Collisionless Damping of Fast MHD Waves in Magneto-rotational Winds

We propose collisionless damping of fast MHD waves as an important mechanism for the heating and acceleration of winds from rotating stars. Stellar rotation causes magnetic field lines anchored at the surface to form a spiral pattern and magneto-rotational winds can be driven. If the structure is a magnetically dominated, fast MHD waves generated at the surface can propagate almost radially outward and cross the field lines. The propagating waves undergo collisionless damping owing to interactions with particles surfing on magnetic mirrors that are formed by the waves themselves. The damping is especially effective where the angle between the wave propagation and the field lines becomes moderately large ($\sim 20$ to $80^{\circ}$). The angle tends naturally to increase into this range because the field in magneto-rotational winds develops an increasingly large azimuthal component. The dissipation of the wave energy produces heating and acceleration of the outflow. We show using specified wind structures that this damping process can be important in both solar-type stars and massive stars that have moderately large rotation rates. This mechanism can play a role in coronae of young solar-type stars which are rapidly rotating and show X-ray luminosities much larger than the sun. The mechanism could also be important for producing the extended X-ray emitting regions inferred to exist in massive stars of spectral type middle B and later.Comment: 12 pages, including 7 figures, accepted for publication in Ap

The complete catalogue of gamma-ray bursts observed by the Wide Field Cameras on board BeppoSAX

We present the complete on-line catalogue of gamma-ray bursts observed by the two Wide Field Cameras on board \sax in the period 1996-2002. Our aim is to provide the community with the largest published data set of GRB's prompt emission X-ray light curves and other useful data. This catalogue (BS-GRBWFCcat) contains data on 77 bursts and a collection of the X-ray light curves of 56 GRB discovered or noticed shortly after the event and of other additional bursts detected in subsequent searches. Light curves are given in the three X-ray energy bands (2-5, 5-10, 10-26 keV). The catalogue can be accessed from the home web page of the ASI Science Data Center-ASDC (http://www.asdc.asi.it)Comment: 4 pages, 3 figure

Safe use of radiopharmaceuticals in patients with chronic kidney disease:A systematic review

BACKGROUND: Patients with chronic kidney disease (CKD) may need to have their radiopharmaceutical dosage adjusted to prevent adverse effects and poor outcomes, but there are few recommendations on radiopharmaceutical dosing for this group of patients. The aim of this study is to provide an overview of the available information on radiopharmaceutical dose recommendations for patients with CKD. METHODS: We performed a systematic literature review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. We conducted a literature search in the MEDLINE (PubMed) and Embase databases and screened potentially relevant studies using inclusion and exclusion criteria. We independently assessed the included observational studies’ methodologies and extracted relevant data. RESULTS: Of the 5795 studies first identified, 34 were included in this systematic review. These studies described three radiopharmaceuticals: [(131)I]sodium iodine, [(18)F]fludeoxyglucose, and [(131)I]iobenguane. Twenty-nine studies (85.3%) reported data on patients with CKD stage 5, while only three studies mentioned CKD patients in other stages (8.8%). CONCLUSION: We found no consistent recommendations for radiopharmaceutical dosing in patients with CKD. Although some studies do mention dosing difficulties in patients with CKD, information is available for only a few radiopharmaceuticals, and recommendations are sometimes contradictory. Further research on radiopharmaceutical dosing in patients with CKD is needed to determine whether these patients require specific dosing, especially for therapeutic radiopharmaceuticals where a non-optimised dose may lead to an increased risk of toxicity for non-targeted organs. Including patients with CKD in studies and providing specific information about dosing in these patients should be a priority for the radiopharmaceutical community

Geometric Parameterization of J/ΨJ/\Psi Absorption in Heavy Ion Collisions

We calculate the survival probability of $J/\Psi$ particles in various colliding systems using a Glauber model. An analysis of recent data has reported a $J/\Psi$-nucleon breakup cross section of 6.2$\pm$0.7 mb derived from an exponential fit to the ratio of $J/\Psi$ to Drell-Yan yields as a function of a simple, linearly-averaged mean path length through the nuclear medium. Our calculations indicate that, due to the nature of the calculation, this approach yields an apparent breakup cross section which is systematically lower than the actual value.Comment: LaTex, 7 pages, 2 figure

Patient-Reported Adverse Events of Radiopharmaceuticals:Development and Validation of a Questionnaire

Introduction Radiopharmaceuticals may cause adverse events. Knowledge about adverse events from a patient's perspective could help healthcare professionals to detect, understand, and manage adverse events more efficiently when using radiopharmaceuticals. Researchers need a validated questionnaire that can be used in patients to assess adverse events with radiopharmaceuticals. Objective The aim of this study was to develop, validate the content of, and perform initial testing of a questionnaire assessing patient-reported adverse events of radiopharmaceuticals. Methods Based on existing literature, six professionals drafted and evaluated a first version of the questionnaire. Further content validation was performed using cognitive interviews with six patients undergoing a nuclear medicine examination. After adaptations, the questionnaire was developed into a web-based questionnaire. One hundred patients undergoing nuclear examination tested this version, and the results were used to assess its acceptability and evaluate reported adverse events. Results Questions and answer options were revised in the initial questionnaire to improve clarity. In addition, some questions were removed. The final version consisted of 18 questions. In the test phase, the acceptability of the questionnaire was demonstrated (e.g. 79% of the patients who received the questionnaire completed it, and the median time to complete the questionnaire was 12 min for patients who reported an adverse event). Of the 100 patients (53% men, median age 64 years), 12 reported a total of 22 adverse events. One of these adverse events had a high causal association. Conclusion After validation and testing, the developed questionnaire to study patient-reported adverse events of radiopharmaceuticals is a suitable and valid instrument which can be used in future research

