to uncover gamma-ray blazars missed by
previous attempts. Until recently, searches for blazar counterparts to
unidentified EGRET sources have focused on finding AGN that have 5-GHz radio
flux densities S_5 near or above 1 Jy. However, the recent blazar
identification of 3EG J2006-2321 (S_5 = 260 mJy) and other work suggest that
careful studies of weaker flat-spectrum sources may be fruitful. In this
spirit, error circles of 4 high-latitude unidentified EGRET sources have been
searched for 5-GHz sources. The gamma-ray sources are 3EG J1133+0033, 3EG
J1212+2304, 3EG J1222+2315, and 3EG J1227+4302. Within the error contours of
each of the four sources are found 6 radio candidates; by observing the
positions of the radio sources with the 0.81-m Tenagra II telescope it is
determined that 14 of these 24 radio sources have optical counterparts with R <
22. Eight of these from two different EGRET sources have been observed in the
B, V, and R bands in more than one epoch and the analysis of these data is
ongoing. Any sources that are found to be variable will be the objects of
multi-epoch polarimetry studies.Comment: 6 pages, 2 tables. To appear in Astrophysics & Space Scienc
Compression ultrasonography for false femoral artery aneurysms: Hypocoagulability is a cause of failure
Objectives:false femoral artery aneurysm is an occasional complication of percutaneous cardiovascular radiological procedures. Compression ultrasonography causes thrombosis non-invasively, reducing need for operative intervention. The technique fails in a proportion of cases. Analysis was undertaken to identify causes of failure.Design:prospective open study.Materials and Methods:patients presenting with false femoral artery aneurysm since 1984 were identified from a computerised database (BIPAS). Since 1993 compression ultrasonography has been performed as first line treatment according to a standard protocol. Prospectively collected ultrasonographic data and case notes were reviewed to identify causes of failed compression.Results:false femoral artery aneurysm occurred as a complication in 32/26 687 (0.12%) cardiovascular radiological procedures. Eighteen aneurysms were treated by compression. The technique was successful in 11/18 (61%) cases but primary failure occurred in seven cases. Six out of seven had bleeding abnormalities (Chi-squared analysis with Yates correction 10.55, p=0.0012), four were anticoagulated and compression was subsequently successful following reversal of warfarin therapy in three of these patients. In 4/18 cases surgical repair was necessary.Conclusions:compression ultrasonography is an effective treatment of false femoral aneurysms, however, hypocoagulability is a significant cause of failure. For patients in whom anticoagulation cannot be reversed, primary surgical repair should be considered
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Effect of Corrosion Film Composition and Structure on the Corrosion Kinetics of Ni-Cr-Fe Alloys in High Temperature Water
Nickel alloys such as Alloy 600 undergo Stress Corrosion Cracking (SCC) in pure water at temperatures between about 260 C and the critical point. Increasing the level of Cr in Ni-Fe-Cr alloys increases SCC resistance in aerated and deaerated water. The mechanism is not understood. The effect of Cr composition on oxide microstructure and corrosion kinetics of Ni-Fe-Cr alloys was determined experimentally, to evaluate whether the anodic dissolution model for SCC can account for the effect of Cr on SCC. The alloy corrosion rate and corrosion product oxide microstructure is strongly influenced by the Cr composition. Corrosion kinetics are parabolic and influenced by chromium concentration, with the parabolic constant first increasing then decreasing as Cr increases from 5 to 39%. Surface analyses using Analytical Electron microscopy (AEM) and Auger Electron Spectroscopy (AES) show that the corrosion product film that forms initially on all alloys exposed to high purity high temperature water is a nickel rich oxide. With time, the amount of chromium in the oxide film increases and corrosion proceeds toward the formation of the more thermodynamically stable spinel or hexagonal Cr-rich oxides, similar to high temperature gaseous oxidation. Due to the slower diffusion kinetics at the temperatures of water corrosion compared to those in high temperature gaseous oxidation, however, the films remain as a mixture of NiO, mixed Ni, Fe and Cr spinels, NiCrO{sub 3} and FeCrO{sub 3}. As the amount of Cr in the film increases and the nature of the film changes from NiO to spinel or hexagonal oxides, cation diffusion through the films slows, slowing the corrosion rate. These observations are qualitatively consistent with an anodic dissolution SCC mechanism. However, parametric modeling of the SCC growth process, applying available creep, oxide rupture strain and corrosion kinetics data, indicates that the anodic dissolution mechanism accounts for only a fraction of the effect of Cr on SCC resistance
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