A New General Method to Generate Random Modal Formulae for Testing Decision Procedures

The recent emergence of heavily-optimized modal decision procedures has highlighted the key role of empirical testing in this domain. Unfortunately, the introduction of extensive empirical tests for modal logics is recent, and so far none of the proposed test generators is very satisfactory. To cope with this fact, we present a new random generation method that provides benefits over previous methods for generating empirical tests. It fixes and much generalizes one of the best-known methods, the random CNF_[]m test, allowing for generating a much wider variety of problems, covering in principle the whole input space. Our new method produces much more suitable test sets for the current generation of modal decision procedures. We analyze the features of the new method by means of an extensive collection of empirical tests

Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease

AIMS Arterial spin labelling (ASL) MRI measures perfusion without administration of contrast agent. While ASL has been validated in animals and healthy volunteers (HVs), application to chronic kidney disease (CKD) has been limited. We investigated the utility of ASL MRI in patients with CKD. METHODS We studied renal perfusion in 24 HVs and 17 patients with CKD (age 22-77 years, 40% male) using ASL MRI at 3.0T. Kidney function was determined using estimated glomerular filtration rate (eGFR). T1 relaxation time was measured using modified look-locker inversion and xFB02;ow-sensitive alternating inversion recovery true-fast imaging and steady precession was performed to measure cortical and whole kidney perfusion. RESULTS T1 was higher in CKD within cortex and whole kidney, and there was association between T1 time and eGFR. No association was seen between kidney size and volume and either T1, or ASL perfusion. Perfusion was lower in CKD in cortex (136 ± 37 vs. 279 ± 69 ml/min/100 g; p < 0.001) and whole kidney (146 ± 24 vs. 221 ± 38 ml/min/100 g; p < 0.001). There was significant, negative, association between T1 longitudinal relaxation time and ASL perfusion in both the cortex (r = -0.75, p < 0.001) and whole kidney (r = -0.50, p < 0.001). There was correlation between eGFR and both cortical (r = 0.73, p < 0.01) and whole kidney (r = 0.69, p < 0.01) perfusion. CONCLUSIONS Significant differences in renal structure and function were demonstrated using ASL MRI. T1 may be representative of structural changes associated with CKD; however, further investigation is required into the pathological correlates of reduced ASL perfusion and increased T1 time in CKD

On the emergent Semantic Web and overlooked issues

The emergent Semantic Web, despite being in its infancy, has already received a lotof attention from academia and industry. This resulted in an abundance of prototype systems and discussion most of which are centred around the underlying infrastructure. However, when we critically review the work done to date we realise that there is little discussion with respect to the vision of the Semantic Web. In particular, there is an observed dearth of discussion on how to deliver knowledge sharing in an environment such as the Semantic Web in effective and efficient manners. There are a lot of overlooked issues, associated with agents and trust to hidden assumptions made with respect to knowledge representation and robust reasoning in a distributed environment. These issues could potentially hinder further development if not considered at the early stages of designing Semantic Web systems. In this perspectives paper, we aim to help engineers and practitioners of the Semantic Web by raising awareness of these issues

Radio Weak Gravitational Lensing with VLA and MERLIN

We carry out an exploratory weak gravitational lensing analysis on a combined VLA and MERLIN radio data set: a deep (3.3 micro-Jy beam^-1 rms noise) 1.4 GHz image of the Hubble Deep Field North. We measure the shear estimator distribution at this radio sensitivity for the first time, finding a similar distribution to that of optical shear estimators for HST ACS data in this field. We examine the residual systematics in shear estimation for the radio data, and give cosmological constraints from radio-optical shear cross-correlation functions. We emphasize the utility of cross-correlating shear estimators from radio and optical data in order to reduce the impact of systematics. Unexpectedly we find no evidence of correlation between optical and radio intrinsic ellipticities of matched objects; this result improves the properties of optical-radio lensing cross-correlations. We explore the ellipticity distribution of the radio counterparts to optical sources statistically, confirming the lack of correlation; as a result we suggest a connected statistical approach to radio shear measurements.Comment: 16 pages with 19 figures, accepted for publication in MNRAS; Minor corrections to section 6.3; 2 references adde

A wide-angle outflow with the simultaneous presence of a high-velocity jet in the high-mass Cepheus A HW2 system

