569 research outputs found
Remarques sur le siège de la faculté du langage articulé, suivies d’une observation d’aphémie (perte de la parole)
Perte de la parole, ramouissement chronique et destruction partielle du lobe antérieur gauche du cerveau
Relações da sutura coronária com os sulcos da face súpero-lateral do lobo frontal: aplicações neurocirúrgicas
Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment
In type 2 diabetes, amyloid oligomers, chronic hyperglycemia, lipotoxicity, and pro-inflammatory cytokines are detrimental to beta-cells, causing apoptosis and impaired insulin secretion. The histone acetyl transferase p300, involved in remodeling of chromatin structure by epigenetic mechanisms, is a key ubiquitous activator of the transcriptional machinery. In this study, we report that loss of p300 acetyl transferase activity and expression leads to beta-cell apoptosis, and most importantly, that stress situations known to be associated with diabetes alter p300 levels and functional integrity. We found that proteasomal degradation is the mechanism subserving p300 loss in beta-cells exposed to hyperglycemia or pro-inflammatory cytokines. We also report that melatonin, a hormone produced in the pineal gland and known to play key roles in beta-cell health, preserves p300 levels altered by these toxic conditions. Collectively, these data imply an important role for p300 in the pathophysiology of diabetes
Growth and survival of American oyster Crassostrea virginica on Laguna de las Pilas, Laguna de Términos, Campeche, México: preliminary evaluation [abstract]; Evaluacion preliminar del crecimiento y sobrevivencia del ostion Crassostrea virginica en la Laguna de las Pilas, Laguna de Términos, Campeche, México [resumen]
Distribution and abundance of larvae Callinectes rathbunae in Atasta Lagoon, Terminos Lagoon, Campeche, Mexico [abstract]; Distribucion y abundancia de larvas de Callinectes rathbunae en la Laguna de Atasta, Laguna de Terminos, Campeche, Mexico [resumen]
The pathology of familial breast cancer: The pre-BRCA1/BRCA2 era - historical perspectives
A proportion of breast carcinomas develop as a result of a genetic predispostion to the disease. Prior to cloning of the BRCA1 and BRCA2 genes a limited number of studies were carried out to identify specific histopathological characteristics of hereditary breast cancer. These studies are the subject of this review. The main finding was the association of the (atypical) medullary type of breast cancer with a family history; the most important caveat being that medullary breast cancer is found more frequently in young patients. In view of the frequent bilateral occurrence of lobular cancer, this histologic type is also likely to be associated with a predisposing genetic defect. Future investigations will have to test this hypothesis. In addition to mutations in the BRCA1 and BRCA2 genes, there are as yet unidentified genetic defects predisposing to breast cancer development, and histopathology may well help in identifying these genes in the future
Localização dos sulcos e giros da face súpero-lateral do cérebro na tomografia computadorizada e na ressonância magnética
Definição do limite anterolateral do lobo occipital em peças anatômicas e exames de imagem
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