Defense Expenditures and Economic Growth in Developing Countries

Armed Forces and Society, Summer, 1983.Refereed Journal ArticleStudies of the effect that defense spending has had on economic growth in less-developed countries have produced rather mixed results. We contend that this is because these studies have failed to take into account the relative financial constraints faced by individual countries. In an extension of the seminal work by Emile Benoit on defense spending and its effect on economic growth, 1 we hypothesize that relatively poor countries tend to cut back high-growth development expenditures in favor of maintaining defense programs, while relatively rich countries are much less likely to abandon development expenditures given a constant level of defense preparedness. Thus, we should expect a negative relationship between defense and growth in the poorer countries, but a positive relationship in the richer countries

Quantum Counterfactuals and Locality

Stapp's counterfactual argument for quantum nonlocality based upon a Hardy entangled state is shown to be flawed. While he has correctly analyzed a particular framework using the method of consistent histories, there are alternative frameworks which do not support his argument. The framework dependence of quantum counterfactual arguments, with analogs in classical counterfactuals, vitiates the claim that nonlocal (superluminal) influences exist in the quantum world. Instead it shows that counterfactual arguments are of limited use for analyzing these questions.Comment: 8 pages, 1 PSTricks figur

Ex Vivo Expanded Hematopoietic Stem Cells Overcome the MHC Barrier in Allogeneic Transplantation

SummaryThe lack of understanding of the interplay between hematopoietic stem cells (HSCs) and the immune system has severely hampered the stem cell research and practice of transplantation. Major problems for allogeneic transplantation include low levels of donor engraftment and high risks of graft-versus-host disease (GVHD). Transplantation of purified allogeneic HSCs diminishes the risk of GVHD but results in decreased engraftment. Here we show that ex vivo expanded mouse HSCs efficiently overcame the major histocompatibility complex barrier and repopulated allogeneic-recipient mice. An 8-day expansion culture led to a 40-fold increase of the allograft ability of HSCs. Both increased numbers of HSCs and culture-induced elevation of expression of the immune inhibitor CD274 (B7-H1 or PD-L1) on the surface of HSCs contributed to the enhancement. Our study indicates the great potential of utilizing ex vivo expanded HSCs for allogeneic transplantation and suggests that the immune privilege of HSCs can be modulated

Solitons in Seiberg-Witten Theory and D-branes in the Derived Category

We analyze the "geometric engineering" limit of a type II string on a suitable Calabi-Yau threefold to obtain an N=2 pure SU(2) gauge theory. The derived category picture together with Pi-stability of B-branes beautifully reproduces the known spectrum of BPS solitons in this case in a very explicit way. Much of the analysis is particularly easy since it can be reduced to questions about the derived category of CP1.Comment: 20 pages, LaTex2

Critical scaling of the a.c. conductivity for a superconductor above Tc

We consider the effects of critical superconducting fluctuations on the scaling of the linear a.c. conductivity, \sigma(\omega), of a bulk superconductor slightly above Tc in zero applied magnetic field. The dynamic renormalization- group method is applied to the relaxational time-dependent Ginzburg-Landau model of superconductivity, with \sigma(\omega) calculated via the Kubo formula to O(\epsilon^{2}) in the \epsilon = 4 - d expansion. The critical dynamics are governed by the relaxational XY-model renormalization-group fixed point. The scaling hypothesis \sigma(\omega) \sim \xi^{2-d+z} S(\omega \xi^{z}) proposed by Fisher, Fisher and Huse is explicitly verified, with the dynamic exponent z \approx 2.015, the value expected for the d=3 relaxational XY-model. The universal scaling function S(y) is computed and shown to deviate only slightly from its Gaussian form, calculated earlier. The present theory is compared with experimental measurements of the a.c. conductivity of YBCO near Tc, and the implications of this theory for such experiments is discussed.Comment: 16 pages, submitted to Phys. Rev.

Scleral Proteome in Noninfectious Scleritis Unravels Upregulation of Filaggrin-2 and Signs of Neovascularization

