Management and efficacy of intensified insulin therapy starting in outpatients

Diabetic patients under multiple injection insulin therapy (i.e., intensified insulin therapy, IIT) usually start this treatment during hospitalization. We report here on the logistics, efficacy, and safety of IIT, started in outpatients. Over 8 months, 52 type I and type II diabetics were followed up whose insulin regimens consecutively had been changed from conventional therapy to IIT. Two different IIT strategies were compared: free mixtures of regular and intermediate (12 hrs)-acting insulin versus the basal and prandial insulin treatment with preprandial injections of regular insulin, and ultralente (24 hrs-acting) or intermediate insulin for the basal demand. After 8 months HbA1 levels had decreased from 10.6%±2.4% to 8.0%±1.3% (means±SD). There was no difference between the two regimens with respect to metabolic control; but type II patients maintained the lowered HbA1 levels better than type I patients. Only two patients were hospitalized during the follow-up time because of severe hypoglycemia. An increase of body weight due to the diet liberalization during IIT became a problem in one-third of the patients. Our results suggest that outpatient initiation of IIT is safe and efficacious with respect to near-normoglycemic control. Weight control may become a problem in IIT patients

SEIS: Insight’s Seismic Experiment for Internal Structure of Mars

By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars’ surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking’s Mars seismic monitoring by a factor of ∼ 2500 at 1 Hz and ∼ 200 000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars’ surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of Mw ∼ 3 at 40◦ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution

Doskonalenie jakości edukacji na przykładzie znaku szkoła z klasą

Dochodzenie szkoły do nowoczesności jest procesem długotrwałym. Potrzebne do tego jest zaangażowanie i współdziałanie wszystkich, którym zależy na wysokiej jakości edukacji. W rozdziale przedstawiono znaczenie znaku Szkoła z klasą w aspekcie doskonalenia jakości edukacji

The influence of low-frequency variable magnetic fields in reducing pain experience after dental implant treatment

The paper presents the evaluation of analgesic effect or magnetostimulation and magnetoledtherapy after implantation treatment. The study was conducted on 3 groups (Z applicator, IR applicator and conventional drug therapy) of 10 patients each of whom underwent a single implantation. Magnetostimulation was carried out using Viofor JPS Delux equipment. The patients were exposed to magnetic field for approx. 15 minutes before the treatment and during the visit after 6 hours after the implantation procedure. Pain perception of patients was recorded on the Visual Analogue Scale (VAS). Results: the most intense pain was reported in the control group. The least intense pain appeared in the group with Z applicator. Patients using Z and IR applicators took analgesics less frequently and used much weaker analgesics than the control group. Pain perceived in the first group was between 0 and 2, while in the second group – between 2 and 3, and in the control group – between 3 and 5 in VAS scale. Magnetostimulation reduces patient’s demand for analgesics after implantation procedures and yielded better effects in reduction of pain in comparison with magnetostimulation with LED therapy