Comparison of cell-surface glycoproteins of rat hepatomas and embryonic rat liver.

Cell-surface glycoprotein of 3 rat hepatoma strains and late-embryonic liver was metabolically labelled in vivo with [3H]- or [14C]-fucose. Trypsinization of the cells and exhaustive pronase digestion of combined hepatoma-liver trypsinates followed by gel filtration over Sephadex-Biogel mixtures, yielded elution profiles that contained more early-eluting (high-mol.-wt.) glycopeptides for hepatomas than for liver. At least 3 factors were identified which acted to augment the fraction of early-eluting tumour glycopeptides: (a) increase of neuraminidase-sensitive sialic acid, (b) increase of neuraminidase-insensitive sialic acid that was sensitive to mild HCl hydrolysis, and (c) presence of sugar sulphate groups contributing to a restricted extent, relative to possible unknown factor(s). Whether (a), (b) or (c) operated depended on the hepatoma strain or its mode of growth. Notwithstanding these differences in the nature of the increase in early-eluting glycopeptides, the increase itself appears not to be due to growth per se, nor to an embryonic expression, but rather may serve as a marker of tumourigenicity

Paramecium: An Extensible Object-Based Kernel

In this paper we describe the design of an extensible kernel, called Paramecium. This kernel uses an object-based software architecture which together with instance naming, late binding and explicit overrides enables easy reconfiguration. Determining which components reside in the kernel protection domain is up to the user. An certification authority or one of its delegates certifies which components are trustworthy and therefore permitted to run in the kernel protection domain. These delegates may include validation programs, correctness provers, and system administrators. The main advantage of certifications is that it can handle trust and sharing in a non-cooperative environment

The Architectural Design of Globe: A Wide-Area Distributed System

. Developing large-scale wide-area applications requires an infrastructure that is presently lacking entirely. Currently, applications have to be built on top of raw communication services, such as TCP connections. All additional services, including those for naming, replication, migration, persistence, fault tolerance, and security, have to be implemented for each application anew. Not only is this a waste of effort, it also makes interoperability between different applications difficult or even impossible. We present a novel, object-based framework for developing wide-area distributed applications. The framework is based on the concept of a distributed shared object, which has the characteristic feature that its state can be physically distributed across multiple machines at the same time. All implementation aspects, including communication protocols, replication strategies, and distribution and migration of state, are part of an object and are hidden behind its interface. The curren..

Should Marketing be Cross-Functional? : Conceptual Development and International Empirical Evidence

While it has frequently been stated that decisions on marketing activities should be made cross-functionally, there is no empirical evidence that shows benefits of performing marketing activities in this way. This paper examines the link between the cross-functional dispersion of influence on marketing activities and performance at the SBU level and considers dynamism of the market which may moderate the strength of this relationship. Using data from a cross-national study in three industry sectors, the authors find that cross-functional dispersion of influence on marketing activities increases the performance of the SBU. They also find that the relationship between the cross-functional dispersion of influence on marketing activities is negatively influenced by dynamism of the market. This research thus provides empirical evidence for the positive performance implications of cross-functional interaction in the context of marketing activities

Unifying Internet Services Using Distributed Shared Objects

Developing wide area applications such as those for sharing data across the Internet is unnecessarily difficult. The main problem is the widespread use of a communication paradigm that is too low level. We will show how wide area application development can be made easier when using distributed shared objects instead of a communication-oriented model. An object in our model is physically distributed, with multiple copies of its state on different machines. All implementation aspects such as replication, distribution, and migration of state, are hidden from users through an object's interface. In this paper, we concentrate on the application of distributed shared objects, by providing an outline of a middleware solution that permits integration of the Internet services for e-mail, News, file transfer, and Web documents. vrije Universiteit Faculty of Mathematics and Computer Science 1 Introduction Constructing wide area applications, such as those for sharing data across the Internet,..

Should Marketing be Cross-Functional? : Conceptual Development and International Empirical Evidence

While it has frequently been stated that decisions on marketing activities should be made cross-functionally, there is no empirical evidence that shows benefits of performing marketing activities in this way. This paper examines the link between the cross-functional dispersion of influence on marketing activities and performance at the SBU level and considers dynamism of the market which may moderate the strength of this relationship. Using data from a cross-national study in three industry sectors, the authors find that cross-functional dispersion of influence on marketing activities increases the performance of the SBU. They also find that the relationship between the cross-functional dispersion of influence on marketing activities is negatively influenced by dynamism of the market. This research thus provides empirical evidence for the positive performance implications of cross-functional interaction in the context of marketing activities

Governance mechanisms in transnational business relationships

Empirical research on buyer-supplier relationships has almost exclusively examined domestic (both firms from the same country) exchange. The growing importance of international marketing and global sourcing suggest a need to understand relationships across national boundaries -- transnational business relationships. Drawing on theories of governance, the authors hypothesize differences in governance between domestic and transnational business relationships. They examine the use of three specific governance mechanisms (market governance, trust, and formal contracts) commonly employed in buyer-supplier relationships. Hypotheses are tested with data from 511 purchasing professionals in the United States and Germany (201 reporting on transnational relationships). Results indicate that market governance and trust are used less in transnational than in domestic relationships. No differences are found in the use of contracts. Implications for theory and practice are discussed

Performance impacts of strategic consensus : the role of strategy type and market-related dynamism

The authors examine the relationship between consensus on the type of SBU-level strategy among senior marketing and R&D-managers and organizational performance for a sample of 101 US and German SBUs in three industry sectors: consumer packaged goods, electrical equipment and components, and mechanical machinery. Findings indicate that consensus on the type of strategy increases the performance of the SBU in the case of a differentiation strategy while there are no performance impacts in the case of a low cost strategy. The strength of the relationship between consensus on a differentiation strategy and performance is negatively influenced by market-related dynamism