843 research outputs found
Finite element analysis and computer aided tissue engineering design of a replacement lumbar intervertebral disc
Paper presented at the 2006 IEEE 32nd Annual Northeast Bioengineering Conference, Easton, PA.The treatment of disc degeneration disease of the spine has been a subject of particular interest in the medical community due to its effects on the lifestyle of afflicted patients. Current treatment modalities range from non-invasive treatment with physical therapy, to the invasive surgical repair of the degenerated disc(s). However, despite the existence of these treatment methods, each has its own set of drawbacks and limitations, most notably the use of surgical intervention. Examples of such limitations have included the mechanical failure of spinal implants, the destruction of the vertebral bone structure due to implant subsistence, graft site morbidity due to bone harvesting, and the promotion of disc degeneration at the surrounding spinal units. To overcome these limitations, a new implant design was conceived combining the concepts of arthrodesis, arthroplasty, and fusion via bone graft, allowing for the biological fusion of adjacent vertebra, in conjunction with the use of tissue engineering principals. In addition, this new approach to implant development, utilizing the practices of computer aided tissue engineering, permits the patient specific design of the implant, enhancing the ability to match implant design and architecture with patient anatomy. Resulting from these design criteria, the proposed novel design eliminates the drawbacks associated with the current vertebral implant designs, potentially extending both the lifespan and effectiveness of the implant, thereby improving the long term outcomes for the treatment of spinal disc degeneration
Surface Properties of SiCp/Al Composite by Powder-Mixed EDM
AbstractThis paper uses a kind of moderate volume fraction (40%) of SiC particle reinforced Al matrix composites (SiCp/Al) to research how the surface properties are affected in conventional EDM (EDM) and powder-mixed EDM (PMEDM). By means of environment scanning electron microscope (ESEM) and HIT friction and wear tester, surface micro-topography, elements and wear resistance were analyzed. Experiments and researches indicate that compared with EDM, the surface properties machined by using PMEDM are improved greatly. The PMEDM surface roughness decreases about 31.5%; corrosion resistance is better too; and wear resistance is twice of EDM. Powder-mixed EDM has promising applications in metal matrix composites machining field
Interacting New Agegraphic Dark Energy in a Cyclic Universe
The main goal of this work is investigation of NADE in the cyclic universe
scenario. Since, cyclic universe is explained by a phantom phase (),
it is shown when there is no interaction between matter and dark energy, ADE
and NADE do not produce a phantom phase, then can not describe cyclic universe.
Therefore, we study interacting models of ADE and NADE in the modified
Friedmann equation. We find out that, in the high energy regime, which it is a
necessary part of cyclic universe evolution, only NADE can describe this
phantom phase era for cyclic universe. Considering deceleration parameter tells
us that the universe has a deceleration phase after an acceleration phase, and
NADE is able to produce a cyclic universe. Also it is found valuable to study
generalized second law of thermodynamics. Since the loop quantum correction is
taken account in high energy regime, it may not be suitable to use standard
treatment of thermodynamics, so we turn our attention to the result of
\citep{29}, which the authors have studied thermodynamics in loop quantum
gravity, and we show that which condition can satisfy generalized second law of
thermodynamics.Comment: 8 pages, 3 figure
Electron transport and energy relaxation in dilute magnetic alloys
We consider the effect of the RKKY interaction between magnetic impurities on
the electron relaxation rates in a normal metal. The interplay between the RKKY
interaction and the Kondo effect may result in a non-monotonic temperature
dependence of the electron momentum relaxation rate, which determines the Drude
conductivity. The electron phase relaxation rate, which determines the
magnitude of the weak localization correction to the resistivity, is also a
non-monotonic function of temperature. For this function, we find the
dependence of the position of its maximum on the concentration of magnetic
impurities. We also relate the electron energy relaxation rate to the
excitation spectrum of the system of magnetic impurities. The energy relaxation
determines the distribution function for the out-of-equilibrium electrons.
Measurement of the electron distribution function thus may provide information
about the excitations in the spin glass phase.Comment: 15 pages, 5 figure
Critical magnetic fluctuations induced superconductivity and residual density of states in superconductor
We propose the multiband extension of the spin-fermion model to address the
superconducting d-wave pairing due to magnetic interaction near critical point.
