2,744 research outputs found
Autologous chondrocyte implantation using a bilayer collagen membrane: A preliminary report
Purpose. To present preliminary clinical experience with Matrix-induced autologous chondrocyte implantation, a new tissue-engineering technique for treatment of deep cartilage defects, in which autologous chondrocytes are seeded on a tridimensional scaffold provided by a bilayer type I–III collagen membrane. Methods. From December 1999 to January 2001, 13 patients underwent implantation procedure for deep cartilage defects. Age of patients ranged from 18 to 49 years (mean age, 35 years). The mean defect size was 3.5 cm 2 (range, 2.0–4.5 cm 2 ). Clinical and functional evaluation were performed using various score systems for the ankle and the knee, and magnetic resonance imaging was performed at 6 and 12 months postoperatively. Membrane structure and cellular population were investigated by light microscopy, scanning electron microscopy, and electrophoresis before implantation. Results. The mean follow-up was 6.5 months (range, 2–15 months). No complications were observed in the postoperative period. The 6 patients with a minimum follow-up of 6 months showed an improvement in clinical and functional status after surgery. Magnetic resonance images showed the presence of hyaline-like cartilage at the site of implantation; there was evidence of chondroblasts and type II collagen inside the seeded membrane. Conclusion. Matrix-induced autologous chondrocyte implantation offers several advantages with respect to the traditional cultured cell procedure. These include technical simplicity, short operating time, minimal invasiveness, and easier access to difficult sites. It appears to be a reliable method for the repair of deep cartilage defects
Beauty in mind: Aesthetic appreciation correlates with perceptual facilitation and attentional amplification
A Virtual Navigation Training Promotes the Remapping of Space in Allocentric Coordinates: Evidence From Behavioral and Neuroimaging Data
Preferred music listening is associated with perceptual learning enhancement at the expense of self-focused attention
Can preferred music listening improve following attentional and learning performances? Here we suggest that this may be the case. In Experiment 1, following preferred and non-preferred musical-piece listening, we recorded electrophysiological responses to an auditory roving-paradigm. We computed the mismatch negativity (MMN – the difference between responses to novel and repeated stimulation), as an index of perceptual learning, and we measured the correlation between trial-by-trial EEG responses and the fluctuations in Bayesian Surprise, as a quantification of the neural attunement with stimulus informational value. Furthermore, during music listening, we recorded oscillatory cortical activity. MMN and trial-by-trial correlation with Bayesian surprise were significantly larger after subjectively preferred versus non-preferred music, indicating the enhancement of perceptual learning. The analysis on oscillatory activity during music listening showed a selective alpha power increased in response to preferred music, an effect often related to cognitive enhancements. In Experiment 2, we explored whether this learning improvement was realized at the expense of self-focused attention. Therefore, after preferred versus non-preferred music listening, we collected Heart-Beat Detection (HBD) accuracy, as a measure of the attentional focus toward the self. HBD was significantly lowered following preferred music listening. Overall, our results suggest the presence of a specific neural mechanism that, in response to aesthetically pleasing stimuli, and through the modulation of alpha oscillatory activity, redirects neural resources away from the self and toward the environment. This attentional up-weighting of external stimuli might be fruitfully exploited in a wide area of human learning activities, including education, neurorehabilitation and therapy. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.3758/s13423-022-02127-8
The rubber hand illusion in microgravity and water immersion
Our body has evolved in terrestrial gravity and altered gravitational conditions may affect the sense of body ownership (SBO). By means of the rubber hand illusion (RHI), we investigated the SBO during water immersion and parabolic flights, where unconventional gravity is experienced. Our results show that unconventional gravity conditions remodulate the relative weights of visual, proprioceptive, and vestibular inputs favoring vision, thus inducing an increased RHI susceptibility
All-sky upper limit for gravitational radiation from spinning neutron stars
We present results of the all-sky search for gravitational-wave signals from
spinning neutron stars in the data of the EXPLORER resonant bar detector. Our
data analysis technique was based on the maximum likelihood detection method.
We briefly describe the theoretical methods that we used in our search. The
main result of our analysis is an upper limit of for
the dimensionless amplitude of the continuous gravitational-wave signals coming
from any direction in the sky and in the narrow frequency band from 921.00 Hz
to 921.76 Hz.Comment: 12 pages, 4 figures, submitted to Proceedings of 7th Gravitational
Wave Data Analysis Workshop, December 17-19, 2002, Kyoto, Japa
Quark nuggets search using 2350 Kg gravitational waves aluminum bar detectors
The gravitational wave resonant detectors can be used as detectors of quark
nuggets, like nuclearites (nuclear matter with a strange quark). This search
has been carried out using data from two 2350 Kg, 2 K cooled, aluminum bar
detectors: NAUTILUS, located in Frascati (Italy), and EXPLORER, that was
located in CERN Geneva (CH). Both antennas are equipped with cosmic ray shower
detectors: signals in the bar due to showers are continuously detected and used
to characterize the antenna performances. The bar excitation mechanism is based
on the so called thermo-acoustic effect, studied on dedicated experiments that
use particle beams. This mechanism predicts that vibrations of bars are induced
by the heat deposited in the bar from the particle. The geometrical acceptance
of the bar detectors is 19.5 sr, that is smaller than that of other
detectors used for similar searches. However, the detection mechanism is
completely different and is more straightforward than in other detectors. We
will show the results of ten years of data from NAUTILUS (2003-2012) and 7
years from EXPLORER (2003-2009). The experimental limits we obtain are of
interest because, for nuclearites of mass less than grams, we find a
flux smaller than that one predicted considering nuclearites as dark matter
candidates.Comment: presented to the 33rd International Cosmic Ray Conference Rio de
Janeiro 201
Search for Periodic Gravitational Wave Sources with the Explorer Detector
We have developped a procedure for the search of periodic signals in the data
of gravitational wave detectors. We report here the analysis of one year of
data from the resonant detector Explorer, searching for pulsars located in the
Galactic Center (GC). No signals with amplitude greater than , in the range 921.32-921.38 Hz, were observed using data
collected over a time period of 95.7 days, for a source located at
hours and degrees. Our
procedure can be extended for any assumed position in the sky and for a more
general all-sky search, even with a frequency correction at the source due to
the spin-down and Doppler effects.Comment: One zipped file (Latex+eps figures). 33 pages, 14 figures. This and
related material also at http://grwav3.roma1.infn.it
Effect of cosmic rays on the resonant gravitational wave detector NAUTILUS at temperature T=1.5 K
The interaction between cosmic rays and the gravitational wave bar detector
NAUTILUS is experimentally studied with the aluminum bar at temperature of
T=1.5 K. The results are compared with those obtained in the previous runs when
the bar was at T=0.14 K. The results of the run at T = 1.5 K are in agreement
with the thermo-acoustic model; no large signals at unexpected rate are
noticed, unlike the data taken in the run at T = 0.14 K. The observations
suggest a larger efficiency in the mechanism of conversion of the particle
energy into vibrational mode energy when the aluminum bar is in the
superconductive status.Comment: 7 pages, 3 figures, 2 tables. Accepted by Physics Letters
Muon tracking underground
We present a new design of plastic streamer tubes, optimized to match the experimental requirements of large-area under-ground detectors, where muon identification is needed with good angular resolution
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