324 research outputs found
Neighbourhood characteristics and social isolation of people with psychosis: a multi-site cross-sectional study
Purpose: People with psychosis are vulnerable to social isolation, which is associated with worse clinical outcomes. In general populations, people living in areas with higher population density have more social contacts, while those living in more socially deprived and fragmented areas are less satisfied with their relationships. We assessed whether and how neighbourhood factors are associated with social contacts and satisfaction with friendships for people with psychosis. Methods: We carried out a cross-sectional study including people with psychosis aged 18β65Β years in urban and rural sites in England. Population density and social deprivation and fragmentation indexes were described within Lower Level Super Output Areas (LSOA). Their associations with participantsβ social contacts and satisfaction with friendships were tested with negative binomial and ordinal regression models, respectively. Results: We surveyed 511 participants with psychotic disorders. They had a median of two social contacts in the previous week (interquartile range [IQR] = 1β4), and rated satisfaction with friendships as 5 out of 7 (Manchester Short Assessment of Quality of Life; IQR = 4β6). Higher population density was associated with fewer social contacts (Z-standardised relative risk [RR] = 0.88; 95% CI = 0.79β0.99, p = 0.03), but not with satisfaction with friendships (RR = 1.08; 95% CI = 0.93β1.26, p = 0.31). No associations were found for social contacts or satisfaction with friendships with social deprivation or fragmentation indexes. Conclusions: Clinicians in urban areas should be aware that their patients with psychosis are more socially isolated when more people live around them, and this could impact their clinical outcomes. These findings may inform housing programmes
Nanodiamond Theranostic for Light-Controlled Intracellular Heating and Nanoscale Temperature Sensing
[Image: see text] Temperature is an essential parameter in all biological systems, but information about the actual temperature in living cells is limited. Especially, in photothermal therapy, local intracellular temperature changes induce cell death but the local temperature gradients are not known. Highly sensitive nanothermometers would be required to measure and report local temperature changes independent of the intracellular environment, including pH or ions. Fluorescent nanodiamonds (ND) enable temperature sensing at the nanoscale independent of external conditions. Herein, we prepare ND nanothermometers coated with a nanogel shell and the photothermal agent indocyanine green serves as a heat generator and sensor. Upon irradiation, programmed cell death was induced in cancer cells with high spatial control. In parallel, the increase in local temperature was recorded by the ND nanothermometers. This approach represents a great step forward to record local temperature changes in different cellular environments inside cells and correlate these with thermal biology
Microstructure of Complex Silicon-containing Modifier
Various research methods show that the microstructure of the complex siliconcontaining modifier βInsteel 7β consists of six phases: TiFeSi2, Ca1
On the Cauchy Problem for the Korteweg-de Vries Equation with Steplike Finite-Gap Initial Data I. Schwartz-Type Perturbations
We solve the Cauchy problem for the Korteweg-de Vries equation with initial
conditions which are steplike Schwartz-type perturbations of finite-gap
potentials under the assumption that the respective spectral bands either
coincide or are disjoint.Comment: 29 page
