61 research outputs found
Universal Correlations in Pion-less EFT with the Resonating Group Model: Three and Four Nucleons
The Effective Field Theory "without pions" at next-to-leading order is used
to analyze universal bound state and scattering properties of the 3- and
4-nucleon system. Results of a variety of phase shift equivalent nuclear
potentials are presented for bound state properties of 3H and 4He, and for the
singlet S-wave 3He-neutron scattering length a_0(3He-n). The calculations are
performed with the Refined Resonating Group Method and include a full treatment
of the Coulomb interaction and the leading-order 3-nucleon interaction. The
results compare favorably with data and values from AV18(+UIX) model
calculations. A new correlation between a_0(3He-n) and the 3H binding energy is
found. Furthermore, we confirm at next-to-leading order the correlations,
already found at leading-order, between the 3H binding energy and the 3H charge
radius, and the Tjon line. With the 3H binding energy as input, we get
predictions of the Effective Field Theory "without pions" at next-to-leading
order for the root mean square charge radius of 3H of (1.6\pm 0.2) fm, for the
4He binding energy of (28\pm 2.5) MeV, and for Re(a_0(3He-n)) of (7.5\pm
0.6)fm. Including the Coulomb interaction, the splitting in binding energy
between 3H and 3He is found to be (0.66\pm 0.03) MeV. The discrepancy to data
of (0.10\mp 0.03) MeV is model independently attributed to higher order charge
independence breaking interactions. We also demonstrate that different results
for the same observable stem from higher order effects, and carefully assess
that numerical uncertainties are negligible. Our results demonstrate the
convergence and usefulness of the pion-less theory at next-to-leading order in
the 4He channel. We conclude that no 4-nucleon interaction is needed to
renormalize the theory at next-to-leading order in the 4-nucleon sector.Comment: 24 pages revtex4, including 8 figures as .eps files embedded with
includegraphicx, leading-order results added, calculations include the LO
three-nucleon interaction explicitly, comment on Wigner bound added, minor
modification
Weak Localization and Integer Quantum Hall Effect in a Periodic Potential
We consider magnetotransport in a disordered two-dimensional electron gas in
the presence of a periodic modulation in one direction. Existing quasiclassical
and quantum approaches to this problem account for Weiss oscillations in the
resistivity tensor at moderate magnetic fields, as well as a strong
modulation-induced modification of the Shubnikov-de Haas oscillations at higher
magnetic fields. They do not account, however, for the operation at even higher
magnetic fields of the integer quantum Hall effect, for which quantum
interference processes are responsible. We then introduce a field-theory
approach, based on a nonlinear sigma model, which encompasses naturally both
the quasiclassical and quantum-mechanical approaches, as well as providing a
consistent means of extending them to include quantum interference corrections.
A perturbative renormalization-group analysis of the field theory shows how
weak localization corrections to the conductivity tensor may be described by a
modification of the usual one-parameter scaling, such as to accommodate the
anisotropy of the bare conductivity tensor. We also show how the two-parameter
scaling, conjectured as a model for the quantum Hall effect in unmodulated
systems, may be generalized similarly for the modulated system. Within this
model we illustrate the operation of the quantum Hall effect in modulated
systems for parameters that are realistic for current experiments.Comment: 15 pages, 4 figures, ReVTeX; revised version with condensed
introduction; two figures taken out; reference adde
The 3D Structure of N132D in the LMC: A Late-Stage Young Supernova Remnant
We have used the Wide Field Spectrograph (WiFeS) on the 2.3m telescope at
Siding Spring Observatory to map the [O III] 5007{\AA} dynamics of the young
oxygen-rich supernova remnant N132D in the Large Magellanic Cloud. From the
resultant data cube, we have been able to reconstruct the full 3D structure of
the system of [O III] filaments. The majority of the ejecta form a ring of
~12pc in diameter inclined at an angle of 25 degrees to the line of sight. We
conclude that SNR N132D is approaching the end of the reverse shock phase
before entering the fully thermalized Sedov phase of evolution. We speculate
that the ring of oxygen-rich material comes from ejecta in the equatorial plane
of a bipolar explosion, and that the overall shape of the SNR is strongly
influenced by the pre-supernova mass loss from the progenitor star. We find
tantalizing evidence of a polar jet associated with a very fast oxygen-rich
knot, and clear evidence that the central star has interacted with one or more
dense clouds in the surrounding ISM.Comment: Accepted for Publication in Astrophysics & Space Science, 18pp, 8
figure
Magnetic fields in supernova remnants and pulsar-wind nebulae
We review the observations of supernova remnants (SNRs) and pulsar-wind
nebulae (PWNe) that give information on the strength and orientation of
magnetic fields. Radio polarimetry gives the degree of order of magnetic
fields, and the orientation of the ordered component. Many young shell
supernova remnants show evidence for synchrotron X-ray emission. The spatial
analysis of this emission suggests that magnetic fields are amplified by one to
two orders of magnitude in strong shocks. Detection of several remnants in TeV
gamma rays implies a lower limit on the magnetic-field strength (or a
measurement, if the emission process is inverse-Compton upscattering of cosmic
microwave background photons). Upper limits to GeV emission similarly provide
lower limits on magnetic-field strengths. In the historical shell remnants,
lower limits on B range from 25 to 1000 microGauss. Two remnants show
variability of synchrotron X-ray emission with a timescale of years. If this
timescale is the electron-acceleration or radiative loss timescale, magnetic
fields of order 1 mG are also implied. In pulsar-wind nebulae, equipartition
arguments and dynamical modeling can be used to infer magnetic-field strengths
anywhere from about 5 microGauss to 1 mG. Polarized fractions are considerably
higher than in SNRs, ranging to 50 or 60% in some cases; magnetic-field
