Substituição valvar cardíaca em ovinos – Descrição da técnica operatória e análise dos resultados

To evaluate the technical proceduresof a research protocol with tissue-engineered heartvalves in sheep, the surgical techniques for pulmonic,aortic and mitral valve replacement and the outcomeof 58 heart valve surgeries was analyzed. Thesheeps (age 18 ± 7 weeks and body weigh 30 ± 9.9kg) were implanted with valve bioprosthesis understandard protocols. Forty animals received pulmonicvalve prosthesis, fourteen animals received aorticprosthesis and four animals were implanted withmitral prosthesis. The fourth intercostal space wereconsidered the best for all operative techniques.The cardiopulmonary bypass (CPB) method throughcanulation of descending aorta and right atrial wereconsidered fast and secure. The CPB time of pulmonicvalve replacement was 34 ± 14 minutes and mortalityrate was 7,5%. The CPB time of subcoronarian aorticvalve implantation was 119 ± 5 minutes and themortality rate was 57%. In mitral substitution the CPBtime was 74 ± 22 minutes and mortality was 50%.The technique of pulmonic valve replacement wasvery efficient, however the mortality rate of both aorticand mitral valve surgery, associated with the highlysurgical technical complexity and elevated CPB time,require technical refinements to improve exploitationof the animals on the left side cardiac surgeries.Visando avaliar um protocolo experimentalde pesquisa com próteses valvares cardíacas emovinos, as técnicas cirúrgicas de substituição valvarpulmonar, aórtica e mitral de 58 cirurgias cardíacas foramanalisadas. Através de procedimentos padronizadosos ovinos (idade 18 ± 7 semanas e o peso 30 ± 9.9kg) foram submetidos ao implante de próteses valvaresbiológicas. Quarenta animais receberam prótesesvalvares pulmonares, 14 animais receberam prótesesaórticas e quatro animais receberam próteses mitrais.O quarto espaço inter-costal foi considerado de eleiçãopara realização das três técnicas operatórias avaliadas.O método de circulação extracorpórea (CPB)por canulação da aorta descendente e do átrio direitofoi considerado rápido e seguro. O tempo de CPB durantea substituição valvar pulmonar foi de 34 ± 14minutos e a mortalidade 7,5%. A substituição valvaraórtica, com implante subcoronariano, teve tempo deCPB 119 ± 5 minutos e mortalidade de 57%. Durantea substituição valvar mitral o tempo de CPB foi 74 ±22 minutos e mortalidade 50%. A técnica de implantevalvar pulmonar foi muito eficiente, entretanto a altamortalidade das técnicas de implante valvar aórtico emitral, associadas à maior complexidade cirúrgica eelevado tempo de CPB, faz necessário refinamentostécnicos para melhorar o aproveitamento dos animaisnas cirurgias das valvas cardíadas esquerdas

Disordered Electrons in a Strong Magnetic Field: Transfer Matrix Approaches to the Statistics of the Local Density of States

We present two novel approaches to establish the local density of states as an order parameter field for the Anderson transition problem. We first demonstrate for 2D quantum Hall systems the validity of conformal scaling relations which are characteristic of order parameter fields. Second we show the equivalence between the critical statistics of eigenvectors of the Hamiltonian and of the transfer matrix, respectively. Based on this equivalence we obtain the order parameter exponent $\alpha_0\approx 3.4$ for 3D quantum Hall systems.Comment: 4 pages, 3 Postscript figures, corrected scale in Fig.

Localization in non-chiral network models for two-dimensional disordered wave mechanical systems

Scattering theoretical network models for general coherent wave mechanical systems with quenched disorder are investigated. We focus on universality classes for two dimensional systems with no preferred orientation: Systems of spinless waves undergoing scattering events with broken or unbroken time reversal symmetry and systems of spin 1/2 waves with time reversal symmetric scattering. The phase diagram in the parameter space of scattering strengths is determined. The model breaking time reversal symmetry contains the critical point of quantum Hall systems but, like the model with unbroken time reversal symmetry, only one attractive fixed point, namely that of strong localization. Multifractal exponents and quasi-one-dimensional localization lengths are calculated numerically and found to be related by conformal invariance. Furthermore, they agree quantitatively with theoretical predictions. For non-vanishing spin scattering strength the spin 1/2 systems show localization-delocalization transitions.Comment: 4 pages, REVTeX, 4 figures (postscript