We solve the unrestricted gap equation with a general d-wave symmetry gap and
find that divergent magnetic correlation length leads to the very
unharmonic shape of the gap function with shallow gap regions near nodes. These
regions are extremely sensitive to disorder. Small impurity concentration
induces substantial residual density of states. We argue that we can understand
the large value and its pressure
dependence of the recently discovered superconductor under pressure
within this approach.Comment: 5 figure
Quantum size effects in Pb islands on Cu(111): Electronic-structure calculations
The appearance of "magic" heights of Pb islands grown on Cu(111) is studied
by self-consistent electronic structure calculations. The Cu(111) substrate is
modeled with a one-dimensional pseudopotential reproducing the essential
features, i.e. the band gap and the work function, of the Cu band structure in
the [111] direction. Pb islands are presented as stabilized jellium overlayers.
The experimental eigenenergies of the quantum well states confined in the Pb
overlayer are well reproduced. The total energy oscillates as a continuous
function of the overlayer thickness reflecting the electronic shell structure.
The energies for completed Pb monolayers show a modulated oscillatory pattern
reminiscent of the super-shell structure of clusters and nanowires. The energy
minima correlate remarkably well with the measured most probable heights of Pb
islands. The proper modeling of the substrate is crucial to set the
quantitative agreement.Comment: 4 pages, 4 figures. Submitte
in interacting quintessence model
A model consisting of quintessence scalar field interacting with cold dark
matter is considered. Conditions required to reach are discussed. It
is shown that depending on the potential considered for the quintessence,
reaching the phantom divide line puts some constraints on the interaction
between dark energy and dark matter. This also may determine the ratio of dark
matter to dark energy density at .Comment: 10 pages, references updated, some notes added, minor changes
applied, accepted for publication in Eur. Phys. J.
Proteomic profiling of urine for the detection of colon cancer.
BACKGROUND: Colorectal cancer is the second most common cause of cancer related death in the developed world. To date, no blood or stool biomarkers with both high sensitivity and specificity for potentially curable early stage disease have been validated for clinical use. SELDI and MALDI profiling are being used increasingly to search for biomarkers in both blood and urine. Both techniques provide information predominantly on the low molecular weight proteome (<15 kDa). There have been several reports that colorectal cancer is associated with changes in the serum proteome that are detectable by SELDI and we hypothesised that proteomic changes would also be detectable in urine.
RESULTS: We collected urine from 67 patients with colorectal cancer and 72 non-cancer control subjects, diluted to a constant protein concentration and generated MALDI and SELDI spectra. The intensities of 19 peaks differed significantly between cancer and non-cancer patients by both t-tests and after adjusting for confounders using multiple linear regressions. Logistic regression classifiers based on peak intensities identified colorectal cancer with up to 78% sensitivity at 87% specificity. We identified and independently quantified 3 of the discriminatory peaks using synthetic stable isotope peptides (an 1885 Da fragment of fibrinogen and hepcidin-20) or ELISA (beta2-microglobulin).
CONCLUSION: Changes in the urine proteome may aid in the early detection of colorectal cancer
Interlayer Exchange Coupling Mediated by Valence Band Electrons
The interlayer exchange coupling mediated by valence band electrons in
all-semiconductor IV-VI magnetic/nonmagnetic superlattices is studied
theoretically. A 3D tight-binding model, accounting for the band and magnetic
structure of the constituent superlattice components is used to calculate the
spin-dependent part of the total electronic energy. The antiferromagnetic
coupling between ferromagnetic layers in EuS/PbS superlattices is obtained, in
agreement with the experimental evidences. The results obtained for the
coupling between antiferromagnetic layers in EuTe/PbTe superlattices are also
presented.Comment: 8 pages, 6 figures, to be submitted to Phys.Rev.
A molecular dynamics study on the equilibrium magnetization properties and structure of ferrofluids
We investigate in detail the initial susceptibility, magnetization curves,
and microstructure of ferrofluids in various concentration and particle dipole
moment ranges by means of molecular dynamics simulations. We use the Ewald
summation for the long-range dipolar interactions, take explicitly into account
the translational and rotational degrees of freedom, coupled to a Langevin
thermostat. When the dipolar interaction energy is comparable with the thermal
energy, the simulation results on the magnetization properties agree with the
theoretical predictions very well. For stronger dipolar couplings, however, we
find systematic deviations from the theoretical curves. We analyze in detail
the observed microstructure of the fluids under different conditions. The
formation of clusters is found to enhance the magnetization at weak fields and
thus leads to a larger initial susceptibility. The influence of the particle
aggregation is isolated by studying ferro-solids, which consist of magnetic
dipoles frozen in at random locations but which are free to rotate. Due to the
artificial suppression of clusters in ferro-solids the observed susceptibility
is considerably lowered when compared to ferrofluids.Comment: 33 pages including 12 figures, requires RevTex
- …