204 research outputs found
Impact of survey geometry and super-sample covariance on future photometric galaxy surveys
Photometric galaxy surveys probe the late-time Universe where the density field is highly non-Gaussian. A consequence is the emergence of the super-sample covariance (SSC), a non-Gaussian covariance term that is sensitive to fluctuations on scales larger than the survey window. In this work, we study the impact of the survey geometry on the SSC and, subsequently, on cosmological parameter inference. We devise a fast SSC approximation that accounts for the survey geometry and compare its performance to the common approximation of rescaling the results by the fraction of the sky covered by the survey, fSKY, dubbed ‘full-sky approximation’. To gauge the impact of our new SSC recipe, that we call ‘partial-sky’, we perform Fisher forecasts on the parameters of the (w0, wa)-CDM model in a 3 × 2 point analysis, varying the survey area, the geometry of the mask, and the galaxy distribution inside our redshift bins. The differences in the marginalised forecast errors –with the full-sky approximation performing poorly for small survey areas but excellently for stage-IV-like areas– are found to be absorbed by the marginalisation on galaxy bias nuisance parameters. For large survey areas, the unmarginalised errors are underestimated by about 10% for all probes considered. This is a hint that, even for stage-IV-like surveys, the partial-sky method introduced in this work will be necessary if tight priors are applied on these nuisance parameters. We make the partial-sky method public with a new release of the public code PySSC
The failed liberalisation of Algeria and the international context: a legacy of stable authoritarianism
The paper attempts to challenge the somewhat marginal role of international factors in the study of transitions to democracy. Theoretical and practical difficulties in proving causal mechanisms between international variables and domestic outcomes can be overcome by defining the international dimension in terms of Western dominance of world politics and by identifying Western actions towards democratising countries. The paper focuses on the case of Algeria, where international factors are key in explaining the initial process of democratisation and its following demise. In particular, the paper argues that direct Western policies, the pressures of the international system and external shocks influence the internal distribution of power and resources, which underpins the different strategies of all domestic actors. The paper concludes that analysis based purely on domestic factors cannot explain the process of democratisation and that international variables must be taken into more serious account and much more detailed
Intermediate filament cytoskeleton of the liver in health and disease
Intermediate filaments (IFs) represent the largest cytoskeletal gene family comprising ~70 genes expressed in tissue specific manner. In addition to scaffolding function, they form complex signaling platforms and interact with various kinases, adaptor, and apoptotic proteins. IFs are established cytoprotectants and IF variants are associated with >30 human diseases. Furthermore, IF-containing inclusion bodies are characteristic features of several neurodegenerative, muscular, and other disorders. Acidic (type I) and basic keratins (type II) build obligatory type I and type II heteropolymers and are expressed in epithelial cells. Adult hepatocytes contain K8 and K18 as their only cytoplasmic IF pair, whereas cholangiocytes express K7 and K19 in addition. K8/K18-deficient animals exhibit a marked susceptibility to various toxic agents and Fas-induced apoptosis. In humans, K8/K18 variants predispose to development of end-stage liver disease and acute liver failure (ALF). K8/K18 variants also associate with development of liver fibrosis in patients with chronic hepatitis C. Mallory-Denk bodies (MDBs) are protein aggregates consisting of ubiquitinated K8/K18, chaperones and sequestosome1/p62 (p62) as their major constituents. MDBs are found in various liver diseases including alcoholic and non-alcoholic steatohepatitis and can be formed in mice by feeding hepatotoxic substances griseofulvin and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC). MDBs also arise in cell culture after transfection with K8/K18, ubiquitin, and p62. Major factors that determine MDB formation in vivo are the type of stress (with oxidative stress as a major player), the extent of stress-induced protein misfolding and resulting chaperone, proteasome and autophagy overload, keratin 8 excess, transglutaminase activation with transamidation of keratin 8 and p62 upregulation
What does an interferometer really measure? Including instrument and data characteristics in the reconstruction of the 21cm power spectrum
Combining the visibilities measured by an interferometer to form a
cosmological power spectrum is a complicated process in which the window
functions play a crucial role. In a delay-based analysis, the mapping between
instrumental space, made of per-baseline delay spectra, and cosmological space
is not a one-to-one relation. Instead, neighbouring modes contribute to the
power measured at one point, with their respective contributions encoded in the
window functions. To better understand the power spectrum measured by an
interferometer, we assess the impact of instrument characteristics and analysis
