2,979 research outputs found
Full time nonexponential decay in double-barrier quantum structures
We examine an analytical expression for the survival probability for the time
evolution of quantum decay to discuss a regime where quantum decay is
nonexponential at all times. We find that the interference between the
exponential and nonexponential terms of the survival amplitude modifies the
usual exponential decay regime in systems where the ratio of the resonance
energy to the decay width, is less than 0.3. We suggest that such regime could
be observed in semiconductor double-barrier resonant quantum structures with
appropriate parameters.Comment: 6 pages, 5 figure
Local and chain dynamics in miscible polymer blends: A Monte Carlo simulation study
Local chain structure and local environment play an important role in the
dynamics of polymer chains in miscible blends. In general, the friction
coefficients that describe the segmental dynamics of the two components in a
blend differ from each other and from those of the pure melts. In this work, we
investigate polymer blend dynamics with Monte Carlo simulations of a
generalized bond-fluctuation model, where differences in the interaction
energies between non-bonded nearest neighbors distinguish the two components of
a blend. Simulations employing only local moves and respecting a non-bond
crossing condition were carried out for blends with a range of compositions,
densities, and chain lengths. The blends investigated here have long-chain
dynamics in the crossover region between Rouse and entangled behavior. In order
to investigate the scaling of the self-diffusion coefficients, characteristic
chain lengths are calculated from the packing length of the
chains. These are combined with a local mobility determined from the
acceptance rate and the effective bond length to yield characteristic
self-diffusion coefficients . We find that the
data for both melts and blends collapse onto a common line in a graph of
reduced diffusion coefficients as a function of reduced chain
length . The composition dependence of dynamic properties is
investigated in detail for melts and blends with chains of length twenty at
three different densities. For these blends, we calculate friction coefficients
from the local mobilities and consider their composition and pressure
dependence. The friction coefficients determined in this way show many of the
characteristics observed in experiments on miscible blends.Comment: 12 pages, 13 figures, editorial change
Transport inefficiency in branched-out mesoscopic networks: An analog of the Braess paradox
We present evidence for a counter-intuitive behavior of semiconductor
mesoscopic networks that is the analog of the Braess paradox encountered in
classical networks. A numerical simulation of quantum transport in a two-branch
mesoscopic network reveals that adding a third branch can paradoxically induce
transport inefficiency that manifests itself in a sizable conductance drop of
the network. A scanning-probe experiment using a biased tip to modulate the
transmission of one branch in the network reveals the occurrence of this
paradox by mapping the conductance variation as a function of the tip voltage
and position.Comment: 2nd version with minor stylistic corrections. To appear in Phys. Rev.
Lett.: Editorially approved for publication 6 January 201
Entanglements in Quiescent and Sheared Polymer Melts
We visualize entanglements in polymer melts using molecular dynamics
simulation. A bead at an entanglement interacts persistently for long times
with the non-bonded beads (those excluding the adjacent ones in the same
chain). The interaction energy of each bead with the non-bonded beads is
averaged over a time interval much longer than microscopic times but
shorter than the onset time of tube constraints . Entanglements
can then be detected as hot spots consisting of several beads with relatively
large values of the time-averaged interaction energy. We next apply a shear
flow with rate much faster than the entangle motion. With increasing strain the
chains take zigzag shapes and a half of the hot spots become bent. The chains
are first stretched as a network but, as the bends approach the chain ends,
disentanglements subsequently occur, leading to stress overshoot observed
experimentally.Comment: 19 pages, 11 figure
Multi-Channel Transport in Disordered Medium under Generic Scattering Conditions
Our study of the evolution of transmission eigenvalues, due to changes in
various physical parameters in a disordered region of arbitrary dimensions,
results in a generalization of the celebrated DMPK equation. The evolution is
shown to be governed by a single complexity parameter which implies a deep
level of universality of transport phenomena through a wide range of disordered
regions. We also find that the interaction among eigenvalues is of many body
type that has important consequences for the statistical behavior of transport
properties.Comment: 19 Pages, No Figure
Fragility and hysteretic creep in frictional granular jamming
The granular jamming transition is experimentally investigated in a
two-dimensional system of frictional, bi-dispersed disks subject to
quasi-static, uniaxial compression at zero granular temperature. Currently
accepted results show the jamming transition occurs at a critical packing
fraction . In contrast, we observe the first compression cycle exhibits
{\it fragility} - metastable configuration with simultaneous jammed and
un-jammed clusters - over a small interval in packing fraction (). The fragile state separates the two conditions that define
with an exponential rise in pressure starting at and an exponential
fall in disk displacements ending at . The results are explained
through a percolation mechanism of stressed contacts where cluster growth
exhibits strong spatial correlation with disk displacements. Measurements with
several disk materials of varying elastic moduli and friction coefficients
, show friction directly controls the start of the fragile state, but
indirectly controls the exponential slope. Additionally, we experimentally
confirm recent predictions relating the dependence of on . Under
repetitive loading (compression), the system exhibits hysteresis in pressure,
and the onset increases slowly with repetition number. This friction
induced hysteretic creep is interpreted as the granular pack's evolution from a
metastable to an eventual structurally stable configuration. It is shown to
depend upon the quasi-static step size which provides the only
perturbative mechanism in the experimental protocol, and the friction
coefficient which acts to stabilize the pack.Comment: 12 pages, 10 figure
Factors influencing immune response after in vivo retrovirus-mediated gene transfer to the liver.
