Scaling of load in communications networks

We show that the load at each node in a preferential attachment network scales as a power of the degree of the node. For a network whose degree distribution is p(k) ~ k^(-gamma), we show that the load is l(k) ~ k^eta with eta = gamma - 1, implying that the probability distribution for the load is p(l) ~ 1/l^2 independent of gamma. The results are obtained through scaling arguments supported by finite size scaling studies. They contradict earlier claims, but are in agreement with the exact solution for the special case of tree graphs. Results are also presented for real communications networks at the IP layer, using the latest available data. Our analysis of the data shows relatively poor power-law degree distributions as compared to the scaling of the load versus degree. This emphasizes the importance of the load in network analysis.Comment: 4 pages, 5 figure

Double-sided coaxial circuit QED with out-of-plane wiring

Superconducting circuits are well established as a strong candidate platform for the development of quantum computing. In order to advance to a practically useful level, architectures are needed which combine arrays of many qubits with selective qubit control and readout, without compromising on coherence. Here we present a coaxial circuit QED architecture in which qubit and resonator are fabricated on opposing sides of a single chip, and control and readout wiring are provided by coaxial wiring running perpendicular to the chip plane. We present characterisation measurements of a fabricated device in good agreement with simulated parameters and demonstrating energy relaxation and dephasing times of $T_1 = 4.1\,\mu$s and $T_2 = 5.7\,\mu$s respectively. The architecture allows for scaling to large arrays of selectively controlled and measured qubits with the advantage of all wiring being out of the plane.Comment: 4 pages, 3 figures, 1 tabl

Effect of gut active carbohydrates on plasma IgG concentrations in piglets and calves

Improving immune status in neonates is crucial to health and production. Gut active carbohydrates (GAC) have been associated with increasing immunoglobin levels and immonucompetence development in mammals. The objective of the following studies was to evaluate whether GAC (mannan-oligosaccharides) applied orally to progeny immediately following parturition, improved blood plasma immunoglobulin (Ig) type G concentrations in piglets and calves. Three trials were conducted comparing control groups with those receiving GAC orally. The first two trials used piglets that were monitored for blood IgG at 2 days of age and for changes in body weight (BW), and the third trial monitored calf IgG from birth to 21 days of age. Piglets in the experimental group received 0.75 g GAC in 10 ml saline at birth and 24 h of age. The calf trial compared the control group against calves that received 22.5 g GAC mixed into 4.5 l of colostrum (to give 5 g/l) in the first 24 h after parturition. Blood serum samples were taken at 2 days post partum in piglets, and at several time points from 6 h to 21 days of age in calves, and were analysed for IgG levels by radial immunodiffusion. In the first piglet trial, significantly higher levels (32%) of IgG were observed for piglets fed GAC (P < 0.001), and in the second, IgG concentration was elevated by 23% (P < 0.01) and BW increased by 9% (P = 0.023) with GAC supplementation. Significant improvements for calves were recorded at all time points in those fed GAC (P < 0.05), with an increase in serum IgG observed after the first day, which was maintained throughout the sampling period, resulting in a difference of 39% at the end of the trial (21 d). These findings form a basis for further studies, which are required to investigate possible modes of action involved in enhancing blood immunoglobulin concentrations in young animals, and the longer-term effects this may have on the development of the immune respons

The Large Scale Curvature of Networks

Understanding key structural properties of large scale networks are crucial for analyzing and optimizing their performance, and improving their reliability and security. Here we show that these networks possess a previously unnoticed feature, global curvature, which we argue has a major impact on core congestion: the load at the core of a network with N nodes scales as N^2 as compared to N^1.5 for a flat network. We substantiate this claim through analysis of a collection of real data networks across the globe as measured and documented by previous researchers.Comment: 4 pages, 5 figure

Risk assessment of an offshore wind turbine and remaining useful life estimation of the power converter. Improving availability by prioritising failures with higher risk to operation