Purpose: Scleritis is a severe inflammatory ocular disorder with unknown pathogenesis. We investigated healthy sclera as well as sclera affected by noninfectious scleritis for differentially expressed proteins using a mass spectrometry approach. Methods: We collected scleral samples of enucleated eyes due to severe noninfectious scleritis (n = 3), and control scleral tissues (n = 5), all exenterated eyes for eyelid carcinomas (n = 4), or choroidal melanoma (n = 1) without scleral invasion. Samples were prepared for the nano liquid-chromatography mass spectrometer (LC-MS), data were analyzed using proteomics software (Scaffold), and is available via ProteomeXchange (identifier PXD038727). Samples were also stained for immuno-histopathological evaluation. Results: Mass spectrometry identified 629 proteins within the healthy and diseased scleral tissues, whereof collagen type XII, VI, and I were the most abundantly expressed protein. Collagen type II-XII was also present. Filaggrin-2, a protein that plays a crucial role in epidermal barrier function, was found upregulated in all scleritis cases. In addition, other epithelial associated proteins were upregulated (such as keratin 33b, 34, and 85, epiplakin, transglutaminase-3, galectin 7, and caspase-14) in scleritis. Further, upregulated proteins involved in regulation of the cytoskeleton (vinculin and myosin 9), and housekeeping proteins were found (elongation factor-2 and cytoplasmic dynein 1) in our study. Upregulation of filaggrin-2 and myosin-9 was confirmed with immunohistochemistry, the latter protein showing co-localization with the endothelial cell marker ETC-related gene (ERG), indicating neovascularization in scleral tissue affected by scleritis. Conclusions: We found upregulation of filaggrin-2 and signs of neovascularization in scleral tissue of patients with noninfectious scleritis. Further research, ideally including more scleritis cases, is needed to validate our findings.</p

Vulnérabilité des ressources halieutiques et aquacoles du Pacifique tropical face au changement climatique : résumé à l'intention des Etats et Territoires insulaires océaniens

En complément de l'ouvrage intitulé "Vulnerability of tropical Pacific fisheries and aquaculture to climate change", qui analyse de manière exhaustive les effets possibles du changement climatique sur les plans visant à maximiser les avantages économiques et sociaux tirés de la pêche et de l'aquaculture en Océanie, le présent document fait la synthèse des conclusions de cette évaluation de la vulnérabilité climatique régionale en ce qui concerne les Territoires français du Pacifique. Les mesures d'adaptation, les politiques et les investissements préconisés devraient permettre à chaque Territoire de réduire les menaces que fait peser le changement climatique sur la pêche et l'aquaculture, tout en tirant le meilleur parti des débouchés qui en découlent. Les recommandations formulées répondent directement aux préoccupations de toutes les parties prenantes et de leurs partenaires dans le développement. (Résumé d'auteur

Vulnerability of tropical Pacific fisheries and aquaculture to climate change : summary for Pacific island countries and territories

The purpose of this summary is to present the main results from the regional vulnerability assessment as they apply to each country and territory, making the information easily to use. The practical adaptations, policies and investments described here are needed to maintain the economic and social benefits of fisheries and aquaculture in the face of climate change. They are essential planning tools

Effect of Magnetic Impurities on Suppression of the Transition Temperature in Disordered Superconductors

We calculate the first-order perturbative correction to the transition temperature $T_c$ in a superconductor with both non-magnetic and magnetic impurities. We do this by first evaluating the correction to the effective potential, $\Omega(\Delta)$, and then obtain the first-order correction to the order parameter, $\Delta$, by finding the minimum of $\Omega(\Delta)$. Setting $\Delta=0$ finally allows $T_c$ to be evaluated. $T_c$ is now a function of both the resistance per square, $R_\square$, a measure of the non-magnetic disorder, and the spin-flip scattering rate, $1/\tau_s$, a measure of the magnetic disorder. We find that the effective pair-breaking rate per magnetic impurity is virtually independent of the resistance per square of the film, in agreement with an experiment of Chervenak and Valles. This conclusion is supported by both the perturbative calculation, and by a non-perturbative re-summation technique.Comment: 29 pages, 9 figure

External Validation of the DCD-N Score and a Linear Prediction Model to Identify Potential Candidates for Organ Donation After Circulatory Death:A Nationwide Multicenter Cohort Study

Donation after circulatory death (DCD) is a procedure in which after planned withdrawal of life-sustaining treatment (WLST), the dying process is monitored. A DCD procedure can only be continued if the potential organ donor dies shortly after WLST. This study performed an external validation of 2 existing prediction models to identify potentially DCD candidates, using one of the largest cohorts. METHODS. This multicenter retrospective study analyzed all patients eligible for DCD donation from 2010 to 2015. The first model (DCD-N score) assigned points for absence of neurological reflexes and oxygenation index. The second model, a linear prediction model (LPDCD), yielded the probability of death within 60 min. This study determined discrimination (c-statistic) and calibration (Hosmer and Lemeshow test) for both models. RESULTS. This study included 394 patients, 283 (72%) died within 60 min after WLST. The DCD-N score had a c-statistic of 0.77 (95% confidence intervals, 0.71-0.83) and the LPDCD model 0.75 (95% confidence intervals, 0.68-0.81). Calibration of the LPDCD 60-min model proved to be poor (Hosmer and Lemeshow test, P < 0.001). CONCLUSIONS. The DCD-N score and the LPDCD model showed good discrimination but poor calibration for predicting the probability of death within 60 min. Construction of a new prediction model on a large data set is needed to obtain better calibration