Characterization of CMOS Spiral Inductors

In this work "full-wave" simulations of integrated inductors are presented and compared with measurements of fabricated CMOS chips. The good agreement between measurements and simulations demonstrates the accuracy of the tool, which is, hence, a cheaper alternative to experimental characterization. Furthermore, the proposed approach may give precious hints for performance improvements, by making internal device fields and currents available for the VLSI designer and providing compact, most effective, equivalent models

In vitro and in vivo selection of potentially probiotic lactobacilli from Nocellara del Belice table olives

Table olives are increasingly recognized as a vehicle as well as a source of probiotic bacteria, especially those fermented with traditional procedures based on the activity of indigenous microbial consortia, originating from local environments. In the present study, we report characterization at the species level of 49 Lactic Acid Bacteria (LAB) strains deriving from Nocellara del Belice table olives fermented with the Spanish or Castelvetrano methods, recently isolated in our previous work. Ribosomal 16S DNA analysis allowed identification of 4 Enterococcus gallinarum, 3 E. casseliflavus, 14 Leuconostoc mesenteroides, 19 Lactobacillus pentosus, 7 L. coryniformis, and 2 L. oligofermentans. The L. pentosus and L. coryniformis strains were subjected to further screening to evaluate their probiotic potential, using a combination of in vitro and in vivo approaches. The majority of them showed high survival rates under in vitro simulated gastro-intestinal conditions, and positive antimicrobial activity against Salmonella enterica serovar Typhimurium, Listeria monocytogenes and enterotoxigenic Escherichia coli (ETEC) pathogens. Evaluation of antibiotic resistance to ampicillin, tetracycline, chloramphenicol, or erythromycin was also performed for all selected strains. Three L. coryniformis strains were selected as very good performers in the initial in vitro testing screens, they were antibiotic susceptible, as well as capable of inhibiting pathogen growth in vitro. Parallel screening employing the simplified model organism Caenorhabditis elegans, fed the Lactobacillus strains as a food source, revealed that one L. pentosus and one L. coryniformis strains significantly induced prolongevity effects and protection from pathogen-mediated infection. Moreover, both strains displayed adhesion to human intestinal epithelial Caco-2 cells and were able to outcompete foodborne pathogens for cell adhesion. Overall, these results are suggestive of beneficial features for novel LAB strains, which renders them promising candidates as starters for the manufacturing of fermented table olives with probiotic added value

Thromboembolic events in patients treated with anti-angiogenic drugs

Induction of neo-angiogenesis is a fundamental step in many pathological conditions. The therapeutic value of inhibiting angiogenesis is an interesting area of research in oncology, with vascular endothelial growth factor (VEGF) being the most suitable anti-angiogenic target. In the last decade a number of anti-VEGF drugs have demonstrated, especially in combination with standard chemotherapy, clinical efficacy in the treatment of different solid tumor types. As data from clinical trials on anti-VEGF drugs are becoming available, it is increasingly recognized that VEGF, in addition to being a permeability, proliferation, and migration factor, is also a maintenance and protection factor for endothelial cells, being capable of regulating multiple biological functions, i.e. the production of vasoactive mediators and the expression of components of the thrombolytic and coagulation pathways. Consequently, the disturbance of vascular homeostasis by blocking VEGF may lead to endothelial dysfunction and adverse vascular effects, such as venous and arterial thromboembolic events. In preclinical models angiogenesis and the increased expression of VEGF has been associated to altered expression of proinflammatory genes. These genes may be regulated in a biphasic manner, and it is possible that anti-VEGF therapy may disrupt a negative feedback loop that leads to potential in situ thrombus formation. Accordingly, combination treatment with bevacizumab and chemotherapy, compared with chemotherapy alone, was recently associated with an increased risk of thromboembolism. The present review considers the biological mechanisms and clinical impact of thromboembolic complications during anti-angiogenic treatments in cancer patients

Evidenze della rapida variazione di profondità della Moho, in corrispondenza dell'area di Città di Castello (Appennino Settentrionale), dall'analisi di funzioni ricevitore

