INTERFERENCE OF UNIDIRECTIONAL SHOCK WAVES

Subject of study.We consider interference of unidirectional shock waves or, as they are called, catching up shock waves. The scope of work is to give a classification of the shock-wave structures that arise in this type of interaction of shock waves, and the area of their existence. Intersection of unidirectional shock waves results in arising of a shock-wave structure at the intersection point, which contains the main shock wave, tangential discontinuity and one more reflected gas-dynamic discontinuity of unknown beforehand type. The problem of determining the type of reflected discontinuity is the main problem that one has to solve in the study of catching shock waves interference. Main results.The paper presents the pictures of shock-wave structures arising at the interaction of catching up shock waves. The areas with a regular and irregular unidirectional interaction of shocks are described. Characteristic shock-wave structures are of greatest interest, where reflected gas-dynamic discontinuity degenerates into discontinuous characteristics. Such structures have a number of extreme properties. We have found the areas of existence for such shock-wave structures. There are also areas in which the steady-state solution is not available. The latter has determined revival of interest for the theoretical study of the problem, because the facts of sudden shock-wave structure destruction inside the air intake of supersonic aircrafts at high Mach numbers have been discovered. Practical significance.The theory of interference for unidirectional shock waves and design procedure are usable in the design of supersonic air intakes. It is also relevant for application possibility investigation of catching up oblique shock waves to create overcompressed detonation in perspective detonation air-jet and rocket engines

ENVIRONMENTALLY FRIENDLY METHOD OF GASEOUS FUEL COMBUSTION WITH THE USE OF QUASI-OPTICAL MICROWAVE

Subject of Research.The paper deals with the problem of developing low emission combustors operating on natural gas or LPG, to reduce emissions of nitrogen oxides NOx. The possibility of burning very lean fuel mixtures is studied. To initiate the ignition and combustion stabilization the discharge generated by the quasi-optical microwave is used. Main Results. Initiating ignition by streamer microwave discharge increases the rate of combustion and combustion efficiency about four times as compared with the conventional spark ignition. Streamer discharge ignition by very lean fuel-air mixture is demonstrated with the factor of oxiding agent excess greater than the limit of explosive range under normal conditions. According to indirect indicators, ignition by microwave discharge created by quasi-optical radiation is of non-thermal nature. Microwave discharge excites oxygen atoms, and intense ultra-violet radiation is generated as a result that causes formation of cold nonequilibrium plasma with avalanche growth of free electrons. Streamer discharge propagates at a speed of 5 km /s, so the initiation of the ignition occurs immediately throughout. The temperature of the fuel mixture at the point of ignition initiation does not exceed 400 К.There is no area with a temperature sufficient to initiate thermal Zeldovich mechanism of emission of nitrogen oxides. Combustion rate is high. As a result the Fenimore mechanism of "fast nitrogen oxides" has no chance to be progressing, and NOx emissions in appreciable quantities are excluded. Energy costs are comparable with spark ignition.Practical Relevance. The studied technology is designed for low emission internal combustion engines, power gas turbines, gas compressor units, fueled by natural gas

Ignition of premixed air/fuel mixtures by microwave steamer discharge

A variety of methods exists for fast and efficient combustion of air-fuel mixtures. In this study, a microwave subcritical streamer discharge is used to ignite propane-air mixtures at atmospheric pressure. The streamer is initiated at the inner surface of a dielectric tube with the help of a passive half-wave vibrator. By creating a network of ignition lines, the streamer discharge forms the network of burning channels with large total surface area. This leads to the apparent speed of combustion propagation along the cylinder in excess of 100 m/s, which is more than 200 times the laminar flame propagation speed. The axial propagation of the combustion front in a cylindrical tube filled with the air/propane mixture is investigated by high speed video recording in visible light. A simple model is presented to explain observed results

Somersault of Paramecium in extremely confined environments

We investigate various swimming modes of Paramecium in geometric confinements and a non-swimming self-bending behavior like a somersault, which is quite different from the previously reported behaviors. We observe that Paramecia execute directional sinusoidal trajectories in thick fluid films, whereas Paramecia meander around a localized region and execute frequent turns due to collisions with adjacent walls in thin fluid films. When Paramecia are further constrained in rectangular channels narrower than the length of the cell body, a fraction of meandering Paramecia buckle their body by pushing on the channel walls. The bucking (self-bending) of the cell body allows the Paramecium to reorient its anterior end and explore a completely new direction in extremely confined spaces. Using force deflection method, we quantify the Young’s modulus of the cell and estimate the swimming and bending powers exerted by Paramecium. The analysis shows that Paramecia can utilize a fraction of its swimming power to execute the self-bending maneuver within the confined channel and no extra power may be required for this new kind of self-bending behavior. This investigation sheds light on how micro-organisms can use the flexibility of the body to actively navigate within confined spaces

Benzo[a]pyrene, Aflatoxine B1 and Acetaldehyde Mutational Patterns in TP53 Gene Using a Functional Assay: Relevance to Human Cancer Aetiology

Mutations in the TP53 gene are the most common alterations in human tumours. TP53 mutational patterns have sometimes been linked to carcinogen exposure. In hepatocellular carcinoma, a specific G>T transversion on codon 249 is classically described as a fingerprint of aflatoxin B1 exposure. Likewise G>T transversions in codons 157 and 158 have been related to tobacco exposure in human lung cancers. However, controversies remain about the interpretation of TP53 mutational pattern in tumours as the fingerprint of genotoxin exposure. By using a functional assay, the Functional Analysis of Separated Alleles in Yeast (FASAY), the present study depicts the mutational pattern of TP53 in normal human fibroblasts after in vitro exposure to well-known carcinogens: benzo[a]pyrene, aflatoxin B1 and acetaldehyde. These in vitro patterns of mutations were then compared to those found in human tumours by using the IARC database of TP53 mutations. The results show that the TP53 mutational patterns found in human tumours can be only partly ascribed to genotoxin exposure. A complex interplay between the functional impact of the mutations on p53 phenotype and the cancer natural history may affect these patterns. However, our results strongly support that genotoxins exposure plays a major role in the aetiology of the considered cancers

