138 research outputs found
Reionization by active sources and its effects on the cosmic microwave background
We investigate the possible effects of reionization by active sources on the
cosmic microwave background. We concentrate on the sources themselves as the
origin of reionization, rather than early object formation, introducing an
extra period of heating motivated by the active character of the perturbations.
Using reasonable parameters, this leads to four possibilities depending on the
time and duration of the energy input: delayed last scattering, double last
scattering, shifted last scattering and total reionization. We show that these
possibilities are only very weakly constrained by the limits on spectral
distortions from the COBE FIRAS measurements. We illustrate the effects of
these reionization possibilities on the angular power spectrum of temperature
anisotropies and polarization for simple passive isocurvature models and simple
coherent sources, observing the difference between passive and active models.
Finally, we comment on the implications of this work for more realistic active
sources, such as causal white noise and topological defect models. We show for
these models that non-standard ionization histories can shift the peak in the
CMB power to larger angular scales.Comment: 21 pages LaTeX with 11 eps figures; replaced with final version
accepted for publication in Phys. Rev.
Measuring CMB Polarization with BOOMERANG
BOOMERANG is a balloon-borne telescope designed for long duration (LDB)
flights around Antarctica. The second LDB Flight of BOOMERANG took place in
January 2003. The primary goal of this flight was to measure the polarization
of the CMB. The receiver uses polarization sensitive bolometers at 145 GHz.
Polarizing grids provide polarization sensitivity at 245 and 345 GHz. We
describe the BOOMERANG telescope noting changes made for 2003 LDB flight, and
discuss some of the issues involved in the measurement of polarization with
bolometers. Lastly, we report on the 2003 flight and provide an estimate of the
expected results.Comment: 12 pages, 8 figures, To be published in the proceedings of "The
Cosmic Microwave Background and its Polarization", New Astronomy Reviews,
(eds. S. Hanany and K.A. Olive). Fixed typos, and reformatted citation
Current constraints on Cosmological Parameters from Microwave Background Anisotropies
We compare the latest observations of Cosmic Microwave Background (CMB)
Anisotropies with the theoretical predictions of the standard scenario of
structure formation. Assuming a primordial power spectrum of adiabatic
perturbations we found that the total energy density is constrained to be
while the energy density in baryon and Cold Dark
Matter (CDM) are and ,
(all at 68% C.L.) respectively. The primordial spectrum is consistent with
scale invariance, () and the age of the universe is
Gyrs. Adding informations from Large Scale Structure and
Supernovae, we found a strong evidence for a cosmological constant
and a value of the Hubble parameter
. Restricting this combined analysis to flat universes, we put
constraints on possible 'extensions' of the standard scenario. A gravity waves
contribution to the quadrupole anisotropy is limited to be (95%
c.l.). A constant equation of state for the dark energy component is bound to
be (95% c.l.). We constrain the effective relativistic degrees
of freedom and the neutrino chemical potential and (massless neutrinos).Comment: The status of cosmological parameters before WMAP. In press on Phys.
Rev. D., Rapid Communication, 6 pages, 5 figure
The BOOMERanG experiment and the curvature of the Universe
We describe the BOOMERanG experiment and its main result, i.e. the
measurement of the large scale curvature of the Universe. BOOMERanG is a
balloon-borne microwave telescope with sensitive cryogenic detectors. BOOMERanG
has measured the angular distribution of the Cosmic Microwave Background on
of the sky, with a resolution of arcmin and a sensitivity
of per pixel. The resulting image is dominated by hot and cold
spots with rms fluctuations and typical size of . The
detailed angular power spectrum of the image features three peaks and two dips
at and , respectively. Such very characteristic
spectrum can be explained assuming that the detected structures are the result
of acoustic oscillations in the primeval plasma. In this framework, the
measured pattern constrains the density parameter to be (95% confidence interval). Other cosmological parameters, like the
spectral index of initial density fluctuations, the density parameter for
baryons, dark matter and dark energy, are detected or constrained by the
BOOMERanG measurements and by other recent CMB anisotropy experiments. When
combined with other cosmological observations, these results depict a new,
consistent, cosmological scenario.Comment: Proc. of the Erice School on "Neutrinos in Astro, Particle and
Nuclear Physics", 18.-26. September 2001, Amand Faessler, Jan Kuckei eds,
"Progress in Particle and Nuclear Physics", vol. 4
All-sky search for long-duration gravitational wave transients with initial LIGO
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
All-sky search for long-duration gravitational wave transients with initial LIGO
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
Effects of rare kidney diseases on kidney failure: a longitudinal analysis of the UK National Registry of Rare Kidney Diseases (RaDaR) cohort
Background
Individuals with rare kidney diseases account for 5–10% of people with chronic kidney disease, but constitute more than 25% of patients receiving kidney replacement therapy. The National Registry of Rare Kidney Diseases (RaDaR) gathers longitudinal data from patients with these conditions, which we used to study disease progression and outcomes of death and kidney failure.
