36 research outputs found
On the Detection of a Scalar Stochastic Background of Gravitational Waves
In the near future we will witness the coming to a full operational regime of
laser interferometers and resonant mass detectors of spherical shape. In this
work we study the sensitivity of pairs of such gravitational wave detectors to
a scalar stochastic background of gravitational waves. Our computations are
carried out both for minimal and non minimal coupling of the scalar fields.Comment: 25 pages, 3 figure
Thermal and back-action noises in dual-sphere gravitational-waves detectors
We study the sensitivity limits of a broadband gravitational-waves detector
based on dual resonators such as nested spheres. We determine both the thermal
and back-action noises when the resonators displacements are read-out with an
optomechanical sensor. We analyze the contributions of all mechanical modes,
using a new method to deal with the force-displacement transfer functions in
the intermediate frequency domain between the two gravitational-waves sensitive
modes associated with each resonator. This method gives an accurate estimate of
the mechanical response, together with an evaluation of the estimate error. We
show that very high sensitivities can be reached on a wide frequency band for
realistic parameters in the case of a dual-sphere detector.Comment: 10 pages, 7 figure
Constraints on the cosmic expansion history from GWTC–3
We use 47 gravitational wave sources from the Third LIGO–Virgo–Kamioka Gravitational Wave Detector Gravitational Wave Transient Catalog (GWTC–3) to estimate the Hubble parameter H(z), including its current value, the Hubble constant H0. Each gravitational wave (GW) signal provides the luminosity distance to the source, and we estimate the corresponding redshift using two methods: the redshifted masses and a galaxy catalog. Using the binary black hole (BBH) redshifted masses, we simultaneously infer the source mass distribution and H(z). The source mass distribution displays a peak around 34 M⊙, followed by a drop-off. Assuming this mass scale does not evolve with the redshift results in a H(z) measurement, yielding (68% credible interval) when combined with the H0 measurement from GW170817 and its electromagnetic counterpart. This represents an improvement of 17% with respect to the H0 estimate from GWTC–1. The second method associates each GW event with its probable host galaxy in the catalog GLADE+, statistically marginalizing over the redshifts of each event's potential hosts. Assuming a fixed BBH population, we estimate a value of with the galaxy catalog method, an improvement of 42% with respect to our GWTC–1 result and 20% with respect to recent H0 studies using GWTC–2 events. However, we show that this result is strongly impacted by assumptions about the BBH source mass distribution; the only event which is not strongly impacted by such assumptions (and is thus informative about H0) is the well-localized event GW190814
The Morphological Classification of Acute Lymphoblastic Leukaemia: Concordance among Observers and Clinical Correlations
Reversal of severe bone marrow fibrosis and osteosclerosis following allogeneic bone marrow transplantation for chronic granulocytic leukaemia
Towards a better understanding and new therapeutics of osteopetrosis.
Lack of or dysfunction in osteoclasts result in osteopetrosis, a group of rare but often severe, genetic disorders affecting skeletal tissue. Increase in bone mass results in skeletal malformation and bone marrow failure that may be fatal. Many of the underlying defects have lately been characterized in humans and in animal models of the disease. In humans, these defects often involve mutations in genes expressing proteins involved in the acidification of the osteoclast resorption compartment, a process necessary for proper bone degradation. So far, the only cure for children with severe osteopetrosis is allogeneic hematopoietic stem cell (HSC) transplantation but without a matching donor this form of therapy is far from optimal. The characterization of the genetic defects opens up the possibility for gene replacement therapy as an alternative. Accordingly, HSC-targeted gene therapy in a mouse model of infantile malignant osteopetrosis was recently shown to correct many aspects of the disease
Computational Construction of Antibody–Drug Conjugates Using Surface Lysines as the Antibody Conjugation Site and a Non-cleavable Linker
Characterization of the Virgo seismic environment
The Virgo gravitational wave detector is an interferometer (ITF) with 3 km arms located in Pisa, Italy. From July to October 2010, Virgo performed its third science run (VSR3) in coincidence with the LIGO detectors. Despite several techniques adopted to isolate the ITF from the environment, seismic noise remains an important issue for Virgo. Vibrations produced by the detector infrastructure (such as air conditioning units, water chillers/heaters, pumps) are found to affect Virgo''s sensitivity, with the main coupling mechanisms being through beam jitter and scattered light processes. The Advanced Virgo design seeks to reduce ITF couplings to environmental noise by having most vibration-sensitive components suspended and in vacuum, as well as muffle and relocate loud machines. During the months of June and July in 2010, a Guralp-3TD seismometer was stationed at various locations around the Virgo site hosting major infrastructure machines. Seismic data were examined using spectral and coherence analysis with seismic probes close to the detector. The primary aim of this study was to identify noisy machines which seismically affect the ITF environment and thus require mitigation attention. Analyzed machines are located at various distances from the experimental halls, ranging from 10 to 100 m. An attempt is made to measure the attenuation of emitted noise at the ITF and correlate it with the distance from the source and with seismic attenuation models in soil