Upconversion luminescence of Ca<inf>1-x</inf>Ho<inf>x</inf>F<inf>2+x</inf>and Sr<inf>0.98-x</inf>Er<inf>0.02</inf>Ho<inf>x</inf>F<inf>2.02+x</inf>powders upon excitation by an infrared laser
Β© 2017 Astro Ltd. Fluorite-type Ca 1-x Ho x F 2+x and Sr 0.98-x Er 0.02 Ho x F 2.02+x powders were synthesized using the co-precipitation from water solution technique. The upconversion luminescence of Ca 1-x Ho x F 2+x and Sr 0.98-x Er 0.02 Ho x F 2.02+x powders in the visible spectral region upon excitation of 5 I 7 level Ho 3+ ions and 4 I 13/2 level Er 3+ ions were studied for the first time. The possibility of visualizing near IR laser radiation using Ca 1-x Ho x F 2+x and Sr 0.98-x Er 0.02 Ho x F 2.02+x powders is proposed. Optimal compositions of Ca 1-x Ho x F 2+x and Sr 0.98-x Er 0.02 Ho x F 2.02+x powders for application as visualizers are discussed
Effects of enzymatically depolymerised fucoidan on effector functions of innate and adaptive immunity cells
The use of sulfated polysaccharides (fucoidans) as active pharmaceutical ingredients or adjuvants poses the challenge of obtaining structurally characterised and homogeneous samples or their oligomeric fractions maintaining high biological activity. The authors obtained a highly purified enzymatic hydrolysate of fucoidan from the brown alga FucusΒ evanescens and compared its biological activity with that of a native sample. The aim of the study was to compare, in vitro and in vivo, the effects of depolymerised fucoidan from the brown alga F.Β evanescens and native fucoidan on the effector functions of innate and adaptive immunity cells loaded with ovalbumin (OVA). Materials and methods: the effects of the fucoidan samples (depolymerised and native) on the expression of the main immunophenotypic markers by innate and adaptive immunity cells (neutrophils, monocytes, natural killers, and lymphocytes) were studied in vitro using flow cytometry. The levels of serum OVA-specific antibodies (IgG, IgG1, IgG2Π°) and cytokines (IFN-Ξ³, IL-2, IL-10, IL-12) were studied in vivo using BALB/c mice immunised with OVA. The statistical analysis of the data obtained was performed using the Statistica 10 software package. Results: in vitro, both fucoidan samples altered the expression of the main immunophenotypic markers by innate and adaptive immunity cells, indicating their activation. In vivo, mice treated with the fucoidan samples demonstrated an increase in the levels of OVA-specific antibodies (IgG, IgG1 and IgG2a) and in the production of cytokines (IFN-Ξ³, IL-2, IL-10). Conclusions: the effects of enzymatically depolymerised fucoidan on functional activity of innate and adaptive immunity cells are comparable to those of native fucoidan. The findings indicate the possibility of using enzymatic hydrolysis products of fucoidan as adjuvants for aΒ wide range of prophylactic and therapeutic vaccines
ΠΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΠ΅ Π°ΡΠΏΠ΅ΠΊΡΡ Π½ΠΎΠ²ΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ ΠΈ Π΄Π΅ΡΠ΅ΠΉ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°
Purpose: to identify clinical and laboratory aspects of a new coronavirus infection in newborns and infants. Materials and methods: a retrospective analysis of 131 observations of newborns and infants infected with SARS-CoV-2 treated in children's infectious diseases departments of Izhevsk was carried out. Results. The course of coronavirus infection in newborns and infants who became ill on an outpatient basis and were hospitalized did not have significant specific clinical and laboratory features and was similar to the symptoms of major respiratory infections. Among the hospitalized, 80.9% of children had a mild severity of coronavirus infection, the rest of the children had a moderate course. The clinical picture was dominated by cough (86.3%), nasal congestion (74%) and fever (71.8%). Significant clinical differences were obtained in newborns in the form of predominance of nasal obstruction, and in infants in the predominance of fever and dry cough. Pneumonia was diagnosed in 19.1% in the form of a mild, mainly bilateral lesion.Π¦Π΅Π»Ρ: Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
