818 research outputs found
On the Similarity of Functional Connectivity between Neurons Estimated across Timescales
A central objective in neuroscience is to understand how neurons interact. Such functional interactions have been estimated using signals recorded with different techniques and, consequently, different temporal resolutions. For example, spike data often have sub-millisecond resolution while some imaging techniques may have a resolution of many seconds. Here we use multi-electrode spike recordings to ask how similar functional connectivity inferred from slower timescale signals is to the one inferred from fast timescale signals. We find that functional connectivity is relatively robust to low-pass filtering—dropping by about 10% when low pass filtering at 10 hz and about 50% when low pass filtering down to about 1 Hz—and that estimates are robust to high levels of additive noise. Moreover, there is a weak correlation for physiological filters such as hemodynamic or Ca2+ impulse responses and filters based on local field potentials. We address the origin of these correlations using simulation techniques and find evidence that the similarity between functional connectivity estimated across timescales is due to processes that do not depend on fast pair-wise interactions alone. Rather, it appears that connectivity on multiple timescales or common-input related to stimuli or movement drives the observed correlations. Despite this qualification, our results suggest that techniques with intermediate temporal resolution may yield good estimates of the functional connections between individual neurons
Ten steps or climbing a mountain: A study of Australian health professionals' perceptions of implementing the baby friendly health initiative to protect, promote and support breastfeeding
Background: The Baby Friendly Hospital (Health) Initiative (BFHI) is a global initiative aimed at protecting,
promoting and supporting breastfeeding and is based on the ten steps to successful breastfeeding. Worldwide,
over 20,000 health facilities have attained BFHI accreditation but only 77 Australian hospitals (approximately 23%)
have received accreditation. Few studies have investigated the factors that facilitate or hinder implementation of
BFHI but it is acknowledged this is a major undertaking requiring strategic planning and change management
throughout an institution. This paper examines the perceptions of BFHI held by midwives and nurses working in
one Area Health Service in NSW, Australia.
Methods: The study used an interpretive, qualitative approach. A total of 132 health professionals, working across four maternity units, two neonatal intensive care units and related community services, participated in 10 focus groups. Data were analysed using thematic analysis.
Results: Three main themes were identified: ‘Belief and Commitment’; ‘Interpreting BFHI’ and ‘Climbing a
Mountain’. Participants considered the BFHI implementation a high priority; an essential set of practices that would
have positive benefits for babies and mothers both locally and globally as well as for health professionals. It was
considered achievable but would take commitment and hard work to overcome the numerous challenges including a number of organisational constraints. There were, however, differing interpretations of what was required to attain BFHI accreditation with the potential that misinterpretation could hinder implementation.
A model described by Greenhalgh and colleagues on adoption of innovation is drawn on to interpret the findings.
Conclusion: Despite strong support for BFHI, the principles of this global strategy are interpreted differently by
health professionals and further education and accurate information is required. It may be that the current
processes used to disseminate and implement BFHI need to be reviewed. The findings suggest that there is a
contradiction between the broad philosophical stance and best practice approach of this global strategy and the
tendency for health professionals to focus on the ten steps as a set of tasks or a checklist to be accomplished. The
perceived procedural approach to implementation may be contributing to lower rates of breastfeeding
continuation
Can proprioceptive training improve motor learning
work has investigated the link between motor learning and sensory function in arm movement control. A number of findings are consistent with the idea that motor learning is associated with systematic changes to proprioception (Haith A, Jackson C, Mial R, Vijayakumar S
Interactions between a Trawl Fishery and Spatial Closures for Biodiversity Conservation in the Great Barrier Reef World Heritage Area, Australia
Background\ud
The Queensland East Coast Otter Trawl Fishery (ECOTF) for penaeid shrimp fishes within Australia's Great Barrier Reef World Heritage Area (GBRWHA). The past decade has seen the implementation of conservation and fisheries management strategies to reduce the impact of the ECOTF on the seabed and improve biodiversity conservation. New information from electronic vessel location monitoring systems (VMS) provides an opportunity to review the interactions between the ECOTF and spatial closures for biodiversity conservation.\ud
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Methodology and Results\ud
We used fishing metrics and spatial information on the distribution of closures and modelled VMS data in a geographical information system (GIS) to assess change in effort of the trawl fishery from 2001–2009 and to quantify the exposure of 70 reef, non-reef and deep water bioregions to trawl fishing. The number of trawlers and the number of days fished almost halved between 2001 and 2009 and new spatial closures introduced in 2004 reduced the area zoned available for trawl fishing by 33%. However, we found that there was only a relatively minor change in the spatial footprint of the fishery as a result of new spatial closures. Non-reef bioregions benefited the most from new spatial closures followed by deep and reef bioregions.\ud
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Conclusions/Significance\ud
Although the catch of non target species remains an issue of concern for fisheries management, the small spatial footprint of the ECOTF relative to the size of the GBRWHA means that the impact on benthic habitats is likely to be negligible. The decline in effort as a result of fishing industry structural adjustment, increasing variable costs and business decisions of fishers is likely to continue a trend to fish only in the most productive areas. This will provide protection for most benthic habitats without any further legislative or management intervention
Adaptation to Delayed Force Perturbations in Reaching Movements