choices on the estimator by deriving its exact window functions, outside of the
delay approximation. Focusing on HERA as a case study, we find that
observations made with long baselines tend to correspond to enhanced low-k
tails of the window functions, which facilitate foreground leakage outside the
wedge, whilst the choice of bandwidth and frequency taper can help narrow them
down. With the help of simple test cases and more realistic visibility
simulations, we show that, apart from tracing mode mixing, the window functions
can accurately reconstruct the power spectrum estimator of simulated
visibilities. We note that the window functions depend strongly on the
chromaticity of the beam, and less on its spatial structure - a Gaussian
approximation, ignoring side lobes, is sufficient. Finally, we investigate the
potential of asymmetric window functions, down-weighting the contribution of
low-k power to avoid foreground leakage. The window functions presented in this
work correspond to the latest HERA upper limits for the full Phase I data. They
allow an accurate reconstruction of the power spectrum measured by the
instrument and can be used in future analyses to confront theoretical models
and data directly in cylindrical space.Comment: 18 pages, 18 figures, submitted to MNRAS. Comments welcome
Direct Optimal Mapping Image Power Spectrum and its Window Functions
The key to detecting neutral hydrogen during the epoch of reionization (EoR)
is to separate the cosmological signal from the dominating foreground
radiation. We developed direct optimal mapping (Xu et al. 2022) to map
interferometric visibilities; it contains only linear operations, with full
knowledge of point spread functions from visibilities to images. Here we
present an FFT-based image power spectrum and its window functions based on
direct optimal mapping. We use noiseless simulation, based on the Hydrogen
Epoch of Reionization Array (HERA) Phase I configuration, to study the image
power spectrum properties. The window functions show power leakage
from the foreground-dominated region into the EoR window; the 2D and 1D power
spectra also verify the separation between the foregrounds and the EoR.
Furthermore, we simulated visibilities from a -complete array and
calculated its image power spectrum. The result shows that the foreground--EoR
leakage is further suppressed below , dominated by the tapering
function sidelobes; the 2D power spectrum does not show signs of the horizon
wedge. The -complete result provides a reference case for future 21cm
cosmology array designs.Comment: Submitted to Ap
Euclid preparation. TBD. Forecast impact of super-sample covariance on 3x2pt analysis with Euclid
Deviations from Gaussianity in the distribution of the fields probed by
large-scale structure surveys generate additional terms in the data covariance
matrix, increasing the uncertainties in the measurement of the cosmological
parameters. Super-sample covariance (SSC) is among the largest of these
non-Gaussian contributions, with the potential to significantly degrade
constraints on some of the parameters of the cosmological model under study --
especially for weak lensing cosmic shear. We compute and validate the impact of
SSC on the forecast uncertainties on the cosmological parameters for the Euclid
photometric survey, obtained with a Fisher matrix analysis, both considering
the Gaussian covariance alone and adding the SSC term -- computed through the
public code PySSC. The photometric probes are considered in isolation and
combined in the `32pt' analysis. We find the SSC impact to be
non-negligible -- halving the Figure of Merit of the dark energy parameters
(, ) in the 32pt case and substantially increasing the
uncertainties on , and for cosmic shear;
photometric galaxy clustering, on the other hand, is less affected due to the
lower probe response. The relative impact of SSC does not show significant
changes under variations of the redshift binning scheme, while it is smaller
for weak lensing when marginalising over the multiplicative shear bias nuisance
parameters, which also leads to poorer constraints on the cosmological
parameters. Finally, we explore how the use of prior information on the shear
and galaxy bias changes the SSC impact. Improving shear bias priors does not
have a significant impact, while galaxy bias must be calibrated to sub-percent
level to increase the Figure of Merit by the large amount needed to achieve the
value when SSC is not included.Comment: 22 pages, 13 figure
Targeting Huntington’s disease through histone deacetylases
Huntington’s disease (HD) is a debilitating neurodegenerative condition with significant burdens on both patient and healthcare costs. Despite extensive research, treatment options for patients with this condition remain limited. Aberrant post-translational modification (PTM) of proteins is emerging as an important element in the pathogenesis of HD. These PTMs include acetylation, phosphorylation, methylation, sumoylation and ubiquitination. Several families of proteins are involved with the regulation of these PTMs. In this review, I discuss the current evidence linking aberrant PTMs and/or aberrant regulation of the cellular machinery regulating these PTMs to HD pathogenesis. Finally, I discuss the evidence suggesting that pharmacologically targeting one of these protein families the histone deacetylases may be of potential therapeutic benefit in the treatment of HD
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