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancer cases can be attributed to genetic defects, whereas the remaining 90–95% have their roots in the environment and lifestyle. The lifestyle factors include cigarette smoking, diet (fried foods, red meat), alcohol, sun exposure, environmental pollutants, infections, stress, obesity, and physical inactivity. The evidence indicates that of all cancer-related deaths, almost 25–30% are due to tobacco, as many as 30–35% are linked to diet, about 15–20% are due to infections, and the remaining percentage are due to other factors like radiation, stress, physical activity, environmental pollutants etc. Therefore, cancer prevention requires smoking cessation, increased ingestion of fruits and vegetables, moderate use of alcohol, caloric restriction, exercise, avoidance of direct exposure to sunlight, minimal meat consumption, use of whole grains, use of vaccinations, and regular check-ups. In this review, we present evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it. In addition, we provide evidence that cancer is a preventable disease that requires major lifestyle changes

Cancer Genomics Identifies Regulatory Gene Networks Associated with the Transition from Dysplasia to Advanced Lung Adenocarcinomas Induced by c-Raf-1

Background: Lung cancer is a leading cause of cancer morbidity. To improve an understanding of molecular causes of disease a transgenic mouse model was investigated where targeted expression of the serine threonine kinase c-Raf to respiratory epithelium induced initialy dysplasia and subsequently adenocarcinomas. This enables dissection of genetic events associated with precancerous and cancerous lesions. Methodology/Principal Findings: By laser microdissection cancer cell populations were harvested and subjected to whole genome expression analyses. Overall 473 and 541 genes were significantly regulated, when cancer versus transgenic and non-transgenic cells were compared, giving rise to three distinct and one common regulatory gene network. At advanced stages of tumor growth predominately repression of gene expression was observed, but genes previously shown to be upregulated in dysplasia were also up-regulated in solid tumors. Regulation of developmental programs as well as epithelial mesenchymal and mesenchymal endothelial transition was a hall mark of adenocarcinomas. Additionaly, genes coding for cell adhesion, i.e. the integrins and the tight and gap junction proteins were repressed, whereas ligands for receptor tyrosine kinase such as epi- and amphiregulin were up-regulated. Notably, Vegfr- 2 and its ligand Vegfd, as well as Notch and Wnt signalling cascades were regulated as were glycosylases that influence cellular recognition. Other regulated signalling molecules included guanine exchange factors that play a role in an activation of the MAP kinases while several tumor suppressors i.e. Mcc, Hey1, Fat3, Armcx1 and Reck were significantly repressed. Finally, probable molecular switches forcing dysplastic cells into malignantly transformed cells could be identified. Conclusions/Significance: This study provides insight into molecular pertubations allowing dysplasia to progress further to adenocarcinoma induced by exaggerted c-Raf kinase activity

TRENDS IN THE DEVELOPMENT OF DETONATION ENGINES FOR HIGH-SPEED AEROSPACE AIRCRAFTS AND THE PROBLEM OF TRIPLE CONFIGURATIONS OF SHOCK WAVES. Part II - Research of counterpropagating shock waves and triple shock wave configurations

The paper deals with current issues of the interference theory development of gas-dynamic discontinuities as applied to a problem of propulsion refinement for the air-spacecrafts, designed for hypersonic flight speeds. In the first part of the review we have presented the history of detonation study and different concepts of detonation engines, as well as air intakes designed for hypersonic flight speeds. The second part provides an overview of works on the interference theory development for gas-dynamic discontinuities. We report about classification of the gas-dynamic discontinuities, shock wave propagation, shock-wave structures and triple configurations of shock waves. We have shown that many of these processes are accompanied by a hysteresis phenomenon, there are areas of ambiguity; therefore, in the design of engines and air intakes optimal shock-wave structures should be provided and their sustainability should be ensured. Much attention has recently been given to the use of the air intakes in the shock-wave structures with the rereflection of shock waves and the interference of shock waves in the opposite directions. This review provides increased focus on it, contains references to landmark works, the last calculated and experimental results. Unfortunately, foreign surveys missed many landmark works of the Soviet and Russian researchers, as they were not published in English. At the same time, it was the Soviet school of gas dynamics that has formulated the interference theory of gas-dynamic discontinuities in its present form. To fill this gap is one of this review scopes. The review may be recommended for professionals, engineers and scientists working in the field of aerospace engineering

OBLIQUE SHOCK WAVE REFLECTION FROM THE WALL

Regular and Mach (irregular) reflection of an oblique shock wave from the wall is considered. Criteria for the transition from regular to irregular reflection are described: von Neumann criterion and the criterion for fixed Mach configuration. Specific incident shock wave intensities corresponding to the two criteria for the transition from regular to irregular reflection were plotted. The area of ambiguity solutions was demonstrated in which both regular and Mach reflection is not prohibited by the conditions of dynamic compatibility. Areas in which the transition from one type of reflection to another is possible only by a shock wave were described, as well as areas of a possible smooth transition. Dependence of the magnitude of this abrupt change in reflected discontinuity intensity from the intensity of the incident shock wave was plotted. Intensity dependences of the reflected discontinuity from the intensity of the shock wave incident on the wall for all types of reflections were shown