In questo studio è stata sfruttata l’opportunità di poter analizzare dati provenienti da una densa rete sismica locale temporanea costituita da 30 stazioni a tre componenti, installata nell’ambito di un progetto del Gruppo Nazionale per la Difesa dei Terremoti (GNDT) nel periodo compreso fra l’Ottobre 2000-Maggio 2001, in un’area che si estende per circa 2800 km2 a circa 43° N in Appennino Settentrionale (Piccinini et al., 2003), al fine di ottenere un dettagliato andamento della topografia della Moho, in una zona così complessa, attraverso un’analisi delle Funzioni Ricevitore (Langston, 1979), definendo la struttura di velocità delle onde di taglio (S) al di sotto di ciascuna delle 28 stazioni sismiche. Sono stati analizzati circa 400 eventi telesismici registrati da 28 stazioni con valori di magnitudo M>5 e distanza epicentrale Δ compresi fra 25°-100°. Per il calcolo delle RFs è stato utilizzato il metodo sviluppato da Di Bona (1998), tale metodo consente di ottenere una stima della varianza, permettendo l’utilizzo di forme d’onda generate da eventi di bassa magnitudo (aventi valori di varianza accettabili), con un conseguente ampliamento del data-set. Modellando ampiezze e tempi di arrivo delle fasi Ps in funzione dell’azimuth di provenienza (BAZ) e della relativa distanza epicentrale (Δ), si possono ricostruire le geometrie delle superfici di discontinuità al di sotto delle stazioni sismiche. La fase di modellazione è stata condotta attraverso l’applicazione dell’algoritmo di inversione “neighbourhood” di Sambridge (1999) mediante un approccio monodimensionale. Questo metodo consente di campionare in maniera estensiva lo spazio dei parametri (profondità delle varie interfacce e valori di velocità negli strati compresi fra le interfacce), concentrando la ricerca in quelle regioni dello spazio multiparametrico dove i modelli di velocità trovati hanno un miglior misfit rispetto al dato (la RF) reale. Tale fase di modellazione ha consentito di ricostruire i modelli di velocità delle onde S (Vs) al di sotto di ciascuna stazione. L’analisi comparata dei modelli di velocità delle onde S (Vs) così ottenuti, per ogni singola stazione, mette in luce la natura fortemente eterogenea della porzione più superficiale della crosta dell’area in studio. Nonostante la complessità delle RFs calcolate che si riflette sulla eterogeneità della porzione più superficiale dei profili di Vs ottenuti, è stata individuata con buona continuità l’andamento di una superficie di discontinuità sismica da noi interpretata come transizione crosta-mantello superiore o Moho

Crustal and Upper Mantle Three-Dimensional Stratification and Anisotropy from Receiver Functions (Northern Apennines-Italy)

The Northern Apennines (NA) were predominantly formed by a Meso-Cenozoic sedimentary sequence thrust northeast and stacked over the Adriatic foreland during Late Miocene-Pleistocene. Extension on the Tyrrhenian margin is synchronous with thrust emplacements along the external Apenninic chain and is associated by crustal thinning, normal faulting, ductile deformation, volcanic activity and high heat flow. Both, the extensional and the compressional fronts migrated towards the Adriatic foreland during the Plio-Pleistocene. Crustal extension everywere disrupted structural architectures formed during the preceding compressional phase leading to the development of thinned, uplifted and extended crust in the Tuscany mainland. Several models have been proposed to explain the evolution of the NA that are acknowledged to be tectonically complex. We present results from a Receiver Functions (RFs) analysis of teleseismic events recorded at Arezzo seismic station (Tuscany). A broad-band station (ARZ) is installed on the north-east margin of the “Val di Chiana” extensional syntectonic basin. We selected and grouped in “bins” high signal/noise teleseismic events of four years of recording to compute a data-set of RFs. We applied a classical inversion scheme (a Neighbourhood Algorithm) and we carried out a three-dimensional modelling. As a criterion to identify and to distinguish the effects of azimuthal anisotropy from those of lateral heterogeneity, we included the harmonic angular analysis performed by stacking Radial (R) and Transverse (T) components with weights depending on the backazimuth. The results of these analysis provide a detailed three-dimensional image of the S-velocity lithosphere structure

Analisi strutturale di crosta e mantello in prossimità dell’alta Val di Chiana (Toscana orientale)

