The views of parents concerning the planning of services for rehabilitation of families of children with congenital cardiac disease

Background and purpose: Although much previous research has focused on the medical aspects of congenital cardiac disease, there is a growing body of research which suggests that families may need help and support with the wider issues associated with the medical condition. We have previously ascertained from young people with congenital cardiac disease their views on this subject. The purpose of this study was to obtain the views of their parents about the need for, and shape of, services for rehabilitation. Methods: This was a qualitative study using semi-structured interviews. We interviewed 17 parents in their own home. Interviews were tape-recorded and transcribed. Results: Parents would welcome more help and support from health professionals to enable them to manage more effectively the condition with their children. Particular areas of concern relate to the information they receive about the condition; communication between themselves and health professionals; establishing safe levels of activity; and managing the condition at school. Conclusions: This is a small study of the experiences and views of parents, which provides some important information on ways in which health professionals. could address the current lack of services for rehabilitation

Further studies of the coupled chemically reacting boundary layer and charring ablator. Part 1 - Summary Final report

Computer program development for charring ablative materials, chemically reacting laminar boundary layers, and turbulent boundary layer initiatio

Human Performance Assessments in Cadet Populations

This study assessed potential physiological differences between the Ranger Challenge (RC) Competition team and junior year cadets in an Army Reserve Officer Training Corps (ROTC) program. The method included: RC (m = 11, f = 2) and junior year cadets (m = 7, f = 3) were assessed in the following areas: 1) quickness and agility (5-10-5 shuttle run), 2) total-body power (standing broad jump), and 3) grip strength (hand grip dynamometry) assessed. The 5-10-5 shuttle run was performed twice (opening once to the left and once to the right). The standing broad jump required that cadets stand with their toes behind a line, perform a maximum of three preparatory movements, triple extend their knees, hips, and ankles while using their upper body to propel them as far forward as possible. After the jump the distanced reached was measured from the line to the heel of the nearest foot. Hand grip dynamometry was performed once on each hand. The cadet held the dynamometer out to his or her side and squeezed it as they lowered it to their hip. The results were that there were no significant differences between groups for the 5-10-5 shuttle run (p = 0.91), standing broad jump (p = 0.49), or grip strength (p = 0.31). RC did not outperform

Spectral centrality measures in complex networks

Complex networks are characterized by heterogeneous distributions of the degree of nodes, which produce a large diversification of the roles of the nodes within the network. Several centrality measures have been introduced to rank nodes based on their topological importance within a graph. Here we review and compare centrality measures based on spectral properties of graph matrices. We shall focus on PageRank, eigenvector centrality and the hub/authority scores of HITS. We derive simple relations between the measures and the (in)degree of the nodes, in some limits. We also compare the rankings obtained with different centrality measures.Comment: 11 pages, 10 figures, 5 tables. Final version published in Physical Review

PERCEIVED DIFFERENCES IN SKATING CHARACTERISTICS RESULTING FROM THREE CROSS SECTIONAL SKATE BLADE PROFILES

The purpose of this study was to document differences in perceived skating characteristics resulting from three unique cross sectional skate blade profiles. Sixteen (n=16) University level hockey players were used in this double blind study looking at the perceived performance differences of four different skate blade profiles. No significant differences were found between skate blade profiles, preferred skate blade profile and time to complete given drills. Future research should look at different blade profiles and their interaction at ice level

Did That Just Happen? Sex Differences, Protectiveness, and Perceptions of Sexual Harassment

Sexual harassment (SH) is any unwanted sexual advance, request, or verbal/physical sexual behavior. It must explicitly/implicitly affect employment, interfere with work performance, and create an intimidating, hostile, or offensive atmosphere (Quick & McFadyen, 2017). SH can happen to anyone, but more frequently occurs to females and is perpetrated by men (Gibson et al., 2016; Pryor, 1995). Having a good quality friend has been linked to decreased victimization (Kendrick et al., 2012). The current study looks at the interpretation and identification of SH. Based on the literature, the hypotheses are participants will more likely identify SH when (H1) they are female compared to male (Fitzgerald, 1993; Gibson et al., 2016) and (H2) they score high on friendship quality (Kendrick et al., 2012). It is also hypothesized (H3) that male pronouns will be assigned to the perpetrator and female pronouns will be assigned to the target (Pryor, 1995). Participants were recruited from Amazon MTurk. Participants completed a demographic survey, read one of two scenarios, answered 4-5 questions about what they read, and then answered a 7-question friendship quality scale (Bukowski et al., 1994). In these scenarios, the target of harassment was either the participant or participant’s friend. After reading a scenario, participants were asked to (a) provide a summary of the event, (b) give three words to describe it, (c) decide if it is SH, (d) identify the perpetrator’s gender, and (e) identify the friends’ gender (if applicable). Data collection and preliminary analyses are ongoing