Π°ΡΠΏΠ΅ΠΊΡΠΎΠ² Π½ΠΎΠ²ΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΠΈ Π΄Π΅ΡΠ΅ΠΉ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°. ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΠ΅ΡΡΠΎΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· 131 Π½Π°Π±Π»ΡΠ΄Π΅Π½ΠΈΡ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΠΈ Π΄Π΅ΡΠ΅ΠΉ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°, ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
SARS-CoV-2, ΠΏΠΎΠ»ΡΡΠ°Π²ΡΠΈΡ
Π»Π΅ΡΠ΅Π½ΠΈΠ΅ Π² Π΄Π΅ΡΡΠΊΠΈΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΎΠ½Π½ΡΡ
ΠΎΡΠ΄Π΅Π»Π΅Π½ΠΈΡΡ
Π³. ΠΠΆΠ΅Π²ΡΠΊΠ°. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π’Π΅ΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
ΠΈ Π΄Π΅ΡΠ΅ΠΉ Π³ΡΡΠ΄Π½ΠΎΠ³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°, Π·Π°Π±ΠΎΠ»Π΅Π²ΡΠΈΡ
Π² Π°ΠΌΠ±ΡΠ»Π°ΡΠΎΡΠ½ΡΡ
ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΈ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
, Π½Π΅ ΠΈΠΌΠ΅Π»ΠΎ Π·Π½Π°ΡΠΈΠΌΡΡ
ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΠΈ Π±ΡΠ»ΠΎ ΡΡ
ΠΎΠΆΠ΅ Ρ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΠΌΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΡΠ΅ΡΠΏΠΈΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΉ. Π‘ΡΠ΅Π΄ΠΈ Π³ΠΎΡΠΏΠΈΡΠ°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
Ρ 80,9% Π΄Π΅ΡΠ΅ΠΉ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π»Π° Π»Π΅Π³ΠΊΠ°Ρ ΡΡΠ΅ΠΏΠ΅Π½Ρ ΡΡΠΆΠ΅ΡΡΠΈ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, Ρ ΠΎΡΡΠ°Π»ΡΠ½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ ΠΎΡΠΌΠ΅ΡΠ°Π»ΠΎΡΡ ΡΡΠ΅Π΄Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅. Π ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΊΠ°ΡΡΠΈΠ½Π΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π» ΠΊΠ°ΡΠ΅Π»Ρ (86,3%), Π·Π°Π»ΠΎΠΆΠ΅Π½Π½ΠΎΡΡΡ Π½ΠΎΡΠ° (74%) ΠΈ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠ° (71,8%). ΠΠΎΠ»ΡΡΠ΅Π½Ρ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΠ΅ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΡΠ°Π·Π»ΠΈΡΠΈΡ Ρ Π½ΠΎΠ²ΠΎΡΠΎΠΆΠ΄Π΅Π½Π½ΡΡ
Π² Π²ΠΈΠ΄Π΅ ΠΏΡΠ΅ΠΎΠ±Π»Π°Π΄Π°Π½ΠΈΡ ΠΎΠ±ΡΡΡΡΠΊΡΠΈΠΈ Π½ΠΎΡΠΎΠ²ΡΡ
Ρ
ΠΎΠ΄ΠΎΠ², Π° Ρ Π³ΡΡΠ΄Π½ΡΡ
Π΄Π΅ΡΠ΅ΠΉ Π² ΠΏΡΠ΅Π²Π°Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΠΈ Π»ΠΈΡ
ΠΎΡΠ°Π΄ΠΊΠΈ ΠΈ ΡΡΡ
ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ»Ρ. ΠΠ½Π΅Π²ΠΌΠΎΠ½ΠΈΡ Π±ΡΠ»Π° Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π½Π° Π² 19,1% ΡΠ»ΡΡΠ°Π΅Π² Π² Π²ΠΈΠ΄Π΅ Π½Π΅ΡΡΠΆΠ΅Π»ΠΎΠ³ΠΎ, ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π΄Π²ΡΡΡΠΎΡΠΎΠ½Π½Π΅Π³ΠΎ, ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ
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Cortical and Striatal Reward Processing in Parkinson's Disease Psychosis
Psychotic symptoms frequently occur in Parkinson's disease (PD), but their pathophysiology is poorly understood. According to the National Institute of Health RDoc programme, the pathophysiological basis of neuropsychiatric symptoms may be better understood in terms of dysfunction of underlying domains of neurocognition in a trans-diagnostic fashion. Abnormal cortico-striatal reward processing has been proposed as a key domain contributing to the pathogenesis of psychotic symptoms in schizophrenia. This theory has received empirical support in the study of schizophrenia spectrum disorders and preclinical models of