geometries often suggest a toroidal structure around the pulsar, but this is
not universal. Viewing-angle effects undoubtedly play a role. MHD models of
radio emission in shell SNRs show that different orientations of upstream
magnetic field, and different assumptions about electron acceleration, predict
different radio morphology. In the remnant of SN 1006, such comparisons imply a
magnetic-field orientation connecting the bright limbs, with a non-negligible
gradient of its strength across the remnant.Comment: 20 pages, 24 figures; to be published in SpSciRev. Minor wording
change in Abstrac
Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN
Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving functions have been identified for single circRNAs, how they modulate gene expression in cancer is not well understood. We investigate circRNA expression in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome sequencing in 104 primary neuroblastomas covering all risk groups. We demonstrate that MYCN amplification, which defines a subset of high-risk cases, causes globally suppressed circRNA biogenesis directly dependent on the DHX9 RNA helicase. We detect similar mechanisms in shaping circRNA expression in the pediatric cancer medulloblastoma implying a general MYCN effect. Comparisons to other cancers identify 25 circRNAs that are specifically upregulated in neuroblastoma, including circARID1A. Transcribed from the ARID1A tumor suppressor gene, circARID1A promotes cell growth and survival, mediated by direct interaction with the KHSRP RNA-binding protein. Our study highlights the importance of MYCN regulating circRNAs in cancer and identifies molecular mechanisms, which explain their contribution to neuroblastoma pathogenesis
Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): Study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III)
Background: Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of perinatal care. The only established therapy to improve outcome in these infants is therapeutic hypothermia. Allopurinol is a xanthine oxidase inhibitor that reduces the production of oxygen radicals as superoxide, which contributes to secondary energy failure and apoptosis in neurons and glial cells after reperfusion of hypoxic brain tissue and may further improve outcome if administered in addition to therapeutic hypothermia. Methods: This study on the effects of ALlopurinol in addition to hypothermia treatment for hypoxic-ischemic Brain Injury on Neurocognitive Outcome (ALBINO), is a European double-blinded randomized placebo-controlled parallel group multicenter trial (Phase III) to evaluate the effect of postnatal allopurinol administered in addition to standard of care (including therapeutic hypothermia if indicated) on the incidence of death and severe neurodevelopmental impairment at 24 months of age in newborns with perinatal hypoxic-ischemic insult and signs of potentially evolving encephalopathy. Allopurinol or placebo will be given in addition to therapeutic hypothermia (where indicated) to infants with a gestational age 65 36 weeks and a birth weight 65 2500 g, with severe perinatal asphyxia and potentially evolving encephalopathy. The primary endpoint of this study will be death or severe neurodevelopmental impairment versus survival without severe neurodevelopmental impairment at the age of two years. Effects on brain injury by magnetic resonance imaging and cerebral ultrasound, electric brain activity, concentrations of peroxidation products and S100B, will also be studied along with effects on heart function and pharmacokinetics of allopurinol after iv-infusion. Discussion: This trial will provide data to assess the efficacy and safety of early postnatal allopurinol in term infants with evolving hypoxic-ischemic encephalopathy. If proven efficacious and safe, allopurinol could become part of a neuroprotective pharmacological treatment strategy in addition to therapeutic hypothermia in children with perinatal asphyxia. Trial registration: NCT03162653, www.ClinicalTrials.gov, May 22, 2017
Variation in neurosurgical management of traumatic brain injury
Background: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. Methods: A survey was sent to 68 centers participating in the Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. The questionnaire contained 21 questions, including the decision when to operate (or not) on traumatic acute subdural hematoma (ASDH) and intracerebral hematoma (ICH), and when to perform a decompressive craniectomy (DC) in raised intracranial pressure (ICP). Results: The survey was completed by 68 centers (100%). On average, 10 neurosurgeons work in each trauma center. In all centers, a neurosurgeon was available within 30 min. Forty percent of responders reported a thickness or volume threshold for evacuation of an ASDH. Most responders (78%) decide on a primary DC in evacuating an ASDH during the operation, when swelling is present. For ICH, 3% would perform an evacuation directly to prevent secondary deterioration and 66% only in case of clinical deterioration. Most respondents (91%) reported to consider a DC for refractory high ICP. The reported cut-off ICP for DC in refractory high ICP, however, differed: 60% uses 25 mmHg, 18% 30 mmHg, and 17% 20 mmHg. Treatment strategies varied substantially between regions, specifically for the threshold for ASDH surgery and DC for refractory raised ICP. Also within center variation was present: 31% reported variation within the hospital for inserting an ICP monitor and 43% for evacuating mass lesions. Conclusion: Despite a homogeneous organization, considerable practice variation exists of neurosurgical strategies for TBI in Europe. These results provide an incentive for comparative effectiveness research to determine elements of effective neurosurgical care
Imágenes de alta resolución de remanentes de supernovas galácticos
Como continuación del programa de relevamientos de restos de supernovas galácticos con alta resolución angular y elevada sensibilidad, se presentan observaciones de G 15.9+0.2, G340.4+0.4, G340.6+0.3 y G341.9-0.3 obtenidas con el interferómetro de síntesis de apertura VLA. Las observaciones se realizaron utilizando las configuraciones híbridas CnB y DnC en las frecuencias de 327 MHz, 1500 MHz y 5000 MHz obteniéndose imágenes con una resolución angular de hasta 14".Asociación Argentina de Astronomí
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