Minimal Obstructions for Partial Representations of Interval Graphs

Interval graphs are intersection graphs of closed intervals. A generalization of recognition called partial representation extension was introduced recently. The input gives an interval graph with a partial representation specifying some pre-drawn intervals. We ask whether the remaining intervals can be added to create an extending representation. Two linear-time algorithms are known for solving this problem. In this paper, we characterize the minimal obstructions which make partial representations non-extendible. This generalizes Lekkerkerker and Boland's characterization of the minimal forbidden induced subgraphs of interval graphs. Each minimal obstruction consists of a forbidden induced subgraph together with at most four pre-drawn intervals. A Helly-type result follows: A partial representation is extendible if and only if every quadruple of pre-drawn intervals is extendible by itself. Our characterization leads to a linear-time certifying algorithm for partial representation extension

Effect of a Platinum Chemotherapy Drug on Intracellular Elements During the Cell Cycle, Using X-Ray Microanalysis

Intracellular elemental concentrations were measured in the cytoplasm, nucleus and nucleolus of cultured Chinese hamster ovary (CHO) cells, using energy dispersive electron probe X-ray microanalysis and transmission electron microscopy. Synchronous CHO cell populations were analyzed at different times during the growth cycle. The elements K, P, Mg and Zn were all more concentrated in the nucleus and nucleolus than in the cytoplasm, while no specific subcellular compartmentalization was evident for the elements Na, Cl, Ca, Fe and S. Significant changes in intracellular elemental concentrations were associated with the progression of cells from G1 phase to S phase of the growth cycle. Most significant were the effects on the monovalent ions, Na, K and Cl. The effect of a second generation platinum chemotherapy agent, cis-dichloro-bis (isopropylamine) trans-dihydroxy platinum IV (iproplatin) on intracellular elements was investigated by analyzing subcellular compartments of drug-treated synchronous CHO cell populations. Changes in intracellular elemental levels occurred, most notably in the nucleus of G1 phase cells, when a general depletion of most essential elements was evident. Attempts to analyze cells for their Pt content proved disappointing, since quantitation for Pt was not possible. However, measurement of Pt peak/background ratio yielded significant Pt peaks on analyzing lysosomes of cells treated with high concentrations of iproplatin. These Pt peaks were associated with high levels of S and Fe

A New Approach to Time Domain Classification of Broadband Noise in Gravitational Wave Data

Broadband noise in gravitational wave (GW) detectors, also known as triggers, can often be a deterrant to the efficiency with which astrophysical search pipelines detect sources. It is important to understand their instrumental or environmental origin so that they could be eliminated or accounted for in the data. Since the number of triggers is large, data mining approaches such as clustering and classification are useful tools for this task. Classification of triggers based on a handful of discrete properties has been done in the past. A rich information content is available in the waveform or 'shape' of the triggers that has had a rather restricted exploration so far. This paper presents a new way to classify triggers deriving information from both trigger waveforms as well as their discrete physical properties using a sequential combination of the Longest Common Sub-Sequence (LCSS) and LCSS coupled with Fast Time Series Evaluation (FTSE) for waveform classification and the multidimensional hierarchical classification (MHC) analysis for the grouping based on physical properties. A generalized k-means algorithm is used with the LCSS (and LCSS+FTSE) for clustering the triggers using a validity measure to determine the correct number of clusters in absence of any prior knowledge. The results have been demonstrated by simulations and by application to a segment of real LIGO data from the sixth science run.Comment: 16 pages, 16 figure

Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis

The goal of this investigation was to determine whether chenodeoxycholic acid (CDCA)-induced apoptosis is prevented by ursodeoxycholic acid (UDCA) or tauroursodeoxycholic acid (TUDC) and to characterize the involvement of mitochondria in the process. Cultured human HepG2 cells were treated in a dose- and time-dependent protocol in order to establish a sufficiently low exposure to CDCA that causes apoptosis but not necrosis. Low-dose CDCA induced an S-phase block and G2 arrest of the cell cycle, as determined by flow cytometry. As a result, cell proliferation was inhibited. CDCA-induced apoptosis, as determined by fluorescence microscopy of Hoechst 33342-stained nuclei, was evident upon coincubation with TUDC. Additionally, after exposure to UDCA plus CDCA, the cell membrane was permeable to fluorescent dyes. Caspase-9-like activity, poly(ADP-ribose) polymerase (PARP) cleavage, and extensive DNA fragmentation were detected in CDCA-exposed cells and in cells coincubated with TUDC, but not UDCA. CDCA caused a decrease in mitochondrial membrane potential and depletion of ATP, both of which were potentiated by UDCA but not TUDC. The results suggest that UDCA potentiates CDCA cytotoxicity, probably at the level of induction of the mitochondrial permeability transition (MPT). Consequently, as suggested by the lack of the main hallmarks of the apoptotic pathway, in the presence of UDCA, CDCA-induced apoptosis is not properly executed but degenerates into necrosis