The Missing Luminous Blue Variables and the Bistability Jump

We discuss an interesting feature of the distribution of luminous blue variables on the H-R diagram, and we propose a connection with the bistability jump in the winds of early-type supergiants. There appears to be a deficiency of quiescent LBVs on the S Dor instability strip at luminosities between log L/Lsun = 5.6 and 5.8. The upper boundary, is also where the temperature-dependent S Dor instability strip intersects the bistability jump at about 21,000 K. Due to increased opacity, winds of early-type supergiants are slower and denser on the cool side of the bistability jump, and we postulate that this may trigger optically-thick winds that inhibit quiescent LBVs from residing there. We conduct numerical simulations of radiation-driven winds for a range of temperatures, masses, and velocity laws at log L/Lsun=5.7 to see what effect the bistability jump should have. We find that for relatively low stellar masses the increase in wind density at the bistability jump leads to the formation of a modest to strong pseudo photosphere -- enough to make an early B-type star appear as a yellow hypergiant. Thus, the proposed mechanism will be most relevant for LBVs that are post-red supergiants. Yellow hypergiants like IRC+10420 and rho Cas occupy the same luminosity range as the ``missing'' LBVs, and show apparent temperature variations at constant luminosity. If these yellow hypergiants do eventually become Wolf-Rayet stars, we speculate that they may skip the normal LBV phase, at least as far as their apparent positions on the HR diagram are concerned.Comment: 20 pages, 4 figs, accepted by Ap

Transversity and Transverse Spin in Nucleon Structure through SIDIS at Jefferson Lab

The JLab 12 GeV upgrade with a proposed solenoid detector and the CLAS12 detector can provide the granularity and three-dimensional kinematic coverage in longitudinal and transverse momentum, $0.1\le x \le 0.5$, $0.3 \le z \le 0.7$ with $P_T \le 1.5 {\rm GeV}$ to precisely measure the leading twist chiral-odd and $T$-odd quark distribution and fragmentation functions in SIDIS. The large $x$ experimental reach of these detectors with a 12 GeV CEBAF at JLab makes it {\em ideal} to obtain precise data on the {\em valence-dominated} transversity distribution function and to access the tensor charge.Comment: 7 Pages, 2 figures. Summary of the working group on Transversity and Transverse Spin Physics, from the workshop, "Inclusive and Semi-Inclusive Spin Physics with High Luminosity and LargeAcceptance at 11 GeV", Thomas Jefferson National Accelerator Facility (JLAB), December 13-14, 2006, Jefferson Lab, Newport News, VA USA. Serves as input for the Nuclear Physics Long Range Plan on QCD and Hadron Physic

Single-Cell Detection of Secreted A and sAPP from Human IPSC-Derived Neurons and Astrocytes

Secreted factors play a central role in normal and pathological processes in every tissue in the body. The brain is composed of a highly complex milieu of different cell types and few methods exist that can identify which individual cells in a complex mixture are secreting specific analytes. By identifying which cells are responsible, we can better understand neural physiology and pathophysiology, more readily identify the underlying pathways responsible for analyte production, and ultimately use this information to guide the development of novel therapeutic strategies that target the cell types of relevance. We present here a method for detecting analytes secreted from single human induced pluripotent stem cell (iPSC)-derived neural cells and have applied the method to measure amyloid β (Aβ) and soluble amyloid precursor protein-alpha (sAPPα), analytes central to Alzheimer's disease pathogenesis. Through these studies, we have uncovered the dynamic range of secretion profiles of these analytes from single iPSC-derived neuronal and glial cells and have molecularly characterized subpopulations of these cells through immunostaining and gene expression analyses. In examining Aβ and sAPPα secretion from single cells, we were able to identify previously unappreciated complexities in the biology of APP cleavage that could not otherwise have been found by studying averaged responses over pools of cells. This technique can be readily adapted to the detection of other analytes secreted by neural cells, which would have the potential to open new perspectives into human CNS development and dysfunction.W. M. Keck FoundationNational Institute of Mental Health (U.S.) (R21MH096233)National Institute on Aging (R33AG049864)National Cancer Institute (U.S.) (P30-CA14051

Gamma rays and neutrinos from the Crab Nebula produced by pulsar accelerated nuclei

We investigate the consequences of the acceleration of heavy nuclei (e.g. iron nuclei) by the Crab pulsar. Accelerated nuclei can photodisintegrate in collisions with soft photons produced in the pulsar's outer gap, injecting energetic neutrons which decay either inside or outside the Crab Nebula. The protons from neutron decay inside the nebula are trapped by the Crab Nebula magnetic field, and accumulate inside the nebula producing gamma-rays and neutrinos in collisions with the matter in the nebula. Neutrons decaying outside the Crab Nebula contribute to the Galactic cosmic rays. We compute the expected fluxes of gamma-rays and neutrinos, and find that our model could account for the observed emission at high energies and may be tested by searching for high energy neutrinos with future neutrino telescopes currently in the design stage.Comment: 8 pages, 4 figures, LaTeX uses revtex.sty, submitted to Phys. Rev. Let