22 research outputs found
Joint effects of storm surge and sea-level rise on US Coasts: new economic estimates of impacts, adaptation, and benefits of mitigation policy
Recent literature, the US Global Change Research Programâs National Climate Assessment, and recent events, such as Hurricane Sandy, highlight the need to take better account of both storm surge and sea-level rise (SLR) in assessing coastal risks of climate change. This study combines three modelsâa tropical cyclone simulation model; a storm surge model; and a model for economic impact and adaptationâto estimate the joint effects of storm surge and SLR for the US coast through 2100. The model is tested using multiple SLR scenarios, including those incorporating estimates of dynamic ice-sheet melting, two global greenhouse gas (GHG) mitigation policy scenarios, and multiple general circulation model climate sensitivities. The results illustrate that a large area of coastal land and property is at risk of damage from storm surge today; that land area and economic value at risk expands over time as seas rise and as storms become more intense; that adaptation is a cost-effective response to this risk, but residual impacts remain after adaptation measures are in place; that incorporating site-specific episodic storm surge increases national damage estimates by a factor of two relative to SLR-only estimates, with greater impact on the East and Gulf coasts; and that mitigation of GHGs contributes to significant lessening of damages. For a mid-range climate-sensitivity scenario that incorporates dynamic ice sheet melting, the approach yields national estimates of the impacts of storm surge and SLR of ); GHG mitigation policy reduces the impacts of the mid-range climate-sensitivity estimates by 100 billion.United States. Environmental Protection Agency. Climate Change Division (Contract EP-D-09-054)United States. Environmental Protection Agency. Climate Change Division (Contract EP-BPA-12-H-0024
Morphing Ensemble Kalman Filters
A new type of ensemble filter is proposed, which combines an ensemble Kalman
filter (EnKF) with the ideas of morphing and registration from image
processing. This results in filters suitable for nonlinear problems whose
solutions exhibit moving coherent features, such as thin interfaces in wildfire
modeling. The ensemble members are represented as the composition of one common
state with a spatial transformation, called registration mapping, plus a
residual. A fully automatic registration method is used that requires only
gridded data, so the features in the model state do not need to be identified
by the user. The morphing EnKF operates on a transformed state consisting of
the registration mapping and the residual. Essentially, the morphing EnKF uses
intermediate states obtained by morphing instead of linear combinations of the
states.Comment: 17 pages, 7 figures. Added DDDAS references to the introductio
Comparison of HIV-1 Genotypic Resistance Test Interpretation Systems in Predicting Virological Outcomes Over Time
Background: Several decision support systems have been developed to interpret HIV-1 drug resistance genotyping results. This study compares the ability of the most commonly used systems (ANRS, Rega, and Stanford's HIVdb) to predict virological outcome at 12, 24, and 48 weeks. Methodology/Principal Findings: Included were 3763 treatment-change episodes (TCEs) for which a HIV-1 genotype was available at the time of changing treatment with at least one follow-up viral load measurement. Genotypic susceptibility scores for the active regimens were calculated using scores defined by each interpretation system. Using logistic regression, we determined the association between the genotypic susceptibility score and proportion of TCEs having an undetectable viral load (<50 copies/ml) at 12 (8-16) weeks (2152 TCEs), 24 (16-32) weeks (2570 TCEs), and 48 (44-52) weeks (1083 TCEs). The Area under the ROC curve was calculated using a 10-fold cross-validation to compare the different interpretation systems regarding the sensitivity and specificity for predicting undetectable viral load. The mean genotypic susceptibility score of the systems was slightly smaller for HIVdb, with 1.92±1.17, compared to Rega and ANRS, with 2.22±1.09 and 2.23±1.05, respectively. However, similar odds ratio's were found for the association between each-unit increase in genotypic susceptibility score and undetectable viral load at week 12; 1.6 [95% confidence interval 1.5-1.7] for HIVdb, 1.7 [1.5-1.8] for ANRS, and 1.7 [1.9-1.6] for Rega. Odds ratio's increased over time, but remained comparable (odds ratio's ranging between 1.9-2.1 at 24 weeks and 1.9-2.