BACKGROUND: Highly efficient retrovirus-mediated gene transfer into hepatocytes in vivo triggers an immune response directed against transduced hepatocytes. This effect may be due either to spreading of retroviral vectors in the blood stream with subsequent infection of antigen presenting cells (APCs) or to cross-presentation of the transgene product present as a contaminant in the viral stock. In order to decrease immune response, we evaluated the effect of asanguineous perfusion of the liver as well as purification of the viral stock on long-term transduction of hepatocytes using the nls-lacZ marker gene.
METHODS: Animals were divided in four groups. In group 1, the viral supernatant was perfused in the regenerating liver after complete vascular exclusion of the organ. In group 2, using the same strategy, animals received retroviral supernatant that was passed through a beta-galactosidase affinity column to reduce beta-galactosidase contamination. In two control groups (respectively groups 3 and 4) the corresponding viral supernatants were delivered via peripheral injection.
RESULTS: In group 1, 23.1% of animals had no immune response 2 months after gene delivery vs. 33.4% in group 2, 4.3% in control group 3, and 0% in control group 4. Statistical analysis of the results demonstrated that only the difference between groups 2 and 3 was statistically significant. This indicated that both asanguineous perfusion together with passage through an affinity column were required to decrease significantly immune response.
CONCLUSIONS: Our present results suggest that both supernatant contamination and viral spreading contribute to immune response after retrovirus-mediated gene delivery to the liver
Quantum mechanics of lattice gas automata. I. One particle plane waves and potentials
Classical lattice gas automata effectively simulate physical processes such
as diffusion and fluid flow (in certain parameter regimes) despite their
simplicity at the microscale. Motivated by current interest in quantum
computation we recently defined quantum lattice gas automata; in this paper we
initiate a project to analyze which physical processes these models can
effectively simulate. Studying the single particle sector of a one dimensional
quantum lattice gas we find discrete analogues of plane waves and wave packets,
and then investigate their behaviour in the presence of inhomogeneous
potentials.Comment: 19 pages, plain TeX, 14 PostScript figures included with epsf.tex
(ignore the under/overfull \vbox error messages), two additional large
figures available upon reques
Dynamics of Strongly Deformed Polymers in Solution
Bead spring models for polymers in solution are nonlinear if either the
finite extensibility of the polymer, excluded volume effects or hydrodynamic
interactions between polymer segments are taken into account. For such models
we use a powerful method for the determination of the complete relaxation
spectrum of fluctuations at {\it steady state}. In general, the spectrum and
modes differ significantly from those of the linear Rouse model. For a tethered
polymer in uniform flow the differences are mainly caused by an inhomogeneous
distribution of tension along the chain and are most pronounced due to the
finite chain extensibility. Beyond the dynamics of steady state fluctuations we
also investigate the nonlinear response of the polymer to a {\em large sudden
change} in the flow. This response exhibits several distinct regimes with
characteristic decay laws and shows features which are beyond the scope of
single mode theories such as the dumbbell model.Comment: 7 pages, 3 figure
On the origin of the -transition in liquid Sulphur
Developing a novel experimental technique, we applied photon correlation
spectroscopy using infrared radiation in liquid Sulphur around ,
i.e. in the temperature range where an abrupt increase in viscosity by four
orders of magnitude is observed upon heating within few degrees. This allowed
us - overcoming photo-induced and absorption effects at visible wavelengths -
to reveal a chain relaxation process with characteristic time in the ms range.
These results do rehabilitate the validity of the Maxwell relation in Sulphur
from an apparent failure, allowing rationalizing the mechanical and
thermodynamic behavior of this system within a viscoelastic scenario.Comment: 5 pages, 4 eps figures, accepted in Phys. Rev. Let
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