Agenda Disputes and Strategic Venue Preferences: The Doha Crisis and Europe’s Flight to Regionalism

Agenda-setting disputes have become increasingly central to the conduct of multilateral trade negotiations. Introducing some simple concepts from Negotiations Theory, we focus on the dynamic interplay between the Doha Round’s agenda setting and bargaining stages, underlining their implications for the European Union’s evolving win-set in the negotiations. We argue that, by successful enshrining a narrow agenda, key developing countries reduced the set of possible final settlements that were both multilaterally viable and attractive from the point of view of key European interests. In an attempt to avoid imposing concentrated costs on those interests, the European Commission has responded by pursuing its best alternative to a multilateral agreement, shifting negotiating resources away from the multilateral table and towards regional FTA negotiations.Trade Policy-making, Doha Round, EU, sectoral lobbying, trade negotiations

Identification of an Alternative Exon in a GABA Receptor Gene

The central dogma of biology states that DNA is transcribed into mRNA, which is then translated into proteins. In order for translation to occur, pre-mRNAs first must be processed. In pre-mRNA processing, parts of the nucleotide sequence called introns are spliced out from the transcript, so the final mRNA is made up entirely of exons. In alternative splicing, an exon is spliced out of the pre-mRNA transcript much like an intron. An mRNA transcript produced as a result of alternative splicing could produce a different protein than the mRNA without alternative splicing. Alternative splicing of an mRNA transcript could also result in a premature termination codon (PTC) within the mRNA sequence. This premature termination codon causes translation to stop before the full transcript has been translated, resulting in a truncated protein. Nonsense Mediated Decay (NMD) functions by degrading mRNA transcripts containing a PTC. NMD occurs during translation by an intricate series of protein-protein and protein-mRNA interactions that detect a PTC and result in the cleavage of PTC-containing mRNAs. We discovered an alternative exon in a zebrafish GABA receptor gene that leads to a PTC when excluded from the final mRNA and investigated the role of NMD in degrading the PTC-containing transcript

Fast nucleon emission as a probe of the isospin momentum dependence

In this article we investigate the structure of the non-local part of the symmetry term, that leads to a splitting of the effective masses of protons and neutrons in asymmetric matter. Based on microscopic transport simulations we suggest some rather sensitive observables in collisions of neutron-rich (unstable) ions at intermediate ($RIA$) energies. In particular we focus the attention on pre-equilibrium nucleon emissions. We discuss interesting correlations between the N/Z content of the fast emitted particles and their rapidity or transverse momentum, that show a nice dependence on the prescription used for the effective mass splitting.Comment: 5 pages, 6 figures, revtex

Effect of the Hydrological Keyline Design on the Growth and Quality of the Naturalized Grassland in the Dry Central Zone of Chile

The effect of climate change in the central, semi-arid zone of Chile has altered precipitation patterns, shortening the growing season of the naturalized annual grasslands and reducing forage yields. Water harvesting techniques such as the hydrological keyline design, may improve the distribution of precipitation, reduce erosion, and enhance soil water harvesting. It may therefore reduce the impact of climate change in rainfed areas. A trial was implemented to evaluate the effect of the keyline water harvesting practice on soil variables, and pasture production and quality in three farms of the semi-arid O\u27Higgins region. Rains began in April and amounted to a total of 399 mm. Pasture species germinated in August, and growth peaked in October. The keyline design influenced soil moisture and temperature, crude protein (CP), neutral detergent fiber, and acid detergent fiber of the grasses. Yields varied between months and locations. Overall, keyline management significantly increased compressed forage height and yield by 44 and 25% respectively, relative to the control. Considering that there was an effect of location it is necessary to determine the effects of variables such as soil fertility, slope, and orientation, among others

Prefazione

Le politiche sull’ambiente assumono un ruolo fondamentale e sempre più importante, perché possono riuscire a modificare quei comportamenti che, se accompagnati a politiche economiche di sostenibilità, possono permetterci di raggiungere un equilibrio tra la salvaguardia delle risorse naturali esistenti, e un loro corretto utilizzo, in modo da proteggerne l’integrità. Il volume contiene i contributi presentati in occasione del convegno organizzato dall’AIL e dall’Università degli studi di Palermo su “Cancerogenesi Ambientale” (Palermo 2013)

Consideration of the Mechanisms for Tidal Bore Formation in an Idealized Planform Geometry

A tidal bore is a positive wave traveling upstream along the estuary of a river, generated by a relatively rapid rise of the tide, often enhanced by the funneling shape of the estuary. The swell produced by the tide grows and its front steepens as the flooding tide advances inland, promoting the formation of a sharp front wave, i.e., the tidal bore. Because of the many mechanisms and conditions involved in the process, it is difficult to formulate an effective criterion to predict the bore formation. In this preliminary analysis, aimed at bringing out the main processes and parameters that control tidal bore formation, the degrees of freedom of the problem are largely reduced by considering a rectangular channel of constant width with uniform flow, forced downstream by rising the water level at a constant rate. The framework used in this study is extremely simple, yet the problem is still complex and the solution is far from being trivial. From the results of numerical simulations, three distinctive behaviors emerged related to conditions in which a tidal bore forms, a tidal bore does not form, and a weak bore forms; the latter has a weakly steep front and after the bore formed it rapidly vanishes. Based on these behaviors, some criteria to predict the bore formation are proposed and discussed. The more effective criterion, suitably rearranged, is checked against data from real estuaries and the predictions are found to compare favorably with the available data

Ultrasound Guidance in Paravertebral Injections of Oxygen-Ozone: Treatment of Low Back Pain

Background: Paravertebral injection of ozone is an established clinical practice for the treatment of Low Back Pain (LBP). The role of Ultrasound Guidance (USG) in mini invasive procedures has become important in many clinical practice thanks to the greater precision this technique can add. As matter of fact, a large volume of ozone in a single administration may have some adverse or side effects. In this study we wanted to verify if the use of USG in Oxygen/ Ozone (O2/O3) infiltrations could allow the administration of a smaller volume of gas mixture, increasing the safety and the comfort of the procedure itself, obtaining however similar or better results in pain decrease. Methods: We compared two groups of 25 patients affected by LBP, undergoing 10 infiltrations of O2/O3, by using USG (group U) or only anatomical landmarks (group AL). Pain intensity, by calculating Visual Analogical Scale (VAS) difference before and after the treatment, and the discomfort were evaluated in both groups. Results: The mean of the VAS before the treatment was 6.44 in group U and 6.48 in group AL. The mean of the VAS after the treatment was 2.22 in group U and 3.04 in group AL. The mean of discomfort rate was 2.84 in group U and 5.44 in group AL. The number of patients with unbearable discomfort was 0 in group U and 7 in group AL. Conclusions: As many other treatment, also paravertebral injections of O2/O3 benefits of the advantages of the US device which makes this treatment safer and more accurate