By 2014, almost 2500 offshore wind turbines were installed in Europe representing 8GW of capacity connected to the grid and, there is a growing market penetration for the next years. Offshore wind farm operators are facing many challenges related to disparate data sources utilisation for O&M logistic optimisation. Therefore, the decision-making process needs to be based on sound analysis of the wind farm information or data available. According to several technical reports operation and maintenance (O&M) cost could reach until 30% of the levelised cost of energy (LCOE). Understanding the reliability of an offshore wind turbine and the resources required to maintain it is crucial to reduce O&M costs and thus, to reduce the levelised cost of energy (LCOE). There is a need to reduce unnecessary tasks, prioritise the most urgent tasks, improve usage of vessels, crew and technicians, reduce the cost of spare parts held and schedule preventative maintenance to minimise downtime and maximise revenue. Currently, risk assessment plays an important role in the operation and maintenance (O&M) strategies of offshore wind farms. A comprehensive failure mode and effect analysis (FMEA) has been carried out to determine critical assemblies of a generic offshore wind turbine with an induction generator, three stages gearbox and monopile foundation. The main objectives of undertaking this comprehensive FMEA was to identify those failures with significant impact on the wind turbine operation and to identify or highlight areas of risk for maintainability and availability. The FMEA is validated with; widely-used data available in the public domain; Lloyd’s Register’s experience of working with wind farm operators and; Lloyd’s Register experience of working on reliability of the mechanical system of different industrial sectors for decades. The FMEA is further augmented and updated by the use of on-going measurements from operating wind farms. Yaw system, pitch system, power converter and gearbox have been identified in the FMEA as the most critical assemblies regarding risk to the turbine operation. Power converter analysis shows high failure rates and a large proportion of undetectable failures, therefore maintenance resources have been spent on fault finding with its corresponding cost. New approaches are necessary to tackle electrical or electronic failures, especially on the power converter. To improve overall reliability, a method to estimate the remaining useful life (RUL) of a fully-rated converter in a variable speed wind turbine is proposed using data commonly available for offshore wind farm operators. Studies show that the economic impact is dominated by failures related to power electronic components such as IGBTs and capacitors due to their higher repair cost. Mathematical models have been developed to correlate turbine operation variables and environmental conditions with failure root causes to define wear and maintenance actions based on the probability of failur

Effect of Pelleting Temperature on the Activity of Different Enzymes

The effects of different pelleting temperatures on the activity of cellulase, bacterial amylase, fungal amylase, and pentosanase were tested. Samples of a commercial barley-wheat-soybean diet containing different enzyme preparations were pelleted at 60, 70, 80, 90, and 100 C (pellet temperature measured at the die outlet) through a die containing holes 2.5 mm in diameter. Enzymatic analyses were conducted on either soluble substrates or by measuring the ability of the tested enzymes to decrease the viscosity of the diet. Measurements made on soluble substrates suggest that cellulase, fungal amylase, and pentosanase maintained activity when being pelleted at temperatures up to 80 C and bacterial amylase maintained activity at temperatures up to 90 C. Pentosanase and amylases showed little or no effect on the viscosity of the diet. Cellulase addition decreased the viscosity at all temperature levels, even after being pelleted at 90 and 100 C (P < 0.05). No cellulolytic activity was detected on the soluble substrate after these pelleting temperatures. Measurements on a soluble substrate might therefore not always reflect the true stability of a preparation because the ability of a carbohydrase to decrease the viscosity of the digesta is important to its effect in the gastrointestinal tract. Measurements on soluble substrates suggest that cellulase, fungal amylase, and pentosanase can be pelleted at temperatures up to at least 80 C and bacterial amylase up to 90 C without a considerable loss in analyzed activit

Importance of relative humidity in the oxidative ageing of organic aerosols: case study of the ozonolysis of maleic acid aerosol