L’Appennino Settentrionale è una catena montuosa NE-vergente ed è il risultato dell’affioramento del prisma di accrezione originato in seguito alla subduzione della litosfera adriatica sotto il mar Tirreno ed ancora in atto (Faccenna et al., 2001). Dall’Oligocene ad oggi, l’Appennino Settentrionale è stato interessato da due fasi deformative: inizialmente compressiva con la formazione di thrusts e più recentemente distensiva (Elter et al., 1975). Attualmente è caratterizzato da un regime crostale distensivo con una velocità stimata circa 2.5 mm/anno (Hunstad et al., 2003). Gli effetti e le conseguenze di questi episodi deformativi sono ben visibili attraverso un’analisi geologica e geofisica. L’area in studio è posta in corrispondenza della transizione tra la successione Toscana ed il settore Tirrenico del dominio Umbro-Marchigiano, quindi, una zona particolarmente dibattuta da un punto di vista geodinamico, a causa della presenza di diverse tipologie crostali, flusso di calore e anomalie gravimetriche

Imaging of crustal scatterers using multiple seismic arrays

Array seismology is an useful tool to perform a detailed investigation of the Earth’s interior. Seismic arrays by using the coherence properties of the wavefield are able to extract directivity information and to increase the ratio of the coherent signal amplitude relative to the amplitude of incoherent noise. The Double Beam Method (DBM), developed by Krüger et al. (1993, 1996), is one of the possible applications to perform a refined seismic investigation of the crust and mantle by using seismic arrays. The DBM is based on a combination of source and receiver arrays leading to a further improvement of the signal-to-noise ratio by reducing the error in the location of coherent phases. Previous DBM works have been performed for mantle and core/mantle resolution (Krüger et al., 1993; Scherbaum et al., 1997; Krüger et al., 2001). An implementation of the DBM has been presented at 2D large-scale (Italian data-set for Mw=9.3, Sumatra earthquake) and at 3D crustal-scale as proposed by Rietbrock & Scherbaum (1999), by applying the revised version of Source Scanning Algorithm (SSA; Kao & Shan, 2004). In the 2D application, the rupture front propagation in time has been computed. In 3D application, the study area (20x20x33 km3), the data-set and the source-receiver configurations are related to the KTB-1994 seismic experiment (Jost et al., 1998). We used 60 short-period seismic stations (200-Hz sampling rate, 1-Hz sensors) arranged in 9 small arrays deployed in 2 concentric rings about 1 km (A-arrays) and 5 km (B-array) radius. The coherence values of the scattering points have been computed in the crustal volume, for a finite time-window along all array stations given the hypothesized origin time and source location. The resulting images can be seen as a (relative) joint log-likelihood of any point in the subsurface that have contributed to the full set of observed seismograms

Vertical MEMS Resonators for Real-Time Clock Applications

MEMS resonators are today widely investigated as a desirable alternative to quartz resonators in real-time clock applications, because of their low-cost, integration capability properties. Nevertheless, MEMS resonators performances are still not competitive, especially in terms of frequency stability and device equivalent resistance (and, then, power consumption). We propose a new structure for a MEMS resonator, with a vertical-like transduction mechanism, which exhibits promising features. The vertical resonator can be fabricated with the low-cost, high performance THELMA technology, and it is designed to be efficiently frequency tunable. With respect to the commonly investigated lateral resonators, it is expected to have lower equivalent resistances and improved large-scale repeatability characteristics

Moho-depth and subglacial sedimentary layer thickness in the Wilkes Basin from Receiver Function Analysis

Wilkes Basin lies to the east of the Transantarctic Mountains. The origin of this sub-glacial basin is still controversial. Flexural uplift of the Transantarctic Mountains has been suggested as the geophysical process which generated the basin (Stern & ien Brink, 1989). Other studies proposed a continental rift structure for this region (Ferraccioli et al., 2001). The two models differ mainly in the crustal structure predicted beneath the basin. In the former, crustal thickning is expected to be originated from the high rigidity of the East Antarctic Craton lithosphere. Otherwise, the rift structure hypothesis is consistent with a broad crustal thinning. During the WIBEM 2003 campaign, we deployed five broadband seismic stations across the basin. We selected high signal/noise teleseismic recording to compute a data-set of receiver functions. We applied a classical inversion scheme, the Neighbourhood Algorithm, to our data-set. Here, two different and complementary studies are presented. We constrain the Moho geometry beneath the Wilkes Basin from the analysis of low-frequency P-to-S conversion at the base of the crust. Also, we investigate the nature of the basin mapping the presence of subglacial sediments using the P-to-S conversion at the ice-bedrock interface