psychosis, but has not been tested in the psychosis associated with PD. We, therefore, investigated brain responses associated with reward expectation and prediction error signaling during reinforcement learning in PD-associated psychosis. An instrumental learning task with monetary gains and losses was conducted during an fMRI study in PD patients with (nβ=β12), or without (nβ=β17), a history of psychotic symptoms, along with a sample of healthy controls (nβ=β24). We conducted region of interest analyses in the ventral striatum (VS), ventromedial prefrontal and posterior cingulate cortices, and whole-brain analyses. There was reduced activation in PD patients with a history of psychosis, compared to those without, in the posterior cingulate cortex and the VS during reward anticipation (pβ<β0.05 small volume corrected). The results suggest that cortical and striatal abnormalities in reward processing, a putative pathophysiological mechanism of psychosis in schizophrenia, may also contribute to the pathogenesis of psychotic symptoms in PD. The finding of posterior cingulate dysfunction is in keeping with prior results highlighting cortical dysfunction in the pathogenesis of PD psychosis.This study was supported by a Medical Research Council Clinician Scientist award (G0701911), and an Isaac Newton Trust award to Dr. Murray; by support to Dr. Fletcher from the Wellcome Trust and Bernard Wolfe Health Neuroscience Fund; by a Wellcome Trust strategic award to University of Cambridge (097814/Z/11), by the NIHR Cambridge Biomedical Research Centre and University of Cambridge Behavioural and Clinical Neuroscience Institute, supported by a joint award from the Medical Research Council (G1000183) and Wellcome Trust (093875/Z/10/Z)
EARLY DIAGNOSIS OF IMMUNE DISTURBANCES AND ITS CORRECTION IN THE TREATMENT OF MULTIORGAN FAILURE AND SEPTIC COMPLICATIONS AFTER OPERATIONS WITH ARTIFICIAL AND ASSIST CIRCULATION
The study has shown that early diagnosis of the type and degree of immune disturbances in preparation for the operation and the first signs of multiorgan failure and septic complications in the postoperative period in cardiac surgery patients were the rationale for the earlier substitution immunocorrection by immunomodulators of cytokine nature and intravenous immunoglobulin. It allowed increasing the efficiency of the treatment of postoperative complications and lower mortality after operations with artificial and assist circulation
ΠΠΠΠΠΠΠ€Π€ΠΠ ΠΠΠ¦ΠΠ ΠΠΠΠΠΠ«Π ΠΠΠ Π ΠΠΠ―Π¦ΠΠΠΠΠ«Π ΠΠΠΠΠΠΠΠΠΠ‘Π’ΠΠΠ― ΠΠΠΠΠ£ ΠΠΠΠΠΠΠ’ΠΠΠ―ΠΠ ΠΠΠΠΠΠ ΠΠΠΠΠΠΠΠΠΠΠ Π£ ΠΠΠΠΠΠ ΠΠΠ ΠΠΠΠΠΠΠ‘Π’ΠΠΠΠ ΠΠ ΠΠΠΠΠ’ΠΠ§ΠΠ‘ΠΠΠΠ ΠΠ ΠΠΠ ΠΠ’Π ΠΠΠ’ΠΠ 1.2
The effect of the probiotic preparation Vetom 1.2 on the basis of Bacillus subtilis VKPM B-10641, Bacillus amyloliquefaciens VKPM B-10642 and Bacillus amyloliquefaciens VKPM B-10643 in different doses on the correlation interactions between the parameters of turkey hemoglobin exchange, blood erythrocytes and blood red blood cells direct and total bilirubin, total protein and serum albumin was studies. Correlations were calculated using Spearman formula, the reliability of correlations was checked by Student. The formulation was used for turkeys once a day for 30 days in doses of 12.5; 25; fifty; 75 and 100 mg / kg body weight. It was found that Vetom 1.2 in minimal doses leads to an inverse correlation between iron and total bilirubin, direct bilirubin, total protein and albumin, an increase in the concentration of the formulation leads to the disappearance of this effect with a gradual subsequent decrease in this indicator. Vetom 1.2 in doses up to 50 mg / kg leads to an inverse correlation between the concentrations of hemoglobin and direct bilirubin, total protein and serum albumin, at a dose of 75 mg / kg there is a direct correlation between these indicators, and at a dose of 100 mg / kg returns a negative correlation. The probiotic preparation Vetom 1.2 leads to a direct dependence of the concentration of bilirubins (total and direct) in serum on the concentrations of hemoglobin and red blood cells when used in most doses, except 75 mg / kg, which reduces the correlation.