Methods
People aged 0–96 years living with 28 types of rare kidney diseases were recruited from 108 UK renal care facilities. The primary outcomes were cumulative incidence of mortality and kidney failure in individuals with rare kidney diseases, which were calculated and compared with that of unselected patients with chronic kidney disease. Cumulative incidence and Kaplan–Meier survival estimates were calculated for the following outcomes: median age at kidney failure; median age at death; time from start of dialysis to death; and time from diagnosis to estimated glomerular filtration rate (eGFR) thresholds, allowing calculation of time from last eGFR of 75 mL/min per 1·73 m2 or more to first eGFR of less than 30 mL/min per 1·73 m2 (the therapeutic trial window).
Findings
Between Jan 18, 2010, and July 25, 2022, 27 285 participants were recruited to RaDaR. Median follow-up time from diagnosis was 9·6 years (IQR 5·9–16·7). RaDaR participants had significantly higher 5-year cumulative incidence of kidney failure than 2·81 million UK patients with all-cause chronic kidney disease (28% vs 1%; p<0·0001), but better survival rates (standardised mortality ratio 0·42 [95% CI 0·32–0·52]; p<0·0001). Median age at kidney failure, median age at death, time from start of dialysis to death, time from diagnosis to eGFR thresholds, and therapeutic trial window all varied substantially between rare diseases.
Interpretation
Patients with rare kidney diseases differ from the general population of individuals with chronic kidney disease: they have higher 5-year rates of kidney failure but higher survival than other patients with chronic kidney disease stages 3–5, and so are over-represented in the cohort of patients requiring kidney replacement therapy. Addressing unmet therapeutic need for patients with rare kidney diseases could have a large beneficial effect on long-term kidney replacement therapy demand.
Funding
RaDaR is funded by the Medical Research Council, Kidney Research UK, Kidney Care UK, and the Polycystic Kidney Disease Charity
The Cholecystectomy As A Day Case (CAAD) Score: A Validated Score of Preoperative Predictors of Successful Day-Case Cholecystectomy Using the CholeS Data Set
Background
Day-case surgery is associated with significant patient and cost benefits. However, only 43% of cholecystectomy patients are discharged home the same day. One hypothesis is day-case cholecystectomy rates, defined as patients discharged the same day as their operation, may be improved by better assessment of patients using standard preoperative variables.
Methods
Data were extracted from a prospectively collected data set of cholecystectomy patients from 166 UK and Irish hospitals (CholeS). Cholecystectomies performed as elective procedures were divided into main (75%) and validation (25%) data sets. Preoperative predictors were identified, and a risk score of failed day case was devised using multivariate logistic regression. Receiver operating curve analysis was used to validate the score in the validation data set.
Results
Of the 7426 elective cholecystectomies performed, 49% of these were discharged home the same day. Same-day discharge following cholecystectomy was less likely with older patients (OR 0.18, 95% CI 0.15–0.23), higher ASA scores (OR 0.19, 95% CI 0.15–0.23), complicated cholelithiasis (OR 0.38, 95% CI 0.31 to 0.48), male gender (OR 0.66, 95% CI 0.58–0.74), previous acute gallstone-related admissions (OR 0.54, 95% CI 0.48–0.60) and preoperative endoscopic intervention (OR 0.40, 95% CI 0.34–0.47). The CAAD score was developed using these variables. When applied to the validation subgroup, a CAAD score of ≤5 was associated with 80.8% successful day-case cholecystectomy compared with 19.2% associated with a CAAD score >5 (p < 0.001).
Conclusions
The CAAD score which utilises data readily available from clinic letters and electronic sources can predict same-day discharges following cholecystectomy
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