We present five epochs of VLBI water maser observations around the massive protostar Cepheus A HW2 with 0.4 mas (0.3 AU) resolution. The main goal of these observations was to follow the evolution of the remarkable water maser linear/arcuate structures found in earlier VLBI observations. Comparing the data of our new epochs of observation with those observed five years before, we find that at "large" scales of > 1" (700 AU) the main regions of maser emission persist, implying that both the surrounding medium and the exciting sources of the masers have been relatively stable during that time span. However, at smaller scales of < 0.1" (70 AU) we see large changes in the maser structures, particularly in the expanding arcuate structures R4 and R5. R4 traces a nearly elliptical patchy ring of ~ 70 mas size (50 AU) with expanding motions of ~ 5 mas/yr (15 km/s). This structure is probably driven by the wind of a still unidentified YSO located at the centre of the ring (~ 0.18" south of HW2). On the other hand, the R5 expanding bubble structure (driven by the wind of a previously identified YSO located ~ 0.6" south of HW2) is currently dissipating in the circumstellar medium and losing its previous degree of symmetry, indicating a very short-lived event. In addition, our results reveal, at scales of ~ 1" (700 AU), the simultaneous presence of a relatively slow (~ 10-70 km/s) wide-angle outflow (opening angle of ~ 102 deg, traced by the masers, and the fast (~ 500~km/s) highly collimated radio jet associated with HW2 (opening angle of ~ 18 deg, previously observed with the VLA. This simultaneous presence of a wide-angle outflow and a highly collimated jet associated with a massive protostar is similar to what is found in some low-mass YSOs. The implications of these results in the study of the formation of high-mass stars are discussed.Comment: 28 pages, 7 figures. Animations will be included as supporting material online (MNRAS web page

On-demand semiconductor single-photon source with near-unity indistinguishability

Single photon sources based on semiconductor quantum dots offer distinct advantages for quantum information, including a scalable solid-state platform, ultrabrightness, and interconnectivity with matter qubits. A key prerequisite for their use in optical quantum computing and solid-state networks is a high level of efficiency and indistinguishability. Pulsed resonance fluorescence (RF) has been anticipated as the optimum condition for the deterministic generation of high-quality photons with vanishing effects of dephasing. Here, we generate pulsed RF single photons on demand from a single, microcavity-embedded quantum dot under s-shell excitation with 3-ps laser pulses. The pi-pulse excited RF photons have less than 0.3% background contributions and a vanishing two-photon emission probability. Non-postselective Hong-Ou-Mandel interference between two successively emitted photons is observed with a visibility of 0.97(2), comparable to trapped atoms and ions. Two single photons are further used to implement a high-fidelity quantum controlled-NOT gate.Comment: 11 pages, 11 figure

Averages of bb-hadron, cc-hadron, and τ\tau-lepton properties as of summer 2014

This article reports world averages of measurements of $b$-hadron, $c$-hadron, and $\tau$-lepton properties obtained by the Heavy Flavor Averaging Group (HFAG) using results available through summer 2014. For the averaging, common input parameters used in the various analyses are adjusted (rescaled) to common values, and known correlations are taken into account. The averages include branching fractions, lifetimes, neutral meson mixing parameters, $CP$ violation parameters, parameters of semileptonic decays and CKM matrix elements.Comment: 436 pages, many figures and tables. Online updates available at http://www.slac.stanford.edu/xorg/hfag

Transient peak-strain matching partially recovers the age-impaired mechanoadaptive cortical bone response

Mechanoadaptation maintains bone mass and architecture; its failure underlies age-related decline in bone strength. It is unclear whether this is due to failure of osteocytes to sense strain, osteoblasts to form bone or insufficient mechanical stimulus. Mechanoadaptation can be restored to aged bone by surgical neurectomy, suggesting that changes in loading history can rescue mechanoadaptation. We use non-biased, whole-bone tibial analyses, along with characterisation of surface strains and ensuing mechanoadaptive responses in mice at a range of ages, to explore whether sufficient load magnitude can activate mechanoadaptation in aged bone. We find that younger mice adapt when imposed strains are lower than in mature and aged bone. Intriguingly, imposition of short-term, high magnitude loading effectively primes cortical but not trabecular bone of aged mice to respond. This response was regionally-matched to highest strains measured by digital image correlation and to osteocytic mechanoactivation. These data indicate that aged bone’s loading response can be partially recovered, non-invasively by transient, focal high strain regions. Our results indicate that old murine bone does respond to load when the loading is of sufficient magnitude, and bones’ age-related adaptation failure may be due to insufficient mechanical stimulus to trigger mechanoadaptation