Adaptation to deterministic force perturbations during reaching movements was extensively studied in the last few decades. Here, we use this methodology to explore the ability of the brain to adapt to a delayed velocity-dependent force field. Two groups of subjects preformed a standard reaching experiment under a velocity dependent force field. The force was either immediately proportional to the current velocity (Control) or lagged it by 50 ms (Test). The results demonstrate clear adaptation to the delayed force perturbations. Deviations from a straight line during catch trials were shifted in time compared to post-adaptation to a non-delayed velocity dependent field (Control), indicating expectation to the delayed force field. Adaptation to force fields is considered to be a process in which the motor system predicts the forces to be expected based on the state that a limb will assume in response to motor commands. This study demonstrates for the first time that the temporal window of this prediction needs not to be fixed. This is relevant to the ability of the adaptive mechanisms to compensate for variability in the transmission of information across the sensory-motor system
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Characterisation of proguanylin expressing cells in the intestine – evidence for constitutive luminal secretion
Abstract: Guanylin, a peptide implicated in regulation of intestinal fluid secretion, is expressed in the mucosa, but the exact cellular origin remains controversial. In a new transgenic mouse model fluorescent reporter protein expression driven by the proguanylin promoter was observed throughout the small intestine and colon in goblet and Paneth(-like) cells and, except in duodenum, in mature enterocytes. In Ussing chamber experiments employing both human and mouse intestinal tissue, proguanylin was released predominantly in the luminal direction. Measurements of proguanylin expression and secretion in cell lines and organoids indicated that secretion is largely constitutive and requires ER to Golgi transport but was not acutely regulated by salt or other stimuli. Using a newly-developed proguanylin assay, we found plasma levels to be raised in humans after total gastrectomy or intestinal transplantation, but largely unresponsive to nutrient ingestion. By LC-MS/MS we identified processed forms in tissue and luminal extracts, but in plasma we only detected full-length proguanylin. Our transgenic approach provides information about the cellular origins of proguanylin, complementing previous immunohistochemical and in-situ hybridisation results. The identification of processed forms of proguanylin in the intestinal lumen but not in plasma supports the notion that the primary site of action is the gut itself
Influences of tongue biomechanics on speech movements during the production of velar stop consonants: a modeling study
This study explores the following hypothesis: forward looping movements of
the tongue that are observed in VCV sequences are due partly to the anatomical
arrangement of the tongue muscles and how they are used to produce a velar
closure. The study uses an anatomically based 2D biomechanical tongue model.
Tissue elastic properties are accounted for in finite-element modeling, and
movement is controlled by constant-rate control parameter shifts. Tongue
raising and lowering movements are produced by the model with the combined
actions of the genioglossus, styloglossus and hyoglossus. Simulations of V1CV2
movements were made, where C is a velar consonant and V is [a], [i] or [u]. If
V1 is one of the vowels [a] and [u], the resulting trajectories describe
movements that begin to loop forward before consonant closure and continue to
slide along the palate during the closure. This prediction is in agreement with
classical data published in the literature. If V1 is vowel [i], we observe a
small backward movement. This is also in agreement with some measurements on
human speakers, but it is also in contradiction with the original data
published by Houde (1967). These observations support the idea that the
biomechanical properties of the tongue could be the main factor responsible for
the forward loops when V1 is a back vowel. In the left [i] context, it seems
that additional factors have to be taken into considerations, in order to
explain the observations made on some speaker
Mechanisms of Interference in Vibrotactile Working Memory
In previous studies of interference in vibrotactile working memory, subjects were presented with an interfering distractor stimulus during the delay period between the target and probe stimuli in a delayed match-to-sample task. The accuracy of same/different decisions indicated feature overwriting was the mechanism of interference. However, the distractor was presented late in the delay period, and the distractor may have interfered with the decision-making process, rather than the maintenance of stored information. The present study varies the timing of distractor onset, (either early, in the middle, or late in the delay period), and demonstrates both overwriting and non-overwriting forms of interference
Mechanisms explaining transitions between tonic and phasic firing in neuronal populations as predicted by a low dimensional firing rate model
Several firing patterns experimentally observed in neural populations have
been successfully correlated to animal behavior. Population bursting, hereby
regarded as a period of high firing rate followed by a period of quiescence, is
typically observed in groups of neurons during behavior. Biophysical
membrane-potential models of single cell bursting involve at least three
equations. Extending such models to study the collective behavior of neural
populations involves thousands of equations and can be very expensive
computationally. For this reason, low dimensional population models that
capture biophysical aspects of networks are needed.
\noindent The present paper uses a firing-rate model to study mechanisms that
trigger and stop transitions between tonic and phasic population firing. These
mechanisms are captured through a two-dimensional system, which can potentially
be extended to include interactions between different areas of the nervous
system with a small number of equations. The typical behavior of midbrain
dopaminergic neurons in the rodent is used as an example to illustrate and
interpret our results.
\noindent The model presented here can be used as a building block to study
interactions between networks of neurons. This theoretical approach may help
contextualize and understand the factors involved in regulating burst firing in
populations and how it may modulate distinct aspects of behavior.Comment: 25 pages (including references and appendices); 12 figures uploaded
as separate file
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