13 research outputs found
Anomalous Hall effect in the Co-based Heusler compounds CoFeSi and CoFeAl
The anomalous Hall effect (AHE) in the Heusler compounds CoFeSi and
CoFeAl is studied in dependence of the annealing temperature to achieve a
general comprehension of its origin. We have demonstrated that the crystal
quality affected by annealing processes is a significant control parameter to
tune the electrical resistivity as well as the anomalous Hall
resistivity . Analyzing the scaling behavior of in
terms of points to a temperature-dependent skew scattering as the
dominant mechanism in both Heusler compounds
Local charge and spin currents in magnetothermal landscapes
A scannable laser beam is used to generate local thermal gradients in
metallic (Co2FeAl) or insulating (Y3Fe5O12) ferromagnetic thin films. We study
the resulting local charge and spin currents that arise due to the anomalous
Nernst effect (ANE) and the spin Seebeck effect (SSE), respectively. In the
local ANE experiments, we detect the voltage in the Co2FeAl thin film plane as
a function of the laser spot position and external magnetic field magnitude and
orientation. The local SSE effect is detected in a similar fashion by
exploiting the inverse spin Hall effect in a Pt layer deposited on top of the
Y3Fe5O12. Our findings establish local thermal spin and charge current
generation as well as spin caloritronic domain imaging
Anomalous Hall effect in perpendicularly magnetized Mn3-xGa thin films
Glas M, Ebke D, Imort I-M, Thomas P, Reiss G. Anomalous Hall effect in perpendicularly magnetized Mn3-xGa thin films. Journal Of Magnetism And Magnetic Materials. 2013;333:134-137.Mn3-xGa (x=0.1, 0.4, 0.7) thin films on MgO and SrTiO3 substrates were investigated with magnetic anisotropy perpendicular to the film plane. An anomalous Hall effect was observed for the tetragonal distorted lattice in the crystallographic D0(22) phase. The Hall resistivity Q(xy) was measured in a temperature range from 20 to 330 K. The determined skew scattering and side jump coefficients are discussed with regard to the film composition and used substrate and compared to the crystallographic and magnetic properties. (C) 2012 Elsevier By. All rights reserved
Effects of Differentiation-Inducing Agents on Synthesis, Maturation and Secretion of Cathepsin D in U937 and HL-60 Cells
Structural Insights into the Mechanism of pH-dependent Ligand Binding and Release by the Cation-dependent Mannose 6-Phosphate Receptor*S⃞
The cation-dependent mannose 6-phosphate receptor (CD-MPR) is a key
component of the lysosomal enzyme targeting system that binds newly
synthesized mannose 6-phosphate (Man-6-P)-containing acid hydrolases and
transports them to endosomal compartments. The interaction between the MPRs
and its ligands is pH-dependent; the homodimeric CD-MPR binds lysosomal
enzymes optimally in the pH environment of the trans Golgi network
(pH ∼ 6.5) and releases its cargo in acidic endosomal compartments (<pH
5.5) and at the cell surface. In addition, CD-MPR binding affinities are
modulated by divalent cations. Our previous crystallographic studies have
shown that at pH 6.5, the CD-MPR bound to Man-6-P adopts a significantly
different quaternary conformation than the CD-MPR in a ligand-unbound state, a
feature unique among known lectin structures. To determine whether different
pH conditions elicit conformational changes in the receptor that alters ligand
binding affinities, we have obtained additional crystal structures
representative of the various environments encountered by the receptor
including: 1) the CD-MPR bound at pH 6.5 (i.e. trans Golgi network)
to a high affinity ligand (the terminally phosphorylated trisaccharide
P-Man(α1,2)Man(α1,2)Man-O-(CH2)8COOMe), 2)
the CD-MPR at pH 4.8 in an unbound state (i.e. endosome), and 3) the
CD-MPR at pH 7.4 (i.e. cell surface). A detailed comparison of the
available CD-MPR structures reveals the positional invariability of specific
binding pocket residues and implicates intermonomer contact(s), as well as the
protonation state of Man-6-P, as regulators of pH-dependent carbohydrate
binding
Intermonomer Interactions Are Essential for Lysosomal Enzyme Binding by the Cation-Dependent Mannose 6-Phosphate Receptor
Size-dependent electrical transport properties in Co nanocluster-assembled granular films
Half-Metallic Ferrimagnetic Characteristics of Co2YZ (Z = P, As, Sb, and Bi) New Full-Heusler Alloys: a DFT Study
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Randomised multicentre effectiveness trial of rapid syndromic testing by panel assay in children presenting to European emergency departments with acute respiratory infections-trial protocol for the ADEQUATE Paediatric trial
Introduction Syndromic panel assays, that is, using one test to simultaneously target multiple pathogens with overlapping signs and symptoms, have been integrated into routine paediatric care over the past decade, mainly for more severely ill and hospitalised patients. Their wider availability and short turnaround times open the possibility to apply them to non-hospitalised patients as well. In this context, it is important to trial how clinicians make use of pathogen detection data and if their early availability influences management decisions, particularly antibiotic use and hospitalisation.
Methods and analysis Advanced Diagnostics for Enhanced QUality of Antibiotic prescription in respiratory Tract infections in Emergency rooms is an individually randomised, controlled, open-label effectiveness trial comparing the impact of a respiratory pathogen panel assay (BIOFIRE Respiratory Panel 2.1plus) used as a rapid syndromic test on nasopharyngeal swabs in addition to the standard of care versus standard of care alone. The trial will 1:1 randomise 520 participants under the age of 18 at 7 paediatric emergency departments in 5 European countries. Inclusion criteria for the trial consist of two sets, with the first describing respiratory tract infections in paediatric patients and the second describing the situation of potential management uncertainty in which test results may immediately affect management decisions. Enrolment started in July 2021 and is expected to be completed in early 2024. We will perform a two-sample t-test assuming a pooled variance estimate to compare the log-transformed mean time on antibiotic treatment (in hours) and number of days alive out of the hospital within 14 days after study enrolment between the control and intervention arms.
Ethics and dissemination The trial protocol and materials were approved by research ethics committees in all participating countries. The respiratory pathogen panel assay is CE marked (assessed to meet European regulations) and FDA (United States Food and Drug Administration) cleared for diagnostic use. Participants and caregivers provide informed consent prior to study procedures commencing. The trial results will be published in peer-reviewed journals and at national and international conferences. Key messages will also be disseminated via press and social media where appropriate