ΠΠ·ΡΡΠ΅Π½ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΠΏΡΠΎΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΠ΅ΡΠΎΠΌ 1.2 Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ Bacillus subtilis ΠΠΠΠ Π-10641, Bacillus amyloliquefaciens ΠΠΠΠ Π-10642 ΠΈ Bacillus amyloliquefaciens ΠΠΠΠ Π-10643 Π² ΡΠ°Π·Π½ΡΡ
Π΄ΠΎΠ·Π°Ρ
Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠ΅ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΎΠ±ΠΌΠ΅Π½Π° Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π° ΠΈΠ½Π΄Π΅Π΅ΠΊ β ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ, Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π° ΠΊΡΠΎΠ²ΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΆΠ΅Π»Π΅Π·Π°, ΠΏΡΡΠΌΠΎΠ³ΠΎ ΠΈ ΠΎΠ±ΡΠ΅Π³ΠΎ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π°, ΠΎΠ±ΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ° ΠΈ Π°Π»ΡΠ±ΡΠΌΠΈΠ½ΠΎΠ² ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ. ΠΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»ΠΈΡΡ ΠΏΠΎ ΡΠΎΡΠΌΡΠ»Π΅ Π‘ΠΏΠΈΡΠΌΠ΅Π½Π°, Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎΡΡΡ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΉ ΠΏΡΠΎΠ²Π΅ΡΡΠ»ΠΈΡΡ ΠΏΠΎ Π‘ΡΡΡΠ΄Π΅Π½ΡΡ. ΠΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΏΡΠΈΠΌΠ΅Π½ΡΠ»ΠΈ ΠΈΠ½Π΄Π΅ΠΉΠΊΠ°ΠΌ 1 ΡΠ°Π· Π² ΡΡΡΠΊΠΈ Π½Π° ΠΏΡΠΎΡΡΠΆΠ΅Π½ΠΈΠΈ 30 ΡΡΡΠΎΠΊ Π² Π΄ΠΎΠ·Π°Ρ
12,5; 25; 50; 75 ΠΈ 100 ΠΌΠ³/ΠΊΠ³ ΠΆΠΈΠ²ΠΎΠΉ ΠΌΠ°ΡΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΠ΅ΡΠΎΠΌ 1.2 Π² ΠΌΠΈΠ½ΠΈΠΌΠ°Π»ΡΠ½ΡΡ
Π΄ΠΎΠ·Π°Ρ
ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΆΠ΅Π»Π΅Π·ΠΎΠΌ ΠΈ ΠΎΠ±ΡΠΈΠΌ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½ΠΎΠΌ, ΠΏΡΡΠΌΡΠΌ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½ΠΎΠΌ, ΠΎΠ±ΡΠΈΠΌ Π±Π΅Π»ΠΊΠΎΠΌ ΠΈ Π°Π»ΡΠ±ΡΠΌΠΈΠ½Π°ΠΌΠΈ, ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΈΡΡΠ΅Π·Π½ΠΎΠ²Π΅Π½ΠΈΡ ΡΡΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° Ρ ΠΏΠΎΡΡΠ΅ΠΏΠ΅Π½Π½ΡΠΌ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΡΠΈΠΌ ΠΏΠΎΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ. ΠΠ΅ΡΠΎΠΌ 1.2 Π² Π΄ΠΎΠ·Π°Ρ
Π΄ΠΎ 50 ΠΌΠ³/ΠΊΠ³ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡΠΌΠΈ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π° ΠΊΡΠΎΠ²ΠΈ ΠΈ ΠΏΡΡΠΌΠΎΠ³ΠΎ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π°, ΠΎΠ±ΡΠ΅Π³ΠΎ Π±Π΅Π»ΠΊΠ° ΠΈ Π°Π»ΡΠ±ΡΠΌΠΈΠ½Π°ΠΌΠΈ Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ, ΠΏΡΠΈ Π΄ΠΎΠ·Π΅ 75 ΠΌΠ³/ΠΊΠ³ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΏΡΡΠΌΠ°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½Π°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ, Π° ΠΏΡΠΈ Π΄ΠΎΠ·Π΅ 100 ΠΌΠ³/ΠΊΠ³ Π²ΠΎΠ·Π²ΡΠ°ΡΠ°Π΅ΡΡΡ ΠΎΡΡΠΈΡΠ°ΡΠ΅Π»ΡΠ½Π°Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ. ΠΡΠΎΠ±ΠΈΠΎΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ ΠΠ΅ΡΠΎΠΌ 1.2 ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΠΏΡΡΠΌΠΎΠΉ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ Π±ΠΈΠ»ΠΈΡΡΠ±ΠΈΠ½Π° (ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΈ ΠΏΡΡΠΌΠΎΠ³ΠΎ) Π² ΡΡΠ²ΠΎΡΠΎΡΠΊΠ΅ ΠΊΡΠΎΠ²ΠΈ ΠΎΡ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ Π³Π΅ΠΌΠΎΠ³Π»ΠΎΠ±ΠΈΠ½Π° ΠΈ ΡΡΠΈΡΡΠΎΡΠΈΡΠΎΠ² ΠΊΡΠΎΠ²ΠΈ ΠΏΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ Π΄ΠΎΠ·, ΠΊΡΠΎΠΌΠ΅ 75 ΠΌΠ³/ΠΊΠ³, ΠΏΠΎΠ½ΠΈΠΆΠ°ΡΡΠ΅ΠΉ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΡ ΡΠ²ΡΠ·Ρ
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