Many important atmospheric aerosol processes depend on the chemical composition of the aerosol, e.g. water uptake and particle cloud interactions. Atmospheric ageing processes, such as oxidation reactions, significantly and continuously change the chemical composition of aerosol particles throughout their lifetime. These ageing processes are often poorly understood. In this study we utilize an aerosol flow tube set up and an ultra-high resolution mass spectrometer to explore the effect of relative humidity (RH) in the range of &lt;5–90% on the ozonolysis of maleic acid aerosol which is employed as model organic aerosol system. Due to the slow reaction kinetics relatively high ozone concentrations of 160–200 ppm were used to achieve an appreciable degree of oxidation of maleic acid. The effect of oxidative ageing on the hygroscopicity of maleic acid particles is also investigated using an electrodynamic balance and thermodynamic modelling. RH has a profound effect on the oxidation of maleic acid particles. Very little oxidation is observed at RH &lt; 50% and the only observed reaction products are glyoxylic acid and formic acid. In comparison, when RH &gt; 50% there are about 15 oxidation products identified. This increased oxidation was observed even when the particles were exposed to high humidities long after a low RH ozonolysis reaction. This result might have negative implications for the use of water as an extraction solvent for the analysis of oxidized organic aerosols. These humidity-dependent differences in the composition of the ozonolyzed aerosol demonstrate that water is both a key reactant in the oxidation scheme and a determinant of particle phase and hence diffusivity. The measured chemical composition of the processed aerosol is used to model the hygroscopic growth, which compares favourably with water uptake results from the electrodynamic balance measurements. A reaction mechanism is presented which takes into account the RH dependent observations. This study emphasises the importance of studying the combined effects of several atmospheric parameters such as oxidants and RH to accurately describe the complex oxidation scheme of organic aerosols

New evidence for the intentional use of calomel as a white pigment

In this work we report the results of the in-situ application of micro-Raman spectroscopy to the analysis of two historic painted objects: a 15th-century illuminated manuscript and a late-16th-century portrait miniature. Both objects were unexpectedly found to contain calomel (Hg2Cl2), intentionally used as a white pigment. Calomel was a widespread and popular medicine until it fell out of use at the end of the 19th century due to its toxicity, and a material called ‘mercury white’ is referred to in 16th-century technical literature on painting. However, although calomel has been recognised in the past as a degradation product of cinnabar in both wall and easel paintings, its deliberate use as a pigment on cultural heritage objects has only been documented recently, in white areas painted on 17th-century South American objects. The present study describes the first-ever verified use of calomel as a white pigment on European works of art, both of which pre-date its documented use in South America

Structural and Functional Characterization of Malate Synthase G from Opportunistic Pathogen Pseudomonas aeruginosa

Pseudomonas aeruginosa is an opportunistic human pathogen recognized as a critical threat by the World Health Organization due to the dwindling number of effective therapies available to treat infections. Over the last decade, it has become apparent that the glyoxylate shunt plays a vital role in sustaining P. aeruginosa during infection scenarios. The glyoxylate shunt comprises two enzymes: isocitrate lyase and malate synthase isoform G. Inactivation of these enzymes has been reported to abolish the ability of P. aeruginosa to establish infection in a mammalian model system, yet we still lack the structural information to support drug design efforts. In this work, we describe the first X-ray crystal structure of P. aeruginosa malate synthase G in the apo form at 1.62 Å resolution. The enzyme is a monomer composed of four domains and is highly conserved with homologs found in other clinically-relevant microorganisms. It is also dependent on Mg2+ for catalysis. Metal ion binding led to a change in the intrinsic fluorescence of the protein, allowing us to quantitate its affinity for Mg2+. We also identified putative drug binding sites in malate synthase G using computational analysis and, because of the high resolution of the experimental data, were further able to characterize its hydration properties. Our data reveal two promising binding pockets in malate synthase G that may be exploited for drug design.This work was supported by the European Commission’s Horizon 2020 Grant 642620 to M.W. and A.P. and BBSRC Grant BB/M019411/1 to M.W

Optimum spectral window for imaging of art with optical coherence tomography

Optical Coherence Tomography (OCT) has been shown to have potential for important applications in the field of art conservation and archaeology due to its ability to image subsurface microstructures non-invasively. However, its depth of penetration in painted objects is limited due to the strong scattering properties of artists’ paints. VIS-NIR (400 nm – 2400 nm) reflectance spectra of a wide variety of paints made with historic artists’ pigments have been measured. The best spectral window with which to use optical coherence tomography (OCT) for the imaging of subsurface structure of paintings was found to be around 2.2 μm. The same spectral window would also be most suitable for direct infrared imaging of preparatory sketches under the paint layers. The reflectance spectra from a large sample of chemically verified pigments provide information on the spectral transparency of historic artists’ pigments/paints as well as a reference set of spectra for pigment identification. The results of the paper suggest that broadband sources at ~2 microns are highly desirable for OCT applications in art and potentially material science in general