A new shape diffusion descriptor for brain classification

In this paper, we exploit spectral shape analysis techniques to detect brain morphological abnormalities. We propose a new shape descriptor able to encode morphometric properties of a brain image or region using diffusion geometry techniques based on the local Heat Kernel. Using this approach, it is possible to design a versatile signature, employed in this case to classify between normal subjects and patients affected by schizophrenia. Several diffusion strategies are assessed to verify the robustness of the proposed descriptor under different deformation variations. A dataset consisting of MRI scans from 30 patients and 30 control subjects is utilized to test the proposed approach, which achieves promising classification accuracies, up to 83.33%. This constitutes a drastic improvement in comparison with other shape description techniques

Role of multi-tract tractography in pre-surgical selection and planning of eloquest intra-axial lesions

No abstract availabl

Diffusion tensor imaging corticospinal tractography in gamma knife radiosurgery for arterio-venous malformations.

no availabl

Multimodal schizophrenia detection by multiclassification analysis

We propose a multiclassification analysis to evaluate the relevance of different factors in schizophrenia detection. Several Magnetic Resonance Imaging (MRI) scans of brains are acquired from two sensors: morphological and diffusion MRI. Moreover, 14 Region Of Interests (ROIs) are available to focus the analysis on specific brain subparts. All information is combined to train three types of classifiers to distinguish between healthy and unhealthy subjects. Our contribution is threefold: (i) the classification accuracy improves when multiple factors are taken into account; (ii) proposed procedure allows the selection of a reduced subset of ROIs, and highlights the synergy between the two modalities; (iii) correlation analysis is performed for every ROI and modality to measure the information overlap using the correlation coefficient in the context of schizophrenia classification. We see that we achieve 85.96 % accuracy when we combine classifiers from both modalities, whereas the highest performance of a single modality is 78.95 %. © 2011 Springer-Verlag

Multimodal Schizophrenia Detection by Multiclassification Analysis

We propose a multiclassification analysis to evaluate the relevance of different factors in schizophrenia detection. Several Magnetic Resonance Imaging (MRI) scans of brains are acquired from two sensors: morphological and diffusion MRI. Moreover, 14 Region Of Interests (ROIs) are available to focus the analysis on specific brain subparts. All information is combined to train three types of classifiers to distinguish between healthy and unhealthy subjects. Our contribution is threefold: (i) the classification accuracy improves when multiple factors are taken into account; (ii) proposed procedure allows the selection of a reduced subset of ROIs, and highlights the synergy between the two modalities; (iii) correlation analysis is performed for every ROI and modality to measure the information overlap using the correlation coefficient in the context of schizophrenia classification. We see that we achieve 85.96 % accuracy when we combine classifiers from both modalities, whereas the highest performance of a single modality is 78.95 %. \ua9 2011 Springer-Verlag

Dissimilarity-based detection of schizophrenia.

In this article, a novel approach to schizophrenia classification using magnetic resonance images (MRI) is proposed. The presented method is based on dissimilarity-based classification techniques applied to morphological MRIs and diffusion-weighted images (DWI). Instead of working with features directly, pairwise dissimilarities between expert delineated regions of interest (ROIs) are considered as representations based on which learning and classification can be performed. Experiments are carried out on a set of 59 patients and 55 controls and several pairwise dissimilarity measurements are analyzed. We demonstrate that significant improvements can be obtained when combining over different ROIs and different dissimilarity measures. We show that combining ROIs using the dissimilarity-based representation, we achieve higher accuracies. The dissimilarity-based representation outperforms the feature-based representation in all cases. Best results are obtained by combining the two modalities. In summary, our contribution is threefold: (i) We introduce the usage of dissimilarity-based classification to schizophrenia detection and show that dissimilarity-based classification achieves better results than normal features, (ii) We use dissimilarity combination to achieve better accuracies when carefully selected ROIs and dissimilarity measures are considered, and (iii) We show that by combining multiple modalities we can achieve even better result

Dissimilarity-Based Detection of Schizophrenia

ABSTRACT: In this article, a novel approach to schizophrenia classification using magnetic resonance images (MRI) is proposed. The presented method is based on dissimilarity-based classification techniques applied to morphological MRIs and diffusion-weighted images (DWI). Instead of working with features directly, pairwise dissimilarities between expert delineated regions of interest (ROIs) are considered as representations based on which learning and classification can be performed. Experiments are carried out on a set of 59 patients and 55 controls and several pairwise dissimilarity measurements are analyzed. We demonstrate that significant improvements can be obtained when combining over different ROIs and different dissimilarity measures. We show that combining ROIs using the dissimilaritybased representation, we achieve higher accuracies. The dissimilarity-based representation outperforms the feature-based representation in all cases. Best results are obtained by combining the tw