Tunable Charge Density Wave Transport in a Current-Effect Transistor

The collective charge density wave (CDW) conduction is modulated by a transverse single-particle current in a transistor-like device. Nonequilibrium conditions in this geometry lead to an exponential reduction of the depinning threshold, allowing the CDWs to slide for much lower bias fields. The results are in excellent agreement with a recently proposed dynamical model in which ''wrinkles'' in the CDW wavefronts are ''ironed'' by the transverse current. The experiment might have important implications for other driven periodic media, such as moving vortex lattices or ''striped phases'' in high-Tc superconductors.Comment: 4 pages, 4 figure

Monocyte migration to the synovium in rheumatoid arthritis patients treated with adalimumab

Objectives The mechanism of action of treatment with tumour necrosis factor (TNF) blockers in rheumatoid arthritis (RA) is still not completely understood. The aim of this study was to test if adalimumab treatment could affect the influx of monocytes into the synovium. Methods A novel technique was used to analyse the migration of labelled autologous monocytes before and 14 days after initiation of adalimumab treatment using scintigraphy. CD14 monocytes were isolated from patients with RA, using a positive selection procedure with magnetic-activated cell sorting, and labelled with technetium-99m-hexamethylpropylene-amino-oxime. Scintigraphic scans were made 1, 2 and 3 h after re-infusion. Results As early as 14 days after the start of treatment with adalimumab a significant decrease in disease activity score evaluated in 28 joints was shown. There was no significant decrease in the influx of monocytes into the joint at this time. Conclusions This study indicates that adalimumab treatment does not reduce the influx of monocytes into the synovium early after initiation of treatment. As previous studies showed a rapid decrease in macrophage infiltration after TNF-antibody therapy, which could not be explained by increased cell death, this points to an important role for enhanced efflux of inflammatory cells from the synoviu

Leading-effect vs. Risk-taking in Dynamic Tournaments: Evidence from a Real-life Randomized Experiment

Two 'order effects' may emerge in dynamic tournaments with information feedback. First, participants adjust effort across stages, which could advantage the leading participant who faces a larger 'effective prize' after an initial victory (leading-effect). Second, participants lagging behind may increase risk at the final stage as they have 'nothing to lose' (risk-taking). We use a randomized natural experiment in professional two-game soccer tournaments where the treatment (order of a stage-specific advantage) and team characteristics, e.g. ability, are independent. We develop an identification strategy to test for leading-effects controlling for risk-taking. We find no evidence of leading-effects and negligible risk-taking effects

Effect of FCNC mediated Z boson on lepton flavor violating decays

We study the three body lepton flavor violating (LFV) decays $\mu^- \to e^- e^+ e^-$, $\tau^- \to l_i^- l_j^+ l_j^-$ and the semileptonic decay $\tau \to \mu \phi$ in the flavor changing neutral current (FCNC) mediated $Z$ boson model. We also calculate the branching ratios for LFV leptonic B decays, $B_{d,s} \to \mu e$, $B_{d,s} \to \tau e$, $B_{d,s} \to \tau \mu$ and the conversion of muon to electron in Ti nucleus. The new physics parameter space is constrained by using the experimental limits on $\mu^- \to e^- e^+ e^-$ and $\tau^- \to \mu^- \mu^+ \mu^-$. We find that the branching ratios for $\tau \to eee$ and $\tau \to \mu \phi$ processes could be as large as $\sim {\cal O}(10^{-8})$ and ${\rm Br}B_{d,s} \to \tau \mu, \tau e) \sim {\cal O}(10^{-10})$. For other LFV B decays the branching ratios are found to be too small to be observed in the near future.Comment: 15 pages, 8 figures, typos corrected, one more section added, version to appear in EPJ

Flavon exchange effects in models with abelian flavor symmetry

In models with abelian flavor symmetry the small mixing angles and mass ratios of quarks and leptons are typically given by powers of small parameters characterizing the spontaneous breaking of flavor symmetry by "flavon" fields. If the scale of the breaking of flavor symmetry is near the weak scale, flavon exchange can lead to interesting flavor-violating and CP violating effects. These are studied. It is found that d_e, mu -> e + gamma, and mu-e conversion on nuclei can be near present limits. For significant range of parameters mu-e conversion can be the most sensitive way to look for such effects.Comment: 19 pages, 5 Postscript figures, LATE